Review
Environmental Sciences
Nuria Molist-Brunet, Daniel Sevilla-Sanchez, Emma Puigoriol-Juvanteny, Lorena Bajo-Penas, Immaculada Cantizano-Baldo, Laia Cabanas-Collell, Joan Espaulella-Panicot
Summary: This study compared the impact of place of residence (own home versus nursing home) on the characteristics of the baseline therapeutic plan and post-medication review (MR) therapeutic plan in older patients. The results showed that nursing home patients had a greater improvement in pharmacological parameters related to adverse events after an individualized MR.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Nursing
Binbin Yong, Rongjin Lin, Huimin Xiao
Summary: This systematic review examined the factors associated with adjustment to living in a care facility and identified six distinct categories of related factors. The study suggests taking into account decision-making control, self-efficacy, social support, activities of daily living, and length of stay when assisting residents with relocation to a nursing home. Further research in multiple areas can help improve nursing home adjustment, interventions, and health policies.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2021)
Article
Pharmacology & Pharmacy
Ho Jin Cho, Jungmi Chae, Sang-Heon Yoon, Dong-Sook Kim
Summary: This study evaluated the prevalence of polypharmacy and hyper-polypharmacy in elderly patients in South Korea from 2010 to 2019. The results showed that the prevalence of polypharmacy remained stably high, while the prevalence of hyper-polypharmacy increased over the past 10 years. Therefore, strategies to address polypharmacy need to be implemented, and further research on the clinical outcomes associated with polypharmacy is required.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Geriatrics & Gerontology
Antoinette B. Coe, Karen B. Farris, Erica Solway, Dianne C. Singer, Matthias Kirch, Jeffrey T. Kullgren, Preeti N. Malani, Julie P. W. Bynum
Summary: This study aimed to investigate the receipt of comprehensive medication review (CMR) among older adults and factors associated with it. The results showed that most older adults on multiple medications had not received a CMR, but many were interested in it. Furthermore, the study found that receiving a CMR was associated with taking multiple medications and food insecurity, while poor self-reported physical health was associated with a lower likelihood of receiving a CMR.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Eva Sonnerstam, Maria Gustafsson, Hugo Lovheim
Summary: The study investigated the use of potentially inappropriate medications among older adults in nursing homes. The results showed that while such medication use is common, it is only mildly associated with the length of nursing home stay. Antipsychotics were found to be the most commonly prescribed drug class in the study.
Article
Nutrition & Dietetics
Felipe Mozo-Alonso, Jose P. Novalbos-Ruiz, Juan C. Duran-Alonso, Amelia Rodriguez-Martin
Summary: A study in the Cadiz region of Spain focused on the nutritional status of individuals over 65 who are not institutionalized, revealing a high prevalence of overweight and obesity at 82.2%. The study also identified a negative relationship between physical activity, having full dinners, and the prevalence of overweight and obesity.
Article
Geriatrics & Gerontology
Manav V. Vyas, Jennifer A. Watt, Amy Y. X. Yu, Sharon E. Straus, Moira K. Kapral
Summary: The study found that loneliness in older adults is associated with increased daily use of opioids and benzodiazepines, but not with non-opioid analgesics. Additionally, loneliness is associated with polypharmacy.
Article
Geriatrics & Gerontology
Shanna C. Trenaman, Susan K. Bowles, Susan Kirkland, Melissa K. Andrew
Summary: Prescribing cascades in older adults with dementia were studied using administrative databases in Nova Scotia. It was found that the combination of diuretics following CCB was the most common prescribing cascade and bladder anticholinergics following cholinesterase inhibitors the second most common. Women were more likely to be associated with the risk of bladder anticholinergics following cholinesterase inhibitors and diuretics following CCBs. However, exposure to the inciting medications did not increase the risk of exposure to the second treatments.
Article
Health Care Sciences & Services
Thomas Byrne, Jill S. Roncarati, Daniel P. Miller
Summary: This study examines the risk factors for nursing home admission among older adults who first entered an emergency shelter, finding that older age, alcohol use disorder, overall disease burden, and prior history of nursing home admission are associated with higher risk.
Article
Geriatrics & Gerontology
Avantika Saraf Shah, Emily Kay Hollingsworth, Matthew Stephen Shotwell, Amanda S. Mixon, Sandra Faye Simmons, Eduard Eric Vasilevskis
Summary: A multipronged approach was used to obtain the best possible medication history (BPMH) for hospitalized older adults, revealing high prevalence of medication discrepancies in the study cohort. Factors such as lower age, greater prehospital medication count, and admission from assisted living or skilled nursing facility were significantly associated with greater medication discrepancies. These findings highlight the importance of addressing medication discrepancies prior to hospital discharge in order to support safe prescribing practices for multimorbid older adults.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Pharmacology & Pharmacy
Sarah N. Hilmer, Sarita Lo, Patrick J. Kelly, Rosalie Viney, Fiona M. Blyth, David G. Le Couteur, Andrew J. McLachlan, Sheena Arora, Lutfun Hossain, Danijela Gnjidic
Summary: This study comprehensively investigates the prescribing practices for hospitalized older people, focusing on polypharmacy, potentially inappropriate medications (PIMs) based on Beers criteria, and cumulative exposure to anticholinergic and sedative medications using the Drug Burden Index (DBI). The study aims to quantify the exposure to these measures on admission, analyze changes between admission and discharge, and assess the associations with adverse outcomes and medication costs. The findings show an increase in the number of medications during hospitalization and slight reductions in PIMs and DBI, with varying associations with adverse outcomes.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Geriatrics & Gerontology
Ji Won Lee, Mengchi Li, Cynthia M. Boyd, Ariel R. Green, Sarah L. Szanton
Summary: This article provides a systematic review on the evidence of preoperative deprescribing and its impact on postoperative outcomes in older adults. The review shows that preoperative deprescribing can have positive or neutral effects on the outcomes of older adults undergoing surgery.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Pharmacology & Pharmacy
Taylor Elliott, Lynne Eckmann, Daniela C. Moga
Summary: Factors contributing to increased clinical complexity in older adults include potentially inappropriate use of anticholinergic medications, polypharmacy, and communication barriers among members of the healthcare team. The case presented highlights the challenges posed by a patient with a complex medical history.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Jonathan D. Norton, Chan Zeng, Elizabeth A. Bayliss, Susan M. Shetterly, Nicole Williams, Emily Reeve, Matthew K. Wynia, Ariel R. Green, Melanie L. Drace, Kathy S. Gleason, Orla C. Sheehan, Cynthia M. Boyd
Summary: This study conducted a survey of primary care physicians to understand the factors influencing their decisions to deprescribe medications for older adults with moderate dementia. The results showed that patient or family reports and prescriptions from other physicians were the greatest barriers to deprescribing.
Article
Surgery
Timothy R. Holden, Bradley S. Kushner, Julia L. Hamilton, Britta Han, Sara E. Holden
Summary: This study found that polypharmacy is common in older adults undergoing TAR and is associated with in-hospital complications, postoperative delirium, cardiac events, ICU stay, length of stay, and discharge to a skilled nursing facility.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Nutrition & Dietetics
Gianluca Gortan Cappellari, Christelle Guillet, Eleonora Poggiogalle, Maria D. Ballesteros Pomar, John A. Batsis, Yves Boirie, Irene Breton, Stefano Frara, Laurence Genton, Yftach Gepner, Maria Cristina Gonzalez, Steven B. Heyms, Eva Kiesswetter, Alessandro Laviano, Carla M. Prado, Ferruccio Santini, Mireille J. Serlie, Mario Siervo, Dennis T. Villareal, Dorothee Volkert, Trudy Voortman, Peter J. M. Weijs, Mauro Zamboni, Stephan C. Bischoff, Luca Busetto, Tommy Cederholm, Rocco Barazzoni, Lorenzo M. Donini
Summary: The European Society for Clinical Nutrition and Metabolism (ESPEN) and the European Association for the Study of Obesity (EASO) launched the Sarcopenic Obesity Global Leadership Initiative (SOGLI) to reach expert consensus on a definition and diagnostic criteria for Sarcopenic Obesity (SO). The present paper describes the proceeding of the Sarcopenic Obesity Global Leadership Initiative (SOGLI) meeting that was held on November 25th and 26th, 2022 in Rome, Italy. This consortium involved the participation of 50 researchers from different geographic regions and countries. The document outlines an agenda advocated by the SOGLI expert panel regarding the pathophysiology, screening, diagnosis, staging, and treatment of SO that needs to be prioritized for future research in the field.
CLINICAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Riccardo Calvani, Jacopo Gervasoni, Anna Picca, Francesca Ciciarello, Vincenzo Galluzzo, Helio Jose Coelho-Junior, Clara Di Mario, Elisa Gremese, Sara Lomuscio, Anna Maria Paglionico, Lavinia Santucci, Barbara Tolusso, Andrea Urbani, Federico Marini, Emanuele Marzetti, Francesco Landi, Matteo Tosato
Summary: Altered L-arginine metabolism and lower nitric oxide (NO) bioavailability were observed in adults with long COVID. Supplementation of L-arginine plus vitamin C significantly increased L-arginine concentrations and L-arginine/ADMA in these individuals, suggesting its potential as a remedy to improve NO bioavailability in long COVID patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Stefano Cacciatore, Riccardo Calvani, Emanuele Marzetti, Anna Picca, Helio Jose Coelho-Junior, Anna Maria Martone, Claudia Massaro, Matteo Tosato, Francesco Landi
Summary: Muscle strength is associated with aging. While the relationship between adherence to Mediterranean diet and muscle strength in older adults remains inconclusive, this study found that those with higher adherence to Mediterranean diet had a lower risk of probable sarcopenia.
Article
Biochemistry & Molecular Biology
Helio Jose Coelho-Junior, Riccardo Calvani, Anna Picca, Matteo Tosato, Giulia Savera, Francesco Landi, Emanuele Marzetti
Summary: The study aimed to investigate the relationship between protein intake and blood pressure, glucose levels, and blood cholesterol in a large sample of Italian older adults. The findings showed that high protein intake was negatively associated with diastolic blood pressure and positively associated with total blood cholesterol levels in a large cohort of Italian older adults.
Article
Neurosciences
Alessio Simonetti, Evelina Bernardi, Stella Margoni, Antonello Catinari, Antonio Restaino, Valentina Ieritano, Marta Palazzetti, Federico Mastrantonio, Delfina Janiri, Matteo Tosato, Francesco Landi, Gabriele Sani
Summary: This study aimed to compare the burden of post-COVID-19 syndrome in depressed and non-depressed patients and investigate the correlation between the burden of post-COVID-19 syndrome and the severity of mixed depression. The findings showed that patients with depression had higher burden of post-COVID-19 syndrome and the severity of mixed depression was associated with the frequency of syndrome symptoms. These findings can help clinicians choose appropriate treatment options.
Article
Public, Environmental & Occupational Health
Marina Giuliano, Dorina Tiple, Piergiuseppe Agostoni, Benedetta Armocida, Ludovico Biardi, Anna Rita Bonfigli, Andrea Campana, Maria Ciardi, Fabiano Di Marco, Marco Floridia, Paola Gnerre, Tiziana Grassi, Ignazio Grattagliano, Paola Kruger, Matilde Leonardi, Rocco Liguori, Elisabetta Pagani, Elisa Perger, Flavia Pricci, Marinella Ruggeri, Andrea Silenzi, Francesco Spannella, Carlo Tascini, Giulia Tete, Matteo Tosato, Simona Vecchi, Marika Villa, Graziano Onder
Summary: A significant number of people experience persistent or new symptoms after acute SARS-CoV-2 infection, known as Long-COVID. In Italy, dedicated health facilities were established for the management of Long-COVID, but there is significant variation in the services provided. To address this, a multidisciplinary panel was formed to create recommendations for the clinical management of Long-COVID.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Health Care Sciences & Services
Helio Jose Coelho-Junior, Riccardo Calvani, Anna Picca, Matteo Tosato, Francesco Landi, Emanuele Marzetti
Summary: The study aimed to examine the relationship between adherence to specific exercise modalities and the severity of sarcopenia in older adults in Italy. The data was collected as part of the Longevity Check-Up 7+ (Lookup 7+) project. The results showed that engagement in running and/or swimming and strength training with or without stretching had a positive impact on reducing the severity of sarcopenia in older adults.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Critical Care Medicine
Teresa Michi, Chiara Mattana, Luca Menga, Maria Grazia Bocci, Melania Cesarano, Tommaso Rosa, Maria Rosaria Gualano, Jonathan Montomoli, Savino Spadaro, Matteo Tosato, Elisabetta Rota, Francesco Landi, Salvatore Cutuli, Eloisa Tanzarella, Gabriele M. Pintaudi, Edoardo Piervincenzi, Giuseppe Bello, Tommaso Tonetti, Paola Rucci, Gennaro De Pascale, Salvatore Maggiore, Domenico Luca Grieco, Giorgio Conti, Massimo Antonelli
Summary: This study assessed the 6-month outcomes of COVID-19 hypoxemic respiratory failure patients treated with helmet noninvasive ventilation (NIV) or high-flow nasal oxygen. The results showed similar quality of life and functional outcomes for both treatment methods. Worse outcomes were associated with the need for invasive mechanical ventilation. These data suggest that helmet NIV can be safely used in hypoxemic patients.
JOURNAL OF INTENSIVE CARE
(2023)
Article
Health Care Sciences & Services
Aysan Mahmoudi Asl, Suzanne Kouters, Alvaro Castro-Gonzalez, Henriette Van der Roest, Manuel Franco Martin, Rose-Marie Droes
Summary: Investigated stakeholders' attitude, facilitators, and barriers to implementing the social robot MINI in community-based meeting centers for people with dementia and carers. Found that key facilitators included human resources, funding, impact on users and programs, innovation characteristics, and collaboration. However, barriers included physical context and functionalities, user context, and activity policies.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Health Care Sciences & Services
Antonella Gallo, Marcello Covino, Alice Lipari, Simona Pellegrino, Francesca Ibba, Maria Chiara Agnitelli, Matteo Tosato, Francesco Landi, Massimo Montalto
Summary: This retrospective analysis examines the long-term impact of COVID-19 disease and finds that patients infected with COVID-19 require more chronic medication treatment. Disease severity and age are identified as the best predictors for an increase in medication usage, while anti-SARS-CoV-2 vaccination provides significant protection. Multidisciplinary and integrated care pathways should be implemented for older, frail patients and those with severe disease.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Alessio Simonetti, Cristina Pais, Vezio Savoia, Maria Camilla Cipriani, Matteo Tosato, Delfina Janiri, Evelina Bernardi, Ottavia Marianna Ferrara, Stella Margoni, Georgios D. Kotzalidis, Daniela Chieffo, Massimo Fantoni, Rosa Liperoti, Francesco Landi, Roberto Bernabei, Gabriele Sani
Summary: DEL and DEP may impair the course and severity of acute respiratory illness in inpatients with COVID-19. Delirium has a more severe impact on COVID-19 compared to depression.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Andrea Grandieri, Caterina Trevisan, Susanna Gentili, Davide Liborio Vetrano, Giuseppe Liotta, Stefano Volpato
Summary: The prevalence of non-communicable diseases, especially among older individuals, has increased in recent years, leading to the need for complex drug regimens. However, many patients struggle with medication adherence. This study examined the relationship between interest in medication adherence, health literacy, and self-care, and how it changed during the COVID-19 pandemic.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Calogero Casa, Barbara Corvari, Francesco Cellini, Patrizia Cornacchione, Andrea D'Aviero, Sara Reina, Silvia Di Franco, Alessandra Salvati, Giuseppe Ferdinando Colloca, Alfredo Cesario, Stefano Patarnello, Mario Balducci, Alessio Giuseppe Morganti, Vincenzo Valentini, Maria Antonietta Gambacorta, Luca Tagliaferri
Summary: During the COVID-19 pandemic, the Radiation Oncology Department in Italy implemented an eHealth platform for televisit/monitoring/consultation to reduce patient exposure to the virus. Data collected from patients who underwent televisit/teleconsultation showed that the eHealth system was useful and user-friendly. Further research is needed to support widespread adoption.
Article
Geriatrics & Gerontology
Alberto Pilotto, Carlo Custodero, Katie Palmer, Elisabet Maria Sanchez-Garcia, Eva Topinkova, Maria Cristina Polidor
Summary: This article describes the evidence on the usefulness of a Comprehensive Geriatric Assessment (CGA)-based approach during the COVID-19 pandemic. The multidimensional, CGA-based approach allows better identification of individual risk profiles and frailty status of infected, recovered but with a post-COVID-19 condition, and non-infected older adults. Capturing older patients' needs through CGA may offer the possibility to guide clinical decision and implement personalized medicine.
EUROPEAN GERIATRIC MEDICINE
(2023)
Article
Geriatrics & Gerontology
Helio Jose Coelho-Junior, R. Calvani, A. Picca, G. Savera, M. Tosato, F. Landi, E. Marzetti
Summary: This study examines the relationships between protein intake from different food sources and cardiometabolic risk markers in older Italian adults. The results suggest that the association between dietary protein and cardiometabolic risk factors depends on sex and the specific food sources.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
