Journal
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Volume 33, Issue 5, Pages 541-550Publisher
WILEY
DOI: 10.1111/j.1365-2036.2010.04568.x
Keywords
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Funding
- AstraZeneca
- Abbott
- Berlex
- Boehringer Engelheim
- Bristol-Myers Squibb
- Centocor
- Elan/Biogen
- Genentech
- Millennium
- Novartis
- Osiris
- Otsuka
- Proctor and Gamble
- Protein Design Labs
- Schering-Plough
- Schering Canada
- Synta
- Tillotts
- UCB Pharma
- Abbott Laboratories
- Bristol Meyers Squibb
- CentocorOrthoBiotech
- Millennium Pharmaceuticals
- Pfizer Inc.
- Shire Pharmaceuticals
- Warner Chilcott
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P>Background Crohn's disease (CD) is associated with impaired health-related quality of life (HRQoL). Certolizumab pegol, administered either every 2 weeks (q2w) or q4w, maintains efficacy in patients previously failing on the anti-TNF agent infliximab (WELCOME study). Aim To investigate the impact of certolizumab pegol administered q2w and q4w on work productivity and HRQoL in the WELCOME study. Methods Patients with loss of response to infliximab received open-label certolizumab pegol induction and were randomised to receive double-blind maintenance treatment with certolizumab pegol 400 mg either q4w or q2w through week 24, with a final evaluation at week 26. Work productivity and HRQoL were assessed using the Work Productivity and Activity Impairment:CD questionnaire and Inflammatory Bowel Disease Questionnaire respectively. Results Baseline HRQoL burden was representative of moderately to severely active CD. HRQoL, daily activity and work productivity improved in both treatment groups as early as week 6 and were maintained through week 26. Treatment benefits to HRQoL, daily activity and work productivity were similar between the certolizumab pegol q2w vs. q4w groups. Conclusions Certolizumab pegol therapy results in meaningful improvements in work productivity, daily activities and HRQoL in patients with active CD who previously responded to but either lost response or could not tolerate infliximab (ClinicalTrials.gov number: NCT00308581).
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