Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 76, Issue -, Pages 310-319Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2015.03.001
Keywords
Extremophiles; Mauran; Nanoparticles; Cancer therapy; Antioxidant mechanism; Polysaccharides
Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
- program of the strategic research foundation at private universities by the MEXT, Japan [S1101017]
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Polysaccharides that show finest bioactivities and physicochemical properties are always promising for bionanoscience applications. Mauran is such a macromolecule extracted from halophilic bacterium, Halomonas maura for biotechnology and nanoscience applications. Antioxidant properties of MR/CH nanoparticles were studied using biochemical assays to prove the versatility of these test nanoparticles for biomedical applications. Here, we demonstrate the prospects of extremophilic polysaccharide, mauran based nanoparticles for scavenging reactive oxygen species in both in vitro and ex vivo conditions. 5-fluorouracil loaded MR/CH nanoparticles were tested for anticancer proliferation and compared their therapeutic efficiency using breast adenocarcinoma and glioma cells. Fluorescently labeled nanoparticles were employed to show the cellular uptake of these nanocarriers using confocal microscopic imaging and flow cytometry. (C) 2015 Elsevier B.V. All rights reserved.
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