Engineered adenoviruses combine enhanced oncolysis with improved virus production by mesenchymal stromal carrier cells

Phenotype, donor age and gender affect function of human bone marrow-derived mesenchymal stromal cells

(2013) Georg Siegel et al.   BMC Medicine

TRAIL on trial: preclinical advances in cancer therapy

(2013) Daniel W. Stuckey et al.   TRENDS IN MOLECULAR MEDICINE

TRAIL-engineered pancreas-derived mesenchymal stem cells: characterization and cytotoxic effects on pancreatic cancer cells

(2012) M R Moniri et al.   CANCER GENE THERAPY

A Phase I Clinical Trial of Ad5.SSTR/TK.RGD, a Novel Infectivity-Enhanced Bicistronic Adenovirus, in Patients with Recurrent Gynecologic Cancer

(2012) K. H. Kim et al.   CLINICAL CANCER RESEARCH

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

Oncolytic virotherapy

(2012) Stephen J Russell et al.   NATURE BIOTECHNOLOGY

On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics

(2012) L Y Dimberg et al.   ONCOGENE

Establishment and Characterization of a Highly Tumourigenic and Cancer Stem Cell Enriched Pancreatic Cancer Cell Line as a Well Defined Model System

(2012) Johannes Fredebohm et al.   PLoS One

The oncolytic adenovirus AdΔΔ enhances selective cancer cell killing in combination with DNA-damaging drugs in pancreatic cancer models

(2011) G Cherubini et al.   GENE THERAPY

Five Primary Human Pancreatic Adenocarcinoma Cell Lines Established by the Outgrowth Method

(2011) Felix Rückert et al.   JOURNAL OF SURGICAL RESEARCH

Mesenchymal stem cells as carriers and amplifiers in CRAd delivery to tumors

(2011) Xi Xia et al.   Molecular Cancer

Concise Review: Mesenchymal Stem Cell Tumor-Homing: Detection Methods in Disease Model Systems

(2011) Michaela R. Reagan et al.   STEM CELLS

Human CD34+ cells engineered to express membrane-bound tumor necrosis factor-related apoptosis-inducing ligand target both tumor cells and tumor vasculature

(2010) C. Lavazza et al.   BLOOD

TRAIL-transduced multipotent mesenchymal stromal cells (TRAIL-MSC) overcome TRAIL resistance in selected CRC cell lines in vitro and in vivo

(2010) L P Mueller et al.   CANCER GENE THERAPY

Treatment of metastatic neuroblastoma with systemic oncolytic virotherapy delivered by autologous mesenchymal stem cells: an exploratory study

(2010) J García-Castro et al.   CANCER GENE THERAPY

Improved Potency and Selectivity of an Oncolytic E1ACR2 and E1B19K Deleted Adenoviral Mutant in Prostate and Pancreatic Cancers

(2010) D. Oberg et al.   CLINICAL CANCER RESEARCH

Oncolytic Adenovirus ICOVIR-7 in Patients with Advanced and Refractory Solid Tumors

(2010) P. Nokisalmi et al.   CLINICAL CANCER RESEARCH

Mesenchymal Stem Cells and Cancer: Tumor-Specific Delivery Vehicles or Therapeutic Targets?

(2010) R.M. Dwyer et al.   HUMAN GENE THERAPY

Selectivity and Efficiency of Late Transgene Expression by Transcriptionally Targeted Oncolytic Adenoviruses Are Dependent on the Transgene Insertion Strategy

(2010) Christina Quirin et al.   HUMAN GENE THERAPY

Treatment of Cancer Patients With a Serotype 5/3 Chimeric Oncolytic Adenovirus Expressing GMCSF

(2010) Anniina Koski et al.   MOLECULAR THERAPY

Antitumor activity of Ad-IU2, a prostate-specific replication-competent adenovirus encoding the apoptosis inducer, TRAIL

(2009) J A Jiménez et al.   CANCER GENE THERAPY

Reduction of nontarget infection and systemic toxicity by targeted delivery of conditionally replicating viruses transported in mesenchymal stem cells

(2009) J L Dembinski et al.   CANCER GENE THERAPY

Armed replicating adenoviruses for cancer virotherapy

(2009) J J Cody et al.   CANCER GENE THERAPY

Human Bone Marrow-Derived Mesenchymal Stem Cells for Intravascular Delivery of Oncolytic Adenovirus  24-RGD to Human Gliomas

(2009) R. L. Yong et al.   CANCER RESEARCH

Mesenchymal Stem Cell Carriers Protect Oncolytic Measles Viruses from Antibody Neutralization in an Orthotopic Ovarian Cancer Therapy Model

(2009) E. K. Mader et al.   CLINICAL CANCER RESEARCH

TRAIL Gene Therapy: From Preclinical Development to Clinical Application

(2009) Thomas Griffith et al.   CURRENT GENE THERAPY

Cell Carriers for Oncolytic Viruses: Fed Ex for Cancer Therapy

(2009) Candice Willmon et al.   MOLECULAR THERAPY

Current Issues and Future Directions of Oncolytic Adenoviruses

(2009) Masato Yamamoto et al.   MOLECULAR THERAPY

Transgene expression by oncolytic adenoviruses is modulated by E1B19K deletion in a cell type-dependent manner

(2009) Stanimira Rohmer et al.   VIROLOGY

Suitability of human mesenchymal stem cells for gene therapy depends on the expansion medium

(2008) Anja Apel et al.   EXPERIMENTAL CELL RESEARCH

Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded

(2008) Roberto Cattaneo et al.   NATURE REVIEWS MICROBIOLOGY

Mesenchymal Stem Cells Effectively Deliver an Oncolytic Adenovirus to Intracranial Glioma

(2008) Adam M. Sonabend et al.   STEM CELLS