Review
Gastroenterology & Hepatology
Maria de Brito Nunes, Matthias Knecht, Reiner Wiest, Jaume Bosch, Annalisa Berzigotti
Summary: This study aimed to evaluate the incidence of post-banding ulcer bleeding (PBUB) in patients with cirrhosis treated with esophageal varices endoscopic band ligation (EBL) and identify predictors of PBUB. The results showed that the incidence of PBUB was 5.5% and the mean time for it to occur was 11 days. A high Model for End-stage Liver Disease (MELD) score and emergency EBL were identified as independent predictors of post-ligation ulcer bleeding. The treatment options included drugs, endoscopic procedures, and transjugular intrahepatic portosystemic shunt.
LIVER INTERNATIONAL
(2023)
Review
Medicine, General & Internal
Maria Corina Plaz Torres, Lawrence M. J. Best, Suzanne C. Freeman, Danielle Roberts, Nicola J. Cooper, Alex J. Sutton, Davide Roccarina, Amine Benmassaoud, Laura Iogna Prat, Norman R. Williams, Mario Csenar, Dominic Fritche, Tanjia Begum, Sivapatham Arunan, Maxine Tapp, Elisabeth Jane Milne, Chavdar S. Pavlov, Brian R. Davidson, Emmanuel Tsochatzis, Kurinchi Selvan Gurusamy
Summary: A network meta-analysis was conducted to compare different initial treatments for the secondary prevention of variceal bleeding in cirrhotic patients with a history of oesophageal varices. Variceal band ligation may result in fewer serious adverse events compared to sclerotherapy, while TIPS may lead to a larger decrease in symptomatic rebleed than variceal band ligation. However, there remains considerable uncertainty regarding the effects of interventions across different comparisons. High-quality randomized comparative clinical trials are needed to provide more definitive evidence.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Gastroenterology & Hepatology
Zixuan Hu, Shaojun Liu, Tao Liu, Wei Zhu, Jiake Li
Summary: This study aimed to explore the incidence of bleeding from ulcers due to premature band slippage and identify associated factors. It found that the presence of high-risk stigmata, a greater number of varices, and fewer bands per variceal site were associated with an increased risk of post-band ligation (BL) bleeding. The use of proton pump inhibitors did not have a statistically significant effect on bleeding incidents.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Colin Hartgerink, Faisal M. Nimri, Tobias Zuchelli, Syed-Mohammed Jafri, Cyrus Piraka
Summary: This case series demonstrates the effectiveness of band ligation in the treatment of Barrett's esophagus and esophageal varices. It shows successful eradication of the pathology and positive outcomes in addressing dysplasia.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Jang Han Jung, Jung Hyun Jo, Sung Eun Kim, Chang Seok Bang, Seung In Seo, Chan Hyuk Park, Se Woo Park
Summary: The number of band ligations during the first endoscopic session for acute variceal bleeding remains debatable. In this study, minimal EVL was associated with lower rates of hypoxia and shock during the procedure but had a higher risk of treatment failure compared to maximal EVL. Patient characteristics such as age, liver disease severity scores, liver function classification, presence of hepatocellular carcinoma, and initial blood pressure were also associated with treatment failure.
Article
Medicine, General & Internal
Ding Shi, Jianping Liu
Summary: This study evaluated the efficacy of using large-volume ligators for endoscopic band ligation in patients with cirrhosis and non-bleeding gastric varices. The results showed that large-volume ligators have similar eradication rates to tissue glue, but are safer.
Article
Health Care Sciences & Services
Kazunori Nagashima, Atsushi Irisawa, Ken Kashima, Fumi Sakuma, Takahito Minaguchi, Akira Yamamiya, Akane Yamabe, Koki Hoshi, Keiichi Tominaga, Makoto Iijima, Kenichi Goda
Summary: This study found that Red color sign-positive small straight esophageal varices (F1) have a high risk of bleeding, requiring prophylactic treatment, with a lower bleeding rate in the treatment group. Patients with a history of bleeding are more likely to experience early bleeding in varices that include HCS or are combined with RC.
Review
Gastroenterology & Hepatology
Naoyoshi Nagata, Ryota Niikura, Naoki Ishii, Mitsuru Kaise, Fumio Omata, Naoyuki Tominaga, Tomoyuki Kitagawa, Takashi Ikeya, Katsumasa Kobayashi, Yohei Furumoto, Toshiaki Narasaka, Eri Iwata, Mitsushige Sugimoto, Takao Itoi, Naomi Uemura, Takashi Kawai
Summary: Band ligation therapy is more effective than clipping in reducing the recurrence of colonic diverticular hemorrhage, with lower rates of early and late rebleeding, as well as a lower probability of requiring transcatheter arterial embolization or surgery.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Pharmacology & Pharmacy
Saleh A. Alqahtani, Sunguk Jang
Summary: Cirrhosis is the fifth leading cause of death in adults, with variceal bleeding posing a significant risk in patients with advanced cirrhosis. Management involves primary prophylaxis, active bleeding intervention, and secondary prophylaxis, all aimed at preventing variceal bleeding. Emergency swift intervention is required for active variceal bleeding to achieve durable hemostasis.
Review
Gastroenterology & Hepatology
Liwei Jing, Qiumeng Zhang, Ziwei Chang, Hui Liu, Xuan Shi, Xingyu Li, Jing Wang, Yanbo Mo, Xiujing Zhang, Lizhuan Ma, Zhiting Li, Chao Zhang
Summary: This study evaluated the effectiveness of non-surgical secondary prophylaxis interventions for esophageal varices rebleeding in cirrhotic patients. The results showed that TIPS was more effective in reducing the incidence of rebleeding, rebleeding-related mortality, and overall mortality in cirrhotic patients compared to other interventions.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Yara Sarkis, Howard Masuoka, Marwan Ghabril, Aditya Gutta, Mohammad A. Al-Haddad, Sarah Stainko, Lainna Cohen, Anthony Perkins, John M. Dewitt
Summary: This study evaluates the safety and efficacy of endoscopic ultrasound (EUS)-guided injection of cyanoacrylate (CYA) for primary prophylaxis (PP) of gastric varices (GV). The results show that posttreatment GV bleeding and adverse events (AEs) are similar following primary and secondary GV prophylaxis.
DIGESTIVE ENDOSCOPY
(2023)
Review
Gastroenterology & Hepatology
Lolwa N. Al-Obaid, Ahmad Najdat Bazarbashi, Marvin Ryou
Summary: This article highlights alternative therapies for gastric and esophageal variceal bleeding and their potential role in management.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Eliabe Silva de Abreu, Mateus Jorge Nardelli, Andre Mourao Costa Lima, Jaqueline Brito Cardoso, Fernanda Maria Farage Osorio, Teresa Cristina de Abreu Ferrari, Luciana Costa Faria, Claudia Alves Couto, Guilherme Grossi Lopes Cancado
Summary: This study compared the effects of propranolol and carvedilol in preventing secondary UVB in HSS, and found that carvedilol may be equally effective as propranolol during a 12-month follow-up.
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Medicine, General & Internal
Monica Dzwonkowski, Umair Iqbal, Seth W. Kaufer, Yakub I. Khan, Kishore Kumar
Summary: Ectopic variceal bleeding is a rare cause of gastrointestinal bleeding with a high mortality rate. Treatment guidelines are lacking due to the infrequent occurrence of this condition. This case report describes a middle-aged woman with cirrhosis who underwent emergency esophagogastroduodenoscopy for actively bleeding duodenal varices, which were successfully treated with variceal band ligation. The patient also underwent embolization of varices due to the risk of recurrent bleeding.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Jung Hee Kim, Se Woo Park, Jang Han Jung, Da Hae Park, Chang Seok Bang, Chan Hyuk Park, Ji Won Park, Jae Gun Park
Summary: A new risk-scoring model was developed to predict 6-week mortality in cirrhotic patients undergoing endoscopic band ligation for acute variceal bleeding. The model demonstrated superior predictive accuracy and discriminative performance compared to existing scoring systems, aiding in the individualized treatment strategies for high-risk cirrhotic patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
