Review
Medicine, General & Internal
Alessia Dalila Guarino, Gaetano Luglio, Nicola Imperatore, Giuseppe Cerciello, Novella Pugliese, Fabiana Castiglione, Francesca Paola Tropeano, Anna Testa, Oriana Olmo, Antonio Rispo
Summary: Cyclic neutropenia is a rare hematological condition characterized by periodic fluctuations in neutrophil counts. It is crucial to differentiate it from inflammatory bowel disease, as the two conditions can have similar symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Michael L. Horsey, Debra Lai, Aalap Herur-Raman, Richard Amdur, Matthew Chandler, Matthew Ng, Vincent Obias
Summary: This study using the NSQIP database demonstrates that minimally invasive small bowel resection is associated with equivalent or improved morbidity compared to open surgery in select patients with small bowel Crohn's Disease. The findings suggest that in select patients, minimally invasive small bowel resection can be a safe and effective option for those with isolated small bowel Crohn's Disease.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Soo Young Oh, Young Il Kim, Yong Sik Yoon, Min Soo Cho, Min Young Park, Seung-Bum Ryoo, Jong Lyul Lee, Chan Wook Kim, In Ja Park, Seok-Byung Lim, Chang Sik Yu
Summary: This study reviewed the surgical records of patients with Crohn's disease in multiple centers in Korea and evaluated the effectiveness of surgical interventions. The results showed that the excision and primary repair of duodenal fistula, combined with additional complementary procedures, can successfully treat duodenal fistula in patients with Crohn's disease.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Shintaro Akiyama, Akihiro Yamada, Jacob E. Ollech, Yuga Komaki, Fukiko Komaki, Joel Pekow, Sushila R. Dalal, Russell D. Cohen, David T. Rubin, Atsushi Sakuraba
Summary: This study aimed to assess postoperative outcomes and validate the simple endoscopic score to predict Crohn's disease (CD) patients' disease-related outcomes. The findings showed that patients with colon-dominant disease had a higher risk of postoperative clinical recurrence, and SES-CD was effective in predicting postoperative clinical recurrence in CD patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Elise Maria Meima-van Praag, Christianne Johanna Buskens, Roel Hompes, Wilhelmus Adrianus Bemelman
Summary: The surgical management of Crohn's disease is diverse and evolving, with surgery playing an increasingly important role in the multidisciplinary management of the disease. The decision for surgical intervention depends on the location and severity of the disease, and should be discussed within a multidisciplinary team.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Medicine, General & Internal
Ilker Ozgur, Cemil Burak Kulle, Melek Buyuk, Asli Ormeci, Filiz Akyuz, Emre Balik, Turker Bulut, Metin Keskin
Summary: This study investigated predictors for disease recurrence in long-term follow-up of Crohn's disease patients after surgery. The results indicate that age at diagnosis, penetrating disease behavior, intra-abdominal abscess, and concomitant fistula and abscess are risk factors for CD recurrence after surgery.
Article
Gastroenterology & Hepatology
Robert H. Hollis, Nicholas Smith, Ipek Sapci, Benjamin Click, Miguel Regueiro, Tracy L. Hull, Amy L. Lightner
Summary: This retrospective cohort study found that over one third of patients who underwent total proctocolectomy for Crohn's disease were estimated to have small bowel Crohn's recurrence at 5 years after surgery. Patients with a history of small bowel surgery for Crohn's and diagnosis at any early age may have a higher risk of recurrence.
DISEASES OF THE COLON & RECTUM
(2022)
Review
Gastroenterology & Hepatology
U. Ahmed Ali, Ravi P. Kiran
Summary: Crohn's disease can affect the entire gastrointestinal tract and cause various symptoms. Surgery is often considered as a last option due to the availability of effective medical treatments, but the delay in surgery and potential worsening of complications are disadvantages. The choice between surgery and medication is based on patients' preference and guided by healthcare professionals, except in extreme cases where surgery might be the only choice.
GASTROENTEROLOGY REPORT
(2022)
Article
Gastroenterology & Hepatology
Susanna Meade, Kamal V. Patel, Raphael P. Luber, Dearbhaile O'Hanlon, Andra Caracostea, Polychronis Pavlidis, Sailish Honap, Cheran Anandarajah, Nyree Gryffin, Sebastian Zeki, Shuvra Ray, Joel Mawdsley, Mark A. Samaan, Simon H. Anderson, Amir Darakhshan, Katie Adams, Andrew Williams, Jeremy D. Sanderson, Miranda Lomer, Peter M. Irving
Summary: This study found that pre-operative oral enteral nutrition in patients with Crohn's disease undergoing surgery was associated with reduced postoperative complications, particularly non-surgical complications and infectious complications.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Surgery
Wei Liu, Wei Zhou
Summary: Surgery for Crohn's disease has made significant advancements, especially in the field of minimally invasive surgery. This approach offers numerous advantages, such as shorter hospitalization duration, improved cosmetic outcomes, and reduced occurrence of intra-abdominal adhesions. However, the complex characteristics of Crohn's disease pose challenges to the complete implementation of minimally invasive surgery, and further research is needed to explore its applicability.
FRONTIERS IN SURGERY
(2023)
Review
Medicine, General & Internal
Ming-Wei Hsu, Wen-Chi Chen, Ting-Na Wei, Chi-Ping Huang
Summary: This article reports a case of a 34-year-old male patient who presented with abdominal pain. The patient was diagnosed with Crohn's disease through enteroscopy and biopsy, and a fistula between the ileum and urinary bladder was identified through CT. The patient underwent successful surgical treatment and showed no complications or recurrence of urinary tract infections during follow-up.
Review
Surgery
Par Myrelid, Mattias Soop, Bruce D. George
Summary: Crohn's disease is increasing globally and changing toward more colonic and inflammatory behavior. While surgery was previously performed mainly for ileal/ileocaecal location and stricturing behavior, there is now an increasing complexity among patients at the time of surgery with a higher number of patients having abdominal perforating disease. To improve care for patients with penetrating abdominal CD, multidisciplinary team discussions are essential, along with proper surgical planning and evaluation of patients prior to surgery.
FRONTIERS IN SURGERY
(2022)
Article
Medicine, General & Internal
Julian Thomas Schweer, Philipp-Alexander Neumann, Philipp Doebler, Anna Doebler, Andreas Pascher, Rudolf Mennigen, Emile Rijcken
Summary: Anastomotic leakage is a serious complication in colorectal resections, especially in patients with Crohn's disease. A retrospective analysis of an IBD database showed that CD might be independently associated with anastomotic complications and have a detrimental effect on postoperative healing, indicating the need for treatment in dedicated centers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Surgery
Zachary J. Roberts, Alessandro Fichera
Summary: Crohn's disease is a chronic condition with high recurrence and morbidity rates. New therapies have been developed to improve remission and reduce recurrence, with prevention of recurrence being the main goal. Optimal outcomes are achieved through careful patient selection, optimization, and timely performance of the correct surgery by an experienced multidisciplinary team.
UPDATES IN SURGERY
(2023)
Article
Gastroenterology & Hepatology
Susanna Scharrer, Donata Lissner, Christian Primas, Walter Reinisch, Gottfried Novacek, Sieglinde Reinisch, Pavol Papay, Clemens Dejaco, Harald Vogelsang, Wolfgang Miehsler
Summary: The study indicates that passive smoking is an independent risk factor for intestinal surgeries in patients with Crohn's disease, with exposed patients being more likely to undergo surgery. Children exposed to passive smoking are also at a higher risk of becoming active smokers later in life.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Federica Furfaro, Ferdinando D'Amico, Alessandra Zilli, Vincenzo Craviotto, Annalisa Aratari, Cristina Bezzio, Antonino Spinelli, Daniela Gilardi, Simona Radice, Simone Saibeni, Claudio Papi, Laurent Peyrin-Biroulet, Silvio Danese, Gionata Fiorino, Mariangela Allocca
Summary: The aim of this study was to evaluate the diagnostic accuracy of a noninvasive approach in detecting postoperative recurrence in Crohn's disease. The results showed that a combination of bowel ultrasound and fecal calprotectin can accurately detect endoscopic recurrence without the need for colonoscopy. This is significant in providing patients with less invasive and more tolerable treatment options.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Mariangela Allocca, Torsten Kucharzik, David T. Rubin
Letter
Gastroenterology & Hepatology
A. Garcia-Granero, G. Pellino, A. Spinelli, X. Gonzalez-Argente
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Correction
Surgery
Maurizio Degiuli, Monica Ortenzi, Mariano Tomatis, Lucia Puca, Desiree Cianflocca, Daniela Rega, Annalisa Maroli, Ugo Elmore, Francesca Pecchini, Marco Milone, Roberta La Mendola, Erica Soligo, Simona Deidda, Domenico Spoletini, Diletta Cassini, Alessandra Aprile, Michela Mineccia, Herald Nikaj, Francesco Marchegiani, Fabio Maiello, Cristina Bombardini, Michele Zuolo, Michele Carlucci, Luca Ferraro, Armando Falato, Alberto Biondi, Roberto Persiani, Patrizia Marsanich, Daniele Fusario, Leonardo Solaini, Sara Pollesel, Gianluca Rizzo, Claudio Coco, Alberto Di Leo, Davide Cavaliere, Franco Roviello, Andrea Muratore, Domenico D'Ugo, Francesco Bianco, Paolo Pietro Bianchi, Paola De Nardi, Marco Rigamonti, Gabriele Anania, Claudio Belluco, Roberto Polastri, Salvatore Pucciarelli, Sergio Gentilli, Alessandro Ferrero, Stefano Scabini, Gianandrea Baldazzi, Massimo Carlini, Angelo Restivo, Silvio Testa, Dario Parini, Giovanni Domenico De Palma, Micaela Piccoli, Riccardo Rosati, Antonino Spinelli, Paolo Delrio, Felice Borghi, Marco Guerrieri, Rossella Reddavid
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Gastroenterology & Hepatology
A. Spinelli, F. M. Carrano, M. E. Laino, M. Andreozzi, G. Koleth, C. Hassan, A. Repici, M. Chand, V. Savevski, G. Pellino
Summary: Artificial intelligence has the potential to revolutionize surgery in the coming years. This review assessed the role of AI in colorectal surgery and identified various potential applications in the preoperative, intraoperative, and postoperative phases. However, more research is needed as AI in colorectal surgery is still in its early stages.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Surgery
Jasper P. Sijberden, Giuseppe Zimmitti, Simone Conci, Nadia Russolillo, Michele Masetti, Federica Cipriani, Jacopo Lanari, Burak Goergec, Andrea Benedetti Cacciaguerra, Fernando Rotellar, Mathieu D'Hondt, Bjorn Edwin, Robert P. Sutcliffe, Ibrahim Dagher, Mikhail Efanov, Santi Lopez-Ben, John N. Primrose, Felice Giuliante, Antonino Spinelli, Manish Chand, Salud Alvarez, Serena Langella, Simone Nicosia, Andrea Ruzzenente, Marco Vivarelli, Umberto Cillo, Luca Aldrighetti, Elio Jovine, Alessandro Ferrero, Alfredo Guglielmi, Marc G. Besselink, Mohammad Abu Hilal
Summary: This retrospective cohort study aimed to compare the outcomes of simultaneous resection (SIMR) for synchronous colorectal liver metastases (sCRLM) in different settings and identify factors associated with unfavorable outcomes. The results showed that SIMR was feasible for patients requiring minor or technically major liver resection. Compared to major resections, minor and technically major resections had lower complication rates and shorter hospital stays. Factors independently associated with an increased risk of severe morbidity included higher American Society of Anesthesiologists grades (>= 3) and undergoing a major liver resection, while undergoing a left-sided colectomy was associated with a decreased risk.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Hematology
Kevin Talboom, Wernard A. A. Borstlap, Sapho X. Roodbeen, Emma R. J. Bruns, Christianne J. Buskens, Roel Hompes, Kristien M. A. J. Tytgat, Jurriaan B. Tuynman, Esther C. J. Consten, Gijsbert Heuff, Teaco Kuiper, Anna A. W. van Geloven, Gerrit J. Veldhuis, Joost A. B. van der Hoeven, Michael F. Gerhards, Colin Sietses, Antonino Spinelli, Anthony W. H. van de Ven, Edwin S. van der Zaag, Marinke Westerterp, Henderik L. van Westreenen, Marcel L. Dijkgraaf, Nicole P. Juffermans, Wilhelmus A. Bemelman
Summary: This study compared the efficacy of preoperative intravenous and oral iron supplementation in patients with colorectal cancer and iron deficiency anaemia. The results showed that intravenous iron treatment significantly improved the haemoglobin levels in patients, while oral iron treatment did not.
LANCET HAEMATOLOGY
(2023)
Review
Medicine, General & Internal
Virginia Solitano, Arianna Dal Buono, Roberto Gabbiadini, Marek Wozny, Alessandro Repici, Antonino Spinelli, Stefania Vetrano, Alessandro Armuzzi
Summary: Fibro-stenosing Crohn's disease (CD) is a common disease presentation that leads to impaired quality of life and often requires endoscopic treatments or surgery. Currently, there are no existing imaging techniques that can accurately quantify the amount of fibrosis within a stricture, and managing patients is challenging, requiring a multidisciplinary team.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Sara Massironi, Chiara Vigano, Andrea Palermo, Lorena Pirola, Giacomo Mulinacci, Mariangela Allocca, Laurent Peyrin-Biroulet, Silvio Danese
Summary: Inflammatory bowel disease (IBD) has been on the rise worldwide, with impaired nutritional status in patients presenting in various forms such as malnutrition, sarcopenia, and micronutrient deficiency, as well as overweight, obesity, and sarcopenic obesity. Malnutrition can disrupt the gut microbiome, leading to an imbalanced state that triggers inflammation. Despite the clear link between IBD and malnutrition, little is known about the underlying mechanisms that promote inflammation and malnutrition. This Review explores the potential mechanisms behind the vicious cycle of malnutrition and inflammation, and their implications for clinical treatment.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Editorial Material
Surgery
Antonino Spinelli, Michele Carvello
Article
Oncology
Caterina Foppa, Annalisa Maroli, Antonio Luberto, Carlotta La Raja, Paola Spaggiari, Cristiana Bonifacio, Stefano De Zanet, Marco Montorsi, Salvatore Piscuoglio, Luigi Maria Terracciano, Armando Santoro, Antonino Spinelli
Summary: Early-onset rectal cancer (EORC) patients with advanced cancer at diagnosis are more likely to undergo neoadjuvant therapies. This study explores the effect of age of onset on the pathological response to neoadjuvant therapies in locally advanced RC patients. The results indicate a higher rate of incomplete response in EORC patients, with early age of onset being a risk factor for a worse response. Different multimodal strategies are needed for EORC patients.
Article
Surgery
Marcos Gomez Ruiz, Eloy Espin-Basany, Antonino Spinelli, Carmen Cagigas Fernandez, Jesus Bollo Rodriguez, Jose Maria Enriquez Navascues, Tero Rautio, Mindaugas Tiskus
Summary: This study compared intracorporeal and extracorporeal anastomosis as well as laparoscopic and robot-assisted surgery in right hemicolectomies. The results showed that the method of anastomosis and surgical technique did not significantly affect surgical wound infections and severe postoperative complications within 30 days.
BRITISH JOURNAL OF SURGERY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
R. Gabbiadini, P. Spaggiari, A. Dal Buono, M. Iuzzolino, F. Furfaro, F. D'Amico, A. Repici, A. Spinelli, A. Armuzzi
JOURNAL OF CROHNS & COLITIS
(2023)
Correction
Gastroenterology & Hepatology
Bruno Sensi, Jim Khan, Janindra Warusavitarne, Alessandra Nardi, Antonino Spinelli, Karen Zaghiyan, Yves Panis, Gianluca Sampietro, Alessandro Fichera, Eduardo Garcia-Granero, Eloy Espin-Basany, Tsuyoshi Konishi, Leandro Siragusa, Samuel Stefan, Vittoria Bellato, Michele Carvello, Evan Adams, Alice Frontali, Michael Artigue, Matteo Frasson, Marc Marti-Gallostra, Gianluca Pellino, Giuseppe S. Sica
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Surgery
Matteo Rottoli, Antonino Spinelli, Gianluca Pellino, Alice Gori, Giacomo Calini, Maria E. Flacco, Lamberto Manzoli, Gilberto Poggioli
Summary: This study found that colorectal cancer surgery in low-volume centers is associated with suboptimal management, poor postoperative outcomes, and inadequate oncologic resections. Therefore, centralization of rectal cancer cases to high-volume centers should be considered to optimize surgical outcomes.
BRITISH JOURNAL OF SURGERY
(2023)