Article
Biochemistry & Molecular Biology
Lina Wirestam, Pernilla Benjaminsson Nyberg, Todor Dzhendov, Thomas Gasslander, Per Sandstrom, Christopher Sjowall, Bergthor Bjornsson
Summary: The study found a relationship between plasma levels of Osteopontin (OPN) and the severity of acute pancreatitis (AP). OPN levels can reflect tissue injury and changes in OPN over time can help assess the disease progression and identify at-risk patients.
Article
Medicine, General & Internal
Anja Linde, Eva Gerdts, Kare Steinar Tveit, Ester Kringeland, Helga Midtbo
Summary: Psoriasis patients on infliximab treatment had a lower prevalence of cardiac organ damage compared to controls, and hypertension was identified as the major covariable for subclinical cardiac organ damage in psoriasis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Leslie Marisol Lugo-Gavidia, Dylan Burger, Janis M. M. Nolde, Vance B. B. Matthews, Markus P. P. Schlaich
Summary: Elevated circulating platelet-derived extracellular vesicles (pEVs) have been associated with arterial hypertension, but their relationship with hypertension-mediated organ damage, endothelial function, and psychosocial status is unclear. Our study found that pEV levels were associated with macrovascular damage, but not with microvascular damage, endothelial function, or emotional status.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Christelle Haddad, Pierre-Yves Courand, Constance Berge, Brahim Harbaoui, Pierre Lantelme
Summary: This study explored the association between cortisol levels and blood pressure, organ damage, and metabolic parameters in hypertensive patients. Results showed that cortisol weakly influenced blood pressure levels independently from plasma aldosterone, particularly in older patients. Additionally, there was a weak association between cortisol levels and hypertensive-mediated organ damage, suggesting a potential interest in testing specific treatments targeting cortisol excess in selected hypertensive patients.
JOURNAL OF HYPERTENSION
(2021)
Review
Pharmacology & Pharmacy
Xiaolin Liao, Yuanshan Han, Ying He, Jianjun Liu, Yuhong Wang
Summary: Hypertension commonly leads to target organ damage in the heart, brain, kidney, and blood vessels, including atherosclerosis, plaque formation, cardiovascular and cerebrovascular events, and renal failure. Mitochondrial dysfunction has been identified as a crucial factor in hypertensive target organ damage, leading to increasing interest in mitochondria-targeted therapies. Natural compounds have shown potential in ameliorating mitochondrial dysfunction in hypertensive target organ damage. This review summarizes the contribution of mitochondrial dysfunction to the development of target organ damage in hypertension and discusses therapeutic strategies based on natural compounds that target mitochondrial dysfunction, which may be beneficial for preventing and treating hypertensive target organ damage.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Pierre-Yves Courand, Jerome Lenoir, Adrien Grandjean, Damien Garcia, Brahim Harbaoui, Pierre Lantelme
Summary: The study found that SCORE underestimates the 10-year cardiovascular mortality risk in both historical and contemporary cohorts of hypertensive patients. An update to the algorithm predicting cardiovascular mortality in hypertensive patients is needed.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Tomasz Pizon, Marek Rajzer, Wiktoria Wojciechowska, Tomasz Drozdz, Dorota Drozdz, Marta Rojek, Krystian Gruszka, Danuta Czarnecka
Summary: The study aimed to assess the relations between plasma renin activity (PRA), serum aldosterone concentration (ALDO), and selected asymptomatic organ damage (AOD) indices in mild primary arterial hypertension (AH). High PRA patients had higher ALDO levels, and those with simultaneously high PRA and ARR values showed more severe arterial stiffness and renal impairment. Assessment of the influence of the renin-angiotensin-aldosterone system on AOD should consider the relationship between renin and aldosterone.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Zhongyuan Ren, Jun Zhang, Shikai Yu, Song Zhao, Jiamin Tang, Yixing Zheng, Weilun Meng, Chong Xu, Yi Zhang, Yawei Xu
Summary: The study found a significant association between HMOD and hyperhomocysteinemia in elderly Chinese, particularly with renal dysfunction and arterial stiffening.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Nestor Vazquez-Agra, Ana-Teresa Marques-Afonso, Anton Cruces-Sande, Ignacio Novo-Veleiro, Jose-Enrique Lopez-Paz, Antonio Pose-Reino, Alvaro Hermida-Ameijeiras
Summary: The study found that the influence of inflammatory markers on organ damage is not directly related to circadian blood pressure changes, with certain inflammatory markers strongly correlated with HMOD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Chemistry, Medicinal
Xiaolin Liao, Yuanshan Han, Chuanpu Shen, Jianjun Liu, Yuhong Wang
Summary: This review provides an overview of the role of NLRP3 inflammasome in hypertensive target organ damage (TOD) and the natural products and formulations that inhibit it. The activation of NLRP3 inflammasome exacerbates tissue damage and dysfunction in hypertensive TOD, and natural products such as curcumin, resveratrol, triptolide, and allicin have been shown to have protective effects.
PHYTOTHERAPY RESEARCH
(2023)
Article
Pediatrics
Zhiyong Yang, Yanyun Huang, Yan Qin, Yusheng Pang
Summary: The majority of pediatric hypertension cases in this study were secondary, with renal disease being the the leading cause. Elevated levels of serum uric acid, blood urea nitrogen, serum creatinine, and albuminuria may indicate secondary hypertension in childhood. Elevated serum uric acid, blood urea nitrogen, and triglyceride levels were associated with left ventricular hypertrophy, hypertensive encephalopathy, and hypertensive retinopathy, respectively.
FRONTIERS IN PEDIATRICS
(2021)
Article
Peripheral Vascular Disease
Byung Sik Kim, Hyun-Jin Kim, Minhyung Lyu, Wook-Dong Kim, Yonggu Lee, Miso Kim, Suein Lee, Jin-Kyu Park, Jinho Shin, Hyungoo Shin, Changsun Kim, Jeong-Hun Shin
Summary: Data from a cross-sectional study at a tertiary referral center revealed that 5.9% of patients visiting the emergency department had acute severe hypertension, with 24.5% of them experiencing acute hypertension-mediated organ damage (HMOD). The mortality rates for these patients were 4.8% at 3 months, 8.8% at 1 year, and 13.9% at 3 years, with significantly higher mortality rates in patients with HMOD compared to those without. This study highlights the importance of evaluating and managing HMOD in patients with acute severe hypertension to improve outcomes and emphasizes the need for disease-specific guidelines in this area.
JOURNAL OF HYPERTENSION
(2021)
Review
Biochemistry & Molecular Biology
Emma Hansen, Daniela Grimm, Markus Wehland
Summary: Hypertension significantly increases the risk of cardiovascular disease. Firibastat, a new antihypertensive drug, inhibits aminopeptidase A enzyme to decrease blood pressure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pediatrics
Elke Wuehl, Javier Calpe, Dorota Drozdz, Serap Erdine, Fernando Fernandez-Aranda, Adamos Hadjipanayis, Peter F. Hoyer, Augustina Jankauskiene, Susana Jimenez-Murcia, Mieczyslaw Litwin, Giuseppe Mancia, Artur Mazur, Denes Pall, Tomas Seeman, Manish D. Sinha, Giacomo Simonetti, Stella Stabouli, Empar Lurbe
Summary: The joint statement by HyperChildNET and the European Academy of Pediatrics aims to improve the implementation of the 2016 European Society of Hypertension Guidelines on the diagnosis and management of hypertension in youth. Arterial hypertension is a significant risk factor for cardiovascular morbidity and mortality and can lead to organ damage in childhood. Timely treatment is essential to reverse or postpone these changes. Lifestyle measures should be recommended for all hypertensive children and adolescents, while pharmacologic therapy is required if necessary. Regular follow-up and multidisciplinary evaluation are important for monitoring blood pressure control and adherence to treatment.
FRONTIERS IN PEDIATRICS
(2023)
Article
Biology
Stefan Moestl, Fabian Hoffmann, Jan-Niklas Hoenemann, Jose Ramon Alvero-Cruz, Jorn Rittweger, Jens Tank, Jens Jordan
Summary: This study investigates the application and accuracy of pulse wave velocity (PWV) in master athletes. The results show that estimated PWV is mainly correlated with age and does not accurately reflect the true vascular condition, thus unable to detect the beneficial effects of lifelong exercise on vascular health.
Article
Neurosciences
Eduardo Molina-Holgado, Pedro F. Esteban, Angel Arevalo-Martin, Rafael Moreno-Luna, Francisco Molina-Holgado, Daniel Garcia-Ovejero
Summary: Oligodendrocytes in the central nervous system synthesize myelin and have the ability to regulate their functions through interactions with other cells and sensing the environment. They respond to various signals, including the endocannabinoid signaling, which has therapeutic potential for promoting remyelination in central nervous system pathologies.
Article
Peripheral Vascular Disease
Ernest Vinyoles, Clara Puig, Albert Roso-Llorach, Nuria Soldevila, Alejandro de la Sierra, Manuel Gorostidi, Julian Segura, Juan A. Divison-Garrote, Miguel-Angel Munoz, Luis Miguel Ruilope
Summary: This study found that nighttime systolic blood pressure and 24-hour blood pressure are significantly associated with cardiovascular events and cardiovascular mortality in patients without cardiovascular disease.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Review
Urology & Nephrology
Miriam Anfaiha-Sanchez, Emilio Rodrigo Calabia, Alberto Ortiz, Marta Martin-Lorenzo, Gloria Alvarez-Llamas
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure, but ensuring the long-term performance of the transplanted kidney remains challenging. Current research focuses on the risk of primary non-function and delayed graft function as well as recipient survival, making it increasingly difficult to predict if the grafts will provide sufficient kidney function.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Luis M. Ruilope, Alberto Ortiz, Alejandro Lucia, Blanca Miranda, Gloria Alvarez-Llamas, Maria G. Barderas, Massimo Volpe, Gema Ruiz-Hurtado, Bertram Pitt
Summary: Chronic kidney disease (CKD) is a leading cause of death that requires early detection for effective management. The current diagnostic criteria for CKD only identify advanced stages, leaving a 'blind spot' in detection where kidney injury is present but undetectable. Elevated urinary albumin-excretion rate can predict future cardiovascular events. Implementing opportunistic or systematic albuminuria screening and therapy has the potential to improve cardiorenal outcomes and mitigate the projected burden of CKD and cardiovascular diseases in the future.
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Laura Gonzalez-Lafuente, Jose Alberto Navarro-Garcia, Angela Valero-Almazan, Elena Rodriguez-Sanchez, Sara Vazquez-Sanchez, Elisa Mercado-Garcia, Patricia Pineros, Jonay Poveda, Maria Fernandez-Velasco, Makoto Kuro-O, Luis M. Ruilope, Gema Ruiz-Hurtado
Summary: Acute kidney injury (AKI) is associated with an elevated risk of cardiovascular major events and mortality. The presence of AKI and its evolution are significantly associated with an alteration in the anti-aging factor klotho expression. A decrease in klotho expression aggravates cardiac damage after AKI, affecting Ca2+ handling and increasing the risk of Ca2+ pro-arrhythmic events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Peripheral Vascular Disease
Rajiv Agarwal, Luis M. Ruilope, Gema Ruiz-Hurtado, Hermann Haller, Roland E. Schmieder, Stefan D. Anker, Gerasimos Filippatos, Bertram Pitt, Peter Rossing, Marc Lambelet, Christina Nowack, Peter Kolkhof, Amer Joseph, George L. Bakris
Summary: Finerenone, a selective nonsteroidal mineralocorticoid receptor antagonist, was found to reduce 24-hour, daytime, and nighttime systolic blood pressure in patients with chronic kidney disease and type 2 diabetes.
JOURNAL OF HYPERTENSION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
L. M. Ruilope, G. Ruiz-Hurtado
HIPERTENSION Y RIESGO VASCULAR
(2023)
Article
Peripheral Vascular Disease
Felix Mahfoud, Giuseppe Mancia, Roland E. Schmieder, Luis Ruilope, Krzysztof Narkiewicz, Markus Schlaich, Bryan Williams, Flavio Ribichini, Joachim Weil, Khaled Almerri, Faisal Sharif, Lucas Lauder, Marianne Wanten, Martin Fahy, Michael Boehm
Summary: This study investigated whether the number or type of antihypertensive medications were associated with increased long-term blood pressure reductions and cardiovascular outcomes following radiofrequency renal denervation (RDN) in hypertensive patients. The results showed that radiofrequency RDN reduced blood pressure safely through 36 months, regardless of the number and type of baseline antihypertensive medication classes.
Editorial Material
Biochemistry & Molecular Biology
Maria G. G. Barderas, Fernando de la Cuesta
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Natalie Staplin, Alejandro de la Sierra, Luis M. Ruilope, Jonathan R. Emberson, Ernest Vinyoles, Manuel Gorostidi, Gema Ruiz -Hurtado, Julian Segura, Colin Baigent, Bryan Williams
Summary: This study aimed to examine the associations of clinic and 24-h ambulatory blood pressure with all-cause and cardiovascular mortality. The results showed that ambulatory blood pressure, especially night-time blood pressure, was more informative about the risk of all-cause death and cardiovascular death than clinic blood pressure. This study has important implications for the assessment of health outcomes in patients with hypertension.
Article
Medical Laboratory Technology
Nerea Corbacho-Alonso, Tamara Sastre-Oliva, Luis F. Lopez-Almodovar, Jorge Solis, Luis R. Padial, Teresa Tejerina, Montserrat Carrascal, Laura Mourino-Alvarez, Maria G. Barderas
Summary: Diabetes mellitus (DM) increases the risk of severe calcific aortic stenosis (CAS), but the relationship between these two diseases and the impact of DM on CAS progression is unclear. In this study, we analyzed calcified and noncalcified valve tissue from patients with severe CAS, with or without DM, using a proteomic strategy. We found that DM induces changes in the proteome of aortic valves, affecting valve calcification. This finding provides valuable insights into the pathogenesis of CAS and the personalized treatment of patients with both DM and CAS.
TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Nerea Corbacho-Alonso, Elena Rodriguez-Sanchez, Tamara Sastre-Oliva, Elisa Mercado-Garcia, Ines Perales-Sanchez, Cristina Juarez-Alia, Luis F. Lopez-Almodovar, Luis R. Padial, Teresa Tejerina, Laura Mourino-Alvarez, Gema Ruiz-Hurtado, Maria G. Barderas
Summary: Calcific aortic stenosis (CAS) and type 2 diabetes mellitus (T2DM) often coexist and are related, accompanied by common comorbidities. Oxidative stress plays a role in CAS and vascular complications in T2DM. Metformin, a medication for T2DM, may reduce oxidative stress. This study evaluated the oxidative status in plasma from CAS patients, with or without T2DM and metformin treatment, suggesting that reducing oxidative stress or enhancing antioxidant capacity could be a strategy for managing CAS.
Article
Biochemistry & Molecular Biology
Irene Soleto, Cristina Ramirez, Cristina Gomez, Montse Baldan-Martin, Macarena Orejudo, Jorge Mercado, Maria Chaparro, Javier P. Gisbert
Summary: This study reveals that type 2 conventional DCs (cDC2) in patients with inflammatory bowel disease (IBD) exhibit a heightened migratory profile compared to other DC subsets, potentially highlighting new diagnostic biomarkers or immunomodulatory targets for IBD.
Article
Biochemistry & Molecular Biology
Lucia Beltran-Camacho, Santosh D. Bhosale, Daniel Sanchez-Morillo, Ismael Sanchez-Gomar, Marta Rojas-Torres, Sara Eslava-Alcon, Mario Martinez-Torija, M. Angeles Ruiz de Infante, M. Dolores Nieto-Martin, Manuel A. Rodriguez-Iglesias, Juan A. Moreno, Esther Berrocoso, Martin R. Larsen, Rafael Moreno-Luna, M. Carmen Duran-Ruiz
Summary: SARS-CoV-2 infection affects the cardiovascular system, causing vascular damage and thromboembolic events. Endothelial dysfunction is an early response to COVID-19, which may lead to cardiovascular complications and long-term sequelae. However, the molecular mechanisms involved in these processes remain poorly understood.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
