Article
Engineering, Environmental
Kevin J. Erratt, Irena F. Creed, Erika C. Freeman, Charles G. Trick, Judy Westrick, Johnna A. Birbeck, L. Cynthia Watson, Arthur Zastepa
Summary: The risk of human exposure to cyanotoxins is influenced by the location of toxin-producing cyanobacteria in waterbodies. A case study of Sunfish Lake in Ontario, Canada, revealed a deep cyanobacteria layer with toxins. Multiple toxigenic cyanobacteria species were identified in the deep layer. Monitoring the entire water column can help identify waterbodies at elevated risk for deep cyanobacteria layers to protect drinking water supplies.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Neil Binkley, Brian Nickel, Paul A. A. Anderson
Summary: Total joint replacement is common and increasing, but it can lead to bone loss and periprosthetic fractures, which are often overlooked by osteoporosis clinicians. This clinical review aims to raise awareness about these fractures, which are related to osteoporosis, and suggest approaches to reduce their occurrence. It emphasizes the importance of bone health evaluation after a periprosthetic fracture and the need for primary prevention through bone health assessment and optimization prior to elective orthopedic procedures.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Siddhansh Agarwal, Fan Kiat Chan, Bhargav Rallabandi, Mattia Gazzola, Sascha Hilgenfeldt
Summary: This literature introduces an analytical method in inertial microfluidics to derive and quantify the theory of inertial effects, which has been verified through full-scale, three-dimensional direct numerical simulations and revealed previously unexplained experimental phenomena.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Environmental
Owen M. Stefaniak, Steven R. Corsi, Troy D. Rutter, Greg G. Failey
Summary: Airport ice control products contribute to total phosphorus loadings in surface water runoff. They impact TP concentrations in downstream water samples and often exceed aquatic life benchmarks during deicing events. Airport outfall sites and receiving streams experience the highest TP loadings during major runoff events, but this pattern can be influenced by TP in deicer products. This study suggests that airport deicers may be an unrecognized source of phosphorus to adjacent waterways.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wenping Wang, Ximing Wu, Chung S. Yang, Jinsong Zhang
Summary: This study demonstrates that glutamate can effectively inhibit the oxidation of catecholamines and the associated formation of hydroxyl radicals, quinoproteins, and DNA damage. The protective mechanism of glutamate against catecholamine oxidation is attributed to its chelation of copper, restricting its redox activity.
Article
Multidisciplinary Sciences
Emmanouil Tranos, Yannis M. Ioannides
Summary: This paper examines the impact of ICT adoption on urban structure worldwide, finding that it leads to less uniform city size distribution and higher population concentration in larger cities.
Article
Cell Biology
Xinjian Liu, Hao Yuan, Jing Zhou, Qiongling Wang, Xiaoqiang Qi, Catharine Bernal, Diego Avella, Jussuf T. Kaifi, Eric T. Kimchi, Parrett Timothy, Kun Cheng, Yi Miao, Kuirong Jiang, Guangfu Li
Summary: The study identified LIM domain only 7 (LMO7) as a potential target for developing targeted therapy for pancreatic cancer, as loss of LMO7 function significantly suppresses tumor growth and metastasis. This suggests that LMO7 could be an important unrecognized druggable factor in impacting pancreatic cancer progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Anthony Sabulski, Sara Szabo, Kasiani C. Myers, Stella M. Davies, Sonata Jodele
Summary: TMA can injure the testicles and potentially affect fertility, indicating a need for further analysis of reproductive organ involvement in TMA.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Immunology
Aurore C. A. Gay, Martijn C. Nawijn
Summary: Segmental allergen challenge in allergic patients with asthma reveals a new role for monocytes in TH2-dependent inflammation, while allergen unresponsiveness in allergic controls without asthma is maintained through epithelial-myeloid cell cross-talk that prevents TH2 cell activation.
SCIENCE IMMUNOLOGY
(2023)
Editorial Material
Multidisciplinary Sciences
Jef Huisman, Elke Dittmann, Jutta Fastner, J. Merijn Schuurmans, J. Thad Scott, Dedmer B. Van de Waal, Petra M. Visser, Martin Welker, Ingrid Chorus
Summary: Hellweger et al. suggest that phosphorus limitation will lead to higher concentrations of cyanobacterial toxins in lakes. However, their assumptions about molecular, physiological, and ecological mechanisms lack support and contradict other studies. It is concluded that their take-home message about increased toxicity in Lake Erie due to phosphorus load reduction is fundamentally flawed.
Review
Plant Sciences
Gaia Santini, Natascia Biondi, Liliana Rodolfi, Mario R. Tredici
Summary: Cyanobacteria have great potential as a source of new biostimulants, with their ability to produce biologically active molecules that can benefit plant growth and stress tolerance. Research in this area should focus on optimizing biostimulant composition, stability, and mechanisms, while expanding agronomic trials to promote the application of these products in agriculture.
Article
Multidisciplinary Sciences
Sharon Karniely, Adi Faigenboim, Salsabeel Watted, Eran Bacharach, Katia Lapin, Eduard Berenshtein, Avshalom Hurvitz, Arieli Bouznach, Ezra Rozenblut, Massimo Orioles, Marco Galeotti, Irene Salinas, Asaf Berkowitz, Avi Eldar
Summary: Rainbow trout (Oncorhynchus mykiss) in freshwater farming have been found to be affected by a novel virus called Trout Granulomatous Virus (TGV), which causes granulomatous-like hepatitis. The presence of TGV was confirmed through high-throughput sequencing and bioinformatics analyses, and the virus particles were visualized through transmission electron microscopy. The identification and detection of TGV provide a way to control its spread in trout populations.
Article
Food Science & Technology
Robert McPhedran, Krishane Patel, Alice Rayner, Michelle Patel, Joanna Disson, Alice John, Katharine Porter, Katie Thornton, Ben Toombs
Summary: Clear allergen communication in food business operators has a positive impact on customers' perceptions of businesses, with further research needed to investigate the precise size and nature of this effect.
Article
Geriatrics & Gerontology
Rainer Wirth, Christiane Nicola Klimek, Gero Lueg, Maryam Pourhassan, Louisa Maria Danielzik, Caroline Krueger, Ulrike Sonja Trampisch
Summary: This retrospective study found that cognitive changes frequently occur in geriatric patients during acute disease, independent of delirium. The term acute disease induced cognitive dysfunction (ADICD) is proposed for this phenomenon.
Editorial Material
Biochemical Research Methods
Xiaofeng Wu, W. Andy Tao
Summary: A diagnostic fragment ion in tandem mass spectrometry allows for accurate identification of protein lactylation and the discovery of a wide range of lysine modifications beyond histones.
Article
Allergy
Laura A. Nabors, Jonathan A. Bernstein, Tonya A. Winders, Mary Hart, Filiberto Toledano-Toledano
Summary: The study surveyed professionals and parents to assess their knowledge and perceptions about education for self-management of asthma for children with physical and intellectual disabilities, as well as the need for education on asthma and coronavirus for children with IDs. Results showed that teachers had lower knowledge regarding educating children with IDs about asthma management and coronavirus, highlighting the importance of educating teachers on asthma triggers and involving children in self-care.
Article
Allergy
Torsten Zuberbier, Amir Hamzah Abdul Latiff, Mohamed Abuzakouk, Susan Aquilina, Riccardo Asero, Diane Baker, Barbara Ballmer-Weber, Christine Bangert, Moshe Ben-Shoshan, Jonathan A. Bernstein, Carsten Bindslev-Jensen, Knut Brockow, Zenon Brzoza, Herberto Jose Chong Neto, Martin K. Church, Paulo R. Criado, Inna V. Danilycheva, Corinna Dressler, Luis Felipe Ensina, Luz Fonacier, Matthew Gaskins, Krisztian Gaspar, Asli Gelincik, Ana Gimenez-Arnau, Kiran Godse, Margarida Goncalo, Clive Grattan, Martine Grosber, Eckard Hamelmann, Jacques Hebert, Michihiro Hide, Allen Kaplan, Alexander Kapp, Aharon Kessel, Emek Kocaturk, Kanokvalai Kulthanan, Desiree Larenas-Linnemann, Antti Lauerma, Tabi A. Leslie, Markus Magerl, Michael Makris, Raisa Y. Meshkova, Martin Metz, Daniel Micallef, Charlotte G. Mortz, Alexander Nast, Hanneke Oude-Elberink, Ruby Pawankar, Paolo D. Pigatto, Hector Ratti Sisa, Maria Isabel Rojo Gutierrez, Sarbjit S. Saini, Peter Schmid-Grendelmeier, Bulent E. Sekerel, Frank Siebenhaar, Hanna Siiskonen, Angele Soria, Petra Staubach-Renz, Luca Stingeni, Gordon Sussman, Andrea Szegedi, Simon Francis Thomsen, Zahava Vadasz, Christian Vestergaard, Bettina Wedi, Zuotao Zhao, Marcus Maurer
Summary: The updated international guideline for urticaria was developed jointly by multiple international organizations, with participants from 50 countries and international societies, aiming to provide expert guidance on diagnostic and therapeutic approaches for different subtypes of urticaria.
Review
Allergy
Jonathan A. Bernstein, Andrew A. White, Joseph K. Han, David M. Lang, David Elkayam, Fuad M. Baroody
Summary: This study aimed to analyze published reports on the efficacy and safety of corticosteroid irrigation (CSI) in chronic rhinosinusitis (CRS) with nasal polyps and evaluate its clinical implications. CSI is commonly used for the treatment of CRS, but it is not approved by the FDA.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Article
Allergy
Marek Jutel, Giselle S. Mosnaim, Jonathan A. Bernstein, Stefano del Giacco, David A. Khan, Kari C. Nadeau, Isabella Pali-Schoell, Maria J. Torres, Magdalena Zemelka-Wiacek, Ioana Agache
Summary: The One Health approach is a collaborative and interdisciplinary strategy that focuses on the interconnections between human, animal, and environmental health. It can advance the management of allergic diseases and asthma by addressing their complex and multifactorial nature. The impacts of allergens, infectious agents, and irritants on allergic diseases and asthma are influenced by environmental health intertwined with animal health. A coordinated response across sectors such as public health, veterinary medicine, and environmental science is needed, along with activities like monitoring and surveillance, targeted interventions, and research on underlying mechanisms.
Editorial Material
Allergy
Jonathan A. Bernstein
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Article
Immunology
Diti H. H. Patel, Lauren M. M. Fine, Jonathan A. A. Bernstein
Summary: Progestogen Hypersensitivity (PH) is characterized by recurrent cutaneous eruptions and systemic symptoms, caused by increased sensitivity to progestogens. The prevalence of PH is expected to increase due to the widespread use of oral contraceptives and hormonal treatments. A better understanding of the underlying mechanisms and the development of accurate diagnostic tests are needed for improved recognition and management of the condition.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Review
Allergy
Matthew Greenhawt, Timothy E. Dribin, Elissa M. Abrams, Marcus Shaker, Derek K. Chu, David B. K. Golden, Cem Akin, Akterini Anagnostou, Faisal Almuhizi, Waleed Alqurashi, Peter Arkwright, James L. Baldwin, Aleena Banerji, Philippe Begin, Moshe Ben-Shoshan, Jonathan Bernstein, Theresa A. Bingemann, Carsten Bindslev-Jensen, Kim Blumenthal, Aideen Byrne, Julia Cahill, Scott Cameron, Dianne Campbell, Ronna Campbell, Michael Cavender, Edmond S. Chan, Sharon Chinthrajah, Pasquale Comberiati, Jacqueline J. Eastman, Anne K. Ellis, David M. Fleischer, Adam Fox, Pamela A. Frischmeyer-Guerrerio, Remi Gagnon, Lene H. Garvey, Mitchell H. Grayson, Ghislaine Annie Clarisse Isabwe, Nicholas Hartog, David Hendron, Caroline C. Horner, Johnathan O'B Hourihane, Edward Iglesia, Manstein Kan, Blanka Kaplan, Constance H. Katelaris, Harold Kim, John M. Kelso, David A. Khan, David Lang, Dennis Ledford, Michael Levin, Jay A. Lieberman, Richard Loh, Douglas P. Mack, Bruce Mazer, Ketan Mody, Gisele Mosnaim, Daniel Munblit, S. Shahzad Mustafa, Anil Nanda, Richard Nathan, John Oppenheimer, Iris M. Otani, Miguel Park, Ruby Pawankar, Kirsten P. Perrett, Jonny Peter, Elizabeth J. Phillips, Matthieu Picard, Mitchell Pitlick, Allison Ramsey, Trine Holm Rasmussen, Melinda M. Rathkopf, Hari Reddy, Kara Robertson, Pablo Rodriguez del Rio, Stephen Sample, Ajay Sheshadri, Javed Sheik, Sayantani B. Sindher, Jonathan M. Spergel, Cosby A. Stone, David Stukus, Mimi L. K. Tang, James M. Tracy, Paul J. Turner, Timothy K. Vander Leek, Dana V. Wallace, Julie Wang, Susan Wasserman, David Weldon, Anna R. Wolfson, Margitta Worm, Mona-Rita Yacoub
Summary: This guidance provides updates on immediate allergic reactions following COVID-19 vaccines, including recommendations for revaccinating individuals with first-dose allergic reactions and conducting allergy testing. The recommendations were formed by an international panel of experts and are based on recent meta-analyses and diagnostic accuracy studies.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Allergy
Samuel Adabla, Laura A. Nabors, Olutosin Sanyaolu, Afolakemi Olaniyan, Jonathan A. Bernstein
Summary: This study reviewed research on interventions aimed at improving asthma management among children by educating parents and other professionals. Stakeholders developed programs that resulted in improvements in asthma symptoms, knowledge of asthma management, perceptions of health care, and decreased emergency health care visits. Successful interventions involved education about asthma management, providing medications, and partnerships with school staff, healthcare teams, and community members.
Review
Allergy
Wasuchon Chaichan, Chidchanok Ruengorn, Kednapa Thavorn, Brian Hutton, Jacek C. Szepietowski, Jonathan A. Bernstein, Mati Chuamanochan, Surapon Nochaiwong
Summary: A systematic review and network meta-analysis were conducted to compare the safety profiles of different second-generation H1-antihistamines in patients with chronic urticaria. The study found variations in safety profiles, with mizolastine, emedastine, and cetirizine associated with unfavorable safety profiles.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Medicine, General & Internal
Jonathan A. Bernstein, Ana Gimenez-Arnau, Marcus Maurer, Petra Staubach, Nathalie Barbier, Eva Hua, Thomas Severin, Pedro A. Laires, Maria-Magdalena Balp
Summary: This study investigated the association between urticaria activity and health-related quality of life. The results showed that chronic spontaneous urticaria significantly impacted the patients' HRQoL. Patients with complete response to treatment had no impairments on health-related quality of life and improved work capacities compared to those with minimal disease activity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Jonathan A. Bernstein, Jean-Pierre Llanos, Gillian Hunter, Neil Martin, Christopher S. Ambrose
Summary: This study describes the reduction of annualized asthma exacerbation rate (AAER) from randomized controlled trials (RCTs) in patients with allergic severe asthma. The study found that the efficacy of biologics varied considerably overall and by baseline blood eosinophil count (BEC), with tezepelumab consistently demonstrating the greatest reduction in AAER across all subgroups.
ADVANCES IN THERAPY
(2023)
Article
Allergy
P. J. de Kam, S. Zielen, J. A. Bernstein, U. Berger, M. Berger, M. Cuevas, D. Cypcar, A. Fuhr-Horst, W. A. Greisner, M. Jandl, S. Lassmann, M. Worm, J. Matz, E. Sher, C. Smith, G. C. Steven, R. Moesges, M. H. Shamji, L. DuBuske, F. Borghese, K. Oluwayi, T. Zwingers, M. Seybold, O. Armfield, M. D. Heath, S. J. Hewings, M. F. Kramer, M. A. Skinner
Summary: The study evaluated the efficacy and safety of a modified grass allergen subcutaneous immunotherapy for grass-pollen allergic rhinitis/rhinoconjunctivitis. The results showed clinically relevant and statistically significant improvements in symptom and medication scores, as well as a good safety profile.
Editorial Material
Allergy
Raagini Suresh Yedidi, Jonathan A. Bernstein
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Review
Allergy
Hannah Hardin, Wenhai Shao, Jonathan A. Bernstein
Summary: This article provides an updated review on the diagnosis, management, and treatment of pediatric autoimmune neuropsychiatric disorder associated with streptococcus and pediatric autoimmune neuropsychiatric syndrome, also known as idiopathic autoimmune encephalitis (IAE). The study outlines current knowledge on IAE pathophysiology, clinical manifestations, and epidemiology, as well as diagnostic recommendations and treatment guidelines. The article emphasizes the need for interdisciplinary collaboration and further research to improve the recognition and acceptance of this condition.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Article
Allergy
Remy S. Petersen, Laura Bordone, Marc A. Riedl, Raffi Tachdjian, Timothy J. Craig, William R. Lumry, Michael E. Manning, Jonathan A. Bernstein, Jason Raasch, Bruce L. Zuraw, Yiwen Deng, Kenneth B. Newman, Veronica J. Alexander, Cindy Lui, Eugene Schneider, Danny M. Cohn
Summary: The 2-year interim results of this phase 2 open-label extension study of donidalorsen in patients with HAE demonstrated no new safety signals. Donidalorsen was well tolerated with durable efficacy, resulting in a 96% reduction in HAE attacks.