Review
Cardiac & Cardiovascular Systems
Thomas A. Kite, Andrew Ladwiniec, J. Ranjit Arnold, Gerry P. McCann, Alastair J. Moss
Summary: NSTE-ACS presents a wide range of diseases, making accurate diagnosis challenging and potentially leading to unnecessary ICA. Better risk stratification and more research are needed to improve patient management in both invasive and non-invasive strategies.
Article
Cardiac & Cardiovascular Systems
Henrique Andrade R. Fonseca, Remo Holanda M. Furtado, Andre Zimerman, Pedro A. Lemos, Marcelo Franken, Frederico Monfardini, Rodrigo P. Pedrosa, Rodrigo de Lemos S. Patriota, Luiz Carlos S. Passos, Frederico Toledo C. Dall'Orto, Conrado R. Hoffmann Filho, Bruno Ramos Nascimento, Felipe A. Baldissera, Cesar Augusto C. Pereira, Paulo Ricardo A. Caramori, Pedro Beraldo de Andrade, Carlos Esteves, Elke Ferreira Salim, Jefferson Henrique da Silva, Izabela Chave Pedro, Mariana Castaldi R. Silva, Ewerton Hernandes de Pedri, Ana Carla R. D. Carioca, Luciana Pereira A. de Piano, Camila Santos N. Albuquerque, Diogo D. F. Moia, Roberta Grazzielli R. A. P. Momesso, Felipe P. Machado, Lucas P. Damiani, Ronaldo Vicente P. Soares, Guilherme P. Schettino, Luiz Rizzo, Jose Carlos Nicolau, Otavio Berwanger
Summary: This study aimed to evaluate whether double-dose influenza vaccination during hospitalization for acute coronary syndrome (ACS) would further reduce the risk of major cardiopulmonary events. The results showed that double-dose influenza vaccination before discharge did not reduce cardiopulmonary outcomes compared with standard-dose vaccination in the outpatient setting.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Sunga Bae, Jung-Joon Cha, Subin Lim, Hyeon Kim, Hyung Joon Joo, Jae Hyoung Park, Soon Jun Hong, Cheol Woong Yu, Do-Sun Lim, Yongcheol Kim, Woong Chol Kang, Eun Jeong Cho, Sang Yeub Lee, Sang Wook Kim, Eun-Seok Shin, Seung Ho Hur, Seok Kyu Oh, Seong-Hoon Lim, Hyo-Soo Kim, Young Joon Hong, Youngkeun Ahn, Myung Ho Jeong, Tae Hoon Ahn
Summary: This study aimed to investigate the effect of invasive strategy timing from the time of symptom onset on the clinical outcomes of patients with NSTEMI. The results showed that an early invasive strategy was associated with a decreased risk for all-cause mortality in these patients. Further research is needed to validate these findings.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Medicine, General & Internal
Michael Ayad, Karice Hyun, Mario D'Souza, Julie Redfern, Janice Gullick, Mark Ryan, David B. Brieger
Summary: The study found that ACS patients presenting to hospitals with invasive coronary angiography availability were more likely to undergo catheterisation procedures. However, patients with similar baseline characteristics and major adverse cardiovascular events, as well as all-cause death rates, were observed regardless of the hospital's capability for catheterisation. This suggests equitable management of ACS patients across Australia.
MEDICAL JOURNAL OF AUSTRALIA
(2021)
Article
Cardiac & Cardiovascular Systems
Manan Pareek, Kristian H. Kragholm, Anna Meta Dyrvig Kristensen, Muthiah Vaduganathan, Jannik L. Pallisgaard, Christina Byrne, Tor Biering-Sorensen, Christina Ji-Young Lee, Anders Nissen Bonde, Martin Bodtker Mortensen, Michael Maeng, Emil L. Fosbol, Lars Kober, Niels Thue Olsen, Gunnar H. Gislason, Deepak L. Bhatt, Christian Torp-Pedersen
Summary: The study found that individuals suspected of acute coronary syndrome who had consecutively elevated high-sensitivity troponin concentrations had the highest risk of death, while those with consecutively normal hsTnT concentrations had very low mortality rates, regardless of changes between measurements.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Matthew G. L. Williams, Amardeep Dastidar, Kate Liang, Thomas W. Johnson, Anna Baritussio, Julian Strange, Nikhil Joshi, Stephen Dorman, Estefania De Garate, Lucrezia Spagnoli, Emiliano Fiori, Christopher Lawton, Giovanni Biglino, Sven Plein, Chiara Bucciarelli-Ducci
Summary: This study evaluates the impact of sex on clinical presentation and outcome in patients with suspected ACS and non-obstructive coronary arteries. The results show that sex does not have a significant effect on all-cause mortality, but men are more likely to have non-ischemic causes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Thuy Mi Nguyen, Daniela Melichova, Eivind W. Aabel, Oyvind H. Lie, Lars Gunnar Klaeboe, Bjornar Grenne, Benthe Sjoli, Harald Brunvand, Kristina Haugaa, Thor Edvardsen
Summary: This study aimed to compare long-term outcomes between NSTEMI and STEMI patients in Southern Norway. The results showed that mortality remained high and unchanged in NSTEMI patients, while mortality decreased in STEMI patients over a decade of treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Masatsugu Miyagawa, Riku Arai, Kurara Takahashi, Yuki Nakajima, Shohei Migita, Saki Mizobuchi, Yudai Tanaka, Katsunori Fukumoto, Tomoyuki Morikawa, Takashi Mineki, Keisuke Kojima, Nobuhiro Murata, Mitsumasa Sudo, Yasuo Okumura
Summary: This study aimed to examine the clinical role of non-gated CT in ruling out fatal chest pain in NSTE-ACS patients. The results showed that NSTE-ACS patients with perfusion defects on non-gated CT had a shorter time from arrival to coronary angiography and lower peak CK levels.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nuo Si, Ke Shi, Na Li, Xiaolin Dong, Chentao Zhu, Yan Guo, Jiesi Hu, Jingjing Cui, Fan Yang, Tong Zhang
Summary: The radiomics analysis of PCAT captured by CCTA showed superior performance in discriminating acute MI from UA, indicating its potential clinical value.
EUROPEAN RADIOLOGY
(2022)
Article
Medicine, General & Internal
Sivabaskari Pasupathy, Sarena La, Rosanna Tavella, Christopher Zeitz, Matthew Worthley, Ajay Sinhal, Margaret Arstall, John F. Beltrame
Summary: This study compares the chest pain characteristics between MINOCA and MICAD patients and finds no significant differences in terms of pain location, quality, associated symptoms, or duration. This suggests that the chest pain experienced by MINOCA patients is similar to that of MICAD patients, indicating an ischemic nature.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Erik Bjorklund, Carl Johan Malm, Susanne J. Nielsen, Emma C. Hansson, Hans Tygesen, Birgitta S. Romlin, Andreas Martinsson, Elmir Omerovic, Aldina Pivodic, Anders Jeppsson
Summary: This study compared clinical outcomes of patients with acute coronary syndrome treated with aspirin and ticagrelor vs aspirin alone after artery bypass grafting. The results showed that dual antiplatelet therapy did not significantly reduce major adverse cardiovascular events compared with aspirin monotherapy, but was associated with an increased risk of major bleeding. Further research is needed to determine optimal antiplatelet therapy in this group.
Article
Multidisciplinary Sciences
Luiz Sergio Fernandes de Carvalho, Gustavo Alexim, Ana Claudia Cavalcante Nogueira, Marta Duran Fernandez, Tito Barbosa Rezende, Sandra Avila, Ricardo Torres Bispo Reis, Alexandre Anderson Munhoz Soares, Andrei Carvalho Sposito
Summary: Acute coronary syndrome (ACS) is a common cause of death in individuals older than 55 years. Young individuals with ACS (yACS) have unique epidemiologic features and require specific prediction rules to improve time-dependent prediction metrics. By exploring temporal framing structures and using subgroup-specific prediction rules, the predictive accuracy for adverse clinical events in yACS can be optimized, leading to a higher detection rate compared to using rules designed for the global cohort.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Aleksandra Milovancev, Milovan Petrovic, Viseslav Popadic, Tatjana Miljkovic, Slobodan Klasnja, Predrag Djuran, Aleksandra Ilic, Mila Kovacevic, Anastazija Stojsic Milosavljevic, Milica Brajkovic, Bogdan Crnokrak, Lidija Memon, Ana Milojevic, Zoran Todorovic, Milenko Cankovic, Mirka Lukic Sarkanovic, Snezana Bjelic, Snezana Tadic, Aleksandar Redzek, Marija Zdravkovic
Summary: ACS in COVID-19 patients is associated with worse outcomes. This study found that COVID-19 ACS patients had more comorbidities and unfavorable clinical characteristics on admission, as well as higher rates of major complications and mortality compared to non-COVID ACS patients. Aortic regurgitation, serum creatinine levels, and respiratory failure therapy were the strongest predictors of mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Pedro Luis Cepas-Guillen, Julio Echarte-Morales, Guillem Caldentey, Eduardo Martinez Gomez, Eduardo Flores-Umanzor, Javier Borrego-Rodriguez, Marc Llagostera, Ana Viana Tejedor, Pablo Vidal, Tomas Benito-Gonzalez, Xavier Quiroga, Antonio Fernandez Ortiz, Xavier Freixa, Armando Perez de Prado, Francisco Noriega Sanz, Felipe Fernandez-Vazquez, Manel Sabate
Summary: This study aimed to analyze characteristics of nonagenarian patients with ACS and found that PCI treatment was associated with a decreased risk of 1-year all-cause death.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Review
Cardiac & Cardiovascular Systems
Frederik T. W. Groenland, Tara Neleman, Hala Kakar, Alessandra Scoccia, Annemieke C. Ziedses des Plantes, Pascal R. D. Clephas, Sraman Chatterjee, Mahova Zhu, Wijnand K. den Dekker, Roberto Diletti, Felix Zijlstra, Karim D. Mahmoud, Nicolas M. Van Mieghem, Joost Daemen
Summary: This is the first systematic review and meta-analysis comparing IVUS-versus angio-guided PCI in patients with AMI, showing a beneficial effect of IVUS-guided PCI on all-cause mortality, MACE and TVR. Results of ongoing dedicated prospective studies are needed to confirm these findings.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Isabelle Durand-Zaleski, Gregory Ducrocq, Maroua Mimouni, Jerome Frenkiel, Cristina Avendano-Sola, Jose R. Gonzalez-Juanatey, Emile Ferrari, Gilles Lemesle, Etienne Puymirat, Laurence Berard, Marine Cachanado, Joan Albert Arnaiz, Manuel Martinez-Selles, Johanne Silvain, Albert Ariza-Sole, Gonzalo Calvo, Nicolas Danchin, Sandra Paco, Elodie Drouet, Helene Abergel, Alexandra Rousseau, Tabassome Simon, Philippe Gabriel Steg
Summary: This study assessed the cost-effectiveness and cost-utility ratios of restrictive vs. liberal transfusion strategy in acute myocardial infarction patients. The results showed that the restrictive strategy was dominant at 30 days, saving costs and improving outcomes, but it no longer maintained non-inferiority on MACE at 1 year.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Michael Miller, Deepak L. Bhatt, Ph Gabriel Steg, Eliot A. Brinton, Terry A. Jacobson, Lixia Jiao, Jean-Claude Tardif, Christie M. Ballantyne, Matthew Budoff, R. Preston Mason
Summary: The study found that the use of IPE can reduce the risk of cardiovascular disease in smokers to the level observed in non-smokers.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Jeremie Abtan, Deepak L. Bhatt, Yedid Elbez, Gregory Ducrocq, Shinya Goto, Sidney C. Smith, E. Magnus Ohman, Kim A. Eagle, Kim Fox, Robert A. Harrington, Lawrence A. Leiter, Shamir R. Mehta, Tabassome Simon, Ivo Petrov, Peter R. Sinnaeve, Prem Pais, Eli Lev, Hector Bueno, Peter Wilson, Philippe Gabriel Steg
Summary: This study aimed to describe the proportion of eligible and ineligible patients for the THEMIS trial in a population with diabetes and stable coronary artery disease. 64.1% of patients did not meet THEMIS eligibility criteria, mainly due to prior myocardial infarction and use of oral anticoagulation. 28.1% of patients were eligible for the trial.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Pediatrics
Noel Peretti, Alexandre Vimont, Emmanuel Mas, Jean Ferrieres, Patrick Tounian, Julie Lemale, Franck Boccara, Mathilde Di Filippo, Sybil Charriere, Philippe Moulin, Pierre Poinsot, Yves Cottin, Pierre-Henri Ducluzeau, Caroline Dourmap, Bertrand Cariou, Michel Farnier, Francois Paillard, Alain Pradignac, Cecile Yelnik, Antonio Gallo, Eric Bruckert, Sophie Beliard
Summary: Childhood and parental factors, including genetic diagnosis and parental vascular disease, are associated with the initiation of statin therapy in children with HeFH. Genetic diagnosis may be useful for cardiovascular prevention in children.
JOURNAL OF PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Andre Lamy, John Eikelboom, Wesley Tong, Fei Yuan, Shrikant Bangdiwala, Jackie Bosch, Stuart Connolly, Eva Lonn, Gilles R. Dagenais, Kelley R. H. Branch, Wei-Jhih Wang, Deepak L. Bhatt, Jeff Probstfield, Georg Ertl, Stefan Stoerk, P. Gabriel Steg, Victor Aboyans, Isabelle Durand-Zaleski, Lars Ryden, Salim Yusuf
Summary: The addition of rivaroxaban 2.5 mg BID to aspirin in patients with stable coronary artery disease or peripheral artery disease was found to reduce direct healthcare costs. In Canada, France, and Germany, the combination of rivaroxaban and aspirin was highly cost-effective in terms of lifetime cost-effectiveness.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Economics
Manon Belhassen, Olivier Hanon, Philippe Gabriel Steg, Isabelle Mahe, Melanie Nee, Flore Jacoud, Faustine Dalon, Francois-Emery Cotte, Dominique Guitard-Dehoux, Claire Marant-Micallef, Eric Van Ganse, Nicolas Danchin
Summary: This study compared the costs of healthcare resource use, stroke/systemic thromboembolism, and major bleedings between non-valvular atrial fibrillation patients who initiated apixaban and other oral anticoagulants. The results showed that patients initiating apixaban had lower costs in terms of healthcare resource use and event-related costs compared to other oral anticoagulants. Apixaban may be cost-saving compared to VKAs and cheaper than other DOACs, although the cost differences are limited.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2023)
Article
Cardiac & Cardiovascular Systems
Batric Popovic, Gregory Ducrocq, Yedid Elbez, Christoph Bode, Shamir. R. Mehta, Charles Pollack, Manel Sabate, Sunil Rao, Alexander Parkhomenko, Laurent J. Feldman, Neila Sayah, Marc S. Sabatine, Philippe Gabriel Steg
Summary: In patients with non-ST-elevation myocardial infarction (NSTEMI), total occlusion of the culprit coronary artery (OCA) is not uncommon. This study aimed to determine the frequency and clinical impact of OCA at presentation in a large population of patients with NSTEMI who underwent early invasive management. The results showed that patients with OCA had earlier coronary angiography, less involvement of the left anterior descending artery, higher prevalence of angiographic thrombus, higher mortality at 7 days, but similar mortality rates at 6 months.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Judith S. Hochman, Rebecca Anthopolos, Harmony. R. Reynolds, Sripal Bangalore, Yifan Xu, Sean M. O'Brien, Stavroula Mavromichalis, Michelle Chang, Aira Contreras, Yves Rosenberg, Ruth Kirby, Balram Bhargava, Roxy Senior, Ann Banfield, Shaun G. Goodman, Renato D. Lopes, Radoslaw Pracon, Jose Lopez-Sendon, Aldo Pietro Maggioni, Jonathan D. Newman, Jeffrey S. Berger, Mandeep S. Sidhu, Harvey D. White, Andrea B. Troxel, Robert A. Harrington, William E. Boden, Gregg W. Stone, Daniel B. Mark, John A. Spertus, David J. Maron
Summary: The ISCHEMIA trial compared the outcomes of initial invasive strategy versus initial conservative strategy in patients with chronic coronary disease and moderate or severe ischemia. The trial found no major difference in most outcomes, but there was lower risk of cardiovascular mortality and higher risk of noncardiovascular mortality with the invasive strategy.
Article
Cardiac & Cardiovascular Systems
Emmanuelle Vidal-Petiot, Yedid Elbez, Jules Mesnier, Gregory Ducrocq, Ian Ford, Michal Tendera, Roberto Ferrari, Jean-Claude Tardif, Kim M. Fox, Philippe Gabriel Steg
Summary: This study compared the benefits of strict vs. standard control of blood pressure with the potential benefits of controlling other modifiable risk factors in patients with chronic coronary syndromes. The results showed that the benefit associated with strict blood pressure control was marginal and driven only by the diastolic component, while uncontrolled other risk factors were associated with a gradually increasing risk. Therefore, optimizing other risk factors should be prioritized over further reduction of systolic blood pressure. The optimal blood pressure target in chronic coronary syndromes may be <=139/79 mmHg.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Guillaume Marquis-Gravel, Laurie-Anne Boivin-Proulx, Zhen Huang, Steven L. Zelenkofske, A. Michael Lincoff, Roxana Mehran, P. Gabriel Steg, Christoph Bode, John H. Alexander, Thomas J. Povsic
Summary: This study compared the effectiveness of vascular closure devices (VCDs) with manual compression in reducing bleeding after transfemoral percutaneous coronary intervention. The results showed that there was no significant difference in bleeding rate between the two groups, but the VCD group had shorter recovery time. Further investigation is needed for high-bleeding risk populations.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Victoria Gauthier, Martin Lafrance, Mael Barthoulot, Louis Rousselet, Michele Montaye, Jean Ferrieres, Samantha Huo Yung Kai, Katia Biasch, Marie Moitry, Philippe Amouyel, Jean Dallongeville, Aline Meirhaeghe
Summary: The study aimed to characterize the long-term risk of first recurrence of ACS among survivors of an incident ACS, based on the STEMI/NSTEMI/UA diagnosis. The risk of recurrence did not depend on the type of the incident ACS, but major complications and impaired LVEF increased the risk. The most frequent forms of recurrence were NSTEMI and UA.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Health Care Sciences & Services
Jean Ferrieres, Eric Bruckert, Michel Farnier, Michel Krempf, Jean-Jacques Mourad, Baptiste Roux, Francois Schiele
Summary: This online survey studied French cardiologists' lipid-lowering approaches in patients with hypercholesterolemia and high cardiovascular risk. The results showed that most physicians underestimated the cardiovascular risk and selected higher-than-recommended LDL-C targets and less intensive treatment.
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Christopher W. Baugh, Yonathan Freund, Philippe Gabriel Steg, Richard Body, David J. Maron, Maame Yaa A. B. Yiadom
Summary: Emergency department (ED) crowding is a global problem caused by hospital capacity and other health system challenges. Patients with cardiovascular emergencies are particularly vulnerable due to the crowding, which may lead to avoidance of the ED, premature departure, or delays in receiving care. This paper discusses the causes of crowding, its impact on cardiovascular emergencies, and potential solutions.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
Article
Cardiac & Cardiovascular Systems
Alexandre Gautier, Fabien Picard, Gregory Ducrocq, Yedid Elbez, Kim M. Fox, Roberto Ferrari, Ian Ford, Jean-Claude Tardif, Michal Tendera, Philippe Gabriel Steg
Summary: This study found that new-onset atrial fibrillation (NOAF) is common among patients with chronic coronary syndromes (CCS) and is associated with increased risk of cardiovascular adverse events. Age, body mass index, glomerular filtration rate, ethnicity, alcohol intake, and left ventricular ejection fraction were identified as predictors of NOAF. The study suggests that more intensive preventive measures and systematic screening for atrial fibrillation should be considered in this patient population.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Manoj Kumar Honaryar, Rodrigue Allodji, Gaelle Jimenez, Mathieu Lapeyre, Loic Panh, Jeremy Camilleri, David Broggio, Jean Ferrieres, Florent De Vathaire, Sophie Jacob
Summary: This study aimed to evaluate the development of atherosclerotic plaques over 2 years after breast cancer radiotherapy (RT) and their associations with cardiac exposure. The results showed that the risk of overall plaque development was significantly associated with doses to the coronary arteries.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
