Adrenocortical tumors and insulin resistance: What is the first step?

Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, randomised, phase 3 study

(2015) Martin Fassnacht et al.   LANCET ONCOLOGY

WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear β-Catenin depend on active PI3K signaling

(2015) Steffen Ormanns et al.   Oncotarget

Phase I Study of Intermittent Oral Dosing of the Insulin-like Growth Factor-1 and Insulin Receptors Inhibitor OSI-906 in Patients With Advanced Solid Tumors

(2014) R. L. Jones et al.   CLINICAL CANCER RESEARCH

A Phase I Study of Continuous Oral Dosing of OSI-906, a Dual Inhibitor of Insulin-Like Growth Factor-1 and Insulin Receptors, in Patients with Advanced Solid Tumors

(2014) I. Puzanov et al.   CLINICAL CANCER RESEARCH

Patients With Apparently Nonfunctioning Adrenal Incidentalomas May Be at Increased Cardiovascular Risk Due to Excessive Cortisol Secretion

(2014) Ioannis I. Androulakis et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Prospective evaluation of tumor size and hormonal status in adrenal incidentalomas

(2014) S. Yener et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Role of adrenal gland scintigraphy in patients with subclinical hypercortisolism and incidentally discovered adrenal mass

(2014) F. Donadio et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Advances in the epidemiology, pathogenesis, and management of Cushing’s syndrome complications

(2014) G. Arnaldi et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Integrated genomic characterization of adrenocortical carcinoma

(2014) Guillaume Assié et al.   NATURE GENETICS

IGF2 Promotes Growth of Adrenocortical Carcinoma Cells, but Its Overexpression Does Not Modify Phenotypic and Molecular Features of Adrenocortical Carcinoma

(2014) Marine Guillaud-Bataille et al.   PLoS One

Hyperglycemia, a Neglected Factor during Cancer Progression

(2014) Wanxing Duan et al.   Biomed Research International

Apicidin-Resistant HA22T Hepatocellular Carcinoma Cells strongly activated the Wnt/β-Catenin Signaling Pathway and MMP-2 Expression via the IGF-IR/PI3K/Akt Signaling Pathway Enhancing Cell Metastatic Effect

(2013) Cheng-Hong HSIEH et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Nondiabetic patients with either subclinical Cushing's or nonfunctional adrenal incidentalomas have lower insulin sensitivity than healthy controls: Clinical implications

(2013) Miomira Ivović et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Single Nucleotide Polymorphism Array Profiling of Adrenocortical Tumors - Evidence for an Adenoma Carcinoma Sequence?

(2013) Cristina L. Ronchi et al.   PLoS One

Laparoscopic adrenalectomy in patients with subclinical Cushing syndrome

(2013) Iraklis Perysinakis et al.   SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES

Progression to Adrenocortical Tumorigenesis in Mice and Humans through Insulin-Like Growth Factor 2 and β-Catenin

(2012) Joanne H. Heaton et al.   AMERICAN JOURNAL OF PATHOLOGY

Diabetes and Cause-Specific Mortality in a Prospective Cohort of One Million U.S. Adults

(2012) P. T. Campbell et al.   DIABETES CARE

Analysis of the Role of Igf2 in Adrenal Tumour Development in Transgenic Mouse Models

(2012) Coralie Drelon et al.   PLoS One

Effects of Cortisol and Dexamethasone on Insulin Signalling Pathways in Skeletal Muscle of the Ovine Fetus during Late Gestation

(2012) Juanita K. Jellyman et al.   PLoS One

Adrenalectomy may improve cardiovascular and metabolic impairment and ameliorate quality of life in patients with adrenal incidentalomas and subclinical Cushing's syndrome

(2012) Maurizio Iacobone et al.   SURGERY

Insulin signaling – mathematical modeling comes of age

(2012) Elin Nyman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Urine metabolomics analysis for adrenal incidentaloma activity detection and biomarker discovery

(2011) Alicja Kotłowska et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Insulin-like growth factor system on adrenocortical tumorigenesis

(2011) Tamaya Castro Ribeiro et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Prevalence of adrenal masses in Japanese patients with type 2 diabetes mellitus

(2011) Naoki Hiroi et al.   Diabetology & Metabolic Syndrome

Regulation of Insulin-like Growth Factor–Mammalian Target of Rapamycin Signaling by MicroRNA in Childhood Adrenocortical Tumors

(2010) Mabrouka Doghman et al.   CANCER RESEARCH

The size of adrenal incidentalomas correlates with insulin resistance. Is there a cause-effect relationship?

(2010) Giovanna Muscogiuri et al.   CLINICAL ENDOCRINOLOGY

Acute and 2-week exposure to prednisolone impair different aspects of β-cell function in healthy men

(2010) Daniël H van Raalte et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Beneficial Metabolic Effects of Prompt Surgical Treatment in Patients with an Adrenal Incidentaloma Causing Biochemical Hypercortisolism

(2010) Iacopo Chiodini et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adrenal incidentalomas and cardiometabolic morbidity: an emerging association with serious clinical implications

(2010) M. Peppa et al.   JOURNAL OF INTERNAL MEDICINE

Insulin resistance and metabolic syndrome in patients with nonfunctioning adrenal incidentalomas: a cause-effect relationship?

(2010) Melpomeni Peppa et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Bénéfices tensionnels, anthropométriques et métaboliques de l’exérèse chirurgicale des adénomes cortisoliques infracliniques

(2009) S. Mauclère-Denost et al.   ANNALES D ENDOCRINOLOGIE

Surgical Versus Conservative Management for Subclinical Cushing Syndrome in Adrenal Incidentalomas: A Prospective Randomized Study

(2009) Antonio Toniato et al.   ANNALS OF SURGERY

Clinical management of adrenocortical carcinoma

(2009) Martin Fassnacht et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

The urinary steroid profile in patients diagnosed with adrenal incidentaloma

(2009) Alicja Kotłowska et al.   CLINICAL BIOCHEMISTRY

Molecular Classification and Prognostication of Adrenocortical Tumors by Transcriptome Profiling

(2009) T. J. Giordano et al.   CLINICAL CANCER RESEARCH

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Diabetes and cancer

(2009) Paolo Vigneri et al.   ENDOCRINE-RELATED CANCER

Rosiglitazone impairs proliferation of human adrenocortical cancer: preclinical study in a xenograft mouse model

(2009) Michaela Luconi et al.   ENDOCRINE-RELATED CANCER

Atherosclerotic risk factors and complications in patients with non-functioning adrenal adenomas treated with or without adrenalectomy: a long-term follow-up study

(2009) Márta Sereg et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Adrenocortical carcinoma in the United States

(2008) Karl Y. Bilimoria et al.   CANCER

High frequency of loss of heterozygosity at 11p15 and IGF2 overexpression are not related to clinical outcome in childhood adrenocortical tumors positive for the R337H TP53 mutation

(2008) Roberto Rosati et al.   CANCER GENETICS AND CYTOGENETICS

Expression of Insulin-Like Growth Factor-II and Its Receptor in Pediatric and Adult Adrenocortical Tumors

(2008) Madson Q. Almeida et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Preclinical Targeting of the Type I Insulin-Like Growth Factor Receptor in Adrenocortical Carcinoma

(2008) Ferdous M. Barlaskar et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Rosiglitazone Inhibits Adrenocortical Cancer Cell Proliferation by Interfering with the IGF-IR Intracellular Signaling

(2008) Giulia Cantini et al.   PPAR Research

Hyper-insulinaemia and cancer, meta-analyses of epidemiological studies

(2008) Paola Pisani   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY