Enhancing the efficacy of cytotoxic agents for cancer therapy using photochemical internalisation

Dual-effect liposomes encapsulated with doxorubicin and chlorin e6 augment the therapeutic effect of tumor treatment

(2015) Po-Chun Peng et al.   LASERS IN SURGERY AND MEDICINE

Studies of the photosensitizer disulfonated meso-tetraphenyl chlorin in an orthotopic rat bladder tumor model

(2015) Yan Baglo et al.   Photodiagnosis and Photodynamic Therapy

Evaluation of Biodegradable Peptide Carriers for Light-Directed Targeting

(2015) Jens Andreas Lindin Jørgensen et al.   Nucleic Acid Therapeutics

A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA Delivery

(2014) Matt Gooding et al.   Chemical Biology & Drug Design

Expression of HER-2 in Rectal Cancers Treated With Preoperative Radiotherapy

(2014) Yun-Feng Yao et al.   DISEASES OF THE COLON & RECTUM

Photochemical internalization augments tumor vascular cytotoxicity and specificity of VEGF121/rGel fusion toxin

(2014) Anette Weyergang et al.   JOURNAL OF CONTROLLED RELEASE

Photochemical activation of the recombinant HER2-targeted fusion toxin MH3-B1/rGel; Impact of HER2 expression on treatment outcome

(2014) Bente Bull-Hansen et al.   JOURNAL OF CONTROLLED RELEASE

Photochemical internalization (PCI)-mediated enhancement of bleomycin cytotoxicity by liposomal mTHPC formulations in human head and neck cancer cells

(2014) Wei Peng et al.   LASERS IN SURGERY AND MEDICINE

The novel EpCAM-targeting monoclonal antibody 3–17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines

(2014) Kaja Lund et al.   mAbs

Light-Triggered, Efficient Cytosolic Release of IM7-Saporin Targeting the Putative Cancer Stem Cell Marker CD44 by Photochemical Internalization

(2014) Monica Bostad et al.   MOLECULAR PHARMACEUTICS

Harnessing photochemical internalization with dual degradable nanoparticles for combinatorial photo–chemotherapy

(2014) George Pasparakis et al.   Nature Communications

Physical energy for drug delivery; poration, concentration and activation

(2013) Shanmugamurthy Lakshmanan et al.   ADVANCED DRUG DELIVERY REVIEWS

Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity

(2013) Eva Wessel Stratford et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Photodynamic therapy plus regulatory T-cell depletion produces immunity against a mouse tumour that expresses a self-antigen

(2013) E Reginato et al.   BRITISH JOURNAL OF CANCER

Circumvention of resistance to photodynamic therapy in doxorubicin-resistant sarcoma by photochemical internalization of gelonin

(2013) Cathrine Elisabeth Olsen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties

(2013) Monica Bostad et al.   JOURNAL OF CONTROLLED RELEASE

Tetraphenylporphyrin Tethered Chitosan Based Carriers for Photochemical Transfection

(2013) Vivek S. Gaware et al.   JOURNAL OF MEDICINAL CHEMISTRY

The quest to overcome resistance to EGFR-targeted therapies in cancer

(2013) Curtis R Chong et al.   NATURE MEDICINE

Vascular endothelial cells as targets for photochemical internalization (PCI)

(2013) Marie Vikdal et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Fluorescence Lifetime Imaging and FRET-Induced Intracellular Redistribution of Tat-Conjugated Quantum Dot Nanoparticles through Interaction with a Phthalocyanine Photosensitiser

(2013) Elnaz Yaghini et al.   Small

The effect of photochemical internalization of bleomycin in the treatment of urothelial carcinoma of the bladder: An in vitro study

(2013) Harm C. Arentsen et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Mechanisms and insights into drug resistance in cancer

(2013) Hiba Zahreddine et al.   Frontiers in Pharmacology

Photochemical internalization (PCI) of HER2-targeted toxins

(2012) Maria Brandal Berstad et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Photochemical internalisation: the journey from basic scientific concept to the threshold of clinical application

(2012) DK Adigbli et al.   CURRENT OPINION IN PHARMACOLOGY

Antitumor effects of combining metronomic chemotherapy with the antivascular action of ultrasound stimulated microbubbles

(2012) Margarita Todorova et al.   INTERNATIONAL JOURNAL OF CANCER

Photochemical internalization of bleomycin for glioma treatment

(2012) Marlon S. Mathews et al.   JOURNAL OF BIOMEDICAL OPTICS

Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug

(2012) Pål Kristian Selbo et al.   JOURNAL OF CONTROLLED RELEASE

Photophysical and photobiological properties of a sulfonated chlorin photosensitiser TPCS2afor photochemical internalisation (PCI)

(2012) Julie T.-W. Wang et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Dendrimer phthalocyanine-encapsulated polymeric micelle-mediated photochemical internalization extends the efficacy of photodynamic therapy and overcomes drug-resistance in vivo

(2011) Hsueh-Lin Lu et al.   JOURNAL OF CONTROLLED RELEASE

Photochemical internalisation of a macromolecular protein toxin using a cell penetrating peptide-photosensitiser conjugate

(2011) Julie T.-W. Wang et al.   JOURNAL OF CONTROLLED RELEASE

Combination approaches to potentiate immune response after photodynamic therapy for cancer

(2011) Tyler G. St. Denis et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Disulfonated tetraphenyl chlorin (TPCS2a), a novel photosensitizer developed for clinical utilization of photochemical internalization

(2011) Kristian Berg et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Stimulation of anti-tumor immunity by photodynamic therapy

(2010) Pawel Mroz et al.   Expert Review of Clinical Immunology

Photochemical internalization provides time- and space-controlled endolysosomal escape of therapeutic molecules

(2010) Pål Kristian Selbo et al.   JOURNAL OF CONTROLLED RELEASE

Photodynamic Therapy of Tumors Can Lead to Development of Systemic Antigen-Specific Immune Response

(2010) Pawel Mroz et al.   PLoS One

Photochemical Internalization of Bleomycin Before External-Beam Radiotherapy Improves Locoregional Control in a Human Sarcoma Model

(2009) Ole-Jacob Norum et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Intracellular re-localisation by photochemical internalisation enhances the cytotoxic effect of gelonin — Quantitative studies in normal rat liver

(2009) Josephine Woodhams et al.   JOURNAL OF CONTROLLED RELEASE

Targeted delivery of bleomycin to the brain using photo-chemical internalization of Clostridium perfringens epsilon prototoxin

(2009) Henry Hirschberg et al.   JOURNAL OF NEURO-ONCOLOGY

Photochemical internalization (PCI) in cancer therapy: From bench towards bedside medicine

(2009) Ole-Jacob Norum et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Electroporation for the Delivery of DNA-based Vaccines and Immunotherapeutics: Current Clinical Developments

(2009) Angela M Bodles-Brakhop et al.   MOLECULAR THERAPY

Photochemical internalization as an adjunct to marginal surgery in a human sarcoma model

(2009) Ole-Jacob Norum et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Multi-Modality Therapeutics with Potent Anti-Tumor Effects: Photochemical Internalization Enhances Delivery of the Fusion Toxin scFvMEL/rGel

(2009) Pål K. Selbo et al.   PLoS One

Photochemical Internalization of Bleomycin is Superior to Photodynamic Therapy Due to the Therapeutic Effect in the Tumor Periphery

(2008) Ole-Jacob Norum et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Photodynamic therapy plus low-dose cyclophosphamide generates antitumor immunity in a mouse model

(2008) A. P. Castano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA