Journal
ALCOHOL
Volume 44, Issue 4, Pages 351-357Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.alcohol.2009.11.004
Keywords
Blood alcohol concentration; HATR-FTIR; GC-MS; Ethanol
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Numerous methods like distillation followed by iodometric titrations, gas chromatograph (GC)-flame ionization detector, gas chromatograph-mass spectrophotometer, GC-Headspace, Breath analyzer, and biosensors including alcohol dehydrogenase (enzymatic) have been used to determine blood alcohol concentration (BAC). In the present study, horizontal attenuated total reflectance-Fourier transform infrared spectroscopy had been used to determine BAC in whole blood. The asymmetric stretching frequency of C-C-O group of ethanol in water (1,045 cm(-1)) had been used to calculate BAC using Beer's Law. A seven-point calibration curve of ethanol was drawn in the concentration range 24-790 mg dL(-1). The curve showed good linearity over the concentration range used (r(2) = 0.999, standard deviation = 0.0023). The method is accurate, reproducible, rapid, simple, and nondestructive in nature. (C) 2010 Elsevier Inc. All rights reserved.
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