Article
Medicine, General & Internal
Andrew F. Whyte, Jasmeet Soar, Amy Dodd, Anna Hughes, Nicholas Sargant, Paul J. Turner
Summary: Anaphylaxis is a serious systemic hypersensitivity reaction that requires prompt treatment with intramuscular adrenaline. However, many patients do not receive this intervention as recommended, highlighting the importance of updated guidelines for recognition, management, observation, and follow-up of patients with anaphylaxis.
Review
Health Care Sciences & Services
Leong Chow Wei, Mohd Boniami Yazid, Mohd Noor Norhayati, Abu Yazid Md Noh, Andey Rahman
Summary: This study aimed to compare the individual's ability to use new/modified model AI devices with old model AI devices for treating anaphylaxis. The results showed that the new/modified model AI devices were associated with better safety, but there was no significant difference in successful administration compared to the old model AI devices.
Article
Health Policy & Services
Michael Khalemsky, Abdelouahab Bellou, Mehmet Mockel, Martin G. Mockel, Luis Garcia Castrillo, David Schwartz
Summary: Physicians showed positive attitudes towards AERC, with 88.4% seeing potential and 62.9% believing it should be implemented immediately. While physicians were willing to provide advice for patients to join AERC, concerns still existed, such as being left without AAI, expired AAI, and wrong AAI administration.
HEALTH POLICY AND TECHNOLOGY
(2022)
Review
Critical Care Medicine
Amy Dodd, Anna Hughes, Nicholas Sargant, Andrew F. Whyte, Jasmeet Soar, Paul J. Turner
Summary: The Resuscitation Council UK has updated its Guideline for healthcare providers on the Emergency treatment of anaphylaxis, with significant changes including repeating intramuscular adrenaline doses, no longer routinely recommending corticosteroids, interventions for refractory reactions, a recommendation against antihistamines, and guidance on observation duration and timing of discharge.
Article
Medicine, General & Internal
Yen-Yue Lin, Hsin-An Chang, Yung-Hsi Kao, Chih-Pin Chuu, Wen-Fang Chiang, Ya-Chieh Chang, Yuan-Kuei Li, Chi-Ming Chu, Jenq-Shyong Chan, Po-Jen Hsiao
Summary: This retrospective study investigated the use of epinephrine in patients with anaphylaxis in an emergency department in Taiwan. The use of epinephrine was determined by factors such as ambulance arrival, hypotension, airway compromise, and altered consciousness. Emergent care focusing on airway, breathing, and circulation (ABC) could compensate for the underuse of epinephrine and ensure patient safety.
FRONTIERS IN MEDICINE
(2023)
Article
Allergy
Fabiana A. Nunes, Fabio Zanini, Camilla de S. Braga, Andreza L. da Silva, Fatima R. Fernandes, Dirceu Sole, Gustavo F. Wandalsen
Summary: The study assessed the incidence of anaphylaxis in the emergency room of a private pediatric hospital in Sao Paulo, Brazil. The results showed a low incidence rate, with food being the most suspected trigger and most cases presenting with mild symptoms.
WORLD ALLERGY ORGANIZATION JOURNAL
(2022)
Article
Allergy
Evangeline Clark, Luciana Kase Tanno, Tram Vo, Brigitte Blanc, Pascal Demoly, Davide Caimmi
Summary: This study aimed to assess the appropriateness of epinephrine use in children with allergies in the emergency department, and identify factors associated with epinephrine administration, auto-injector prescription, and referral to an allergist. The study found that only 17% of children received epinephrine injections and 57.1% consulted an allergist after the acute episode. This highlights the need for improved management and care pathways for pediatric anaphylaxis.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Article
Allergy
Guillaume Pouessel, Sabrina Alonzo, Amandine Divaret-Chauveau, Pascale Dumond, Elena Bradatan, Valerie Liabeuf, Pascale Beaumont, Selina Tscheiller, Remy Diesnis, Jean-Marie Renaudin, Dominique Sabouraud-Leclerc
Summary: A retrospective analysis was conducted on severe anaphylaxis cases recorded by the Allergy-Vigilance (R) Network (2002-2020) to evaluate the characteristics associated with survival, age, and allergens. The results showed that food was the main allergen for severe anaphylaxis in both children and adults, and young age, asthma history, and exercise were characteristic features of severe food anaphylaxis.
Article
Pediatrics
Kristina Rueter, Natasha Moseley, Brennan Ta, Natasha Bear, Meredith L. Borland, Susan L. Prescott
Summary: This study aims to assess changes in rates, characteristics, and management of infant anaphylaxis in a pediatric ED. The results show an increase in the incidence and severity of anaphylaxis in children under 2 years old, highlighting the importance of timely recognition and optimal management in this age group.
Article
Immunology
Lucy Deng, Kathryn Tapper, Deepali Thosar, Emma Goeman, Louise Baker, Stephen Adelstein, Michael Boyle, David A. Brown, Louise Evans, Connie Katelaris, Frederick Lee, Jamma Li, Sanjay Swaminathan, Mark S. Taylor, Melanie Wong, Nicholas Wood
Summary: This study examined the clinical profiles of individuals who received adrenaline following COVID-19 vaccination. Less than one in five individuals who received adrenaline met the criteria for anaphylaxis, and many reactions treated with adrenaline had little diagnostic certainty of anaphylaxis. Increased awareness and education on objective signs and symptoms of anaphylaxis is needed to ensure appropriate use of adrenaline.
Review
Allergy
Debra de Silva, Chris Singh, Antonella Muraro, Margitta Worm, Cherry Alviani, Victoria Cardona, Audrey DunnGlvin, Lene Heise Garvey, Carmen Riggioni, Elizabeth Angier, Stefania Arasi, Abdelouahab Bellou, Kirsten Beyer, Diola Bijlhout, M. Beatrice Bilo, Knut Brockow, Montserrat Fernandez-Rivas, Susanne Halken, Britt Jensen, Ekaterina Khaleva, Louise J. Michaelis, Hanneke Oude Elberink, Lynne Regent, Angel Sanchez, Berber Vlieg-Boerstra, Graham Roberts
Summary: This systematic review found limited and uncertain evidence on the diagnosis, management, and prevention strategies of anaphylaxis. Adrenaline is commonly used for emergency management, but robust research on its effectiveness is lacking.
Article
Medicine, General & Internal
Maria De Filippo, Martina Votto, Maria Albini, Riccardo Castagnoli, Mara De Amici, Alessia Marseglia, Alessandro Pizzo, Gian Luigi Marseglia, Amelia Licari
Summary: This study retrospectively analyzes the features and management approach of anaphylactic reactions in children evaluated at a pediatric clinic in Pavia. The results show that 80% of severe cases of anaphylaxis had other atopic comorbidities. The low usage of adrenaline highlights the importance of raising awareness of anaphylactic management in the medical community.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Health Care Sciences & Services
Anca Angela Simionescu, Bianca Mihaela Danciu, Ana Maria Alexandra Stanescu
Summary: Anaphylactic reactions during pregnancy can lead to unpredictable outcomes for both the mother and fetus, including death and neurological diseases. Common allergens identified include antibiotics, anesthetic drugs, latex, and other medications. Favorable outcomes are achievable with a high level of observation, multidisciplinary cooperation, and prompt treatment.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Allergy
Nandinee Patel, Emily Isaacs, Bettina Duca, Nanthagopan Nagaratnam, Jackie Donovan, Sara Fontanella, Paul J. Turner
Summary: This study evaluated the effects of self-injection of 300 μg or 500 μg adrenaline on plasma adrenaline levels and cardiovascular parameters in teenagers at risk of anaphylaxis. The results showed that the 500 μg adrenaline injection resulted in a higher and more prolonged peak concentration and greater area-under-curve for plasma adrenaline compared to the 300 μg dose. Adrenaline also caused a significant increase in heart rate regardless of dose and device used.
Article
Pediatrics
Gavriela Feketea, John Lakoumentas, Evangelia Papatriantafyllou, Nikolaos Douladiris, Dimitris Efthymiou, Luminita Aurelia Stanciu, Emilia Vassilopoulou
Summary: An observational study in Greece found that school staff have limited knowledge about food allergies in schoolchildren. Female teachers showed more concern about the availability of trained personnel to manage food allergy symptoms. Schools should provide training on food allergy management, improve emergency treatment plans, and ensure access to emergency tools.
Letter
Allergy
Margitta Worm, Valerie Glatzel, Sabine Baumgart, Henrik E. Mei, Till Soerensen, Andreas Gruetzkau, Guido Heine
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Editorial Material
Allergy
Steffen Schubert, Margitta Worm, Heinrich Dickel, Nicola Wagner, Richard Brans, Claudia Schroder-Kraft, Andrea Bauer, Andre Koch, Johannes Geier
CONTACT DERMATITIS
(2023)
Review
Allergy
Caroline Beutner, Jochen Schmitt, Margitta Worm, Martin Wagenmann, Christian Albus, Timo Buhl
Summary: Allergen immunotherapy (AIT) involves gradually increasing the dose of allergen extract until immunologic tolerance is achieved. Adherence to AIT is crucial for long-term success, but measuring adherence and persistence rates has been inconsistent. The development of standardized tools and parameters for measuring adherence in AIT is necessary. Additionally, exploring methods from adherence research in other chronic diseases could help improve outcomes in AIT.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Dermatology
Elke Weisshaar, Philipp Bentz, Christian Apfelbacher, Eva Haufe, Luise Heinrich, Annice Heratizadeh, Susanne Abraham, Inken Harder, Andreas Kleinheinz, Andreas Wollenberg, Knut Schaekel, Franca Wiemers, Julia Ertner, Matthias Augustin, Julia Wildberger, Ralph von Kiedrowski, Margitta Worm, Alexander Zink, Isaak Effendy, Andrea Asmussen, Mario Pawlak, Michael Sticherling, Melanie Hilgers, Christiane Handrick, Sven Quist, Beate Schwarz, Magnus Bell, Petra Staubach-Renz, Sung-Hei Hong-Weldemann, Bernhard Homey, Jens-Joachim Bruecher, Stephan Weidinger, Thomas Werfel, Jochen Schmitt
Summary: TREATgermany is a disease registry that investigates the severity, symptoms, treatment, and quality of life in patients with moderate to severe atopic dermatitis. The results show that 97.2% of patients experienced itch, and the severity of itch is correlated with the patient's self-reported disease severity.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Allergy
Theresa Hanschmann, Wojciech Francuzik, Sabine Doelle-Bierke, Kathrin Scherer Hofmeier, Linus Grabenhenrich, Franziska Rueff, Jean-Marie Renaudin, Claudia Pfoehler, Regina Treudler, M. Beatrice Bilo, Roland Lang, Luis Felipe Ensina, George Christoff, Victoria Cardona, Nicola Wagner, Norbert Reider, Sabine Mueller, Heinrich Dickel, Margitta Worm
Summary: This study analyzes a large dataset on drug induced anaphylaxis and provides insights into its causes, risk factors, symptoms, and treatment. Drugs, particularly analgesics and antibiotics, are found to be the third most common cause of anaphylactic reactions. Female gender and older age are identified as relevant risk factors, while children are less affected by drug induced anaphylaxis.
Biographical-Item
Allergy
Stephanie Dramburg, Susanne Lau, Paolo Matricardi, Margitta Worm, Cezmi A. Akdis, Claus Bachert, Bruce Bochner, Stephen Durham, Johannes Ring, Heimo Breiteneder, Rudolf Valenta, Claudia Traidl-Hoffman
Letter
Dermatology
Elke Weisshaar, Philipp Bentz, Eva Haufe, Luise Heinrich, Christian Apfelbacher, Annice Heratizadeh, Susanne Abraham, Inken Harder, Andreas Kleinheinz, Andreas Wollenberg, Knut Schaekel, Franca Wiemers, Konstantin Ertner, Matthias Augustin, Julia Wildberger, Ralph von Kiedrowski, Margitta Worm, Alexander Zink, Isaak Effendy, Andrea Asmussen, Mario Pawlak, Michael Sticherling, Melanie Hilgers, Christiane Handrick, Sven Quist, Beate Schwarz, Magnus Bell, Petra Staubach-Renz, Su-Hei Hong-Weldemann, Bernhard Homey, Jens Bruecher, Stephan Weidinger, Thomas Werfel, Jochen Schmitt
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Allergy
Veronika Hoefer, Matteo Martini, Sabine Doelle-Bierke, Margitta Worm, Maria Beatrice Bilo
Summary: The impact on health-related quality of life (HRQL) is crucial for patients with allergies and anaphylaxis. This narrative review focuses on HRQL in allergic patients with food and venom allergies, which are the most common triggers for severe and life-threatening reactions. The review highlights the availability of standardized assessment tools for measuring HRQL in these patients and the various factors that can influence HRQL, including sociodemographic data and external factors. The review also emphasizes the importance of considering lifestyle factors and measuring individual changes in HRQL during specific immunotherapy.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Review
Allergy
J. Bousquet, E. Melen, T. Haahtela, G. H. Koppelman, A. Togias, R. Valenta, C. A. Akdis, W. Czarlewski, M. Rothenberg, A. Valiulis, M. Wickman, M. Akdis, D. Aguilar, A. Bedbrook, C. Bindslev-Jensen, S. Bosnic-Anticevich, L. P. Boulet, C. E. Brightling, L. Brussino, E. Burte, M. Bustamante, G. W. Canonica, L. Cecchi, J. C. Celedon, C. Chaves Loureiro, E. Costa, A. A. Cruz, M. Erhola, B. Gemicioglu, W. J. Fokkens, J. Garcia-Aymerich, S. Guerra, J. Heinrich, J. C. Ivancevich, T. Keil, L. Klimek, P. Kuna, M. Kupczyk, V. Kvedariene, D. E. Larenas-Linnemann, N. Lemonnier, K. C. Lodrup Carlsen, R. Louis, M. Makela, M. Makris, M. Maurer, I. Momas, M. Morais-Almeida, J. Mullol, R. N. Naclerio, K. Nadeau, R. Nadif, M. Niedoszytko, Y. Okamoto, M. Ollert, N. G. Papadopoulos, G. Passalacqua, V. Patella, R. Pawankar, N. Pham-Thi, O. Pfaar, F. S. Regateiro, J. Ring, P. W. Rouadi, B. Samolinski, J. Sastre, M. Savoure, N. Scichilone, M. H. Shamji, A. Sheikh, V. Siroux, B. Sousa-Pinto, M. Standl, J. Sunyer, L. Taborda-Barata, S. Toppila-Salmi, M. J. Torres, I. Tsiligianni, E. Valovirta, O. Vandenplas, M. T. Ventura, S. Weiss, A. Yorgancioglu, L. Zhang, A. H. Abdul Latiff, W. Aberer, I. Agache, M. Al-Ahmad, I. Alobid, I. J. Ansotegui, S. H. Arshad, E. Asayag, C. Barbara, A. Baharudin, L. Battur, K. S. Bennoor, E. C. Berghea, K. C. Bergmann, D. Bernstein, M. Bewick, H. Blain, M. Bonini, F. Braido, R. Buhl, R. S. Bumbacea, A. Bush, M. Calderon, M. Calvo-Gil, P. Camargos, L. Caraballo, V. Cardona, W. Carr, P. Carreiro-Martins, T. Casale, A. M. Cepeda Sarabia, R. Chandrasekharan, D. Charpin, Y. Z. Chen, I. Cherrez-Ojeda, T. Chivato, E. Chkhartishvili, G. Christoff, D. K. Chu, C. Cingi, J. Correia de Sousa, C. Corrigan, A. Custovic, G. D'Amato, S. Del Giacco, F. De Blay, P. Devillier, A. Didier, M. do Ceu Teixeira, D. Dokic, H. Douagui, M. Doulaptsi, S. Durham, M. Dykewicz, T. Eiwegger, Z. A. El-Sayed, R. Emuzyte, A. Fiocchi, N. Fyhrquist, R. M. Gomez, M. Gotua, M. A. Guzman, J. Hagemann, S. Hamamah, S. Halken, D. M. G. Halpin, M. Hofmann, E. Hossny, M. Hrubisko, C. Irani, Z. Ispayeva, E. Jares, T. Jartti, E. Jassem, K. Julge, J. Just, M. Jutel, I. Kaidashev, O. Kalayci, A. F. Kalyoncu, P. Kardas, B. Kirenga, H. Kraxner, I. Kull, M. Kulus, S. La Grutta, S. Lau, L. Le Tuyet Thi, M. Levin, B. Lipworth, O. Lourenco, B. Mahboub, E. Martinez-Infante, P. Matricardi, N. Miculinic, N. Migueres, F. Mihaltan, Y. Mohammad, M. Moniuszko, S. Montefort, H. Neffen, K. Nekam, E. Nunes, D. Nyembue Tshipukane, R. O'Hehir, I. Ogulur, K. Ohta, K. Okubo, S. Ouedraogo, H. Olze, I. Pali-Schoell, O. Palomares, K. Palosuo, C. Panaitescu, P. Panzner, H. S. Park, C. Pitsios, D. Plavec, T. A. Popov, F. Puggioni, S. Quirce, M. Recto, M. S. Repka-Ramirez, C. Robalo Cordeiro, N. Roche, M. Rodriguez-Gonzalez, J. Romantowski, N. Rosario Filho, M. Rottem, H. Sagara, F. S. Serpa, Z. Sayah, S. Scheire, P. Schmid-Grendelmeier, J. C. Sisul, D. Sole, M. Soto-Martinez, M. Sova, A. Sperl, O. Spranger, R. Stelmach, C. Suppli Ulrik, M. Thomas, T. To, A. Todo-Bom, P. V. Tomazic, M. Urrutia-Pereira, M. Valentin-Rostan, E. Van Ganse, M. van Hage, T. Vasankari, P. Vichyanond, G. Viegi, D. Wallace, D. Y. Wang, S. Williams, M. Worm, P. Yiallouros, O. Yusuf, F. Zaitoun, M. Zernotti, M. Zidarn, J. Zuberbier, J. A. Fonseca, T. Zuberbier, J. M. Anto
Summary: Asthma, rhinitis, and atopic dermatitis are interrelated clinical phenotypes. The concept of one-airway-one-disease, which simplifies the links between upper and lower airway allergic diseases, needs to be reassessed based on new data.
Article
Allergy
Steffen Schubert, Johannes Geier, Richard Brans, Annice Heratizadeh, Birger Kraenke, Axel Schnuch, Andrea Bauer, Heinrich Dickel, Timo Buhl, Dieter Vieluf, Nicola Wagner, Margitta Worm
Summary: Positive patch test reactions to Limonene hydroperoxides (Lim-OOHs) and Linalool hydroperoxides (Lin-OOHs) were frequent in consecutive patients, but most of the reactions were weak, doubtful, or irritant in nature. Patients with irritant reactions to sodium lauryl sulphate (SLS) were more likely to react to Lim-OOHs and Lin-OOHs. It is recommended to chemically monitor test preparations to reduce irritancy and interpret patch test results carefully.
CONTACT DERMATITIS
(2023)
Letter
Dermatology
M. Michaelidou, D. Redhu, V. Kumari, M. Babina, M. Worm
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Farzan Solimani, Alberto Mesas-Fernandez, Amrei Dilling, Alexander Nast, Franz J. Hilke, Franziska C. Ghoreschi, Margitta Worm, Kamran Ghoreschi, Katharina Meier
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Medicine, General & Internal
Jonathan I. Silverberg, Emma Guttman-Yassky, Diamant Thaci, Alan D. Irvine, Linda Stein Gold, Andrew Blauvelt, Eric L. Simpson, Chia-Yu Chu, Zhuqing Liu, Renata Gontijo Lima, Sreekumar G. Pillai, Julien Seneschal
Summary: Two 52-week trials showed that treatment with lebrikizumab was effective in improving skin condition and reducing itch severity in patients with moderate-to-severe atopic dermatitis. The incidence of adverse events was generally mild to moderate and did not lead to trial discontinuation.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Allergy
Matteo Martini, Mariateresa Di Taranto, Veronika Hoefer, Margitta Worm, Maria Beatrice Bilo
Summary: This study evaluated the prevalence, severity, and risk factors of health-related quality of life (HRQoL) and mental health in patients with drug hypersensitivity reactions (DHRs), and found that these patients commonly experience depression and anxiety, and have significantly impaired HRQoL, especially in the case of drug-induced anaphylaxis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Medicine, General & Internal
Jonathan I. Silverberg, Emma Guttman-Yassky, Diamant Thaci, Alan D. Irvine, Linda Stein Gold, Andrew Blauvelt, Eric L. Simpson, Chia-Yu Chu, Zhuqing Liu, Renata Gontijo Lima, Sreekumar G. Pillai, Julien Seneschal
Summary: The study shows that lebrikizumab is effective in treating moderate-to-severe atopic dermatitis in both adolescents and adults, with significant improvements in skin lesions and reduction of itch symptoms during the 16-week induction period.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)