Article
Allergy
Gyaviira Nkurunungi, Jacent Nassuuna, Harriet Mpairwe, Joyce Kabagenyi, Margaret Nampijja, Richard E. Sanya, Emily L. Webb, Alison M. Elliott
Summary: Our study suggests that the balance between IgG4 and IgE, as well as the balance between total IgE and allergen-specific IgE, are more important than the absolute levels of total, helminth- or allergen-specific antibodies in inhibiting allergies in tropical regions. High IgG4/IgE ratios were associated with beneficial responses in allergen immunotherapy, while helminth infections were positively correlated with total IgE and allergen-specific IgE responses. Additionally, asthmatic schoolchildren had higher levels of total and allergen-specific IgE, but lower ratios of allergen-specific IgG4/IgE and total IgE/allergen-specific IgE compared to non-asthmatic controls.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Nutrition & Dietetics
Severina Terlouw, Frank E. van Boven, Monika Borsboom-van Zonneveld, Catharina de Graaf-in 't Veld, Marloes E. van Splunter, Paul L. A. van Daele, Maurits S. van Maaren, Marco W. J. Schreurs, Nicolette W. de Jong
Summary: The study compared the SPT results of homemade food allergen extracts with commercially available extracts, finding that homemade hazelnut and walnut extracts can be good alternatives in the absence of commercial extracts. The agreement between SPT results and food allergen-specific symptoms were comparable for homemade and commercial extracts, except for peach.
Review
Ophthalmology
Marie Louise Roed Rasmussen, Maria D'Souza, Divan Gabriel Topal, Josefine Gradman, Dorte Ancher Larsen, Bettina Behrmann Lehrmann, Henrik Fomsgaard Kjaer, Line Kessel, Yousif Subhi
Summary: This study aimed to determine the prevalence of allergic sensitization in patients with vernal keratoconjunctivitis (VKC) and provided an overview of published studies on this topic. The results showed that the prevalence of allergic sensitization in patients with VKC is 57.7%, with a higher focus on inhaled allergens. The most common positive allergens identified were house dust mites and pollen. These findings can be useful in managing VKC, such as avoiding contact with environmental allergens or pursuing allergy-specific treatment.
ACTA OPHTHALMOLOGICA
(2023)
Article
Biochemical Research Methods
Aljali Hamed, Ian Todd, Patrick J. Tighe, Richard J. Powell, Tim Harrison, Lucy C. Fairclough
Summary: This study found differences in serum IgE and IgG4 levels between suspected asthmatic patients and controls, and also identified correlations between sIgE and sIgG4 with skin prick test results. Suspected asthmatic patients showed higher reactivity to multiple allergens, with sIgE demonstrating higher correlation with cat, dog, house dust mite, and grass allergens compared to clinical test results.
JOURNAL OF IMMUNOLOGICAL METHODS
(2021)
Article
Endocrinology & Metabolism
Agnes Sola-Gazagnes, Catherine Pecquet, Stefano Berre, Peter Achenbach, Laure-Anne Pierson, Isabelle Virmoux-Buisson, Jocelyne M'Bemba, Fabienne Elgrably, Philippe Moguelet, Christian Boitard, Sophie Caillat-Zucman, Moussa Laanani, Joel Coste, Etienne Larger, Roberto Mallone
Summary: The study aimed to develop a management workflow for diagnosing insulin allergy and evaluate the diagnostic performance of confirmatory tests. Clinical criteria were validated as effective diagnostic guides, and the IDR test showed the best diagnostic performance.
Article
Multidisciplinary Sciences
Xu Gao, Lan Hong, Qin Xiang
Summary: We investigated the risk factors for allergic conjunctivitis in Chinese children. Through questionnaire, eye examinations, and skin prick tests, we found that parental allergic history and concomitant diseases were associated with a higher likelihood of AC in children.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Ghada A. A. Mokhtar, Manar G. G. Gebriel, Noha M. M. Hammad, Sylvia W. W. Roman, Osama Attia, Ahmed Behiry, Nagwan A. A. Ismail, Mohamed Salah Abd El Azeem El Sayed, Ahmed Nagy Hadhoud, Yosra A. A. Osama, Ahmed A. A. Ali, Heba M. M. Kadry
Summary: This study aimed to identify the common fungal aeroallergen sensitization patterns among airway-allergic patients in Zagazig, Egypt. The results showed that mixed mold sensitization ranked fourth among the most frequent aeroallergens, and Alternaria alternata was the most frequently encountered fungal aeroallergen in the Zagazig locality.
Article
Public, Environmental & Occupational Health
Hang Zheng, Xinxin Zeng, Qiuling Xie, Yuhang Wu, Quanhua Liu, Qian Chen, Lisu Huang, Weixi Zhang
Summary: This study analyzed the association between prenatal environmental antibiotic levels and allergic diseases, finding that early-life environmental antibiotic exposure may be correlated with an increased risk of asthma, wheeze, atopic dermatitis, and skin prick test positivity for food allergens in 5-year-old children.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Allergy
Jose Cristian Vidal-Quist, Carmen Vidal, Fernando Escolar, Bart N. Lambrecht, Stephane Rombauts, Pedro Hernandez-Crespo
Summary: The study identified seven RNA viruses in Dermatophagoides pteronyssinus, with picornavirus-like viral particles detected in the digestive system and fecal pellets. These viruses could be persistently transmitted to other mite colonies and detected in house dust samples and commercial extracts. The presence of viral infections in D. pteronyssinus suggests potential implications for mite populations and allergenicity in humans.
Article
Nutrition & Dietetics
Sylvie Tagliati, Simona Barni, Mattia Giovannini, Giulia Liccioli, Lucrezia Sarti, Tatiana Alicandro, Erika Paladini, Giancarlo Perferi, Chiara Azzari, Elio Novembre, Francesca Mori
Summary: Nut allergies are increasingly common in Italian children, with hazelnuts and walnuts being common allergens. Clinical manifestations include anaphylaxis and gastrointestinal symptoms, with a majority of patients having a family history of allergy or concomitant allergic disorders.
Article
Immunology
Yasmeen S. El Ansari, Cynthia Kanagaratham, Oliver T. Burton, Jenna V. Santos, Brianna-Marie A. Hollister, Owen L. Lewis, Harald Renz, Hans C. Oettgen
Summary: Mast cells and basophils play important roles in IgE-mediated hypersensitivity reactions. IgG and IgA antibodies can regulate the activation of these cells by activating or inhibiting receptors. This study found that IgA antibodies can bind to mast cells and basophils, and inhibit their activation to maintain immune homeostasis at mucosal sites.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Thimo Ruethers, Roni Nugraha, Aya C. Taki, Andrea O'Malley, Shaymaviswanathan Karnaneedi, Stephanie Zhang, A. Brenda Kapingidza, Sam Mehr, Sandip D. Kamath, Maksymilian Chruszcz, Graham Mackay, Dianne E. Campbell, Andreas L. Lopata
Summary: This study reveals the clinical relevance of IgE-binding proteins in crocodile meat for fish-allergic patients. The major fish allergen parvalbumin (PV) was found to trigger allergic reactions in fish-allergic patients when present in heated crocodile meat. Crocodile beta-PV was identified as the major IgE-binding protein, but less abundant than alpha-PV. It is recommended that fish-allergic individuals seek specialist advice before consuming crocodile meat.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Review
Allergy
Mohamed H. Shamji, Rudolf Valenta, Theodore Jardetzky, Valerie Verhasselt, Stephen R. Durham, Peter A. Wurtzen, R. J. Joost van Neerven
Summary: IgE-mediated allergy is a common hypersensitivity disease impacting over 30% of the population. Allergen-specific IgE triggers release of inflammatory mediators, while inducing IgG and IgA antibodies can compete with IgE for allergen binding to prevent allergic responses. Anti-IgE treatment can also prevent IgE from binding to receptors on mast cells and basophils to inhibit allergic reactions.
Review
Allergy
Subhabrata Moitra, Padukudru Anand Mahesh, Saibal Moitra
Summary: India is home to 20% of the global population, with 1.35 billion people. Allergic diseases, such as allergic rhinitis and asthma, have increased in India over the past decades, especially among adolescents. However, there is a lack of adequate epidemiological studies in rural and suburban areas, leading to a potential misrepresentation of the true burden. Environmental exposures, genetic factors, and new risk factors like presence of dumpsters and exposure to artificial light at night have been found to be associated with allergic rhinitis. Despite international guidelines, diagnosis and management of allergic rhinitis in India are often suboptimal due to factors such as lack of specialized training, diagnostic facilities, and expensive medications. This review emphasizes the need for a strategic approach to improve care for allergic diseases in India through education, awareness, and accessibility.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Otorhinolaryngology
Sasiwimon Traiyan, Wiparat Manuyakorn, Watcharoot Kanchongkittiphon, Cherapat Sasisakulporn, Wanlapa Jotikasthira, Potjanee Kiewngam, Wasu Kamchaisatian, Suwat Benjaponpitak
Summary: Both SPT and Phadiatop have good and comparable sensitivity and specificity for diagnosing aeroallergen-induced allergic rhinitis in children. SPT showed a sensitivity of 89.6% and specificity of 88.3% for AR, while Phadiatop provided a sensitivity of 88.6% and specificity of 95.3%.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2021)
Article
Allergy
Hajar Ali, Collin Brooks, Yu-Chieh Tzeng, Julian Crane, Richard Beasley, Peter Gibson, Philip Pattemore, Thorsten Stanley, Neil Pearce, Jeroen Douwes
Summary: This study found that autonomic nervous system activity is not associated with pathophysiology or inflammatory phenotype in young asthmatics with generally well-controlled asthma. However, enhanced sympathetic nervous system activity can be detected in asthmatics with airway hyperreactivity or who use beta-agonist medication.
Article
Public, Environmental & Occupational Health
William Mueller, Miranda Loh, Tony Fletcher, Sarah Rhodes, Lucy Pembrey, Neil Pearce, Martie van Tongeren
Summary: This study investigated the burden of COVID-19 in the UK food and drink processing industry. The results showed that infection rates were associated with deprivation, proportions of remote workers and workers in close proximity, and the number of workers.
ANNALS OF WORK EXPOSURES AND HEALTH
(2023)
Article
Allergy
Sandra G. Tedner, Susanna Klevebro, Anna Bergstrom, Inger Kull, Niklas Andersson, Magnus P. Borres, Natalia Ballardini, Marit Westman, Jon R. Konradsen, Marianne van Hage, Caroline Nilsson, Erik Melen, Anna Asarnoj
Summary: This study found that sensitization to peanut extract after the age of 4 is mainly caused by cross-sensitization to birch, and IgE sensitization to Ara h 2 rarely occurs after the age of 8. Storage protein sensitization is associated with respiratory and systemic inflammation.
Article
Allergy
Pauline Peftoulidou, Maria Gioulvanidou, Elissavet-Anna Chrysochoou, Elpis Hatziagorou
Summary: This study aimed to assess the association between lung function, physical activity, and quality of life (QoL) in children with well-controlled asthma. The results showed a significant correlation between QoL and both lung function and physical activity levels. However, despite reasonable asthma control, the children exhibited low physical activity levels, which negatively impacted their QoL.
Article
Immunology
Patricia Ramos-Ramirez, Jielu Liu, Sofia Mogren, Joshua Gregory, Malin Noreby, Anne Petren, Ying Lei, Henric Olsson, Marianne van Hage, Jukka Kervinen, Lars Hellman, Cecilia Andersson, Gunnar Nilsson, Mikael Adner
Summary: This study evaluated the effects of two common allergens (house dust mite and cat dander) on histopathological changes and the composition of mast cells in the lungs of guinea pigs. The results showed that exposure to these allergens caused asthma-like histopathology, including inflammation, airway remodelling, and accumulation of primarily mucosal mast cells. Therefore, these allergens can be used to establish a clinically relevant asthma model in guinea pigs.
JOURNAL OF IMMUNOLOGY RESEARCH
(2023)
Editorial Material
Public, Environmental & Occupational Health
Neil Pearce, Jan P. Vandenbroucke
Article
Public, Environmental & Occupational Health
Angela Pinot De Moira, Neil Pearce, Marie Pedersen, Anne-Marie Nybo Andersen
Summary: This study explored factors that may modify associations of early-life animal exposure with asthma and allergic disease, and found that type of animal, source of exposure, parental history of asthma or allergy, and timing of exposure can modify these associations. It is important to consider these factors when assessing the risks associated with early-life animal exposure.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Pediatrics
Renato T. Stein, Heather J. Zar
Summary: RSV represents a significant global healthcare burden, especially for children under 5 years old. There is no vaccine available, and treatment options are limited. The COVID-19 pandemic has disrupted RSV seasonality and epidemiology, providing an opportunity to study the transmission of RSV and inform future preventive strategies. This review discusses the RSV burden and epidemiology during the COVID-19 pandemic and how new data may impact decisions regarding RSV prevention.
PEDIATRIC PULMONOLOGY
(2023)
Article
Pediatrics
Nikolaos Karantaglis, Fotios Kirvassilis, Elpis Hatziagorou, Antonios Gkantaras, Kalliopi Kontouli, John Tsanakas, Maria Emporiadou
Summary: Bronchial provocation tests, such as the mannitol challenge, can help identify and measure the severity of bronchial hyperresponsiveness in asthmatic patients. This study aimed to compare the bronchial hyperresponsiveness to mannitol in treatment-naive asthmatic children before and after receiving asthma prophylaxis. The results showed that the provocative dose of mannitol increased significantly after treatment, suggesting that bronchial hyperresponsiveness to mannitol could be a potential monitoring tool in pediatric asthmatic patients.
Article
Allergy
Magnus Lindqvist, Katja Biering Leth-Moller, Allan Linneberg, Inger Kull, Anna Bergstrom, Antonios Georgellis, Magnus P. Borres, Agneta Ekebom, Marianne van Hage, Erik Melen, Marit Westman
Summary: Patients with pollen-induced allergic rhinitis face a high risk of persistent disease for at least 20 years, with childhood to adolescence being the most critical period for disease progression. The study findings underscore the close relationship between sensitization, allergic rhinitis, and asthma.
Article
Allergy
Musa Khaitov, Igor Shilovskiy, Rudolf Valenta, Milena Weber, Artem Korneev, Inna Tulaeva, Pia Gattinger, Marianne van Hage, Gerhard Hofer, Jon R. Konradsen, Walter Keller, Oluwatoyin Akinfenwa, Alina Poroshina, Nataliya Ilina, Elena Fedenko, Olga Elisyutina, Alla Litovkina, Evgenii Smolnikov, Aleksandra Nikonova, Sergei Rybalkin, Vladimir Aldobaev, Valeriy Smirnov, Nadezhda Shershakova, Olga Petukhova, Dmitriy Kudlay, Artem Shatilov, Anastasiya Timofeeva, Raffaela Campana, Sergei Udin, Veronica Skvortsova
Summary: The study designed a hypoallergenic vaccine based on the recombinant protein AB-PreS, and demonstrated through experiments that this vaccine has low immunoreactivity in allergic patients and can better inhibit the binding of IgE to allergens. Additionally, the vaccine also induced HBV-specific antibodies, potentially protecting against HBV infection.
Article
Public, Environmental & Occupational Health
Pilar Tavares Veras Florentino, Thiago Cerqueira-Silva, Luciana Freire De Carvalho, Flavia Jose Oliveira Alves, Vinicius De Araujo Oliveira, Gislani Mateus Oliveira Aguilar, Rodrigo De Sousa Prado, Daniel Soranz, Neil Pearce, Viviane Boaventura, Guilherme Loreiro Werneck, Gerson Oliveira Penna, Mauricio Lima Barreto, Marcio Henrique De Oliveira Garcia, Manoel Barral-Netto, Enny Santos da Paixao
Summary: This study provides evidence that COVID-19 vaccination during pregnancy, regardless of the vaccine type (CoronaVac or BNT162b2), is safe and does not increase the risk of adverse birth outcomes or neonatal deaths.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Pediatrics
Sotirios Fouzas, Christos Kogias, Maria Gioulvanidou, Aris Bertzouanis, Elisavet-Anna Chrysochoou, Michael B. Anthracopoulos, John Tsanakas, Elpis Hatziagorou
Summary: The study investigates the utility of lower-frequency forced oscillations technique (FOT) in assessing ventilation inhomogeneity in cystic fibrosis (CF) patients. The specific respiratory conductance (sGrs) at 5 Hz was found to be strongly correlated with the lung clearance index (LCI) and unaffected by lung hyperinflation.
PEDIATRIC PULMONOLOGY
(2023)
Article
Pediatrics
Marilyn Urrutia-Pereira, Lucas Pitrez Mocelin, Philippa Ellwood, Luis Garcia-Marcos, Laura Simon, Pietro Rinelli, Herberto Jose Chong-Neto, Dirceu Sole
Summary: The study aimed to determine the prevalence of allergic rhinitis and factors associated with it in adolescents and their parents/guardians. A cross-sectional study was conducted involving 1,058 adolescents and 896 parents/guardians in Uruguaiana, Brazil. The results showed that the prevalence of allergic rhinitis was 28.0% in adolescents and 31.7% in adults. Factors such as low physical exercise, having only one older sibling, and daily meat consumption were associated with allergic rhinitis in adolescents, while exposure to fungi at home and weekly meat consumption were associated with allergic rhinitis in adults.
REVISTA PAULISTA DE PEDIATRIA
(2023)
Article
Biochemistry & Molecular Biology
Daria Trifonova, Mirela Curin, Ksenja Riabova, Antonina Karsonova, Walter Keller, Hans Groenlund, Ulrika Kaeck, Jon R. Konradsen, Marianne van Hage, Alexander Karaulov, Rudolf Valenta, Kurt A. Jellinger
Summary: More than 10% of the world's population suffers from an IgE-mediated allergy to cats, which mainly manifests as respiratory symptoms. Several cat allergens have been identified, and Fel d 1, Fel d 4, and Fel d 7 show high allergenic activity in patients with respiratory allergies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
