Letter
Medicine, General & Internal
Aileen S. Ahiskali, Dimitri M. Drekonja, Jonathan D. Alpern
Summary: This study examines the prevalence of conflicts of interest (COI) among Infectious Diseases Society of America guideline authors regarding guideline-recommended drugs, and evaluates their compliance with guidelines from the Council on Medical Specialty Societies and Institute of Medicine.
Article
Gastroenterology & Hepatology
Anju Murayama, Sae Kamamoto, Nanami Murata, Ryota Yamasaki, Kohki Yamada, Erika Yamashita, Hiroaki Saito, Tetsuya Tanimoto, Akihiko Ozaki
Summary: This study found extensive financial conflicts of interest between pharmaceutical companies and guideline authors in Japan, with over 40% of recommendations based on low-quality evidence. The Japanese Society of Gastroenterology guideline development process lacks transparency and sufficient conflict of interest policies compared to global standards.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Nutrition & Dietetics
Julie Obbagy, Ramkripa Raghavan, Natasha Chong Cole, Laural K. K. English, Molly Higgins, Joanne M. M. Spahn, Charlotte L. L. Bahnfleth, Emily Callahan, Amanda Fultz, Julia H. H. Kim, Brittany J. J. Kingshipp, Julie E. H. Nevins, Sara R. R. Scinto-Madonich, Allison Webster, Eve Stoody
Summary: The U.S. Department of Agriculture's Nutrition Evidence Systematic Review Branch develops systematic reviews and other evidence synthesis products related to food and nutrition. The NESR has become a key resource for the Federal government in making evidence-informed decisions. NESR's rigorous methodology, involving collaboration with various stakeholders, ensures the production of high-quality and trustworthy systematic reviews.
FRONTIERS IN NUTRITION
(2023)
Review
Medicine, General & Internal
S. Scott Graham, Martha S. Karnes, Jared T. Jensen, Nandini Sharma, Joshua B. Barbour, Zoltan P. Majdik, Justin F. Rousseau
Summary: This study conducted a methodological review on the effects of conflicts of interest (COIs) in research contexts. The review found that industry funding and author COI can bias biomedical research outcomes. However, the available research has not adequately assessed the differential risks of COI types or magnitudes. Targeted research is necessary to inform COI management policies effectively.
Article
Medicine, General & Internal
Maryam Mooghali, Laura Glick, Reshma Ramachandran, Joseph S. Ross
Summary: This study aimed to evaluate the prevalence and accuracy of industry-related financial conflict of interest (COI) disclosures among US physician guideline authors. The results showed that among 270 US physician authors, 37.4% disclosed industry-related financial COIs, while 73.7% were found to have received payments from industry. It was found that 26.7% of the authors accurately disclosed their financial COIs.
Review
Gastroenterology & Hepatology
Hiroshi Nakase, Motoi Uchino, Shinichiro Shinzaki, Minoru Matsuura, Katsuyoshi Matsuoka, Taku Kobayashi, Masayuki Saruta, Fumihito Hirai, Keisuke Hata, Sakiko Hiraoka, Motohiro Esaki, Ken Sugimoto, Toshimitsu Fuji, Kenji Watanabe, Shiro Nakamura, Nagamu Inoue, Toshiyuki Itoh, Makoto Naganuma, Tadakazu Hisamatsu, Mamoru Watanabe, Hiroto Miwa, Nobuyuki Enomoto, Tooru Shimosegawa, Kazuhiko Koike
Summary: Inflammatory bowel disease (IBD) encompasses chronic or remitting/relapsing inflammatory diseases of the intestinal tract, including ulcerative colitis (UC) and Crohn's disease (CD). The etiology of IBD involves disease susceptibility genes, environmental factors, and intestinal bacteria. Optimal management depends on evidence-based interventions tailored by physicians.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Nutrition & Dietetics
Vivica I. Kraak
Summary: Judgments and integrity are crucial in maintaining professionalism, as failure to manage conflicts of interest (COIs) can lead to a erosion of trust. This article examines the standards for nutrition researchers and practitioners in managing COIs for the Dietary Guidelines for Americans (DGA) process and analyzes a study by Mialon et al. which raised concerns about the selection process and COI management of experts serving on a federal advisory committee. The analysis found that the study failed to provide a proper context for the COI risk and concluded that the committee members were in compliance with federal ethics rules.
ADVANCES IN NUTRITION
(2023)
Article
Multidisciplinary Sciences
J. Henry Brems, Taylor Wagner, Julia Diamant, Andrea Davis, Ellen Wright Clayton
Summary: This study aimed to assess the prevalence of intellectual conflicts of interest (COI) and corresponding management strategies in cardiology and pulmonology clinical practice guidelines (CPGs). The study found that 64% of authors had at least one intellectual COI among the 39 guidelines, and COI was more prevalent in cardiology guidelines. Only some guidelines utilized management strategies. Therefore, greater attention and improvement in management of intellectual COI are needed by CPG-producing organizations.
Review
Pharmacology & Pharmacy
Valeria Dipasquale, Giuseppe Cicala, Edoardo Spina, Claudio Romano
Summary: This study reviewed the use of biosimilars in pediatric inflammatory bowel disease (IBD) patients and found that the effectiveness of CT-P13, a biosimilar of anti-TNF-alpha, was similar to that of the originator drug IFX in terms of clinical response and remission rates.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Gastroenterology & Hepatology
Mathilde Barrau, Manon Duprat, Pauline Veyrard, Quentin Tournier, Nicolas Williet, Jean Marc Phelip, Louis Waeckel, Adam S. Cheifetz, Konstantinos Papamichael, Xavier Roblin, Stephane Paul
Summary: This study systematically reviewed the feasibility of using drug-tolerant assays to monitor patients treated with anti-TNFs. Most ADAb detection methods are drug-sensitive and cannot be used close to drug administration, but several drug-tolerant techniques have been developed to overcome this limitation.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Obstetrics & Gynecology
Amelia K. Mardon, Hayley B. Leake, Kimberley Szeto, Thomas Astill, Sandra Hilton, Graham Lorimer Moseley, Katherine Jane Chalmers
Summary: Women with persistent pelvic pain (PPP) receive varied treatments despite the existence of clinical practice guidelines. This study aimed to identify and summarize treatment recommendations for PPP management from multiple guidelines and evaluate their quality. The findings showed that the quality of the guidelines was generally poor, with a significant number of recommendations for pharmaceutical and surgical interventions. Psychological, physiotherapy, and conservative interventions had more variable recommendations. The biopsychosocial aspects of PPP were acknowledged by several guidelines, but biomedical interventions were predominantly recommended.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Review
Health Care Sciences & Services
Rachel Thompson, Zoe Paskins, Barry G. Main, Thaddeus Mason Pope, Evelyn C. Y. Chan, Ben W. Moulton, Michael J. Barry, Clarence H. Braddock
Summary: This narrative review examined the effects of conflict of interest management strategies and patients' perspectives on conflicts of interest. The evidence showed significant noncompliance with prevailing requirements on conflict of interest management strategies, and highlighted the diverse views of patients on the acceptability of conflicts of interest, as well as the importance of conflict type and monetary value to patients. However, no research on the effects of IPDAS Collaboration conflict of interest quality standards on patient decision making or outcomes was identified.
MEDICAL DECISION MAKING
(2021)
Review
Immunology
Shuangyuan Hu, Maoyaun Zhao, Wei Li, Pengfei Wei, Qingsong Liu, Shuanglan Chen, Jinhao Zeng, Xiao Ma, Jianyuan Tang
Summary: This study summarized the effects of quercetin on inflammatory bowel disease in animal models, finding that it has anti-inflammatory, antioxidant, protective, and regulatory effects on the intestine. However, due to limited quality and quantity of studies, there may be some discrepancies between the actual effects and the findings of the study.
INFLAMMOPHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Sara Dahlen, Dean Connolly, Isra Arif, Muhammad Hyder Junejo, Susan Bewley, Catherine Meads
Summary: The study aimed to identify and critically appraise published clinical practice guidelines regarding healthcare of gender minority/trans people. The results showed a lack of high-quality guidelines for gender minority/trans people, with limited focus on HIV and transition, and a need for improvement in future CPG quality through methods such as reference to AGREE II and stakeholder participation.
Review
Health Care Sciences & Services
Xiaomei Yao, Jun Xia, Yinghui Jin, Quan Shen, Qi Wang, Ying Zhu, Sheila McNair, Jonathan Sussman, Zhiwen Wang, Ivan D. Florez, Xian-Tao Zeng, Melissa Brouwers
Summary: This study provides an overall summary of the currently available approaches and tools for the development, reporting, or assessment of clinical practice guidelines, aiming to improve users' understanding and facilitate informed choice and application.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Abhijeet Yadav, Satya Kurada, Joshua Foromera, Kenneth R. Falchuk, Joseph D. Feuerstein
DIGESTIVE AND LIVER DISEASE
(2018)
Letter
Gastroenterology & Hepatology
J. D. Feuerstein, D. A. Leffler, A. S. Cheifetz
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2013)
Letter
Gastroenterology & Hepatology
J. D. Feuerstein, D. A. Leffler, A. S. Cheifetz
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2013)
Letter
Medicine, General & Internal
Joseph D. Feuerstein, Daniel A. Leffler
ANNALS OF INTERNAL MEDICINE
(2013)
Article
Endocrinology & Metabolism
Daniel Prabakaran, Baogui Wang, Joseph D. Feuerstein, Jennifer A. Sinclair, Priti Bijpuria, Lisa I. Jepeal, M. Michael Wolfe
REGULATORY PEPTIDES
(2010)
Editorial Material
Gastroenterology & Hepatology
Joseph D. Feuerstein, Adam S. Cheifetz, Corey A. Siegel
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2012)
Editorial Material
Gastroenterology & Hepatology
William T. Clarke, Joseph D. Feuerstein
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2019)
Review
Medicine, General & Internal
Joseph D. Feuerstein, Alan C. Moss, Francis A. Farraye
MAYO CLINIC PROCEEDINGS
(2019)
Article
Gastroenterology & Hepatology
Daniel J. Stein, Matthew B. Moore, Gila Hoffman, Joseph D. Feuerstein
Summary: Over the past decade, the mortality rate for patients undergoing PEG placement has decreased by approximately 40% without a decrease in complication rates, indicating a potential improvement in patient selection. Despite similar patient characteristics, this trend suggests a positive outcome in terms of patient outcomes.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Vitaliy Y. Poylin, Jose Cataneo Serrato, Jonathan Pastrana Del Valle, Joseph D. Feuerstein
Summary: This study aimed to compare the effect of vedolizumab and anti-TNF therapy on perioperative complications in IBD patients undergoing surgery. The results showed a lower leak rate in the vedolizumab group, and that vedolizumab does not increase perioperative complication rates in IBD surgery when compared to anti-TNF medications.
INTESTINAL RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Vikas Taneja, Rajsavi S. Anand, Mohammed El-Dallal, Jeffrey Dong, Nisa Desai, Isha Taneja, Joseph D. Feuerstein
Summary: Patients with inflammatory bowel disease (IBD) who have undergone solid organ transplant can safely use biologic and small molecule therapy for their IBD treatment. The rates of infections associated with these treatments are similar to those of patients without IBD who have received solid organ transplant.
INFLAMMATORY BOWEL DISEASES
(2023)
Letter
Medicine, General & Internal
Joseph D. Feuerstein
AMERICAN JOURNAL OF MEDICINE
(2017)
Letter
Medicine, General & Internal
Joseph D. Feuerstein, Daniel A. Leffler, Adam S. Cheifetz
NEW ENGLAND JOURNAL OF MEDICINE
(2012)