Journal
ALZHEIMERS & DEMENTIA
Volume 10, Issue 1, Pages 93-98Publisher
WILEY
DOI: 10.1016/j.jalz.2013.01.003
Keywords
Subjective cognition; Preclinical Alzheimer's disease; Mild cognitive impairment; Cognitive aging
Categories
Funding
- NIA [R01AG031581, P30AG19610]
- Arizona Alzheimer's Consortium
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Background: It is unclear whether self- or informant-based subjective cognition better distinguishes emotional factors from early-stage Alzheimer's disease (AD). Methods: Healthy members (n = 447) of the Arizona apolipoprotein E (APOE) cohort and their informants completed the self and informant paired Multidimensional Assessment of Neurodegenerative Symptoms questionnaire (MANS). Results: Decline on the MANS was endorsed by 30.6% of members and 26.2% of informants. Self- and informant-based decliners had higher scores of psychological distress and slightly lower cognitive scores than nondecliners. Over the next 6.7 years, 20 developed mild cognitive impairment (MCI). Converters were older at entry than nonconverters (63.8 [7.0] vs 58.8 [7.3] years, P = .003), 85% were APOE epsilon 4 carriers (P < .0001), and they self-endorsed decline earlier than informants (58.9 [39.2] vs 28.0 [40.4] months before MCI; P = .002). Conclusions: Self-and informant-based subjective decline correlated with greater psychological distress and slightly lower cognitive performance. Those with incident MCI generally self-endorsed decline earlier than informants. (C) 2014 The Alzheimer's Association. All rights reserved.
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