Article
Biochemistry & Molecular Biology
Zeinab Khademi, Sanaz Pourreza, Soudabeh Hamedi-Shahraki, Farshad Amirkhizi
Summary: The present study found that serum levels of selenium (Se) and selenoprotein-P (SePP) were positively correlated with serum adiponectin and visfatin levels, and negatively correlated with markers of glucose metabolism. However, there was no significant correlation between serum Se and SePP levels and serum omentin-1 levels.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Geriatrics & Gerontology
Insiya B. Poonawalla, Yihua Xu, Rainelle Gaddy, Alex James, Matt Ruble, Salina Burns, Suzanne W. Dixon, Brandon T. Suehs
Summary: The use of anticholinergic medications is linked to an increased risk of cognitive decline in the elderly. However, little is known about this association from a health plan perspective.
Article
Geriatrics & Gerontology
Marjaana Koponen, Blair Rajamaki, Piia Lavikainen, J. Simon Bell, Heidi Taipale, Antti Tanskanen, Sirpa Hartikainen, Anna-Maija Tolppanen
Summary: This study assessed whether antipsychotic initiation increases the risk of stroke in individuals with Alzheimer's disease (AD) and whether there is a difference in stroke risk between the two most commonly used antipsychotics, risperidone and quetiapine. The results showed that antipsychotic use was associated with an increased risk of stroke within 60 days of initiation, but there was no significant overall association between antipsychotic use and stroke risk. There was also no difference in stroke risk between risperidone and quetiapine.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Endocrinology & Metabolism
Karina Gasbarrino, Anouar Hafiane, Ioanna Gianopoulos, Huaien Zheng, Christos S. Mantzoros, Stella S. Daskalopoulou
Summary: This study found a positive association between circulating adiponectin and cholesterol efflux capacity, and high cholesterol efflux capacity was associated with more favorable post-surgical outcomes.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Genetics & Heredity
Aiym Kaiyrlykyzy, Bauyrzhan Umbayev, Abdul-Razak Masoud, Aida Baibulatova, Andrey Tsoy, Farkhad Olzhayev, Dinara Alzhanova, Gulnaz Zholdasbekova, Kairat Davletov, Ainur Akilzhanova, Sholpan Askarova
Summary: This study investigated the levels of adiponectin, methylation of the adiponectin gene promoter, and expression of adiponectin receptors in blood samples from Alzheimer's disease (AD) patients and healthy controls. The results showed higher levels of adiponectin in AD patients, with a positive correlation between adiponectin and MMSE scores and high-density lipoprotein cholesterol. The study also found differences in methylation of the adiponectin gene promoter and higher levels of AdipoR1 in AD patients. These findings contribute to a better understanding of the factors contributing to dementia and the development of predictive biomarkers for AD.
BMC MEDICAL GENOMICS
(2022)
Article
Neurosciences
Malin Wennstrom, Shorena Janelidze, K. Peter R. Nilsson, Geidy E. Serrano, Thomas G. Beach, Jeffrey L. Dage, Oskar Hansson
Summary: Recent studies have identified p-tau217 as a potential plasma biomarker for Alzheimer's disease (AD), but its relationship with specific brain pathological events is still unclear. This study found that p-tau217 is mainly found in neurofibrillary tangles and neuropil threads, and differs from other p-tau variants. Individuals with a high likelihood of AD had significantly higher p-tau217 levels in specific brain areas and these levels correlated with amyloid-beta and NFT brain load. Additionally, the levels of p-tau217 in plasma correlated with its concentrations in individuals with amyloid plaques.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Georgios K. Vasileiadis, Anna-Carin Lundell, Yuan Zhang, Kerstin Andersson, Inger Gjertsson, Anna Rudin, Cristina Maglio
Summary: The study found a positive association between total adiponectin and pro-inflammatory chemokines, as well as markers of inflammation in patients with untreated newly diagnosed RA. However, high-molecular weight adiponectin was only associated with specific chemokines. Leptin and resistin showed no association with plasma chemokines, markers of inflammation, or disease activity scores.
Article
Medicine, General & Internal
Jiazhen Zheng, Can Ni, Yingchai Zhang, Jinghan Huang, Daniel Nyarko Hukportie, Buwen Liang, Shaojun Tang
Summary: Using large-scale observational and Mendelian randomization analyses, the study finds evidence of potential causal associations between glucosamine use and lower risk for dementia. However, further validation through randomized controlled trials is needed.
Review
Geriatrics & Gerontology
Jun-hui Tong, Shi-qiang Gong, Yan-song Zhang, Jian-ru Dong, Xin Zhong, Min-jie Wei, Ming-yan Liu
Summary: With the development of medicine, research on Alzheimer's disease (AD) has deepened, but the mechanism of occurrence and development is still not fully understood, and there is no effective treatment. Apolipoprotein AI (ApoA-I) has been found to affect the development of AD by binding to amyloid beta (A beta), but the relationship between circulating levels of ApoA-I and AD is still controversial. A meta-analysis of 18 studies found that serum and plasma levels of ApoA-I were significantly reduced in AD patients, suggesting ApoA-I deficiency as a potential risk factor for AD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Huanquan Liao, Dong Pan, Zhenhong Deng, Jingru Jiang, Jinhua Cai, Ying Liu, Baixuan He, Ming Lei, Honghong Li, Yi Li, Yongteng Xu, Yamei Tang
Summary: This study found that shift work is associated with an increased risk of dementia, but night shift work is not significantly associated with dementia risk. The increased incidence of dementia in shift workers does not differ between participants with different genetic susceptibility to dementia.
Article
Nutrition & Dietetics
Huei-Ying Chiu, Hsin-Te Chang, Po-Chi Chan, Pai-Yi Chiu
Summary: This study conducted a retrospective analysis on post-menopausal women and found that the lowest quartile of total cholesterol levels increased the risk of developing dementia, while hormone replacement therapy did not have an impact on dementia conversion.
Article
Endocrinology & Metabolism
Mika Hasegawa, Jumpei Taniguchi, Hiromichi Ueda, Mikio Watanabe
Summary: In this study, the methylation level of CpG sites was examined as an environmental factor affecting adiponectin levels using monozygotic twins with the same genetic background. Epigenetic factors and genetic factors associated with sensitivity to acquired changes in adiponectin were identified.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Rheumatology
Yi-Lin Dan, Peng Wang, Zhongle Cheng, Qian Wu, Xue-Rong Wang, De-Guang Wang, Hai-Feng Pan
Summary: The study used Mendelian randomization analysis to investigate the causal relationship between circulating adiponectin levels and the risk of SLE, and found no significant association between the two factors. The results suggest that circulating adiponectin levels may not be a causal factor for SLE, and support the absence of a significant relationship between circulating adiponectin levels and the risk of SLE.
Article
Neurosciences
Oscar Hou In Chou, Jiandong Zhou, Lifang Li, Jeffrey Shi Kai Chan, Danish Iltaf Satti, Vanessa Hou Cheng Chou, Wing Tak Wong, Sharen Lee, Bernard Man Yung Cheung, Gary Tse, Carlin Chang, Tong Liu
Summary: This retrospective population-based cohort study aimed to explore the association between neutrophil-to-lymphocyte ratio (NLR) and dementia. The results showed that patients with NLR >5.44 had an increased risk of developing Alzheimer's disease and related dementia, but not non-Alzheimer's dementia. Utilizing baseline NLR during family medicine consultation may help predict the risks of dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Shuqi Wang, Jiao Wang, Abigail Dove, Jie Guo, Wenzhe Yang, Xiuying Qi, David A. Bennett, Weili Xu
Summary: This study found that impaired kidney function is associated with an increased risk of dementia, particularly Alzheimer's dementia. Additionally, impaired kidney function is significantly related to a higher burden of cerebral amyloid angiopathy, but not other brain pathologies.
ALZHEIMERS & DEMENTIA
(2023)
