Review
Medicine, General & Internal
Lucian Mocan
Summary: Gastric cancer is the fifth most common cancer worldwide, with surgery being the only curative treatment. Early detection and screening combined with neoadjuvant therapy can reduce the incidence of gastric cancer, but patients are often diagnosed at an advanced stage.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Kristina Staley, Kourosh R. Ahmadi, Karyl Carter, Katherine Cowan, Heidi Seage, Petra Visser, Nicola Ward, Martyn Hooper
Summary: This study aimed to establish a JLA Priority Setting Partnership to identify research priorities related to pernicious anaemia. Through surveys and workshops, the top 10 research questions were determined, focusing on areas such as diagnosis, treatment, and management.
Review
Medicine, General & Internal
Anouk Rijken, Robin J. Lurvink, Misha D. P. Luyer, Grard A. P. Nieuwenhuijzen, Felice N. van Erning, Johanna W. van Sandick, Ignace H. J. T. de Hingh
Summary: This review summarized the incidence, risk factors, and survival of synchronous peritoneal metastases from gastric cancer, highlighting potential risk factors such as younger age, non-cardia gastric cancer, female sex, signet ring cell carcinoma, and the poor prognosis associated with gastric peritoneal metastases. Further research on diagnostic features and treatment options is needed to improve survival rates.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Aileen Moncur, Manish Chowdhary, Yajing Chu, Nader K. Francis
Summary: The study aimed to review the prevalence and impact of postoperative anaemia in colorectal cancer patients. Six studies with a total of 1714 participants were included, showing high prevalence of anaemia and negative impact on clinical and long-term outcomes. Further research is needed to standardize measurement and understand the true impact of correcting postoperative anaemia on functional and oncological outcomes.
COLORECTAL DISEASE
(2021)
Review
Oncology
Susumu Shibasaki, Koichi Suda, Shigeo Hisamori, Kazutaka Obama, Masanori Terashima, Ichiro Uyama
Summary: In comparing robotic gastrectomy (RG) with conventional laparoscopic gastrectomy (LG), RG has shown advantages in terms of lower intraoperative blood loss, shorter hospital stay, and shorter learning curve, but it has disadvantages such as longer procedural time and higher costs. Although the morbidity rate and long-term outcomes are similar, RG has shown superior potentials.
Review
Immunology
Noemi Zadori, Lajos Szako, Szilard Vancsa, Nora Voerhendi, Eduard Ostarijas, Szabolcs Kiss, Levente Frim, Peter Hegyi, Jozsef Czimmer
Summary: Pernicious anemia, Graves' disease, dermatomyositis, diabetes mellitus type I, inflammatory myopathies, and systemic lupus erythematosus are associated with higher incidence rates of gastric cancer. Regular gastroenterological follow-up or diagnostic procedures such as gastroscopy may be beneficial for patients with these autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Dan Ruan, Liang Zhao, Jiayu Cai, Weizhi Xu, Long Sun, Jiayi Li, Jingjing Zhang, Xiaoyuan Chen, Haojun Chen
Summary: This review analyzes the superiority of Ga-68-FAPI PET/CT over F-18-FDG PET/CT in the evaluation of gastric cancer (GC). The meta-analysis of 14 studies suggests that Ga-68-FAPI PET/CT shows higher sensitivity, specificity, and area under the curve (AUC) compared to F-18-FDG PET/CT. Ga-68-FAPI PET/CT has the potential to replace F-18-FDG PET/CT in the diagnosis, staging, and detection of recurrence/metastases of GC.
Review
Oncology
Romy M. van Amelsfoort, Karen van der Sluis, Winnie Schats, Edwin P. M. Jansen, Johanna W. van Sandick, Marcel Verheij, Iris Walraven
Summary: In patients with locally advanced gastric cancer, surgery and chemoradiotherapy have a significant impact on short-term HRQOL, but a recovery is seen after 6-12 months. More research is needed to implement HRQOL in clinical decision making.
Review
Environmental Sciences
Eryn K. Matich, Jonathan A. Laryea, Kathryn A. Seely, Shelbie Stahr, L. Joseph Su, Ping-Ching Hsu
Summary: The systematic literature review found both positive and inverse associations between pesticide exposure and CRC risk, with no overall conclusion on whether there is a positive or inverse relationship. Certain pesticides were highlighted as of great or moderate concern for their elevated risk of CRC, particularly due to their legal or illegal usage in the US. This study’s results shed light on the health disparities related to CRC in rural communities with pesticide exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Medicine, General & Internal
Chuyan Chen, Yi Yang, Peng Li, Haiyi Hu
Summary: This study systematically analyzed the incidence rate of gastric cancer, low-grade dysplasia, and type-1 gastric neuroendocrine tumor development in adults with autoimmune metaplastic atrophic gastritis (AMAG). Thirteen studies were included and the meta-analysis showed a relative risk of 11.05 for gastric cancer development in AMAG patients. The study emphasizes the potential for malignant transformation of precancerous lesions and the importance of careful esophagogastroduodenoscopy screening.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Tomasz Muszynski, Karina Polak, Aleksandra Fratczak, Bartosz Miziolek, Beata Bergler-Czop, Antoni Szczepanik
Summary: This study conducted a systematic review of the serum vitamin D level in post-gastrectomy gastric cancer patients and found that the initial rate of vitamin D deficiency in these patients is similar to the global population deficiency. In post-gastrectomy survivors, the level of 25(OH)D may remain stable or decrease, while the level of 1, 25(OH)(2)D remains normal. Supplementation with vitamin D improves its serum concentration and positively affects bone mineral density.
Review
Oncology
Norah Alsadhan, Alaa Almaiman, Mar Pujades-Rodriguez, Cathy Brennan, Farag Shuweihdi, Sultana A. Alhurishi, Robert M. West
Summary: This review describes variations in the methods used to estimate colorectal cancer incidence trends. It highlights the inadequate reporting and variations in calculation methods, emphasizing the need for increased clarity and transparency in reporting methods.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Marcela de Araujo Fagundes, Alex Richard Costa Silva, Gisele Aparecida Fernandes, Maria Paula Curado
Summary: Phenolic compounds, especially polyphenols, have been found to reduce the risk of gastric cancer, with a greater effect in females and in studies conducted in Europe and Asia. Further research on the relationship between dietary polyphenol intake and gastric cancer in Latin American populations is needed for a comprehensive understanding of the impact.
Review
Endocrinology & Metabolism
Mariacarla Moleti, Tommaso Aversa, Salvatore Crisafulli, Gianluca Trifiro, Domenico Corica, Giorgia Pepe, Laura Cannavo, Maria Di Mauro, Giuseppe Paola, Andrea Fontana, Fabrizio Calapai, Salvatore Cannavo, Malgorzata Wasniewska
Summary: Differentiated thyroid cancer (DTC) is rare in childhood and adolescence but represents the most frequent endocrine malignancy in this population. This systematic review and meta-analysis aimed to estimate the overall incidence and prevalence of DTCs in patients aged 0-19 years. The study found that PTC is the most common histological type of DTC in children, and the implementation of a prospective international registry on pediatric DTC is proposed.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Computer Science, Information Systems
Yuxue Zhao, Bo Hu, Ying Wang, Xiaomeng Yin, Yuanyuan Jiang, Xiuli Zhu
Summary: The application of artificial intelligence in gastric cancer identification relies heavily on convolutional neural networks, which have been shown to perform well in identifying gastric cancer.
MULTIMEDIA TOOLS AND APPLICATIONS
(2022)
Article
Gastroenterology & Hepatology
Gianluca Esposito, Maria Cazzato, Maria Rinzivillo, Emanuela Pilozzi, Edith Lahner, Bruno Annibale, Francesco Panzuto
Summary: This study evaluated the outcome of patients with type 1 gastric neuroendocrine neoplasia treated with different endoscopic approaches. The results showed that for tumors with a diameter <5 mm, noninterventional endoscopic surveillance after initial incomplete resection is feasible. The recurrence rate did not significantly differ among the different endoscopic techniques used.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Medicine, General & Internal
Francesca Falangone, Gianluca Esposito, Stefano Angeletti, Emanuela Pilozzi, Vito Domenico Corleto, Emilio Di Giulio, Bruno Annibale, Marilia Carabotti
Summary: The prevalence of segmental colitis associated with diverticulosis (SCAD) remains debated in patients with colonic diverticulosis, with suspected SCAD patients showing significantly lower age. The diagnosis of SCAD poses a challenge in clinical practice due to the heterogeneity of endoscopic findings and lack of stated histological criteria.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medical Laboratory Technology
Edith Lahner, Emanuele Dilaghi, Sophia Cingolani, Giulia Pivetta, Ludovica Dottori, Gianluca Esposito, Ilaria Marzinotto, Vito Lampasona, Raffaella Buzzetti, Bruno Annibale
Summary: Gender-sex differences in autoimmune atrophic gastritis (AAG) show that females are predominant in AAG cases, with higher rates of positivity for specific antibodies and genetic markers compared to males. Clinical profiles differ between male and female patients, with distinct associations to specific risk factors. Gender and sex stratification should be considered in future studies on AAG.
TRANSLATIONAL RESEARCH
(2022)
Article
Medicine, General & Internal
Maria Rinzivillo, Francesco Panzuto, Gianluca Esposito, Edith Lahner, Alberto Signore, Bruno Annibale
Summary: This retrospective study explores the usefulness of [Ga-68]Ga-DOTA-SST PET/CT in the management of patients with T1gNENs and suggests that it can be useful in a restricted and selected group of patients with gastric neuroendocrine neoplasia with relevant risk factors to establish the most appropriate therapeutic strategy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Laura Conti, Gloria Galli, Chiara Ligato, Marilia Carabotti, Bruno Annibale, Edith Lahner
Summary: The aim of this study was to assess the frequency of autoimmune atrophic gastritis (AAG) and coeliac disease (CD) association and compare the clinical, biochemical, and histological features of adults affected by both diseases. The results showed that the association between AAG and CD is rare, with a prevalence of 2% in AAG patients with CD. Adults with both AAG and CD were younger and had a higher prevalence of normocytic anaemia compared to those with AAG only.
DIGESTIVE AND LIVER DISEASE
(2023)
Editorial Material
Immunology
Marco Vincenzo Lenti, Bruno Annibale, Antonio Di Sabatino, Edith Lahner
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Gastroenterology & Hepatology
Edith Lahner, Emanuele Dilaghi, Ludovica Dottori, Bruno Annibale
Article
Nutrition & Dietetics
Barbara Polese, Marilia Carabotti, Sara Rurgo, Camilla Ritieni, Giovanni Sarnelli, Giovanni Barbara, Fabio Pace, Rosario Cuomo, Bruno Annibale
Summary: The study aimed to evaluate the differences in dietary habits between patients with diverticular disease (DD) and controls without diverticula. The results showed that patients with DD had lower daily calories and lipids intake compared to the controls. Protein consumption was lower in previous diverticulitis (PD) patients compared to those with asymptomatic diverticulosis (D). Fiber and dietary vitamins intake were also lower in DD patients compared to the controls. These findings suggest that DD patients have distinct dietary habits compared to the control subjects.
Article
Nutrition & Dietetics
Gloria Galli, Marilia Carabotti, Laura Conti, Silvia Scalamonti, Bruno Annibale, Edith Lahner
Summary: In adults, celiac disease (CD) diagnosis is based on specific serology and duodenal histology. This study aimed to compare the clinical, histological, and biochemical differences between adult CD patients with high tTG IgA titer (HT) and low titer (LT) at diagnosis and follow-up. HT patients had more severe histological damage and persistent antibodies positivity at follow-up compared to LT patients, although they recovered similarly after a Gluten-free diet.
Article
Nutrition & Dietetics
Ludovica Dottori, Daniil Corleone Tsar'kov, Emanuele Dilaghi, Giulia Pivetta, Silvia Scalamonti, Irene Ligato, Gianluca Esposito, Bruno Annibale, Edith Lahner
Summary: This retrospective study evaluated the safety and efficacy of ferric carboxymaltose (FCM) in treating Corpus Atrophic Gastritis (CAG)-related iron deficiency anaemia (IDA). The results showed that FCM was both safe and effective in improving haemoglobin and iron storage in patients, leading to quick and long-lasting recovery. However, there is a risk of IDA relapse.
Review
Medicine, General & Internal
Caterina Sbarigia, Camilla Ritieni, Bruno Annibale, Marilia Carabotti, Alessandro Armuzzi
Summary: This narrative review aimed to report the SCAD diagnostic criteria adopted in different studies, highlighting the current challenges and main pitfalls in its diagnosis. The analysis of fourteen studies showed that SCAD diagnosis is often based on not fully adequate macroscopic colonic description and scant biopsy protocol sampling. An accurate clinical and endoscopic evaluation, with an adequate sampling biopsy protocol, with attention to differential diagnosis, seemed to be crucial for a prompt SCAD diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Microbiology
Giulia Pivetta, Ludovica Dottori, Federico Fontana, Sophia Cingolani, Irene Ligato, Emanuele Dilaghi, Christian Milani, Marco Ventura, Marina Borro, Gianluca Esposito, Bruno Annibale, Edith Lahner
Summary: This study aimed to assess gender differences in gastric bacterial microbiota between subjects with healthy stomachs and those with autoimmune atrophic gastritis. Results showed that women with healthy stomachs had a higher gastric bacterial abundance and less microbial diversity compared to men. Autoimmune atrophic gastritis seems to reset gender differences in gastric bacterial abundance and reduce biodiversity in males.
Article
Endocrinology & Metabolism
Ludovica Magi, Daniela Prosperi, Giuseppe Lamberti, Matteo Marasco, Valentina Ambrosini, Maria Rinzivillo, Davide Campana, Guido Gentiloni, Bruno Annibale, Alberto Signore, Francesco Panzuto
Summary: This study aimed to evaluate the role of [F-18]FDG PET/CT in low-grade gastroenteropancreatic neuroendocrine neoplasia. The retrospective study included 55 patients with grade 1 GEP-NETs. The results showed that approximately half of the patients had positive findings on [F-18]FDG PET/CT, which had a negative impact on clinical outcomes. These findings support the potential use of [F-18]FDG PET/CT in selected cases to detect patients at higher risk for an unfavorable disease course.
Article
Radiology, Nuclear Medicine & Medical Imaging
Damiano Caruso, Michela Polici, Maria Rinzivillo, Marta Zerunian, Ilaria Nacci, Matteo Marasco, Ludovica Magi, Mariarita Tarallo, Simona Gargiulo, Elsa Iannicelli, Bruno Annibale, Andrea Laghi, Francesco Panzuto
Summary: The aim of this study was to test the radiomic approach in patients with metastatic neuroendocrine tumors (NETs) treated with Everolimus, and the results showed that radiomics could be used as an imaging biomarker to predict progression-free survival (PFS) and death.
