Article
Biochemistry & Molecular Biology
Rabia Javed, Farwa Rais, Muhammad Kaleem, Bushra Jamil, Muhammad Arslan Ahmad, Tianhao Yu, Saba Waqar Qureshi, Qiang Ao
Summary: This study presents the utilization of chitosan capped CuO nanoparticles in the healthcare system, showing enhanced antibacterial, antioxidant, cytotoxic, and antidiabetic activity compared to CuO nanoparticles. The amalgamation of these nanoparticles into dentine bonding agents results in efficient remedy against secondary caries, with significant reduction of harmful bacteria. Additionally, the synthesized CuO nanoparticles and CuO-Chitosan nanoparticles exhibit promising potential in drug delivery and nanotheranostics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Andrea Loncarevic, Karla Ostojic, Inga Urlic, Anamarija Rogina
Summary: The aim of this study was to prepare bimetallic chitosan microgels and investigate the effects of metal-ion type and content on the properties of the microgels. The microgels were produced using electrohydrodynamic atomization process, and their size and morphology were influenced by the quantity of Cu2+ ions. The bimetallic chitosan microgels showed good stability during enzymatic degradation and exhibited good cytocompatibility.
Article
Chemistry, Applied
Tomer A. Dickstein, Ergang Zhou, Kian K. Hershberger, Angela K. Haskell, David Gene Morgan, Maren Pink, Barry D. Stein, Linda Zh. Nikoshvili, Valentina G. Matveeva, Lyudmila M. Bronstein
Summary: A one-pot solvothermal method was developed for the synthesis of magnetically recoverable catalysts with Ru or Ag nanoparticles capped by chitosan. The method allowed for the stabilization of 2.2 nm monodisperse Ru NPs with high catalytic activity, while leading to exceptionally large Ag nanocrystals. The catalyst displayed extraordinary shelf-life and reusability, making it promising for nitroarene reduction.
CARBOHYDRATE POLYMERS
(2021)
Review
Pharmacology & Pharmacy
Julie Frigaard, Janicke Liaaen Jensen, Hilde Kanli Galtung, Marianne Hiorth
Summary: Nanotechnology has found unique applications in drug delivery, cosmetics, fabrics, water treatment, and food packaging. Chitosan, a nanoparticle derived from natural polysaccharide chitin, has gained attention in modern medicine for its unique properties. This review examines the cytotoxicity of chitosan nanoparticles in biomedical research, revealing low cytotoxicity regardless of particle composition or assay method. However, thorough characterization and cytotoxicity assessment are recommended for new chitosan derivatives and compositions before market implementation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Maria Leticia Bravi Costantino, Maria Soledad Belluzo, Tamara G. Oberti, Ana M. Cortizo, Maria Susana Cortizo
Summary: The present study introduces a novel copolymer synthesis and its application in membrane design, showcasing the efficient interaction with chitosan through cross-linking for potential biomedical applications. The obtained terpolymer, combined with a natural polymer, presents an interesting strategy to obtain a biomaterial with possible applications in regenerative medicine.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Materials Science, Ceramics
Alireza Shabanzadeh-Kouyakhi
Summary: This study successfully synthesized gadolinium oxide nanoparticles through a multi-stage processing method and enhanced their biocompatibility through surface modification and encapsulation. Experimental results showed that different synthesis parameters affected the size, structure, and magnetic properties of Gd2O3 nanoparticles.
CERAMICS INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Mohsen M. El-Sherbiny, Rawan S. Elekhtiar, Mohamed E. El-Hefnawy, Hoda Mahrous, Sultan Alhayyani, Soha T. Al-Goul, Mohamed I. Orif, Ahmed A. Tayel
Summary: This study investigated the potential use of bioactive anticancer nanoconjugates composed of chitosan, curcumin, and eugenol for the treatment of cancer cells. The synthesized nanoparticles showed elevated anti-proliferative activities against colorectal adenocarcinoma and breast adenocarcinoma cells, causing serious DNA damages and fragmentation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Matthew J. Osmond, Melissa D. Krebs
Summary: The study introduces a potential regenerative pulp capping agent by embedding calcium phosphate nanoparticles in carboxymethyl-chitosan and a diglycidyl ether polymer hydrogel, demonstrating promising potential for restoring tooth function and healthy dentin tissue.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Polymer Science
Alexey Lunkov, Mariya Konovalova, Balzhima Shagdarova, Yuliya Zhuikova, Alla Il'ina, Valery Varlamov
Summary: Quaternary chitosan derivative with covalently bonded antioxidant was used to synthesize selenium nanoparticles, which were characterized using AFM, TEM, and DLS methods. The results showed the formation of stable nanoparticles with a positive charge and a size in a specific range. The SeNPs exhibited antibacterial and fungicidal activity, with the highest activity against C. albicans. The modified SeNPs showed significantly higher toxicity to eukaryotic cells, particularly those synthesized at 55 degrees C, and SeNPs loaded with DOX demonstrated effective inhibition of hepatocarcinoma and keratinocytes.
Article
Biochemistry & Molecular Biology
Sante Di Gioia, Giuseppe Fracchiolla, Stefania Cometa, Filippo Maria Perna, Andrea Francesca Quivelli, Giuseppe Trapani, Valeria Daniello, Concetta Nobile, Md Niamat Hossain, Adriana Trapani, Massimo Conese
Summary: In this study, two novel macromolecular conjugates were synthesized and characterized for their stability, release rate, formation of polymeric nanoparticles, antioxidant activity, and cytocompatibility. The results showed that the conjugates exhibited good stability at high temperatures, with the O-carboxymethyl chitosan-DA conjugate having a faster release rate. The formation of polymeric nanoparticles was observed using TEM and Photon correlation spectroscopy. Additionally, the conjugates showed antioxidant activity and were found to be non-toxic to neuroblastoma cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Heba M. Abdallah, Mahmoud H. Abu Elella, Marwa M. Abdel-Aziz
Summary: Tuberculosis (TB) is a highly lethal infectious disease. Traditional anti-TB drugs have limitations in terms of toxicity and treatment efficacy. In recent years, the development of new anti-TB drugs using natural biopolymers has gained attention due to their biodegradability, biocompatibility, and non-toxicity. This study successfully engineered chitosan biguanidine (ChBG) nanoparticles as a safe and effective anti-TB drug. The nanoparticles showed uniform distribution and a small particle size of approximately 38 nm. They exhibited significant inhibitory activity against different M. tuberculosis strains, including drug-resistant strains, with minimal inhibitory concentrations (MIC) lower than that of isoniazid. Furthermore, the ChBG nanoparticles showed no cytotoxicity against normal lung cells in the tested concentration range.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Shaoxiang Lee, Meng Zhang, Guohui Wang, Wenqiao Meng, Xin Zhang, Dong Wang, Yue Zhou, Zhonghua Wang
Summary: Polyvinyl alcohol/starch composite films with p-coumaric acid modified chitosan (P-CS) and chitosan nanoparticles (P-CSNPs) at different concentrations were prepared, showing that P-CS significantly increased the tensile strength of the film, while P-CSNPs films exhibited better thermal stability and antibacterial activity.
CARBOHYDRATE POLYMERS
(2021)
Article
Electrochemistry
S. Sivakala, E. Rishad Baig, C. Molji, Aravind Aashish, Asha S. Kumar, Sudha J. Devaki
Summary: This study successfully tuned the shape of silver nanoparticles through a bio-based surfactant capping method and elucidated the mechanism for the formation of different shapes. It was found that silver nanowires exhibited superior catalytic efficiency, which can be utilized for studying other organic reactions.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
S. Fuentes, J. Valenzuela, J. Leon, S. Guzman-Salas, R. V. Zarate, D. Arancibia
Summary: New imaging agents using nanomaterials have been developed for cancer diagnosis. In this study, a heterostructure based on barium titanate, zinc oxide and erbium coated with chitosan was prepared and assessed for stability and compatibility with biological systems. The coated nanoparticles demonstrated better stability and prevented cytotoxic effects compared to naked nanoparticles.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
A. A. Yaroslavov, A. A. Efimova, E. A. Krasnikov, K. S. Trosheva, A. S. Popov, N. S. Melik-Nubarov, G. G. Krivtsov
Summary: Anionic liposomes were electrostatically adsorbed onto cationic chitosan particles, forming multi-liposomal containers (MLCs) for encapsulation of bioactive substances. The size of chitosan particles and MLCs increased with the molecular mass of chitosan. The proteolytic complex Morikrase induced degradation of MLCs, with slower degradation for higher molecular mass chitosan. pH and cholesterol incorporation had minor effects on MLCs' biodegradation rate, and both MLCs and their degradation products exhibited low cytotoxicity. The results are promising for developing biodegradable carriers for bioactive substances.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
M. Leo Edward, K. C. Dharanibalaji, K. Thileep Kumar, A. Raghu Subash Chandrabose, A. M. Shanmugharaj, V Jaisankar
Summary: A bioactive and non-toxic biopolymer-based electrolyte, extracted from shrimp shells and prepared successfully, shows great potential for applications in electrochemical devices with excellent ionic conductivity and mechanical properties. The electrolyte was characterized using various techniques, confirming its superior performance and stability.
Article
Environmental Sciences
T. Veldevi, S. Raghu, R. A. Kalaivani, A. M. Shanmugharaj
Summary: The uncontrolled accumulation of end-of-life tires poses serious environmental concerns, but converting them into value added products can be a viable solution. By developing carbonaceous-based anode materials through a novel chemical activation strategy, significant improvement in lithium battery performance can be achieved, providing a new roadmap for recycling waste tires for energy storage applications.
Article
Chemistry, Multidisciplinary
G. Sivagaami Sundari, K. Thileep Kumar, E. Senthil Kumar, A. M. Shanmugaraj, R. Kalaivani, S. Raghu
Summary: A scalable synthesis of 3D porous graphitized carbon powder using carbonization and activation of Prosopis juliflora has been reported for symmetric supercapacitor applications. The optimized carbon material showed significant improvement in surface area and specific capacitance, making it a promising alternative electrode material for high energy supercapacitors.
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
(2022)
Article
Chemistry, Multidisciplinary
K. Thileep Kumar, S. Raghu, A. M. Shanmugharaj
Summary: Blister packing materials made of foamed plastics are a major environmental concern due to their disposal methods, and the effective recycling of these materials has become a research focus. This study successfully prepared defect-engineered graphene-like turbostratic carbon materials derived from waste plastics and found that they exhibited excellent electrochemical properties and cycling stability when used as anodes for lithium-ion batteries. The research opens up a new pathway for generating value-added carbon materials from blister pack waste.
Article
Chemistry, Physical
H. Irfan, A. M. Shanmugharaj
Summary: In this study, a novel organosilane coating strategy is used to form an artificial SEI, effectively controlling dendrite growth in lithium metal anodes and promoting stable cycling. Li/Li cells fabricated using coated lithium metal exhibit stable cycling and improved charge/discharge performance.
APPLIED SURFACE SCIENCE
(2022)
Article
Energy & Fuels
L. Prettencia, E. Soundarrajan, A. M. Shanmugharaj, R. A. Kalaivani, S. Raghu
Summary: This article presents the synthesis of Li [Li0.1Ni0.3Mn0.7]O-2 cathode material for lithium-ion batteries using the co-precipitation method and rapid combustion with organic fuels. The physical characterizations confirm the structure and surface morphology of the material. The research findings show that the fine-tuned cathode material exhibits stable cycling at high voltage and high capacity with lower expense.
JOURNAL OF ENERGY STORAGE
(2022)
Article
Nanoscience & Nanotechnology
Seshendra Reddy Ch, Ravindra N. Bulakhe, Jeevan Kumar Reddy Modigunta, G. Murali, A. Reddy Sivasankar, Jiyeong Kim, Eunji Park, Byungin Kang, Insik In, Arup Kumer Roy, Kiruthiga Ramakrishnan, Udayabhaskar Rednam
Summary: Tin oxide and nitrogen-doped graphene quantum dots composite nanotubes were successfully fabricated using electrospinning and annealing methods, and applied as electrodes in supercapacitors. The composite exhibited excellent electrochemical performance, including high capacity retention and maximum specific capacitance, in 2M KOH electrolyte at different scan rates and current densities.
JOURNAL OF NANOMATERIALS
(2022)
Review
Chemistry, Multidisciplinary
G. Murali, Jeevan Kumar Reddy Modigunta, Young Ho Park, Jong-Hoon Lee, Jishu Rawal, Seul-Yi Lee, Insik In, Soo-Jin Park
Summary: Photocatalytic water splitting, CO2 reduction, and pollutant degradation are promising strategies for addressing environmental and energy crises. The use of expensive noble-metal cocatalysts is necessary to enhance photocatalytic performance, but the development of efficient, inexpensive, and noble-metal-free cocatalysts is desirable. MXenes have shown great potential as alternatives to noble-metal cocatalysts, with their 2D morphology, metallic electrical conductivity, hydrophilic surface, and high specific surface area. This review focuses on the synthesis, stability, and application of MXenes-based photocatalysts for H2 evolution, CO2 reduction, and pollutant degradation, and discusses the challenges and future directions for enhancing their photocatalytic performance.
Review
Engineering, Chemical
A. M. Shanmugharaj, V. Vijayabaskar, Anil K. Bhowmick
Summary: Electron beam (EB) processing is a viable technique for developing three-dimensional network structures with improved physical and chemical properties in polymeric or composite systems. The grafting or crosslinking process induced by EB modification is responsible for the formation of these networks without the need for chemical agents or heat. EB radiation technology offers advantages of speed, cleanliness, and precision, making it essential for crosslinking polymeric compounds. However, the level of radiation dose used determines whether crosslinking or chain scission occurs during the process. This paper provides a review of the effects of irradiation dose on crosslinking and structure formation in various soft matrices, such as elastomers and latexes, as well as the improvements in properties observed in EB processed elastomers and their composites. The paper also discusses the crosslinking to scission ratio in pristine and filled rubbers based on the Charlesby-Pinner equation, and highlights the application of electron beam curing technology in the cable and sealing industries.
INTERNATIONAL POLYMER PROCESSING
(2022)
Article
Physics, Applied
C. Thota, G. Murali, R. Dhanalakshmi, M. Reddeppa, N. -H. Bak, G. Nagaraju, S. -G. Kim, J. K. R. Modigunta, Y. H. Park, Insik In, M. -D. Kim
Summary: In this study, 2D MXene nanosheets were spin-coated on 1D GaN nanorods to establish a van der Waals Schottky junction for efficient UV detection. The built-in electric field developed through this junction formation enhances the separation of electron-hole pairs, resulting in better UV detection performance compared to pristine GaN nanorods.
APPLIED PHYSICS LETTERS
(2023)
Article
Materials Science, Multidisciplinary
N. Venkatesan, A. M. Shanmugharaj, M. J. K. Reddy, K. H. Won, S. H. Ryu
Summary: Constructing heteronanostructures to induce built-in charge transfer driving forces can lead to fascinating materials for high speed electronics, optoelectronics, and energy storage applications. In this study, SnS-SnO2/NRGO composites were successfully fabricated and exhibited outstanding performance as an electrode material in lithium-ion batteries.
JOURNAL OF MATERIALS RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Deepa Gangaraju, A. M. Shanmugharaj, Vadahanambi Sridhar, Hyun Park
Summary: This article reports a method for synthesizing nano meter-sized Ni-MOF/CNT and evaluates its morphological characteristics and chemical changes. The results show the potential applications of this material as an electro-catalyst in urea oxidation reactions and in the removal of arsenic from contaminated water, and demonstrate the applicability of a similar method for synthesizing nano meter-sized Fe-MOF/CNT.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Physical
Srinivas Billakanti, Anjana K. Othayoth, Heeralal Vignesh Babu, Andikkadu M. Shanmugharaj, Prachuritha Bantumelli, Krishnamurthi Muralidharan
Summary: This paper presents the synthesis, characterization, and Li-ion conductivity of catechol-based copolymer of polyphosphates (P1-P4) for solid polymer electrolyte (SPE) applications in Li-ion batteries. The results show that the Li-ion conductivity of the synthesized polymers is highest at 80 degrees C compared to previous literature. Galvanostatic charge-discharge cycling studies on the coin cells fabricated using one of the SPEs demonstrate stable cycling behavior for about 2000 cycles.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Chandrasekaran Nithya, Jeevan Kumar Reddy Modigunta, Insik In, Soye Kim, Sukumaran Gopukumar
Summary: Hierarchical nanocomposites with surface active bonding features are efficient electrode materials for high-performance Li-/Na-/K-ion batteries. Tuning the physiochemical properties of these nanocomposites has a great impact on their electrochemical performance, attributed to the synergistic effect of different components. In this study, a hierarchical nanocomposite of bismuth sulfide (Bi2S3) nanorod bonded to reduced graphene oxide (rGO) matrix was synthesized and investigated as an anode material for potassium-ion batteries. The nanocomposite exhibited high reversible capacity, long-term cycling stability, and outstanding rate capability. The excellent performance was attributed to the active sites in rGO nanosheets that enhance electrical conductivity of Bi2S3 nanorods and prevent shuttle effect of polysulfide. The proposed phase transformation mechanism and structural stability of Bi2S3 nanorods were confirmed by ex-situ X-ray diffraction and high-resolution transmission electron microscopy analysis respectively. The surface dominated pseudocapacitive K-ion storage also played a major role in improving the electrochemical performance. A K-ion full cell was successfully assembled and showed stable cycling performance after 100 cycles at 1 C rate.
ACS APPLIED NANO MATERIALS
(2023)
Article
Energy & Fuels
Jeevan Kumar Reddy Modigunta, Keun No Park, Su Cheol Shin, G. Murali, Udhayakumar Hari Haran, Jeongmin Kim, Jemin Yeon, Seongmin Park, Hyunju Jang, Young Ho Park, Ji-Young Noh, Jung-Hyurk Lim, Jihoon Lee, Seung Jun Lee, Kyung-Min Kim, Insik In
Summary: In this study, a waterborne spontaneous coating of CAPOSS on hydrophobic substrates was achieved, resulting in a nano-scale level coating with robust adhesion, enhanced hydrophilicity, electrolyte wettability, mechanical strength, and thermal stability. The CA-POSS coated PE separator showed improved performance in lithium ion batteries.
JOURNAL OF ENERGY STORAGE
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
