Article
Psychiatry
Nur Dikmeer, Lutfullah Besiroglu, Maria A. Di Biase, Andrew Zalesky, Meltem I. Kasal, Aslihan Bilge, Ercan Durmaz, Serap Polat, Fazil Gelal, Nabi Zorlu
Summary: In comparison to healthy controls, OCD patients showed reduced FA and increased RD in certain key areas of the brain. OCD group also exhibited weaker connectivity in the right hemisphere compared to controls. Siblings of OCD patients had intermediate levels of white matter microstructure and connectivity, suggesting a familial predisposition for OCD.
ACTA PSYCHIATRICA SCANDINAVICA
(2021)
Article
Clinical Neurology
M. Alemany-Navarro, M. Tubio-Fungueirino, S. Diz-de Almeida, R. Cruz, A. Lombroso, E. Real, V. Soria, S. Bertolin, M. Fernandez-Prieto, P. Alonso, J. M. Menchon, A. Carracedo, C. Segalas
Summary: This study analyzed the association of SNPs with neurocognitive variables in a sample of 133 OCD probands. The results suggest that studying neurocognitive variables in GWAS may provide more insight into the genetic basis of OCD and facilitate the development of individualized treatment approaches.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Editorial Material
Clinical Neurology
Trevor. W. Robbins
Summary: This scientific commentary discusses the research conducted by Kim et al. on the unbalanced fronto-pallidal neurocircuit underlying set shifting in patients with obsessive-compulsive disorder, published in the journal Brain.
Article
Neuroimaging
Lutfullah Besiroglu, Andrew Zalesky, Meltem Kasal, Nur Dikmeer, Ercan Durmaz, Serap Polat, Fazil Gelal, Nabi Zorlu
Summary: This study aimed to examine cortical thickness and surface area differences between patients with obsessive-compulsive disorder (OCD) and their unaffected siblings. The results showed that both OCD patients and unaffected siblings had significantly lower cortical thickness in the right anterior insula. Additionally, OCD patients had reduced surface areas in the superior frontal gyrus, paracentral gyrus, and precuneus of the right hemisphere. These findings suggest that lower cortical thickness in the right anterior insula may represent a potential structural endophenotype for OCD.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Clinical Neurology
M. Tubio-Fungueirino, M. Alemany-Navarro, P. Alonso, M. Arrojo, E. Real, S. Bertolin, J. M. Menchon, A. Carracedo, M. Fernandez-Prieto, C. Segalas
Summary: This study found that OCD patients have deficits in non-verbal memory and organizational abilities. Responders to pharmacological treatment also displayed better executive functioning and fluid intelligence. Organizational ability can be a predictor of pharmacological response to SSRI monotherapy, controlling for anxious symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Stephan Heinzel, Katharina Bey, Rosa Gruetzmann, Julia Klawohn, Christian Kaufmann, Leonhard Lennertz, Michael Wagner, Norbert Kathmann, Anja Riesel
Summary: The study found impairments in spatial working memory (SWM) performance in individuals with OCD, but it is unclear whether this deficit is a core cognitive endophenotype of OCD. Performance in SWM was best in healthy controls, intermediate in unaffected relatives of OCD individuals, and worst in those with OCD, with no significant difference between healthy controls and relatives.
Review
Clinical Neurology
Maral Melkonian, Sarah McDonald, Amelia Scott, Eyal Karin, Blake F. Dear, Bethany M. Wootton
Summary: Obsessive-compulsive disorder (OCD) is a chronic and unremitting condition with low rates of symptom improvement and spontaneous remission in the absence of treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Gregory S. Chasson, Junhan Cho, Mark Zimmerman, Adam M. Leventhal
Summary: This study provides evidence for the comorbidity between obsessive-compulsive symptoms and nicotine dependence in clinical and non-clinical populations. The results suggest that the link between obsessive-compulsive symptoms and nicotine dependence may be obscured when obsessive-compulsive phenomena is modeled as a dichotomous diagnostic variable rather than as a dimensional construct.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Katharina Bey, Rafael Campos-Martin, Julia Klawohn, Benedikt Reuter, Rosa Gruetzmann, Anja Riesel, Michael Wagner, Alfredo Ramirez, Norbert Kathmann
Summary: The study found a relationship between increased methylation in the OXTR gene and the occurrence and worsened treatment response of OCD. This hypermethylation was also associated with childhood trauma and stressful life events. While the hypermethylation was negatively related to treatment response in OCD patients and associated with stressful life events, there were no significant mediation effects.
Article
Clinical Neurology
Clara Law, Snigdha Kamarsu, Immanuela C. Obisie-Orlu, Gina M. Belli, Maria Mancebo, Jane Eisen, Steven Rasmussen, Christina L. Boisseau
Summary: Personality traits may impact the course and symptom presentation of OCD, with low extraversion being associated with a decreased rate of remission. Other personality traits were not associated with remission.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychiatry
Louise Destree, Mary-Ellen E. Brierley, Lucy Albertella, Laura Jobson, Leonardo F. Fontenelle
Summary: This study conducted a systematic review on the relationships between childhood trauma and obsessive-compulsive symptoms (OCS) severity. The results showed a significant relationship between exposure to childhood trauma and OCS severity in both clinical and non-clinical populations. It was also found that a range of childhood trauma types, rather than a single type, was associated with OCD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Agriculture, Dairy & Animal Science
Belinda R. Walsh
Summary: Repetitive behaviors in dogs are often considered symptoms of canine compulsive disorder analogous to obsessive-compulsive disorder in humans, but the cognitive behavioral perspective finds insufficient evidence to support this equivalence. There are no clear indications of the same neuroanatomy or physiology being specifically associated with both disorders, suggesting that abnormal repetitive behaviors in dogs may not be the equivalent of human obsessive-compulsive disorder. Further research is needed to explore the cognitive, behavioral, and emotional components of canine repetitive behaviors.
APPLIED ANIMAL BEHAVIOUR SCIENCE
(2021)
Review
Psychology, Clinical
Behrang Mahjani, Katharina Bey, Julia Boberg, Christie Burton
Summary: Obsessive-compulsive disorder (OCD) is a heritable, polygenic disorder with contributions from both common and rare genetic variants. Genetics play an important role in the susceptibility to OCD, with discrete OCD symptom dimensions having both shared and unique genetic risks. Genome-wide studies show that OCD shares genetic risk with its comorbid conditions.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychiatry
Janardhanan C. Narayanaswamy, Aditi Subramaniam, Anushree Bose, Mahavir Agarwal, Sunil Kalmady, Dania Jose, Boban Joseph, Venkataram Shivakumar, Samuel B. Hutton, Ganesan Venkatasubramanian, Y. C. Janardhan Reddy
Summary: The study found that OCD patients performed poorly in antisaccade tasks, supporting CSTC abnormalities in OCD, independent of illness severity. Examining this in remitted patients and unaffected relatives could help ascertain their endophenotype validity.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Clinical Neurology
Ricardo A. Najera, Sean T. Gregory, Ben Shofty, Adrish Anand, Ron Gadot, Brett E. Youngerman, Eric A. Storch, Wayne K. Goodman, Sameer A. Sheth
Summary: This study conducted a cost-effectiveness analysis of stereotactic radiosurgical capsulotomy (SRS-C) for treatment-resistant obsessive-compulsive disorder (TROCD) and found that SRS-C is more cost-effective compared to treatment as usual (TAU).
JOURNAL OF NEUROSURGERY
(2022)
Article
Biochemistry & Molecular Biology
Katharina Bey, Rafael Campos-Martin, Julia Klawohn, Benedikt Reuter, Rosa Gruetzmann, Anja Riesel, Michael Wagner, Alfredo Ramirez, Norbert Kathmann
Summary: The study found a relationship between increased methylation in the OXTR gene and the occurrence and worsened treatment response of OCD. This hypermethylation was also associated with childhood trauma and stressful life events. While the hypermethylation was negatively related to treatment response in OCD patients and associated with stressful life events, there were no significant mediation effects.
Article
Psychology, Biological
Kai Haerpfer, Hannes Per Carsten, Kim Loewisch, Nele Westermann, Anja Riesel
Summary: Enhanced amplitudes of the error-related negativity (ERN) have been suggested to be a transdiagnostic neural risk marker for internalizing psychopathology. Previous studies propose worry to be an underlying mechanism driving the association between enhanced ERN and anxiety. The present study examines the effects of trait and state worry on ERN using different designs. The results indicate that ERN is not sensitive to variations in state worry, but an elevated ERN is associated with trait-like tendency to worry and internalizing psychopathology.
Article
Clinical Neurology
Sandra Paul, Norbert Kathmann, Bjorn Elsner, Benedikt Reuter, Sven Barnow, Daniela Simon, Tanja Endrass, Julia Klawohn
Summary: This study investigated whether the late positive potential (LPP), a neural marker of attention and stimulus processing, could predict the response to cognitive-behavioral therapy (CBT) in patients with obsessive-compulsive disorder (OCD). The results showed that higher LPP responses to negative stimuli were predictive of lower self-reported OCD symptoms after completion of CBT. The findings suggest that patients with increased emotional reactivity may benefit more from CBT, possibly through reduced avoidance of anxiety-provoking stimuli. The LPP shows promise as a prognostic marker for CBT response in OCD, but further research is needed.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Multidisciplinary
Annika C. Konrad, Katharina Foerster, Marcel Kurtz, Tanja Endrass, Emanuel Jauk, Philipp Kanske
Summary: This study found that physical distancing measures during the coronavirus pandemic can lead to increased psychological distress, especially in individuals with pre-existing mental disorders. Factors such as low social resources, empathic disconnection, and perceived social isolation were found to contribute to higher levels of distress in this population. These findings provide valuable information for targeted social interventions to prevent an increase in incidence of mental disorders during physical distancing measures.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Biological
Anja Riesel, Kai Haerpfer, Lars Thoma, Norbert Kathmann, Julia Klawohn
Summary: This study found that the error-related negativity (ERN) is associated with traits such as anxiety and negative affect, while the correct-related negativity (CRN) is specifically associated with compulsivity. These findings suggest that using composite measures and dimensional recruitment can improve our understanding of the characteristics underlying variation in neural performance monitoring.
Article
Neurosciences
Sascha Froelich, Marlon Esmeyer, Tanja Endrass, Michael N. Smolka, Stefan J. Kiebel
Summary: Human behavior often consists of repeated action sequences that become automatic or habitual through extensive repetition. However, we are also required to react flexibly and in a goal-directed manner in response to events in our environment. In this study, we developed a novel behavioral paradigm to investigate how implicitly learned action sequences interfere with goal-directed control.
FRONTIERS IN NEUROSCIENCE
(2023)
Editorial Material
Neurosciences
Tanja Endrass, Franziska Weiss
BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Malin K. Hildebrandt, Kristina Schwarz, Raoul Dieterich, Tanja Endrass
Summary: The study found that hypoactivation in the right inferior frontal gyrus during inhibition is specifically related to substance-related problems in individuals with SUDs. Interestingly, increased activity in the same region may serve as a resilience factor in substance use without SUDs. Future research should differentiate between processes linked to the degree of substance use and substance-related problems to better understand why some substance users develop SUDs while others do not.
BIOLOGICAL PSYCHIATRY
(2023)
Meeting Abstract
Psychology, Biological
M. K. Hildebrandt, R. Dieterich, J. Veredjo-Roman, T. Endrass
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2023)
Meeting Abstract
Psychology, Biological
V. Wuellhorst, R. Overmeyer, R. Dieterich, T. Endrass
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2023)
Meeting Abstract
Psychology, Biological
R. Dieterich, T. Endrass
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2023)
Article
Psychology, Biological
Kerstin Dueck, Rebecca Overmeyer, Holger Mohr, Tanja Endrass
Summary: This study examined the influence and interaction of impulsivity and compulsivity on behavioral performance and neural inhibition effects. The results showed no significant relationship between the self-report measures and behavioral or neural inhibition effects, except for a linear effect of the lack of premeditation subscale on behavioral performance.
Article
Biochemistry & Molecular Biology
Solvej Nickel, Tanja Endrass, Raoul Dieterich
Summary: Craving, induced by substance-related cues, plays a crucial role in continued substance use and relapse. Regulation of craving (ROC) is essential for successful treatment, and engaging with the risks of drug use (reappraisal) may be more beneficial than avoiding craving triggers (distraction). However, these effects do not seem to be mediated by lasting changes in cue-related motivated attention (LPP).
Review
Neurosciences
Nuria Donamayor, Claudia Ebrahimi, Viktoria A. Arndt, Franziska Weiss, Florian Schlagenhauf, Tanja Endrass
Summary: This article provides an overview of the mechanisms underlying goal-directed and habitual behavior in individuals with substance use disorders and summarizes the current state of research on this topic. The evidence regarding alterations in addiction and substance use is mixed and requires further investigation. Increased habitual responding is observed in more severely affected groups, while reduced model-based behavior is mainly observed in alcohol use disorder.
NEUROPSYCHOBIOLOGY
(2022)
Article
Neuroimaging
Rosa Gruetzmann, Julia Klawohn, Bjoern Elsner, Benedikt Reuter, Christian Kaufmann, Anja Riesel, Katharina Bey, Stephan Heinzel, Norbert Kathmann
Summary: This study found that error-related activity of the sensorimotor network (SMN), specifically the postcentral gyrus/precuneus, plays a predictive role in treatment response for individuals with obsessive-compulsive disorder (OCD). Patients with stronger error-related SMN activity at baseline are more likely to show positive response to treatment.
NEUROIMAGE-CLINICAL
(2022)
