Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 80, Issue -, Pages 149-161Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2015.06.041
Keywords
Hydrogel; Crosslinked; Simulated body fluid; Swellability; Metal ions uptake
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Hydrogels composed of N-quaternized chitosan (NQC) and poly(vinyl alcohol) (PVA) in different weight ratios (1:3), (1:1) and (3:1) chemically crosslinked by glutaraldehyde in different weight ratios - 1.0 and 5.0% - have been prepared. The prepared hydrogels were characterized via several analysis tools such as: Fourier transform IR (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM) and thermogravimetric analysis (TGA). Different applications have been done on NQC/PVA hydrogels including; metal ions uptake, swellability in different buffer solutions (pH: 4,7 and 9), swellability and degradation studies in simulated body fluid (SBF) solutions and antimicrobial activity towards bacteria and fungi. The results indicated that crosslinked NQC/PVA hydrogels with glutaraldehyde (GA) are more thermallystable than non crosslinked hydrogels, NQC/PVA hydrogels swell highly in different buffer solutions as PVA content increases and the antimicrobial activity of NQC/PVA hydrogels is higher than NQC itself. (C) 2015 Elsevier B.V. All rights reserved.
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