Article
Materials Science, Multidisciplinary
Madiha M. Yahoum, Sonia Lefnaoui, Nadji Moulai-Mostefa
Summary: The study aimed to develop hydrophilic matrices for the controlled release of Piroxicam utilizing carboxymethyl xanthan gum derivatives (CMX). Different CMXs with varying degrees of substitution were synthesized and characterized, with CMX2 (DS = 1.7) proving to be the most effective in controlling drug release. All matrices followed the Korsmeyer-Peppas model, with F9 showing non-Fickian type release kinetics and the highest mean dissolution time value. The results suggest that CMXs are suitable excipients for sustained release dosage forms for up to 20 hours.
Article
Chemistry, Applied
Augusto Bene Tome Constantino, Edwin Elard Garcia-Rojas
Summary: Microencapsulation of beta-carotene (8-C) in amaranth carboxymethyl starch (CMS) and lactoferrin (LF) complex coacervates was achieved for application in gummy candies. The microcapsules showed spherical morphology and good photolytic and thermal stabilities. Release of 8-C was highest in the intestines and soybean oil, but low in ethanol. Addition of 8-C microcapsules reduced the hardness of gummy candies and allowed 22% bioaccessibility.
FOOD HYDROCOLLOIDS
(2023)
Article
Engineering, Chemical
Mohammadhadi Moradian, Md Nur Alam, Theo G. M. van de Ven
Summary: Modified cellulose-based films were prepared by carboxymethylation process with different carboxyl charge densities affecting fiber dissolution and film properties. Films with 2.5 mmol/g charge density were the most transparent and stretchable, while 1.5 mmol/g films had the highest tenacity. These films can serve as a promising alternative to plastics for packaging.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Review
Chemistry, Applied
Xuewen Yang, Qiuxiang Wang, Aiwen Zhang, Xinyao Shao, Tianqing Liu, Bo Tang, Guihua Fang
Summary: Heparin, a sulfate-containing linear polysaccharide, has shown clinical efficacy in various disorders, but its short half-life requires frequent administration. Additionally, the use of heparin to coat blood-contacting medical devices is limited by its short-term durability on the device surface, and various sustained-release strategies have been developed to extend its in vivo half-life.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Juan Li, Zhenjie Lu, Zhengxing Chen, Cheng Li, Yan Du, Chen Chen, Li Wang, Peibin Yu
Summary: The study focused on utilizing wheat bran arabinoxylan to form pH-responsive microgels for oral protein drug delivery. The modified CMAX microgel showed high stability and pH sensitivity, while the controlled release effect in gastrointestinal tract simulation was explored using BSA as the embedding protein. This research provides a new approach for improving protein drug delivery systems.
Review
Green & Sustainable Science & Technology
D. H. H. Sim, I. A. W. Tan, L. L. P. Lim, B. H. Hameed
Summary: Excessive use of conventional fertilizers leads to environmental issues, while biochar-based fertilizer serves as a slow release option. The integration of encapsulating technology with biochar-based fertilizer can enhance sustained release mechanism.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Chemistry, Multidisciplinary
Qiulin Xu, Huimin Huang, Jie Yan, Zijun Wu, Zhijian Zhou, Xitong Fang, Qiuling Zhong, Qiaoguang Li
Summary: The combination of high drug loading and good sustained-release performance can effectively reduce pesticide losses and improve pesticide utilization, making it an effective way to develop a pesticide-loading system. In this study, a pesticide-loading system was developed by using modified waste soybean oil and polymethylene polyphenyl polyisocyanate as raw materials. The system showed good sustained-release performance and prevented pesticide leakage. The kinetic studies showed controlled diffusion release of the pesticide from the system.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Biochemistry & Molecular Biology
Ting Chen, Haitang Liu, Jing Liu, Jie Li, Yongzhen An, Mingqiang Zhu, Beibei Chen, Fufeng Liu, Rui Liu, Chuanling Si, Meiyun Zhang
Summary: In this study, polysaccharides extracted from eucalyptus pulping waste liquor were used to produce carboxymethyl polysaccharide. The study investigated the effects of preparation conditions on the degree of substitution and characterized the structure and molecular weight of the polysaccharide. It was found that carboxymethyl substitution was successful and the positions of the substituent group were determined. The carboxymethyl xylan polysaccharide showed better biological activity compared to xylan polysaccharide.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Pharmacology & Pharmacy
Ben S. Ou, Olivia M. Saouaf, Julie Baillet, Eric A. Appel
Summary: The immune system plays a crucial role in regulating and protecting human health. Sustained release technologies have shown potential in enhancing adaptive immune responses by prolonging exposure to immunogenic signals.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Applied
Lin Wang, Mengyuan Yuan, Enze Sun, Jiang Wu, Anboyuan Lv, Xu Zhang, Jiaxiang Guo, Yu Zhu, Hongbo Guo, Xiaozhou Li, Ke Wang
Summary: A new active packaging film was developed to prolong the shelf life of chilled pork by releasing natural antimicrobials. The film showed excellent antioxidant and antibacterial abilities and effectively inhibited lipid and protein oxidation, as well as microbial growth. Compared to traditional plastic fresh-keeping films, it demonstrated promising potential in preserving fresh meat products.
FOOD HYDROCOLLOIDS
(2023)
Article
Materials Science, Paper & Wood
Yanan Wang, Hanyu Zhao, Lijie Huang, Guangxue Chen, Zhehao Wei, Qi Mo, Yishan Li, Xiyue Wang, Chongxing Huang, Qifeng Chen
Summary: In this study, a sustained-release gel for chlorine dioxide (ClO2) gas was developed using degradable materials such as carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and beta-cyclodextrin (beta CD) through a simple and benign crosslinking strategy. The gel showed sustained-release property within a wide temperature range and released ClO2 gas effectively for more than 30 days. A new diffusion model based on the Korsmeyer-Peppas model was proposed and achieved an excellent fit. This sustained-release gel provides guidance for the development of sustained-disinfectant-release agents for use in space and offers new insights into the sustained-release model of skeleton-soluble hydrogels.
Article
Dentistry, Oral Surgery & Medicine
Yvette Alania, Mostafa Yourdkhani, Livia Trevelin, Odair Bim-Junior, Heer Majithia, Ladan Farsi, Ana K. Bedran-Russo
Summary: This study evaluated the long-term effect of adding polylactide (PLA) capsules containing proanthocyanidin (PAC) to dental adhesive on the stability of dentin-resin interfaces. The results showed that the addition of capsules did not affect bond strength but increased and maintained protection against micropermeability at the interface.
Review
Pharmacology & Pharmacy
Elizabeth Magill, Sara Demartis, Elisabetta Gavini, Andi Dian Permana, Raghu Raj Singh Thakur, Muhammad Faris Adrianto, David Waite, Katie Glover, Camila J. Picco, Anna Korelidou, Usanee Detamornrat, Lalitkumar K. Vora, Linlin Li, Qonita Kurnia Anjani, Ryan F. Donnelly, Juan Dominguez-Robles, Eneko Larraneta
Summary: Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug administration routes, especially for the treatment of chronic conditions where patient adherence to conventional treatments can be challenging.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Kosei Utatsu, Keiichi Motoyama, Teruya Nakamura, Risako Onodera, Taishi Higashi
Summary: In recent years, a sustained-release system for protein drugs has been developed by exploiting the astringency mechanism of tannic acid. Tannic acid forms insoluble precipitates with various protein drugs through hydrophobic interactions and hydrogen bonds. The complex of lysozyme and tannic acid retains in vitro lytic activity, and the complex of insulin and tannic acid prolongs hypoglycemic effects without loss of activity after subcutaneous administration. The complex of ovalbumin and tannic acid enhances antibody production induced by ovalbumin, possibly due to its sustained-release profile. Therefore, tannic acid is a simple and user-friendly drug delivery system for protein drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Jaffar Irfan, Muhammad Ajaz Hussain, Muhammad Tahir Haseeb, Arshad Ali, Muhammad Farid-ul-Haq, Tahira Tabassum, Syed Zajif Hussain, Irshad Hussain, Muhammad Naeem-ul-Hassan
Summary: A polysaccharide-based hydrogel extracted from psyllium husk was evaluated for its swelling properties at different pH values and in various solutions. The hydrogel displayed pH-dependent swelling behavior and stimuli-responsive swelling and deswelling characteristics. Additionally, sustained release of theophylline from tablets was observed to be concentration-dependent on the psyllium hydrogel content.
Article
Biochemistry & Molecular Biology
D. Das, S. Jha, K. Jayaram Kumar
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2015)
Article
Biochemistry & Molecular Biology
Sameer D. Kulkarni, Barij N. Sinha, K. Jayaram Kumar
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2015)
Article
Biochemistry & Molecular Biology
N. Paramakrishnan, S. Jha, K. Jayaram Kumar
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2015)
Article
Biochemistry & Molecular Biology
P. Jaiswal, K. Jayaram Kumar
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2015)
Article
Biochemistry & Molecular Biology
N. Paramakrishnan, S. Jha, K. Jayaram Kumar
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2016)
Article
Biochemistry & Molecular Biology
Ch. Ashok Kumar Varma, R. K. Koley, Sanjay Singh, A. K. Sen, K. Jayaram Kumar
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2016)
Article
Biochemistry & Molecular Biology
Deepika Vashisht, Anima Pandey, Anca Hermenean, Maria Josefa Yanez-Gascon, Horacio Perez-Sanchez, K. Jayaram Kumar
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2017)
Article
Pharmacology & Pharmacy
K. Jayaram Kumar, Gopal Mohan Panpalia, Surabhi Priyadarshini
ACTA PHARMACEUTICA
(2011)
Article
Biochemistry & Molecular Biology
K. Jayaram Kumar, Ch. Ashok Kumar Varma, S. G. Panpalia
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2014)
Article
Biochemistry & Molecular Biology
Sameer D. Kulkarni, Barij N. Sinha, K. Jayaram Kumar
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2014)
Article
Biochemistry & Molecular Biology
Ch. Ashok Kumar Varma, S. G. Panpalia, K. Jayaram Kumar
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2014)
Article
Chemistry, Analytical
Kartik Chandra Patra, K. Jayaram Kumar
JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC
(2010)
Article
Pharmacology & Pharmacy
Umesh Nandkumar Khatavkar, Shamkant Laxman Shimpi, K. Jayaram Kumar, Kishor Dattatraya Deo
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2012)
Article
Pharmacology & Pharmacy
Umesh Nandkumar Khatavkar, Shamkant Laxman Shimpi, K. Jayaram Kumar, Kishor Dattatraya Deo
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)