Journal
ALLERGY
Volume 66, Issue -, Pages 22-24Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1398-9995.2011.02626.x
Keywords
Allergen uptake; high-affinity IgE receptor; langerhans cells; oral mucosa; tolerance induction
Categories
Funding
- ALK-Abello
- Leti Pharma/Novartis
- Bencard/Allergy Therapeutics
- Stallergenes
- Phadia
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P>The oral epithelium contains oral mucosal Langerhans cells (oLCs) that constitutively express the high-affinity IgE-receptor Fc epsilon RI, the lipopolysaccharide receptor CD14 and toll-like receptor (TLR)4. The distribution of oLCs profoundly differs at distinct oral mucosal sites, with higher numbers of oLCs detectable in the vestibulum compared with the sublingual region. The oLC response to activation of TLR4 and Fc epsilon RI and to binding of allergen suggests that these cells are involved in the maintenance of tolerance towards bacterial components and allergens. Thus, oLCs are important targets for allergens and adjuvants during sublingual immunotherapy, and characterizing them is crucial for improving allergen-specific immunotherapy.
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