Article
Immunology
Yu Zhang, Su-Lan Tan, Juan Du, Ye Chen, Jing Jia, Jian-Guo Feng, Ke-Xuan Liu, Jun Zhou
Summary: The study demonstrated that dexmedetomidine could improve sleep disorders, cognitive impairment, anxiety, abnormal liver function, and brain damage in MHE rats, possibly through activating alpha 2 adrenergic receptors, reducing neuroinflammatory response, and inhibiting the activation of microglia and the NLRP3/Caspase1 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Health Care Sciences & Services
Jakub Gazda, Peter Drotar, Sylvia Drazilova, Juraj Gazda, Matej Gazda, Martin Janicko, Peter Jarcuska
Summary: Hepatic encephalopathy is a brain dysfunction caused by liver insufficiency and/or portosystemic shunting, with a spectrum of manifestations including overt HE, covert HE, and minimal HE. Despite the lack of universally accepted gold standard for diagnosing MHE, significant progress has been made in the application of artificial intelligence in medicine.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Kessarin Thanapirom, Monton Wongwandee, Sirinporn Suksawatamnuay, Panarat Thaimai, Napaporn Siripon, Wanwisar Makhasen, Sombat Treeprasertsuk, Piyawat Komolmit
Summary: The study aimed to establish the normative data of PHES in healthy Thai individuals, assess the prevalence of MHE, and validate the use of S-ANT1 in detecting MHE in cirrhotic patients. The results showed that MHE was present in 26.6% of cirrhotic patients. S-ANT1 had a moderate positive correlation with PHES.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Simon Johannes Gairing, Chiara Mangini, Lisa Zarantonello, Stefania Gioia, Elise Jonasson Nielsen, Sven Danneberg, Anna S. Lok, Philippe Sultanik, Peter Robert Galle, Joachim Labenz, Dominique Thabut, Jens Uwe Marquardt, Patricia P. Bloom, Mette Munk Lauridsen, Sara Montagnese, Silvia Nardelli, Christian Labenz
Summary: This large multicenter study demonstrates that screening for minimal hepatic encephalopathy (MHE) is a useful tool for predicting the development of overt hepatic encephalopathy (OHE) and poorer survival.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Andrew W. McHill, Joseph T. Hull, Elizabeth B. Klerman
Summary: Chronic circadian disruption and insufficient sleep are independently associated with poor health outcomes. This study found that chronic circadian disruption was associated with decreased hunger and appetite, and these changes were correlated with changes in the ghrelin/leptin ratio.
Article
Gastroenterology & Hepatology
Takao Miwa, Tatsunori Hanai, Maeda Toshihide, Yui Ogiso, Kenji Imai, Atsushi Suetsugu, Koji Takai, Makoto Shiraki, Naoki Katsumura, Masahito Shimizu
Summary: Zinc deficiency may predict the development of OHE and mortality in LC patients with MHE.
HEPATOLOGY RESEARCH
(2021)
Article
Clinical Neurology
Qiu-Yi Dong, Jia-Hui Lin, Ye Wu, Yun-Bin Cao, Min-Xiong Zhou, Hua-Jun Chen
Summary: The purpose of this study was to evaluate the ability of neurite orientation dispersion and density imaging (NODDI) to detect white matter microstructural abnormalities in minimal hepatic encephalopathy (MHE). The results showed a significant reduction in neurite density index (NDI) in MHE patients, which was more pronounced than the changes in fractional anisotropy (FA). The study also found that NODDI can provide more precise information about MHE-related pathology than diffusion tensor imaging (DTI).
Article
Gastroenterology & Hepatology
Thananya Jinato, Masoumeh Sikaroodi, Andrew Fagan, Richard K. Sterling, Hannah Lee, Puneet Puri, Brian C. Davis, Michael Fuchs, Edith Gavis, Patrick M. Gillevet, Jasmohan S. Bajaj
Summary: This study found linkages between bacteriophages and cognitive function in patients with cirrhosis, indicating a potential influence on bacteria that produce neuroactive metabolites. These findings suggest that bacteriophages could be explored as treatment options for minimal hepatic encephalopathy (MHE) in cirrhosis.
Article
Biochemistry & Molecular Biology
Juan Jose Gallego, Alessandra Fiorillo, Franc Casanova-Ferrer, Amparo Urios, Maria-Pilar Ballester, Lucia Durban, Javier Megias, Teresa Rubio, Andrea Cabrera-Pastor, Desamparados Escudero-Garcia, Vicente Felipo, Carmina Montoliu
Summary: Minimal hepatic encephalopathy (MHE) is associated with changes in the immune system, and this study found that plasma extracellular vesicles (EVs) from MHE patients have altered miRNA and protein contents, enriched in inflammatory factors. These EVs can modulate the expression of inflammatory factors in cultured CD4+ T lymphocytes, increasing the proportion and activation of specific cell subtypes. These findings suggest that plasma EVs could play an important role in the immune changes observed in MHE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Dalia Rega, Mika Aiko, Nicolas Penaranda, Amparo Urios, Juan-Jose Gallego, Carla Gimenez-Garzo, Franc Casanova, Alessandra Fiorillo, Andrea Cabrera-Pastor, Teresa San-Miguel, Cristina Ipiens, Desamparados Escudero-Garcia, Joan Tosca, Cristina Monton, Maria-Pilar Ballester, Jose Ballester, Luis Aparicio, Maria-Pilar Rios, Lucia Durban, Amparo Mir, Elena Kosenko, Paula Cases, Vicente Felipo, Carmina Montoliu
Summary: Cirrhotic patients with minimal hepatic encephalopathy (MHE) may experience alterations in thermal, vibration, and/or heat pain sensitivity, which are related to cognitive and motor deficits. Studies have found that MHE patients generally exhibit lower sensory abilities and attention deficits compared to cirrhotic patients without MHE, with these alterations appearing early on in the disease process.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Jie-Ru Guo, Jia-Yan Shi, Qiu-Yi Dong, Yun-Bin Cao, Dan Li, Hua-Jun Chen
Summary: This study found abnormal neural activity in patients with minimal hepatic encephalopathy (MHE) through the analysis of static amplitude and dynamic amplitude. Dynamic ALFF shows potential in distinguishing MHE patients from non-MHE patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Anatomy & Morphology
Hua-Jun Chen, Xiao-Hong Zhang, Jia-Yan Shi, Shao-Fan Jiang, Yi-Fan Sun, Ling Zhang, Dan Li, Rong Chen
Summary: The study revealed disrupted thalamic structural connections in cirrhotic patients with MHE, which worsened from NHE to MHE and were correlated with neurocognitive performance. The moderate classification accuracy using CS and MD measurements suggests that thalamic connections could serve as potential biomarkers for diagnosing and monitoring MHE. Further research is recommended to explore structural alterations in other white matter pathways in MHE.
FRONTIERS IN NEUROANATOMY
(2021)
Article
Clinical Neurology
Bradley E. Aouizerat, Eeeseung Byun, Clive R. Pullinger, Caryl Gay, Anners Lerdal, Kathryn A. Lee
Summary: The study found associations between selected genes and plasma markers related to energy homeostasis and sleep disruption in adults with HIV/AIDS. Many of these associations were influenced by HIV disease markers. Higher levels of adiponectin were associated with less wake after sleep onset, while higher levels of ghrelin and glucose were associated with shorter total sleep time, and higher levels of leptin were associated with longer total sleep time.
Article
Medicine, General & Internal
Igor G. Bakulin, Kristina N. Ivanova, Elena Y. Eremina, Natalya V. Marchenko, NORMIND Study Team
Summary: This study aimed to evaluate the effect of different rifaximin-alpha regimens on patients with liver cirrhosis and minimal hepatic encephalopathy. The results showed that continuous rifaximin-alpha therapy had a more pronounced effect on improving patients' quality of life and symptoms compared to cyclic use.
Article
Microbiology
Ming-Wei Wang, Wei-Juan Ma, Yan Wang, Xiao-Han Ma, Yu-Feng Xue, Jing Guan, Xi Chen
Summary: This study aimed to determine the safety and efficacy of different intestinal microecological modulators in the treatment of minimal hepatic encephalopathy (MHE) and explore the potential mechanism through intestinal microbiota analysis. The results showed that probiotics, rifaximin, and lactulose are safe and effective in the treatment of MHE, and they can improve the composition of gut microbiota to some extent.
FRONTIERS IN MICROBIOLOGY
(2023)
