Review
Gastroenterology & Hepatology
Rodrigo Liberal, Ynto S. de Boer, Michael A. Heneghan
Summary: Autoimmune hepatitis is a disease characterized by hypergammaglobulinemia, autoantibodies, and interface hepatitis. Treatment typically involves nonspecific immunosuppression with steroids and azathioprine, but new therapeutic strategies are needed to achieve long-lasting disease remission without broad immunosuppression. Defects in regulatory T cells play a permissive role in enabling autoimmune liver injury.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Immunology
Sandra Phillips, Ravi Jagatia, Shilpa Chokshi
Summary: The last few years have seen significant progress in the development of drugs for hepatitis B, including direct-acting antivirals and host-targeted therapies. Therapeutic vaccines and drugs directly targeting the key factors of hepatitis B persistence hold promise. The field of hepatitis B research also includes other potential treatments.
Review
Gastroenterology & Hepatology
Sun Woong Kim, Jun Sik Yoon, Minjong Lee, Yuri Cho
Summary: Hepatitis B virus (HBV) infection is a serious global public health problem, and there is currently no complete cure. The focus of recent research has been on achieving a functional cure for HBV through combination therapies and immunomodulators. New therapeutic approaches and clinical trials are being conducted to find a long-lasting cure for HBV infection.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Review
Oncology
Paulina Stefaniuk, Julia Onyszczuk, Agnieszka Szymczyk, Monika Podhorecka
Summary: CLL, the most common type of leukemia in adults in western countries, shows heterogeneity in clinical course and response to treatment. TP53 aberrations are the most important factors of poor prognosis. Treatment of patients with TP53-deficiency requires drugs promoting cell death independently of TP53.
CANCER MANAGEMENT AND RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Alice Indini, Fausto Roila, Francesco Grossi, Daniela Massi, Mario Mandala
Summary: Mucosal melanoma is a rare and aggressive subtype of melanoma that has shown poor response to novel treatment approaches. Recent molecular studies have revealed potential therapeutic targets and the potential benefits of immunotherapy in this disease. However, further research is needed to confirm these findings in different studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Bruno A. Lopes, Caroline Pires Poubel, Cristiane Esteves Teixeira, Aurelie Caye-Eude, Helene Cave, Claus Meyer, Rolf Marschalek, Mariana Boroni, Mariana Emerenciano
Summary: Using a machine learning model, we accurately predicted KMT2A-r leukemia and identified 20 genes that can estimate KMT2A-r. The overexpression of SKIDA1 and LAMP5 were found to be better markers associated with KMT2A-r compared to CSPG4. LAMP5 overexpression was also associated with all KMT2A-USP2 fusions. Additionally, drug sensitivity analysis revealed potential treatments for KMT2A-r leukemia, including Foretinib for AML patients with FLT3 activating mutations.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
Jenna Turocy, Zev Williams
Summary: Progress is being made in therapeutic options for recurrent implantation failure, with promising treatments including immune therapies like peripheral blood mononuclear cells, platelet rich plasma, and subcutaneous granulocyte-colony stimulating factor.
FERTILITY AND STERILITY
(2021)
Review
Otorhinolaryngology
Joanna Krajewska, Krzysztof Zub, Adam Slowikowski, Tomasz Zatonski
Summary: Chronic rhinosinusitis (CRS) is commonly seen in cystic fibrosis (CF) patients, with current treatment lacking precise guidelines or recommended therapeutic agents. Targeting the underlying genetic defect, drug therapy, and surgery may be effective in treating CF-related CRS, but further studies are needed to establish consensus for therapy.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Review
Rheumatology
Eleni Papachristodoulou, Loukas Kakoullis, Eleni Tiniakou, Konstantinos Parperis
Summary: The study reviewed different treatment modalities for Cutaneous polyarteritis nodosa (CPAN) and found limited evidence on the management of CPAN patients. Current treatment mainly involves the use of systemic corticosteroids and immunosuppressive agents in combination, but further research is needed to evaluate their impact on disease remission, relapses, and mortality.
Review
Virology
Yi-Wen Huang, Albert Qin, Chan-Yen Tsai, Pei-Jer Chen
Summary: Ropeginterferon alfa-2b is a promising treatment option for MPN and chronic viral hepatitis due to its favorable pharmacokinetic profile and demonstrated efficacy in clinical studies. Administered once every two weeks, it has shown to be well-tolerated and effective in treating chronic hepatitis B, C, and D.
Review
Pharmacology & Pharmacy
Javier Rodriguez-Carrio, Valeria Nucera, Ignazio Francesco Masala, Fabiola Atzeni
Summary: Behcet disease is a complex inflammatory condition characterized by oral and genital ulcers, with potential involvement of multiple organ systems. The etiology is unclear, but it is related to immune system dysregulation. Treatment options are diverse, but the underlying mechanisms of the disease require further exploration.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Qiao-yi Huang, Shao-rong Chen, Jia-ming Chen, Qi-yang Shi, Shu Lin
Summary: Primary ovarian insufficiency is a rare gynecological condition that results in menstrual disturbances, infertility, and other health problems. The development of new therapeutic approaches is underway, but they are still in the experimental stage and require precise design components for conversion into clinical treatments. Each medical practitioner has the responsibility to select suitable therapies for individual patients.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Review
Biology
Delia Szok, Anett Csati, Laszlo Vecsei, Janos Tajti
Summary: Chronic migraine is a prevalent and burdensome disease that significantly affects patients' quality of life. This review provides an overview of the latest classification systems, epidemiological data, and recommended treatment options for chronic migraine. Pharmacological and non-pharmacological approaches, such as injectable botulinum toxin and monoclonal antibodies, are recommended for the preventive treatment of chronic migraine.
Review
Oncology
Stefania Canova, Benedetta Trevisan, Maria Ida Abbate, Francesca Colonese, Luca Sala, Alice Baggi, Sofia Paola Bianchi, Anna D'Agostino, Diego Luigi Cortinovis
Summary: The recent advances in the molecular knowledge of small cell lung cancer (SCLC) and potential new treatment strategies targeting DNA damage pathway, epigenetics, angiogenesis, and oncogenic drivers were reviewed. Addition of immunotherapy to chemotherapy has shown significant improvements in clinical outcomes, but the prognosis remains poor. Genomic alterations have been identified to classify SCLC into different molecular subtypes.
CURRENT ONCOLOGY REPORTS
(2023)
Review
Gastroenterology & Hepatology
Guo-Qing Yin, Jun Li, Bei Zhong, Yong-Fong Yang, Mao-Rong Wang
Summary: Chronic hepatitis B virus infection is a global public health issue, with current nucleos(t)ide analog therapy not leading to complete cure. Persistent low-level viremia can contribute to liver disease progression, but utilizing higher doses of entecavir may improve antiviral efficacy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Virology
Andreas Laras, Margarita Papatheodoridi, Eleni Panopoulou, George Papatheodoridis, Stephanos J. Hadziyannis, Emilia Hadziyannis
Summary: Serum HBV RNA in HBeAg-negative chronically infected patients primarily consists of pgRNA and a minor fraction of preC mRNA transcripts. Serum pgRNA is associated with disease activity and can serve as a marker for the decision of cessation of therapy.
Review
Gastroenterology & Hepatology
Alkistis Papatheodoridi, George Papatheodoridis
Summary: Hepatocellular carcinoma (HCC) is a major public health problem and is one of the leading causes of cancer-related deaths worldwide. Hepatitis B (HBV) and C (HCV) viruses have been identified as oncoviruses and are responsible for most cases of HCC, while the role of hepatitis D (HDV) virus in liver cancer development remains unclear. Coinfection of HDV/HBV is associated with more severe liver damage than HBV mono-infection, and recent studies suggest that HDV/HBV patients are at increased risk of developing HCC compared to those with HBV alone. This review summarizes the current literature on the impact of HDV in HCC development and discusses the potential interactions between HBV, HDV, and neighboring liver tissue in liver carcinogenesis.
LIVER INTERNATIONAL
(2023)
Letter
Gastroenterology & Hepatology
Margarita Papatheodoridi, Anna S. Lok, George V. Papatheodoridis
Review
Gastroenterology & Hepatology
Heiner Wedemeyer, Tammo L. Tergast, Jeffrey V. Lazarus, Homie Razavi, Kostas Bakoyannis, Ricardo Baptista-Leite, Marco Bartoli, Philip Bruggmann, Cristian-Silviu Busoi, Maria Buti, Manuel Carballo, Laurent Castera, Massimo Colombo, Rodrigo Sousa Coutinho, Yuval Dadon, Gamal Esmat, Rafael Esteban, Joan Colom Farran, Mark Gillyon-Powell, David Goldberg, Sharon Hutchinson, Harry L. A. Janssen, George Kalamitsis, Loreta A. Kondili, John S. Lambert, Rui Tato Marinho, Mojca Maticic, Aldo Patricello, Markus Peck-Radosavljevic, Stanislas Pol, Mario Poljak, Cora Pop, Tomislov Sokol, Vana Sypsa, Nurdan Tozun, Zobair Younossi, Alessio Aghemo, George V. Papatheodoridis, Angelos Hatzakis
Summary: In 2016, the Hepatitis B and C Public Policy Association (HepBCPPA) launched the HCV Elimination Manifesto, calling for the elimination of HCV in the EU by 2030. Although progress has been made, most countries are not on track to reach the elimination targets. The COVID-19 pandemic has also hindered efforts, resulting in a decrease in HCV diagnoses and treatment initiations. It is crucial to reinforce action and gain commitment from policymakers to achieve HCV elimination.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Dimitrios S. Karagiannakis, Theodoros Voulgaris, George Markakis, Dimitra Lakiotaki, Elisavet Michailidou, Evangelos Cholongitas, George Papatheodoridis
Summary: This study found that spleen stiffness measurement (SSM) by 2D shear-wave elastography could better predict the probability of liver decompensation and mortality compared to liver stiffness measurement (LSM) and other parameters. SSM showed better diagnostic accuracy for the prediction of 1-year decompensation or death.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
George Papatheodoridis, Vasileios Lekakis, Anna S. Lok, K. Rajender Reddy
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Zobair M. Younossi, Ming-Lung Yu, Yusuf Yilmaz, Khalid Aida Alswat, Maria Buti, Marlen Ivon Castellanos Fernandez, Georgios Papatheodoridis, Saeed S. Hamid, Mohamed El-Kassas, Wah Kheong Chan, Ajay K. Duseja, Stuart C. Gordon, Yuichiro Eguchi, Vasily A. Isakov, Stuart K. Roberts, Jian-Gao Fan, Ashwani K. Singal, Manuel Romero-Gomez, Aijaz Ahmed, Janus Ong, Brian P. Lam, Issah Younossi, Fatema Nader, Andrei Racila, Maria Stepanova, Saleh Alqahtani
Summary: Chronic hepatitis B (CHB) infection is a common cause of cirrhosis and liver cancer worldwide. The Global Liver Registry is being used to assess the clinical and patient-reported outcomes (PROs) of CHB patients from different regions. The study included 1818 CHB patients from 15 countries, with varying rates of advanced fibrosis. HBV subjects from the Middle East/North Africa had the lowest PRO scores, while those from Southeast/East and South Asia had the highest. Factors associated with PRO impairment in CHB patients included advanced fibrosis, non-hepatic comorbidities, and female sex.
JOURNAL OF VIRAL HEPATITIS
(2023)
Article
Medicine, General & Internal
Huai Zhang, Rafael S. Rios, Jerome Boursier, Rodolphe Anty, Wah-Kheong Chan, Jacob George, Yusuf Yilmaz, Vincent Wai-Sun Wong, Jiangao Fan, Jean-Francois Dufour, George Papatheodoridis, Li Chen, Joern M. Schattenberg, Junping Shi, Liang Xu, Grace Lai-Hung Wong, Naomi F. Lange, Margarita Papatheodoridi, Yuqiang Mi, Yujie Zhou, Christopher D. Byrne, Giovanni Targher, Gong Feng, Minghua Zheng
Summary: This study aimed to investigate the utility of cytokeratin-18 (CK-18) M30 concentrations as a non-invasive diagnostic tool for non-alcoholic steatohepatitis (NASH). The results showed that there was a difference in CK-18 M30 levels between NASH and non-alcoholic fatty liver (NAFL) patients, but the sensitivity and positive predictive value were not ideal. Therefore, measurement of CK-18 M30 levels alone has limited value for non-invasively diagnosing NASH.
CHINESE MEDICAL JOURNAL
(2023)
Review
Surgery
Evangelos Cholongitas, Patrizia Burra, Georgia Vourli, George V. Papatheodoridis
Summary: The use of initial/early everolimus appears to be effective and has a satisfactory safety profile, making it a reasonable therapeutic option in liver transplantation.
CLINICAL TRANSPLANTATION
(2023)
Article
Pharmacology & Pharmacy
Dimitrios Bampatsias, Maria-Angeliki Dimopoulou, Dimitrios Karagiannakis, Alexandros Sianis, Eleni Korompoki, Kanella Kantreva, Erasmia Psimenou, Georgia Trakada, George Papatheodoridis, Kimon Stamatelopoulos
Summary: This article reports a case of a HoFH patient who experienced a sudden decrease in blood lipid levels during SARS-CoV-2 infection, followed by a rebound increase refractory to treatment. Marker of liver stiffness increased at 9 months and decreased at 18 months after the infection. The potential interactions of hypolipidemic treatment with the viral replication process and the therapeutic dilemmas in the post-infection period are discussed.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Medicine, General & Internal
Anastasia Katsoula, Georgios Axiaris, Afroditi Mpitouli, Maria Palatianou, Angeliki Christidou, Nikolaos Dimitriadis, Andreas Nakos, Ploutarchos Pastras, Panagiotis Kourkoulis, Pantelis Karatzas, Miltiadis Moutzoukis, Charalampos Zlatinoudis, Athanasios Philippidis, Anastasia Kourikou, Georgios Kokkotis, Antonios Gklavas, Angeliki Machaira, Aikaterini Mantaka, Persefoni Talimtzi, Evaggelia Anagnostopoulou, Ioannis E. Koutroubakis, Ioannis Papaconstantinou, Georgios Bamias, Spilios Manolakopoulos, Nicoletta Mathou, Konstantina Paraskeva, Andreas Protopappas, Eftychia Tsironi, Konstantinos H. H. Katsanos, Dimitrios K. K. Christodoulou, Georgios Papatheodoridis, Georgios Michalopoulos, Georgios Theocharis, Christos Triantos, Ioannis Pachiadakis, Konstantinos Soufleris, Nikolaos Viazis, Gerassimos J. Mantzaris, Georgios Tribonias, Maria Tzouvala, Angeliki Theodoropoulou, Konstantinos Karmiris, Evanthia Zampeli, Spyridon Michopoulos, Anna-Bettina Haidich, Olga Giouleme
Summary: The aim of this study was to validate the content of IBD-Disk in a Greek cohort of IBD patients. The results showed good correlation and consistency between the scores of IBD-Disk and IBD-DI at baseline and follow-up. Female gender and extraintestinal manifestations were significantly associated with a higher IBD-Disk total score. Therefore, the Greek version of IBD-Disk was proven to be a reliable and valid tool for assessing IBD-related disability.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Maria Tampaki, George V. Papatheodoridis, Evangelos Cholongitas
Summary: Patients with decompensated hepatocellular carcinoma (HCC) have limited therapeutic options and are often excluded from clinical trials. Liver transplantation is the best treatment option, but strict criteria and donor shortages limit its availability. Locoregional treatments may provide a survival benefit if well tolerated. Systemic treatments, particularly immunotherapy, may be the safest choice based on real-life data. Close monitoring is necessary due to the high risk of liver disease deterioration.
Article
Microbiology
Nikolaos D. D. Karakousis, Lampros Chrysavgis, Alkistis Papatheodoridi, Aigli-Ioanna Legaki, Panagiotis Lembessis, Evangelos Cholongitas, Antonios Chatzigeorgiou, George Papatheodoridis
Summary: This study investigates the levels of circulating cf-DNA and 5-methyl-2'-deoxycytidine in HBeAg-negative patients with chronic hepatitis B (CHB). The results show that circulating cf-DNA concentration significantly increased after treatment initiation. There was also a trend in increasing levels of 5-methyl-2'-deoxycytidine after treatment initiation in CHB patients. These findings suggest that both cf-DNA and 5-methyl-2'-deoxycytidine may serve as useful biomarkers to monitor liver disease activity and response to antiviral treatment in HBeAg-negative chronic HBV patients.
Article
Gastroenterology & Hepatology
Theodoros Voulgaris, Vassileios Lekakis, Jiannis Vlachogiannakos, Dimitrios Kamberoglou, Afroditi Orfanidou, George Papatheodoridis, George Karamanolis
Summary: In this study, we retrospectively assessed the efficacy of citalopram or amitriptyline versus no treatment in patients with functional chest pain (FCP). The results showed that both citalopram and amitriptyline are effective pharmacological options in the symptomatic relief of almost 50% of patients with well characterized FCP.
ANNALS OF GASTROENTEROLOGY
(2023)
Article
Oncology
Yu-xian Teng, Ping-Ping Guo, Ke-Zhang Qin, Kang Chen, George Papatheodoridis, Bang-De Xiang, Liang Mia, Jian-Hong Zhong
Summary: This study suggests that combination therapy of lenvatinib and immune checkpoint inhibitors may be more effective in improving the overall survival of advanced hepatocellular carcinoma patients with viral etiology, low BMI, or high tumor load.
EURASIAN JOURNAL OF MEDICINE AND ONCOLOGY
(2022)
