Article
Pharmacology & Pharmacy
Kenjiro Matsumoto, Minako Suenaga, Yumi Mizutani, Kohei Matsui, Ayano Yoshida, Tomohiro Nakamoto, Shinichi Kato
Summary: The study investigated TRPV2 expression and its role in acid reflux esophagitis in rats. TRPV2 up-regulation in inhibitory motor neurons was found to be involved in LES relaxation in the esophagitis model, suggesting that TRPV2 inhibition might be beneficial for GERD treatment.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Otorhinolaryngology
Katharina Winiker, Kristin Gozdzikowska, Esther Guiu Hernandez, Seh Ling Kwong, Phoebe Macrae, Maggie-Lee Huckabee
Summary: This study investigated the potential for behavioral modulation of resting pressure at the upper esophageal sphincter (UOS) in healthy adults. Participants were able to increase resting pressure after one week of training, but there was no evidence for purposeful pressure decrease. The capacity for purposeful pressure modulation was influenced by intensive biofeedback training, while healthy subjects may be limited by physiological factors.
Review
Biochemistry & Molecular Biology
Dafni Planta, Tim Gerwinn, Souzan Salemi, Maya Horst
Summary: Spinal dysraphism, specifically myelomeningocele, is the main cause of neurogenic lower urinary tract dysfunction in children. The changes in the bladder wall structure begin during fetal development, resulting in reduced smooth muscle, increased fibrosis, impaired urothelial barrier function, and decreased nerve density. This leads to significant functional impairment characterized by decreased compliance and increased elastic modulus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Nantaporn Promdam, Pissared Khuituan, Pharkphoom Panichayupakaranant
Summary: Standardized [6]-gingerol extracts were prepared using alternative green solvents and showed significant inhibitory effects on mouse ileal contractions and lower esophageal sphincter contractions, indicating their potential as nutraceuticals for alleviating nausea and vomiting.
Article
Medicine, General & Internal
Ronnie Fass, Guy E. Boeckxstaens, Hashem El-Serag, Rachel Rosen, Daniel Sifrim, Michael F. Vaezi
Summary: Gastro-oesophageal reflux disease is common in adults and children, with diagnosis primarily based on history, physical examination, and treatment varying with age. Treatment options include medications, endoscopic interventions, or surgery.
NATURE REVIEWS DISEASE PRIMERS
(2021)
Article
Anesthesiology
Emiri Suganuma, Teruhiko Ishikawa, Yuji Kitamura, Taiichiro Hayashida, Tomoaki Matsumura, Mai Fujie, Natsuko Nozaki-Taguchi, Yasunori Sato, Shiroh Isono
Summary: The recovery of lower oesophageal barrier function during emergence from anesthesia is not significantly different between patients receiving a mixture of atropine and neostigmine or sugammadex, and is completed after recovery of consciousness.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2021)
Article
Medicine, General & Internal
Steven J. Kittner, Padmini Sekar, Mary E. Comeau, Christopher D. Anderson, Gunjan Y. Parikh, Tachira Tavarez, Matthew L. Flaherty, Fernando D. Testai, Michael R. Frankel, Michael L. James, Gene Sung, Mitchell S. V. Elkind, Bradford B. Worrall, Chelsea S. Kidwell, Nicole R. Gonzales, Sebastian Koch, Christiana E. Hall, Lee Birnbaum, Douglas Mayson, Bruce Coull, Marc D. Malkoff, Kevin N. Sheth, Jacob L. McCauley, Jennifer Osborne, Misty Morgan, Lee A. Gilkerson, Tyler P. Behymer, Stacie L. Demel, Charles J. Moomaw, Jonathan Rosand, Carl D. Langefeld, Daniel Woo
Summary: The study reveals that Black and Hispanic patients with intracerebral hemorrhage have a younger mean age compared to White patients, and factors like untreated hypertension and lack of health insurance contribute significantly to the disproportionate burden of intracerebral hemorrhage in these populations.
Article
Plant Sciences
Ante Turudic, Zlatko Liber, Martina Grdisa, Jernej Jakse, Filip Varga, Zlatko Satovic
Summary: The development of bioinformatic solutions requires biological knowledge and often makes assumptions. In this study, we investigated the relationship between chloroplast sequence lengths and taxonomic proximity of species using RefSeq sequences from the asterid and rosid clades. We found that chloroplast length distributions are narrow at the family and genus levels, with outliers indicating possible inaccuracies in sequence assembly.
Article
Multidisciplinary Sciences
Laura Carman, Thor F. Besier, Julie Choisne
Summary: There are two methods for generating paediatric musculoskeletal geometry: scaling generic adult geometry, which is widely accessible but inaccurate, and obtaining geometry from medical imaging, which is accurate but time-consuming and costly. A population-based shape model was developed to generate accurate and accessible musculoskeletal geometry in a paediatric population. The model accurately predicted bone geometry without the need for medical imaging.
SCIENTIFIC REPORTS
(2022)
Article
Veterinary Sciences
Emilie Vangrinsven, Olivier Broux, Laurent Massart, Stephanie Claeys, Cecile Clercx, Frederic Billen
Summary: The study found that using pre- and postoperative antacid treatment in brachycephalic dogs undergoing surgery may improve digestive clinical signs and lesions. The obstruction manoeuvre is an interesting technique for detecting gastro-oesophageal junction abnormalities.
JOURNAL OF SMALL ANIMAL PRACTICE
(2021)
Review
Gastroenterology & Hepatology
Chamara Basnayake, Annelies Geeraerts, Ans Pauwels, Ger Koek, Michael Vaezi, Tim Vanuytsel, Jan Tack
Summary: The prevalence of duodenogastroesophageal reflux (DGER) increases with more advanced esophageal lesions in patients with gastroesophageal reflux disease (GERD) and persists in patients on proton pump inhibitor (PPI) therapy. PPIs appear to be effective in treating DGER, but further research is needed for future therapies.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Medicine, General & Internal
Jessica Tobin, Steven B. Zeliadt, Dawn M. Upchurch, Rian DeFaccio, Jamie Douglas, Hannah M. Gelman, Matt Hawrilenko, Stephen Frochen, Nathan McGinty, Adam Resnick, Nathan Tomlanovich, Joy Toyama, Alison M. Whitehead, Benjamin Kligler, Stephanie L. Taylor
Summary: White individuals are the largest group of users for complementary and integrative health therapies, but this could be due to age, health condition, and location differences. Understanding racial and ethnic differences is crucial in addressing the disparities in care.
Article
Cell Biology
Sarah Abou Alaiwi, Amin H. Nassar, Elio Adib, Stefan M. Groha, Elie W. Akl, Bradley A. McGregor, Edward D. Esplin, Shan Yang, Kathryn Hatchell, Vincent Fusaro, Sarah Nielsen, David J. Kwiatkowski, Guru P. Sonpavde, Mark Pomerantz, Judy E. Garber, Matthew L. Freedman, Huma Q. Rana, Alexander Gusev, Toni K. Choueiri
Summary: This study examined the germline landscape of 1,829 RCC patients from diverse ancestries and found 17% of patients carrying pathogenic and likely pathogenic variants, with 10.3% having potentially actionable variants. Differences in variant frequencies were observed between African and non-African patients, with non-African patients having more actionable variants. This research sheds light on biological disparities in RCC between African and non-African populations and may lead to more comprehensive genomic studies in underrepresented populations.
Article
Multidisciplinary Sciences
Hugo Sanchez Hernandez, Arpine Hovasapian, Belinda Campos
Summary: This study explored whether the display of pride varies across social contexts, ethnic backgrounds, and gender. The results showed similarity in displayed pride across different contexts, but variations were observed in ethnic and gender differences. Latino/a/x Americans verbally expressed less pride compared to European Americans, while women displayed more pride than men.
Review
Respiratory System
Annemijn H. Jonkman, Irene Telias, Elena Spinelli, Evangelia Akoumianaki, Lise Piquilloud
Summary: Personalising ventilator settings through measurement of oesophageal pressure (Poes) allows assessment of respiratory mechanics and quantification of lung stress, guiding individualised ventilator settings and improving assisted ventilation and weaning. This review provides an understanding of relevant physiological concepts assessed using Poes measurements and presents a practical approach for implementing oesophageal manometry at the bedside. Further clinical data is needed to confirm the benefits and determine optimal targets, but potential practical approaches are discussed.
EUROPEAN RESPIRATORY REVIEW
(2023)