Review
Allergy
Rubaiyat Haque, Andrew A. White, David J. Jackson, Claire Hopkins
Summary: AERD is a respiratory disease defined by respiratory hypersensitivity reactions to the cyclooxygenase 1-inhibitory effects of NSAIDs. Patients are diagnosed through aspirin challenges or history, and may require multispecialty evaluation for treatment. Nasal polyposis significantly affects the quality of life for those with AERD.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Zoe Bhujoo, Saskia Ingen-Housz-Oro, Gwendeline Gener, Olivier Gaudin, Margaux Fleck, Muriel Verlinde-Carvalho, Muriel Paul, Olivier Chosidow, Paul Wolkenstein, Haudrey Assier
Summary: This study found that a late reading on day 4 enhanced the positive results of PTs. Positive PT results can help reduce the need for more difficult and costly IDTs. Therefore, late PT readings on day 4 should be considered when exploring NICADRs.
CONTACT DERMATITIS
(2022)
Article
Critical Care Medicine
Evans R. Fernandez Perez, William D. Travis, David A. Lynch, Kevin K. Brown, Kerri A. Johannson, Moises Selman, Jay H. Ryu, Athol U. Wells, Yuh-Chin Tony Huang, Carlos A. C. Pereira, Mary-Beth Scholand, Ana Villar, Naohiko Inase, Richard B. Evans, Stephen A. Mette, Lindsy Frazer-Green
Summary: The article summarizes evidence-based and consensus-derived guidance for clinicians to improve individual diagnostic decision-making for hypersensitivity pneumonitis (HP) and emphasizes the use of a multidisciplinary assessment approach in HP diagnosis. All evidence was of very low quality, indicating the need for further research on the performance and generalizability of diagnostic tools.
Article
Pharmacology & Pharmacy
Chunjiang Wang, Yulu Zhou, Weijin Fang, Zuojun Li, Shaoli Zhao
Summary: This study explores the clinical characteristics of Kounis syndrome (KS) induced by amoxicillin. The findings show that the number of patients receiving amoxicillin treatment is slightly higher than those receiving amoxicillin-clavulanate. The main symptoms include chest pain and allergic reactions, and diagnostic evaluation reveals elevated troponin and coronary artery stenosis with thrombosis. Most patients completely recover after discontinuation of the medication.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Zahra Kanannejad, Ali Pourvali, Hossein Esmaeilzadeh, Raheleh Shokouhi Shoormasti, Mohammad Reza Fazlollahi, Morteza Fallahpour, Fatemeh Zaremehrjardi
Summary: Beta-lactam (BLM) antibiotics, such as amino-penicillin and cephalosporins, are commonly used to treat bacterial infections, but adverse reactions are frequent. Doctors often choose broad-spectrum antibiotics as alternatives, which can have harmful consequences. This review aims to provide guidance on diagnosing BLM hypersensitivity and selecting alternative treatments, focusing on skin tests and drug provocation tests. The review also introduces a stratification approach for T-cell-mediated and IgE-mediated reactions.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Critical Care Medicine
Evans R. Fernandez Perez, William D. Travis, David A. Lynch, Kevin K. Brown, Kerri A. Johannson, Moises Selman, Jay H. Ryu, Athol U. Wells, Yuh-Chin Tony Huang, Carlos A. C. Pereira, Mary-Beth Scholand, Ana Villar, Naohiko Inase, Richard B. Evans, Stephen A. Mette, Lindsy Frazer-Green
Summary: This analysis aimed to provide evidence-based guidance for clinicians to improve diagnostic decision-making for hypersensitivity pneumonitis (HP). Through a systematic review and the use of the PICO format, 12 evidence-based recommendations and 2 ungraded consensus-based statements were developed. It was found that the diagnosis of HP should employ a patient-centered approach, incorporating environmental and occupational exposure history and CT pattern assessment.
Review
Biochemistry & Molecular Biology
Rosa Rodriguez-Perez, Leticia de las Vecillas, Rosario Cabanas, Teresa Bellon
Summary: Drug hypersensitivity reactions can have severe consequences and lifelong effects. Accurate diagnosis and identification of the culprit drug are crucial for prevention and finding alternative treatments. However, diagnosis can be challenging and requires a combination of in vivo and in vitro tests, as well as collaborative research to improve accuracy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Teng Moua, Tananchai Petnak, Antonios Charokopos, Misbah Baqir, Jay H. Ryu
Summary: Recent advances in fibrotic hypersensitivity pneumonitis include improved diagnostic guidance, systematic assessments of immunosuppressive therapy, and the recent availability of antifibrotic therapy. Standardized diagnosis may improve future therapeutic protocols and predict disease or treatment response. This review provides a comprehensive overview of diagnostic and treatment challenges, along with supporting evidence and clinical implications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Ilaria Puxeddu, Fiorella Petrelli, Maria Elena Guerrieri, Stefania Cosio, Isabella Del Corso, Valeria Rocchi, Maria Laura Manca, Paola Migliorini, Angiolo Gadducci
Summary: The development of hypersensitivity reactions to platinum agents limits the re-treatment options for gynecological cancer patients. Skin testing is a simple and sensitive tool for diagnosing and preventing hypersensitivity reactions to platinum agents. It can also help identify cross-reactivity among platinum agents and sensitized patients.
Review
Nutrition & Dietetics
Carlo Caffarelli, Carla Mastrorilli, Angelica Santoro, Massimo Criscione, Michela Procaccianti
Summary: Hazelnut allergies often start in childhood and adolescence, rarely resolving over time. The accuracy of specific-IgE testing for hazelnut proteins in diagnosing hazelnut allergies among children is still debated. Testing IgE levels for Cor a 9 and Cor a 14 may help improve specificity in identifying hazelnut-tolerant children and reduce the need for oral food challenges.
Article
Biochemistry & Molecular Biology
Carlos Fernandez-Lozano, Emilio Solano Solares, Isabel Elias-Saenz, Isabel Perez-Allegue, Monserrat Fernandez-Guarino, Diego Fernandez-Nieto, Laura Diaz Montalvo, David Gonzalez-de-Olano, Ana de Andres, Javier Martinez-Botas, Belen de la Hoz Caballer
Summary: In the first wave of COVID-19, up to 20% of patients experienced skin lesions with variable characteristics. The involvement of the SARS-CoV-2 virus in these cases is unclear, and some lesions may be due to drug hypersensitivity. A study was conducted on 11 patients to analyze the possible cause of the skin lesions. It was found that certain drugs resulted in positive lymphocyte transformation tests (LTT) and mixed Th1/Th2 cytokine secretion in patients with skin lesions, indicating mixed drug hypersensitivity. It is therefore recommended to avoid the culprit drug in all cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Zhiqiang Fan, Yang He, Wei Sun, Zuojun Li, Chao Ye, Chunjiang Wang
Summary: This study aimed to investigate the clinical characteristics of azathioprine-induced Sweet syndrome (AISS) and provide a reference for diagnosis, treatment and prognosis. A retrospective analysis of 44 cases of AISS was conducted, revealing that fever and arthralgia were the most common clinical symptoms, and the skin lesions mainly manifested as pustules, papules, plaques and nodules. Laboratory examination showed neutropenia, elevated C-reactive protein and erythrocyte sedimentation rates. Symptom relief was achieved within a median time of 7 days after azathioprine discontinuation. Recurrence of skin lesions occurred in some patients within 24 hours after readministration of azathioprine.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Medicine, General & Internal
Marcela Daniela Ionescu, Nicoleta Aurelia Popescu, Diana Stanescu, Augustina Enculescu, Mihaela Balgradean, Georgiana Mihaela Capitanescu, Dragos Bumbacea
Summary: Childhood interstitial lung disease (chILD) is a rare respiratory disorder in children with unclear etiology, often presenting as pneumonia or asthma. Complex diagnostic tests may be required, and delayed diagnosis and treatment can lead to chronic respiratory failure.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Joel Castro, Jessica Maddern, Luke Grundy, Jim Manavis, Andrea M. Harrington, Gudrun Schober, Stuart M. Brierley
Summary: This study utilized an autologous mouse model of endometriosis to examine disease features and symptoms including lesion development, chronic inflammatory environment, neuroangiogenesis, sensory hypersensitivity, and altered pain responses. The study found significant increases in lesion size, endometrial glands, stroma, and neuroangiogenesis. Mice with endometriosis displayed enhanced pain sensitivity and altered bladder function compared to control mice.
Review
Medicine, General & Internal
Susan Tuddenham, Matthew M. Hamill, Khalil G. Ghanem
Summary: Approximately 1 in 5 adults in the US had a sexually transmitted infection (STI) in 2018. Rates of gonorrhea, chlamydia, and syphilis in the US have increased, while rates of HSV-1 and HSV-2 have declined. Effective treatments are available for most STIs, but antimicrobial resistance limits oral therapies for gonorrhea and Mycoplasma genitalium, and no cure is available for genital herpes.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Allergy
Christina Krantz, Simone Accordini, Kjell Alving, Angelo G. Corsico, Pascal Demoly, Diogenes S. Ferreira, Bertil Forsberg, Judith Garcia-Aymerich, Thorarinn Gislason, Joachim Heinrich, Rain Jogi, Ane Johannessen, Benedicte Leynaert, Alessandro Marcon, Jesus Martinez-Moratalla Rovira, Elisabet Nerpin, Dennis Nowak, Anna-Carin Olin, Mario Olivieri, Antonio Pereira-Vega, Chantal Raherison-Semjen, Francisco Gomez Real, Torben Sigsgaard, Guilia Squillacioti, Christer Janson, Andrei Malinovschi
Summary: In a multi-center population-based study, an independent association between upper airway inflammatory disorders (UAID) and elevated fractional exhaled nitric oxide (FeNO) levels was found. There was a significant interaction with perennial sensitization and asthma, highlighting the concept of united airway disease.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Editorial Material
Allergy
A. Gauthier, F. Mankouri, P. Demol, A. M. Chiria
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Witchaya Srisuwatchari, Charles A. Tacquard, Anna Borushko, Simon Viville, Rodolphe Stenger, Yoann Ehrhard, Jean-Marc Malinovsky, Paul-Michel Mertes, Pascal Demoly, Anca-Mirela Chiriac
Summary: The aim of this study was to determine the diagnostic performance of serum total tryptase (T-A) to differentiate positive from negative allergy testing suspected perioperative hypersensitivity reaction (POH), and also to analyze the diagnostic performance of serial tryptase levels using several formulas.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Letter
Allergy
Pablo Rodriguez del Rio, Davide Caimmi, Pilar Rico, Carmen Vidal, Moreno Carmen, Ileana M. Pintoiu, Jose M. Beitia Mazuecos, David Gonzalez de Olano, Pedro Cuesta Alvaro, Pascal Demoly, Moises A. Calderon
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Oncology
Camille Bertrand, Christine Le Bihan-Benjamin, Florence Molinie, Agnes Rogel, Jean-Baptiste Meric, Norbert Ifrah, Philippe-Jean Bousquet
Summary: The authors propose an algorithm to identify breast interval cancer (IC) from the French administrative health-care database (SNDS) and compare them to those of women whose cancer was diagnosed through the organized screening programme or outside the organized screening programme. The care pathways of women with IC are intermediate with respect to those of the other groups.
CLINICAL BREAST CANCER
(2022)
Article
Allergy
Luciana Kase Tanno, Pascal Demoly
Summary: The International Classification of Diseases (ICD) serves as a common diagnostic and classification tool worldwide, aiming to improve the accuracy of mortality and morbidity statistics for allergic and hypersensitivity conditions. The recent change in hierarchy in ICD-11 has allowed for a dedicated section addressing these conditions, leading to more accurate classification and definitions. The implementation of ICD-11 was adopted at the 72nd World Health Assembly in May 2019.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Allergy
Paola Leonor Quan, Marina Sabate-Bresco, Carmen Mariana D'Amelio, Mariona Pascal, Blanca Esther Garcia, Gabriel Gastaminza, Natalia Blanca-Lopez, Maria Isabel Alvarado, Javier Fernandez, Carmen Moya, Joan Bartra, Marta Ferrer, Maria Jose Goikoetxea
Summary: Evaluation of the newly introduced microarray platform ALEX showed it has sound technical performance and adequate diagnostic capacity, comparable to ISAC112 and ImmunoCAP.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Review
Allergy
Luciana K. Tanno, Amelie Gauthier, Salome Allichon, Pascal Demoly
Summary: The rate of drug-induced anaphylaxis (DAF) is increasing globally, with the main implicated drugs being antibiotics, anaesthetics, radio-contrast media, and NSAIDs. The main manifestations are cardiovascular and respiratory commitments, and those at risk for DAF are patients over 54 years old with a history of drug allergy, cardiovascular disease, and/or asthma. The use of adrenaline is mentioned in only 29% of the articles.
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
L. Klimek, R. Brehler, R. Moesges, P. Demoly, J. Mullol, D. Y. Wang, R. E. O'Hehir, A. Didier, M. Kopp, C. Bos, E. Karagiannis
Summary: Sublingual immunotherapy (SLIT) is a safe and effective treatment for allergic rhinitis (AR), and Oralair (R) is a SLIT tablet containing natural pollen allergens that has been proven to be clinically effective and safe for patients with grass pollen-induced AR. It also shows potential benefits in reducing the risk or delaying the development of allergic asthma.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Computer Science, Information Systems
Rhode Ghislaine Nguewo Ngassam, Linnea Ung, Roxana Ologeanu-Taddei, Jorick Lartigau, Pascal Demoly, Isabelle Bourdon, Anca Mirela Chiriac
Summary: This study applies action design research to provide actionable knowledge on user perceptions and adoption of personal health records, focusing on the case of the digital allergy card. The research findings propose research proposals on the benefits of, levers for, and barriers to adoption that can be tested for other personal health records.
JOURNAL OF ORGANIZATIONAL AND END USER COMPUTING
(2022)
Review
Allergy
Pascal Demoly, Andrew H. Liu, Pablo Rodriguez del Rio, Soren Pedersen, Thomas B. Casale, David Price
Summary: Asthma is a common disease that affects millions of people worldwide. Genetic predisposition and environmental exposure are the main risk factors for developing asthma. Asthma guidelines recommend using specific IgE testing to identify allergens and personalize treatment plans for diagnosed asthma patients. Other diagnostic methods, such as eosinophil count and fractional exhaled nitric oxide measurement, can also be used to assess the severity of asthma and treatment response. Referral to asthma/allergy specialists is necessary when the initial diagnosis is uncertain or symptoms and exacerbations are recurring or severe.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Article
Allergy
Joana Vitte, Moise Michel, Andrei Malinovschi, Marco Caminati, Adeyinka Odebode, Isabella Annesi-Maesano, Davide Paolo Caimmi, Carole Cassagne, Pascal Demoly, Enrico Heffler, Estelle Menu, Bright Nwaru, Youssouf Sereme, Stephane Ranque, Monika Raulf, Wojciech Feleszko, Christer Janson, Carmen Galan
Summary: Fungi, as permanent players in the human exposome, play a crucial role in human health, yet our knowledge about their distribution, pathogenic effects, and interventions remains scarce. Improved understanding of the fungal exposome sheds light on the epidemiology of fungal-related hypersensitivity diseases, their immunological substrates, and available detection methods and biomarkers. Unmet needs in this field are described, while potential approaches are highlighted for future perspectives.
Article
Allergy
Oliver Pfaar, Philippe Devillier, Jochen Schmitt, Pascal Demoly, Ole Hilberg, Lawrence DuBuske, Nicole Hass, Ted Klok, Caroline Beutner
Summary: The 'Adherence and Persistence in AIT (APAIT)' checklist has been developed as a guide for reporting, designing, and interpreting retrospective studies on adherence or persistence to allergen immunotherapy (AIT). The checklist highlights the importance of transparency in reporting and identifies potential sources of bias in these studies.
Article
Anesthesiology
Paul Michel Mertes, Nadine Petitpain, Charles Tacquard, Marion Delpuech, Cedric Baumann, Jean Marc Malinovsky, Dan Longrois, Aurelie Gouel-Cheron, Diane Le Quang, Pascal Demoly, Jean Louis Gueant, Pierre Gillet, ALPHO Study Grp
Summary: This study assessed the relationship between pholcodine exposure and NMBA-related anaphylaxis. It found that exposure to pholcodine and other quaternary ammonium compounds in the environment can increase sensitivity to NMBAs. Pholcodine and quaternary ammonium sIgEs have a high negative predictive value but a very low positive predictive value for identifying NMBA-related reactions.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Allergy
Teodorikez Wilfox Jimenez-Rodriguez, FranciscoManuel Marco de la Calle, Inmaculada Lozano-Cubo, Rosa Ana Montoyo-Anton, Victor Soriano-Gomis, Purificacion Gonzalez-Delgado, Amparo Burgos-San Jose, Seira Climent-Ballester, Natividad Martinez-Banaclocha, Javier Fernandez-Sanchez
Summary: This study aimed to describe the clinical characteristics of converter phenotype reactions, which affect patients who initially present non-immediate hypersensitivity reactions but later develop immediate reactions upon subsequent exposures. Through retrospective analysis, researchers found that early allergological evaluation based on symptoms of non-immediate drug hypersensitivity reactions can help predict future immediate reactions, and the use of clinical characteristics, skin tests, and biomarkers can guide clinicians in optimizing therapy delivery while ensuring patient safety.
FRONTIERS IN ALLERGY
(2022)
