Article
Pediatrics
Emilia Rizzo, Ailsa Elizabeth Ritchie, Vinay Shivamurthy, Ata Siddiqui, Ming Lim
Summary: Hypertrophic pachymeningitis is a rare chronic inflammatory disorder, with very few reported cases in children. Early initiation of steroid treatment may improve outcomes in pediatric patients with this condition.
Article
Pharmacology & Pharmacy
Lisa Dannenberg, Kajetan Trojovsky, Aysel Ayhan, Carolin Helten, Saif Zako, Rene M'Pembele, Philipp Mourikis, Marcel Benkhoff, Denis Ignatov, Theresia Sarabhai, Tobias Petzold, Ragnar Huhn-Wientgen, Tobias Zeus, Malte Kelm, Bodo Levkau, Amin Polzin
Summary: The study investigated the effect of MTX treatment on postischemic cardiac damage in mice with AMI. The results showed that MTX treatment did not improve cardiac outcome, as evidenced by no significant differences in infarct size, systolic function, and structural parameters compared to the control group. Further trials are needed to explore alternative anti-inflammatory targets for improving cardiovascular outcome.
Article
Multidisciplinary Sciences
Arielle P. Davis, Clare L. Maxwell, Haley Mendoza, Abby Crooks, Shelia B. Dunaway, Sher Storey, Claire Stevens, Lauren C. Tantalo, Sharon K. Sahi, Kevin R. Robertson, Christina M. Marra
Summary: In individuals at high risk for laboratory-defined neurosyphilis, cognitive complaints are not a good indicator of cognitive impairment. Severity of cognitive impairment was greater in those with CSF pleocytosis. Identification and treatment of those with neurosyphilis may mitigate subsequent cognitive decline.
Review
Gastroenterology & Hepatology
Walter Reinisch, Krisztina Gecse, Jonas Halfvarson, Peter M. Irving, Jorgen Jahnsen, Laurent Peyrin-Biroulet, Gerhard Rogler, Stefan Schreiber, Silvio Danese
Summary: This review by European IBD experts discusses the practical use of anti-TNF therapy, including biosimilars, for adult patients with Crohn's disease. Despite the significant impact of TNF inhibitors in changing treatment goals, disparities still exist in translating evidence-based guidelines into actual treatment algorithms. The introduction of biosimilars aims to minimize health inequalities in drug availability and provides clinical guidance for different scenarios encountered during treatment with infliximab and adalimumab biosimilars in patients with moderate to severe CD.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Gastroenterology & Hepatology
Walter Reinisch, Krisztina Gecse, Jonas Halfvarson, Peter M. Irving, Jorgen Jahnsen, Laurent Peyrin-Biroulet, Gerhard Rogler, Stefan Schreiber, Silvio Danese
Summary: The introduction of TNF inhibitors has revolutionized the treatment of Crohn's disease, but there are still differences in the actual application of evidence-based guidelines, leading to treatment disparities between countries. The availability of biosimilars can help reduce health inequalities caused by variations in drug availability.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Michael Due Larsen, Bente Mertz Norgard, Jens Kjeldsen
Summary: This study aimed to evaluate the prognostic impact of disease activity after 14 weeks of biologic therapy on surgery and steroid-free remission in patients with Crohn's disease and ulcerative colitis. The study found that a positive treatment response to biologic therapy predicted a better short-term outcome in CD and UC patients.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Medicine, General & Internal
Petr Matousek, Jakub Lubojacky, Michaela Masarova, Lenka Cabalova, Stanislav Cervenka, Pavel Kominek
Summary: The study aimed to compare the success rates of endoscopic dacryocystorinostomy with and without bicanalicular intubation for the treatment of distal nasolacrimal duct obstruction. It found that the use of bicanalicular intubation did not significantly increase the success rate of the procedure.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Fanji Qiu, Jinfeng Li, Kirsten Legerlotz
Summary: This systematic review and meta-analysis found that additional dietary supplementation during physiotherapeutic treatment can significantly improve the reduction in pain score, but it has no effect on functional outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Dentistry, Oral Surgery & Medicine
H. L. Taylor, S. Rahurkar, T. J. Treat, T. P. Thyvalikakath, T. K. Schleyer
Summary: There is a lack of robust evidence on whether nonsurgical periodontal treatment improves systemic disease outcomes, and current reviews often fall short in methodological rigor. Large-scale databases containing matched medical and dental record data have the potential to inform and complement future studies on the effect of periodontal treatment on systemic outcomes.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Pediatrics
Roland Mannchen, Marco Serafin, Rosamaria Fastuca, Alberto Caprioglio
Summary: The present study aimed to evaluate the benefits of one-phase Class II Early Treatment using extraoral forces and functional appliances, compared to two-phase Class II Late Treatment with extraction and full fixed appliances. The study found that early Class II treatment can significantly reduce treatment effort and lower incisor proclination.
Review
Nutrition & Dietetics
Roeland A. F. Evers, Annemiek M. J. van Wegberg, Anita MacDonald, Stephan C. J. Huijbregts, Vincenzo Leuzzi, Francjan J. van Spronsen
Summary: This systematic review assessed the effects of dietary liberalization following BH4 treatment on PKU patients. The results so far do not provide clear evidence that this dietary liberalization has a positive impact on patients, as most studies did not find significant differences.
Review
Health Care Sciences & Services
Hester Banierink, Anne M. L. Meesters, Kaj ten Duis, Job N. Doornberg, Mostafa El Moumni, Erik Heineman, Inge H. F. Reininga, Frank F. A. IJpma
Summary: The study found that 3D-assisted surgery technologies have a positive effect on operation time, blood loss, fluoroscopy dose, time and frequency, as well as accuracy of screw placement in pelvic ring injury surgery. However, no improvement in clinical outcome in terms of fracture reduction and functional outcome has been established so far.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Cheng-Hsien Lin, Yu-Hsuan Shih, Tsung-Chih Chen, Cheng-Wei Chou, Chiann-Yi Hsu, Chieh-Lin Jerry Teng
Summary: The study found that the clinical characteristics of lymphoma-associated HLH have not substantially changed over the past twenty years, but more patients diagnosed in 2013-2021 were tested for Epstein-Barr virus compared to those diagnosed in 2004-2012. In terms of treatment response, patients treated in 2013-2021 had a slightly higher median OS than those treated in 2004-2012.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Maryia Zhdanava, Zhijie Ding, Ameur M. Manceur, Erik Muser, Patrick Lefebvre, Christopher Holiday, Marie-Helene Lafeuille, Dominic Pilon
Summary: The objective of this study was to compare persistence and describe dose titration among bio-naive patients with Crohn's disease (CD) initiated on ustekinumab or adalimumab. The results showed that patients initiated on ustekinumab had higher persistence on the index biologic compared to those initiated on adalimumab, and they also had lower dose escalation rates and higher de-escalation rates.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Review
Oncology
Ming-Huang Chen, Sheng-Nan Lu, Chien-Hung Chen, Peng-Chan Lin, Jeng-Kai Jiang, Yulia D'yachkova, Mariusz Lukanowski, Rebecca Cheng, Li-Tzong Chen
Summary: GI malignancies have high recurrence rates and poor prognoses, necessitating new therapeutic approaches. Ramucirumab, a monoclonal antibody targeting VEGF receptor 2, has shown promising efficacy and tolerability in phase 3 clinical trials for GI cancers, including difficult-to-treat patient subgroups. Real-world clinical practice outcomes align with trial data, indicating potential benefits of ramucirumab in improving treatment outcomes for GI cancer patients.
Article
Gastroenterology & Hepatology
Dominik Aschenbrenner, Maria Quaranta, Soumya Banerjee, Nicholas Ilott, Joanneke Jansen, Boyd Steere, Yin-Huai Chen, Stephen Ho, Karen Cox, Carolina V. Arancibia-Carcamo, Mark Coles, Eamonn Gaffney, Simon Pl Travis, Lee Denson, Subra Kugathasan, Jochen Schmitz, Fiona Powrie, Stephen N. Sansom, Holm H. Uhlig
Summary: Dysregulated immune responses are the cause of IBDs, with IL-10 and IL-1 identified as critical regulators of monocyte IL-23 production. The study differentiates between homeostatic IL-23 production and hyperinflammation-associated IL-23 production in patients with severe ulcerating active Crohn's disease and anti-TNF treatment non-responsiveness. Subgroups of patients with IBD that might benefit from IL-23p19 and/or IL-1 alpha/IL-1 beta-targeting therapies upstream of IL-23 are identified.
Article
Gastroenterology & Hepatology
Corey A. Siegel, Gil Y. Melmed, Dermot P. B. McGovern, Victoria Rai, Florian Krammer, David T. Rubin, Maria T. Abreu, Marla C. Dubinsky
Article
Gastroenterology & Hepatology
Holm H. Uhlig, Fabienne Charbit-Henrion, Daniel Kotlarz, Dror S. Shouval, Tobias Schwerd, Caterina Strisciuglio, Lissy de Ridder, Johan van Limbergen, Marina Macchi, Scott B. Snapper, Frank M. Ruemmele, David C. Wilson, Simon P. L. Travis, Anne M. Griffiths, Dan Turner, Christoph Klein, Aleixo M. Muise, Richard K. Russell
Summary: This paper provides recommendations for the use of genomics in evaluating potential monogenic causes of IBD, suggesting that routine genetic screening is not recommended for all IBD patients. Instead, genetic testing should be considered based on the age of IBD onset and other criteria, emphasizing the importance of genetic testing in clinical care.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Correction
Gastroenterology & Hepatology
Lieven Pouillon, Simon Travis, Peter Bossuyt, Silvio Danese, Laurent Peyrin-Biroulet
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Sarah M. Goodday, Simon Travis, Alissa Walsh, Stephen H. Friend
Summary: This study found that stress related to the COVID-19 pandemic increased the severity of Crohn's disease symptoms, with nearly half of respondents reporting stress as the primary reason for symptom changes. The impact of the pandemic on disease activity further supports the hypothesis that stress affects Crohn's disease activity.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Letter
Gastroenterology & Hepatology
Colleen G. C. McGregor, Alex Adams, Ross Sadler, Carolina V. Arancibia-Carcamo, Rebecca Palmer, Tim Ambrose, Oliver Brain, Alissa Walsh, Paul Klenerman, Simon P. L. Travis, Nicholas M. Croft, James O. Lindsay, Jack Satsangi
Article
Gastroenterology & Hepatology
Mastura Neyazi, Sraddha S. Bharadwaj, Samuel Bullers, Zofia Varenyiova, Simon Travis, Carolina Arancibia-Carcamo, Fiona Powrie, Alessandra Geremia
Summary: Higher expression of OLFM4, a cancer stemness gene induced by IL-22, is present in PSC-UC, suggesting that IL-22 responses may result in alterations of the intestinal stem-cell niche in these patients. IFN gamma stimulation resulted in the downregulation of LGR5 in EpOCs, whereas higher expression of OLFM4 was observed after IL-22 stimulation, indicating a complex interplay between these cytokines in contributing to carcinogenesis in PSC-UC.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Alissa Walsh, Rena Cao, Darren Wong, Ramona Kantschuster, Lawrence Matini, Jean Wilson, Andrey Kormilitzin, Matthew South, Simon Travis, Sarah Bauermeister
Summary: By utilizing item response theory analysis, the original 9-item SCCAI was simplified into a more efficient 4-item scale, reducing response burden and improving performance in assessing disease activity in ulcerative colitis patients.
BMC GASTROENTEROLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Marla C. Dubinsky, Rory Collins, Maria T. Abreu
Article
Gastroenterology & Hepatology
Kit Curtius, Misha Kabir, Ibrahim Al Bakir, Chang Ho Ryan Choi, Juanda L. Hartono, Michael Johnson, James E. East, James O. Lindsay, Roser Vega, Siwan Thomas-Gibson, Janindra Warusavitarne, Ana Wilson, Trevor A. Graham, Ailsa Hart
Summary: This study identified that patients with large, unresected, multifocal LGD and recent moderate/severe inflammation are at highest risk of developing advanced neoplasia. Personalised risk prediction provided via the Ulcerative Colitis-Cancer Risk Estimator can support treatment decision-making.
Article
Gastroenterology & Hepatology
Lorenzo Norsa, Roberto Berni Canani, Remi Duclaux-Loras, Emeline Bequet, Jutta Koeglmeier, Richard K. Russell, Holm H. Uhlig, Simon Travis, Jennifer Hollis, Sibylle Koletzko, Giusi Grimaldi, Giuseppe Castaldo, Astor Rodrigues, Jaques Deflandre, Lukasz Dembinski, Neil Shah, Peter Heinz-Erian, Andreas Janecke, Saara Leskinen, Satu Wedenoja, Ritva Koskela, Alain Lachaux, Kaija-Leena Kolho, Frank M. Ruemmele
Summary: A significant proportion of patients with Congenital Chloride Diarrhoea develop Inflammatory Bowel Disease, which may require surgery for treatment failure or colon cancer.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Medicine, General & Internal
Kristine Paridaens, John R. Fullarton, Simon P. L. Travis
Summary: A systematic literature review and meta-analysis confirmed the efficacy and safety of oral Pentasa in treating active UC and maintaining remission. Pentasa demonstrated superiority over placebo in inducing and maintaining remission, and had similar efficacy to other 5-ASAs. Additionally, Pentasa was found to be better tolerated than sulfasalazine in maintaining remission.
CURRENT MEDICAL RESEARCH AND OPINION
(2021)
Article
Gastroenterology & Hepatology
Sharib Ali, Adam Bailey, Stephen Ash, Maryam Haghighat, Tgu Investigators, Simon J. Leedham, Xin Lu, James E. East, Jens Rittscher, Barbara Braden
Summary: A novel methodology for measuring Barrett's epithelium risk score automatically was proposed, achieving high accuracy in both phantom and patient data. The method allows quantification of BEA and islands area, and enables interactive 3D visualization of the esophageal surface. The artificial intelligence system demonstrated high accuracy in C&M measurements and has potential for risk stratification and therapy response assessment.
Editorial Material
Gastroenterology & Hepatology
Darren Wong, Simon P. L. Travis
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Nutrition & Dietetics
Stephanie Santos-Paulo, Samuel P. Costello, Samuel C. Forster, Simon P. Travis, Robert V. Bryant
Summary: Mounting evidence suggests a close and dynamic connection between microbiome composition and host energy balance and metabolism. The gut microbiome has emerged as a potential target for combating obesity, with various interventions such as dietary strategies and bariatric surgery showing promise in modulating the microbiota and improving metabolic health in obese populations. While much of the evidence comes from preclinical studies, the role of microbiome modulation in anti-obesity interventions is gaining attention and may offer a novel strategy in the limited arsenal of effective obesity treatments.
NUTRITION RESEARCH REVIEWS
(2022)