Article
Health Care Sciences & Services
Nikolaos Pyrpyris, Maria Kritikou, Xenofon Aggelidis, Ioanna Manolaraki, Michael Makris, Nikolaos G. Papadopoulos, Paraskevi Xepapadaki
Summary: This study analyzes the characteristics of anaphylaxis in a pediatric cohort in Greece and finds a low rate of adrenaline autoinjector administration by lay people. However, drug prescription and counseling after the reaction could help improve correct acute anaphylaxis management in the future.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Allergy
Ioana Maris, Sabine Doelle-Bierke, Jean-Marie Renaudin, Lars Lange, Alice Koehli, Thomas Spindler, Jonathan Hourihane, Kathrin Scherer, Katja Nemat, C. Kemen, Irena Neustaedter, Christian Vogelberg, Thomas Reese, Ismail Yildiz, Zsolt Szepfalusi, Hagen Ott, Helen Straube, Nikolaos G. Papadopoulos, Susanne Haemmerling, Ute Staden, Michael Polz, Tihomir Mustakov, Ewa Cichocka-Jarosz, Renata Cocco, Alessandro Giovanni Fiocchi, Montserrat Fernandez-Rivas, Margitta Worm
Summary: The study showed that peanut allergy is a major cause of severe allergic reactions in European children, with characteristics such as asthma comorbidity and a higher rate of biphasic reactions. The use of intramuscular adrenaline as first-line treatment is low and needs improvement. The European Anaphylaxis Registry provides a valuable tool for continuous assessment of anaphylactic reactions.
Article
Allergy
Allison Hicks, Claire Palmer, Maureen Bauer, Carina Venter
Summary: Accidental ingestions (AI) of food allergens in adolescents may be more frequent and severe compared to children, with a higher percentage of adolescents requiring epinephrine for severe reactions. Regional differences were also noted, with the United States reporting fewer AIs and less severe reactions compared to other countries.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Evan S. Dellon, Marc E. Rothenberg, Margaret H. Collins, Ikuo Hirano, Mirna Chehade, Albert J. Bredenoord, Alfredo J. Lucendo, Jonathan M. Spergel, Seema Aceves, Xian Sun, Matthew P. Kosloski, Mohamed A. Kamal, Jennifer D. Hamilton, Bethany Beazley, Eilish McCann, Kiran Patel, Leda P. Mannent, Elizabeth Laws, Bolanle Akinlade, Nikhil Amin, Wei Keat Lim, Matthew F. Wipperman, Marcella Ruddy, Naimish Patel, David R. Weinreich, George D. Yancopoulos, Brad Shumel, Jennifer Maloney, Angeliki Giannelou, Arsalan Shabbir
Summary: Dupilumab improves histologic outcomes and alleviates symptoms of eosinophilic esophagitis.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Allergy
Angela Gaspar, Natacha Santos, Emilia Faria, Ana Margarida Pereira, Eva Gomes, Rita Camara, Rodrigo Rodrigues-Alves, Luis-Miguel Borrego, Isabel Carrapatoso, Leonor Carneiro-Leao, Mario Morais-Almeida, Luis Delgado, Elisa Pedro, Manuel Branco-Ferreira
Summary: This study found that in the Portuguese pediatric population, food is the leading cause of anaphylaxis, with undertreatment with adrenaline and high recurrence rates highlighting the need for improved diagnosis and therapeutic management of this life-threatening condition.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Oncology
Rebecca S. Parker, Justin Le, Andrew Doan, Paibel Aguayo-Hiraldo, Pia S. Pannaraj, Teresa Rushing, Jemily Malvar, Maurice R. O'Gorman, Jennifer Dien Bard, Chintan Parekh
Summary: Pediatric oncology patients are at higher risk for hospitalization with COVID-19, but the majority can undergo chemotherapy without delays in treatment. Viral load may be a potential predictor for the outcome of COVID-19 in pediatric cancer patients.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Biology
Mikkel Malling Beck, Meaghan Elizabeth Spedden, Martin Jensen Dietz, Anke Ninija Karabanov, Mark Schram Christensen, Jesper Lundbye-Jensen
Summary: Our study found bidirectional coupling in a canonical 'grasping network' associated with precision grip performance across age groups. Additionally, late adolescence showed greater backward coupling from higher-order to lower-order sensorimotor regions, and different associations between connectivity strength in a premotor-prefrontal network and motor performance for different age groups. This suggests a progression towards greater use of top-down and executive control processes with development.
Article
Neurosciences
Laura Saisanen, Mervi Kononen, Eini Niskanen, Timo Lakka, Niina Lintu, Ritva Vanninen, Petro Julkunen, Sara Maatta
Summary: This study used navigated transcranial magnetic stimulation to study the development of motor representation areas in healthy children and adolescents. The results showed that as participants aged, the centers and focus of individual muscles became more concentrated. Additionally, there was less overlap between hand and forearm muscle representations in children, with a greater proportion of hand representation associated with better fine motor ability in the right hemisphere.
Article
Radiology, Nuclear Medicine & Medical Imaging
Q. Wang, Q. Chang, R. Zhang, C. Sun, L. Li, S. Wang, Q. Wang, Z. Li, L. Niu
Summary: This study analyzed the clinicopathological features and ultrasound findings of the diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) and found that DSV-PTC in children/adolescents may be more aggressive than in adults. The study also highlights the unsatisfactory ultrasonic sensitivity in diagnosing contralateral lymph node metastasis and the need for better diagnostic methods.
CLINICAL RADIOLOGY
(2022)
Article
Dermatology
Shari Wright, Andrew Strunk, Amit Garg
Summary: The prevalence of depression is higher among children, adolescents, and adults with HS compared to controls, indicating the need for periodic screening for depression.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Oncology
Mohamed Abdelaal, Pamela J. Mosher, Abha Gupta, Breffni Hannon, Christine Cameron, Malka Berman, Rahim Moineddin, Jonathan Avery, Laura Mitchell, Madeline Li, Camilla Zimmermann, Ahmed Al-Awamer
Summary: Adolescents and young adults with cancer often experience high levels of distress and lack effective palliative care services. Establishing a specialized integrated palliative care and psychiatry clinic has shown promising results in improving symptom scores and end-of-life planning.
Article
Medicine, General & Internal
Debbie S. Gipson, Jonathan P. Troost, Cathie Spino, Samara Attalla, Joshua Tarnoff, Susan Massengill, Richard Lafayette, Virginia Vega-Warner, Sharon Adler, Patrick Gipson, Matthew Elliott, Frederick Kaskel, Damian Fermin, Marva Moxey-Mims, Richard N. Fine, Elizabeth J. Brown, Kimberly Reidy, Katherine Tuttle, Keisha Gibson, Kevin Lemley, Larry A. Greenbaum, Meredith A. Atkinson, Sangeeta Hingorani, Tarak Srivastava, Christine B. Sethna, Kevin Meyers, Cheryl Tran, Katherine M. Dell, Chia-shi Wang, Jennifer Lai Yee, Matthew G. Sampson, Rasheed Gbadegesin, J. J. Lin, Tammy Brady, Michelle Rheault, Howard Trachtman
Summary: This study examined whether there are differences in kidney health outcomes among children, adolescents, and adults with FSGS, and found that the association of FSGS with kidney survival and functional outcomes was comparable at all ages.
Article
Medicine, General & Internal
Casey Lee McAtee, Joseph Lubega, Kristen Underbrink, Kristen Curry, Pavlos Msaouel, Martha Barrow, Eyal Muscal, Timothy Lotze, Poyyapakkam Srivaths, Lisa R. Forbes, Carl Allen, Brooke Bernhardt
Summary: Rituximab, a commonly used immunotherapy in pediatrics, is well tolerated among young people with few serious adverse events. However, infections are common, leading to a prolonged period of B cell count recovery often lasting for longer than a year. Further strategies to prevent infections following rituximab should be explored.
Review
Oncology
Emily H. Yang, Harmonie B. Strohl, H. Irene Su
Summary: Fertility preservation is an important consideration for survivors of childhood, adolescent, and young adult cancer. It is recommended that fertility discussions and options be offered at diagnosis and after treatment. However, there is a need for further research and improvement in risk stratification and access to fertility preservation care.
Review
Medicine, General & Internal
Marie-Madeleine Dolmans, Camille Hossay, Thu Yen Thi Nguyen, Catherine Poirot
Summary: Chemotherapy, pelvic radiotherapy, and ovarian surgery can have harmful effects on the reproductive system, leading to early depletion of the ovarian reserve and increased risk of future fertility problems. Factors such as ovarian reserve, type of treatment, dose, and patient age determine the extent of this risk.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Allergy
Tanzeela Hanif, Lotta E. Ivaska, Freed Ahmad, Ge Tan, Emilia Mikola, Tuomo Puhakka, Oscar Palomares, Cezmi A. Akdis, Sanna Toppila-Salmi, Tuomas Jartti
Summary: This study reveals significant differences in tonsillar gene expression between atopic and non-atopic subjects, as well as between aero-allergen and food-allergen sensitization. These findings contribute to a better understanding of the immune responses and transcriptomic alterations associated with allergic sensitization.
Letter
Allergy
Maria Suprun, Henry T. Bahnson, George du Toit, Gideon Lack, Mayte Suarez-Farinas, Hugh A. Sampson
Article
Allergy
Kirsty Logan, Henry T. T. Bahnson, Alyssa Ylescupidez, Kirsten Beyer, Johanna Bellach, Dianne E. E. Campbell, Joanna Craven, George Du Toit, E. N. Clare Mills, Michael R. R. Perkin, Graham Roberts, Ronald van Ree, Gideon Lack
Summary: This study demonstrates the significant reduction in peanut allergy risk with early peanut introduction. The effect is observed across different risk groups and is more pronounced with earlier age of introduction.
Review
Allergy
Veronika Hoefer, Matteo Martini, Sabine Doelle-Bierke, Margitta Worm, Maria Beatrice Bilo
Summary: The impact on health-related quality of life (HRQL) is crucial for patients with allergies and anaphylaxis. This narrative review focuses on HRQL in allergic patients with food and venom allergies, which are the most common triggers for severe and life-threatening reactions. The review highlights the availability of standardized assessment tools for measuring HRQL in these patients and the various factors that can influence HRQL, including sociodemographic data and external factors. The review also emphasizes the importance of considering lifestyle factors and measuring individual changes in HRQL during specific immunotherapy.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Editorial Material
Allergy
Fabio Candotti, Philippe Eigenmann
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Review
Allergy
Torsten Zuberbier, Robert A. Wood, Carsten Bindslev-Jensen, Alessandro Fiocchi, R. Sharon Chinthrajah, Margitta Worm, Antoine Deschildre, Montserrat Fernandez-Rivas, Alexandra F. Santos, Xavier Jaumont, Paolo Tassinari
Summary: Studies have shown that omalizumab (OMA) as monotherapy or as an adjunct to oral immunotherapy (OMA+OIT) has promising results in patients with single/multiple food allergies. OMA monotherapy significantly increases the tolerated dose of multiple foods, improves quality of life, and reduces food-induced allergic reactions. OMA+OIT significantly increases the tolerated dose of multiple foods, desensitization, and improves quality of life and immunoglobulin G4 levels. Rating: 9/10.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Allergy
Jean Bousquet, Josep M. Anto, Bernardo Sousa-Pinto, Wienczyslawa Czarlewski, Anna Bedbrook, Tari Haahtela, Ludger Klimek, Oliver Pfaar, Piotr Kuna, Maciej Kupczyk, Frederico S. Regateiro, Boleslaw Samolinski, Arunas Valiulis, Arzu Yorgancioglu, Sylvie Arnavielhe, Xavier Basagana, Karl C. Bergmann, Sinthia Bosnic-Anticevich, Luisa Brussino, G. Walter Canonica, Victoria Cardona, Lorenzo Cecchi, Claudia Chaves-Loureiro, Elisio Costa, Alvaro A. Cruz, Bilun Gemicioglu, Wytske J. Fokkens, Juan Carlos Ivancevich, Helga Kraxner, Violeta Kvedariene, Desiree E. Larenas-Linnemann, Daniel Laune, Renaud Louis, Michael Makris, Marcus Maurer, Erik Melen, Yann Micheli, Mario Morais-Almeida, Joaquim Mullol, Marek Niedoszytko, Yoshitaka Okamoto, Nikolaos G. Papadopoulos, Vincenzo Patella, Nhan Pham-Thi, Philip W. Rouadi, Joaquin Sastre, Nicola Scichilone, Aziz Sheikh, Mikhail Sofiev, Luis Taborda-Barata, Sanna Toppila-Salmi, Ioanna Tsiligianni, Erkka Valovirta, Maria Teresa Ventura, Rafael Jose Vieira, Mihaela Zidarn, Rita Amaral, Ignacio J. Ansotegui, Annabelle Bedard, Samuel Benveniste, Michael Bewick, Carsten Bindslev-Jensen, Hubert Blain, Matteo Bonini, Rodolphe Bourret, Fulvio Braido, Pedro Carreiro-Martins, Denis Charpin, Ivan Cherrez-Ojeda, Tomas Chivato, Derek K. Chu, Cemal Cingi, Stefano Del Giacco, Frederic de Blay, Philippe Devillier, Govert De Vries, Maria Doulaptsi, Virginie Doyen, Gerard Dray, Jean-Francois Fontaine, R. Maximiliano Gomez, Jan Hagemann, Enrico Heffler, Maja Hofmann, Ewa Jassem, Marek Jutel, Thomas Keil, Vicky Kritikos, Inger Kull, Marek Kulus, Olga Lourenco, Eve Mathieu-Dupas, Enrica Menditto, Ralph Mosges, Ruth Murray, Rachel Nadif, Hugo Neffen, Stefania Nicola, Robyn O'Hehir, Heidi Olze, Yuliia Palamarchuk, Jean-Louis Pepin, Benoit Petre, Robert Picard, Constantinos Pitsios, Francesca Puggioni, Santiago Quirce, Filip Raciborski, Sietze Reitsma, Nicolas Roche, Monica Rodriguez-Gonzalez, Jan Romantowski, Ana Sa-Sousa, Faradiba S. Serpa, Marine Savoure, Mohamed H. Shamji, Milan Sova, Annette Sperl, Cristiana Stellato, Ana Todo-Bom, Peter Valentin Tomazic, Olivier Vandenplas, Michiel Van Eerd, Tuula Vasankari, Frederic Viart, Susan Waserman, Joao A. Fonseca, Torsten Zuberbier
Summary: MASK-air is a validated mHealth app that has enabled large-scale implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can address unmet patient needs in rhinitis and asthma care. MASK-air is recognized as a Good Practice by DG Sante and a candidate Good Practice by OECD.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Review
Medicine, General & Internal
Dominique Lauque, Anna Khalemsky, Zoubir Boudi, Linda Ostlundh, Chang Xu, Mohammed Alsabri, Churchill Onyeji, Jacqueline Cellini, Geroge Intas, Kapil Dev Soni, Detajin Junhasavasdikul, Jose Javier Trujillano Cabello, Niels K. Rathlev, Shan W. Liu, Carlos A. Camargo, Anna Slagman, Michael Christ, Adam J. Singer, Charles-Henri Houze-Cerfon, Elhadi H. Aburawi, Karim Tazarourte, Lisa Kurland, Phillip D. Levy, James H. Paxton, Dionyssios Tsilimingras, Vijaya Arun Kumar, David G. Schwartz, Eddy Lang, David W. Bates, Gabriele Savioli, Shamai A. Grossman, Abdelouahab Bellou
Summary: This systematic review and meta-analysis aimed to determine the association between emergency department length of stay (EDLOS) and in-hospital mortality (IHM). The analysis of multiple studies showed a significant association between EDLOS over 24 hours and IHM in ICU-admitted patients, as well as a correlation between low EDLOS and IHM in non-ICU admitted patients. This highlights the importance of minimizing prolonged stays in the emergency department and providing special attention to patients admitted after a short ED stay.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Respiratory System
Luke Daines, Bang Zheng, Omer Elneima, Ewen Harrison, Nazir I. Lone, John R. Hurst, Jeremy S. Brown, Elizabeth Sapey, James D. Chalmers, Jennifer K. Quint, Paul Pfeffer, Salman Siddiqui, Samantha Walker, Krisnah Poinasamy, Hamish McAuley, Marco Sereno, Aarti Shikotra, Amisha Singapuri, Annemarie B. Docherty, Michael Marks, Mark Toshner, Luke S. Howard, Alex Horsley, Gisli Jenkins, Joanna C. Porter, Ling-Pei Ho, Betty Raman, Louise V. Wain, Christopher E. Brightling, Rachael A. Evans, Liam G. Heaney, Anthony De Soyza, Aziz Sheikh
Summary: This study aimed to characterize and identify risk factors for patients with persistent breathlessness following COVID-19 hospitalization and develop a prediction model. The results showed that lower socioeconomic status, preexisting depression/anxiety, female sex, and longer hospital stay were risk factors for post-COVID-19 breathlessness. In contrast, Black ethnicity and older age groups were less likely to experience post-COVID-19 breathlessness. Breathlessness was associated with decreased exercise capacity and lung function, but not with obstructive airflow limitation.
Article
Medicine, Research & Experimental
Christopher J. Weir, Imad Adamestam, Rona Sharp, Holly Ennis, Andrew Heed, Robin Williams, Kathrin Cresswell, Omara Dogar, Sarah Pontefract, Jamie Coleman, Richard Lilford, Neil Watson, Ann Slee, Antony Chuter, Jillian Beggs, Sarah Slight, James Mason, Lucy Yardley, Aziz Sheikh
Summary: This study aims to develop a complex ePrescribing-based Anti-Microbial Stewardship intervention (ePAMS+) and conduct a feasibility trial. ePAMS+ includes educational and organisational behavioural elements, plus guideline-based clinical decision support to aid optimal antimicrobial use in hospital inpatients. The study aims to evaluate the feasibility of ePAMS+ through qualitative and quantitative data collection and analysis, and provide data support for future large-scale trial design.
PILOT AND FEASIBILITY STUDIES
(2023)
Editorial Material
Respiratory System
Alexander G. Mathioudakis, Ekaterina Khaleva, Markus Fally, Paula R. Williamson, Jens-Ulrik Jensen, Tim W. Felton, Chris Brightling, Andrew Bush, Tonya Winders, John Linnell, Valeria Ramiconi, Courtney Coleman, Tobias Welte, Graham Roberts, Jurgen Vestbo
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Medicine, General & Internal
Jonathan I. Silverberg, Emma Guttman-Yassky, Diamant Thaci, Alan D. Irvine, Linda Stein Gold, Andrew Blauvelt, Eric L. Simpson, Chia-Yu Chu, Zhuqing Liu, Renata Gontijo Lima, Sreekumar G. Pillai, Julien Seneschal
Summary: Two 52-week trials showed that treatment with lebrikizumab was effective in improving skin condition and reducing itch severity in patients with moderate-to-severe atopic dermatitis. The incidence of adverse events was generally mild to moderate and did not lead to trial discontinuation.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Xuanhui Chen, Jiaxin Li, Guangjian Liu, Xiujuan Chen, Shuai Huang, Huixian Li, Siyi Liu, Dantong Li, Huan Yang, Haiqing Zheng, Lianting Hu, Lingcong Kong, Huazhang Liu, Abdelouahab Bellou, Liming Lei, Huiying Liang
Summary: This retrospective study aimed to predict the outcomes of ventilated ICU patients on the first day of ventilation by deriving their clinical phenotypes. Cluster analysis was performed on the eICU and MIMIC-IV cohorts to identify and validate four clinical phenotypes. These phenotypes showed heterogeneity among ICU patients and were associated with different mortality and extubation success rates. They also responded differently to ventilation strategies in terms of treatment duration, but did not have a difference in mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Allergy
Philippe Eigenmann, Ayobami Akenroye, Marina Atanaskovic Markovic, Fabio Candotti, Motohiro Ebisawa, Jon Genuneit, Oemer Kalayci, Doris Kollmann, Agnes Sze Yin Leung, Rachel L. Peters, Carmen Riggioni
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Allergy
Pekka Hurme, Reetta Sahla, Beate Ruckert, Tero Vahlberg, Riitta Turunen, Tytti Vuorinen, Mubeccel Akdis, Maria Soderlund-Venermo, Cezmi Akdis, Tuomas Jartti
Summary: This study found differences in cytokine response profiles between sole RV and dual RV-HBoV1-induced first wheezing episodes. The RV-HBoV1 group showed lower expression of cytokines compared to the RV group during acute illness and convalescence. The association between hospitalization time and virus group and cytokine response suggests that certain cytokines may be related to shorter hospital stays in the RV-HBoV1 coinfection group.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)