Article
Virology
Xiaohui Zhao, Huijun Yuan, Hang Yang, Yan Liu, Meng Xun, Xiaozhen Li, Tingting Fan, Bo Wu, Shangrui Guo, Hongliang Wang
Summary: EV71 is a common pathogen causing hand, foot, and mouth disease in young children, and it is associated with severe neurological complications. This study found that the ER-resident acetyltransferase NAT8 is a host factor for EV71 infection and promotes viral replication by interacting with viral proteins.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Connor Eastman, William E. E. Tapprich
Summary: In this study, the secondary and tertiary structures of EV-D68 5'UTR RNA were analyzed and compared. Significant changes in secondary structures were observed in domains II, IV, and V of the 2014 isolate KT347251.1 compared to the historical Fermon strain. These structure variations may be related to the neurovirulence of EV-D68 and provide potential targets for the treatment of neurotropic enteroviruses.
Article
Immunology
Chunchen Wu, Luzhi Zeng, Wenfu Yi, Yuanjiu Miao, Yihan Liu, Qiming Wang, Shi Liu, Guoping Peng, Zhenhua Zheng, Jianbo Xia
Summary: This study demonstrates that echovirus infection can induce autophagy, which promotes viral replication and VP1 expression in host cells. The mechanism involves the regulation of the mTOR/ULK1 signaling pathway, providing insight into the potential role of autophagy in echovirus infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Rui Zhang, Jing Chen, Ruidong Zi, Lin Ji, Jingping Hu, Zhiwei Wu, Yuxuan Fu
Summary: This study finds that autophagy response contributes to the packaging of EV71 viral genome into exosomes, playing a crucial role in viral spreading. Inhibition of autophagosomes-MVBs fusion can abolish the sorting of viral RNA into exosomes.
MICROBIAL PATHOGENESIS
(2022)
Review
Virology
Subrat Kumar Swain, Subhasmita Panda, Basanta Pravas Sahu, Rachita Sarangi
Summary: This study aims to investigate the interaction between viral ligands and host receptors, the activation of immune-related signaling pathways, and the involvement of cytokines during host-pathogen interaction. The study also examines the roles of viral proteins and interferons.
Review
Immunology
Feixiang Yang, Ning Zhang, Yuxin Chen, Jiancai Yin, Muchen Xu, Xiang Cheng, Ruyi Ma, Jialin Meng, Yinan Du
Summary: This review summarizes recent advances in understanding the impact of non-coding RNAs on neurological diseases caused by the interaction between EV71 and the host, revealing the potential role of non-coding RNAs in the pathogenesis, diagnosis, and treatment of EV71-induced neurological complications.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Virology
Alexis Bouin, Michelle N. Vu, Ali Al-Hakeem, Genevieve P. Tran, Joseph H. C. Nguyen, Bert L. Semler
Summary: Group B enteroviruses, including coxsackievirus B3 (CVB3), can persistently infect cardiac tissue and cause dilated cardiomyopathy. 5' terminal deletions of viral genomic RNAs have been detected in persistently infected patients, and our study showed that these deletions decreased the levels of viral proteinase activity and synthesis of viral protein and RNA. However, a cooperative interaction was observed when full-length and terminally deleted forms were cotransfected into cardiomyocytes, leading to increased viral production.
JOURNAL OF VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ammar M. Hassanbhai, Meng Chee Phoon, Vincent T. Chow, Bow Ho
Summary: This study investigates the interactions between enterovirus 71 (EV71) and the biofilm formed by Helicobacter pylori. The results show that the H. pylori biofilm can prolong the survival of EV71 and the quantity of biofilm formation affects the viability of the virus. This suggests that the H. pylori biofilm may serve as an additional pathway for EV71 transmission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Ting-Jing Shen, Chia-Ling Chen, Tsung-Ting Tsai, Ming-Kai Jhan, Chyi-Huey Bai, Yu-Chun Yen, Ching-Wen Tsai, Cheng-Yi Lee, Po-Chun Tseng, Chia-Yi Yu, Chiou-Feng Lin
Summary: Diabetes is associated with increased risk of severe dengue diseases, and hyperglycemic environment facilitates dengue virus replication and transmission through PABP-mediated viral translation.
Article
Virology
Shanshan Fan, Zihang Xu, Pengfei Liu, Yali Qin, Mingzhou Chen
Summary: Several viruses inhibit the formation of RNA processing bodies, including enterovirus 71, which relies on its 2A protease to block P-body formation and promote viral replication. The interaction between DDX6 and viral RNA also facilitates viral replication.
JOURNAL OF VIROLOGY
(2021)
Article
Microbiology
Jia-Ying Lu, Gary Brewer, Mei-Ling Li, Kai-Zhe Lin, Chien-Chih Huang, Li-Chen Yen, Jing-Yi Lin
Summary: The study investigates the formation of replication organelles by picornaviruses using enterovirus A71 (EV-A71) as a model. SCAMP3, a host protein, associates with viral 3A protein and plays a critical role in viral RNA synthesis and replication. Additionally, the interaction between 3A protein and SCAMP3 positively regulates enterovirus replication and involves the extracellular signal-regulated kinase (ERK) signaling pathway.
MICROBIOLOGY SPECTRUM
(2021)
Article
Microbiology
Zhihui Ruan, Yicong Liang, Zicong Chen, Jialing Yin, Chengcheng Li, Pan Pan, Qiwei Zhang, Jianguo Wu, Zhen Luo
Summary: This study found that EV71 infection can enhance exosome biogenesis, and EV71 3A protein can promote exosome secretion. Further investigation revealed that VPS25, which is associated with EV71 infection, is located on exosomes and its expression correlates to exosome production. Knock-down of VPS25 decreases exosome biogenesis, thus attenuating viral replication. The exosome inhibitor GW4869 exhibits significant antiviral activity against EV71 replication.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chijioke N. Umunnakwe, Alice Duchon, Olga A. Nikolaitchik, Sheikh Abdul Rahman, Yang Liu, Jianbo Chen, Sheldon Tai, Vinay K. Pathak, Wei-Shau Hu
Summary: This study aimed to investigate the cis-acting elements in the HIV-2 genome important for genome packaging, revealing a hierarchical nature of guanosine-containing sites with mutations at different sites affecting RNA packaging efficiency differently. Additionally, mutations at multiple sites can act synergistically to cause defects in genome packaging, providing key insights into the replication mechanisms of HIV-2.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Seth Scott, You Li, Oya Bermek, Jack D. Griffith, Stanley M. Lemon, Kyung H. Choi
Summary: Hepatitis C virus replication relies on the interaction between cellular factors miR-122 and PCBP2. These factors compete for binding to specific sites on the RNA genome, regulating the viral replication cycle. MiR-122 disrupts genome circularization and promotes recruitment of the viral polymerase by competing with PCBP2 for binding.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemical Research Methods
Xiaolei Zhang, Matthew Wakeling, James Ware, Nicola Whiffin
Summary: Current tools for annotating genetic variants heavily focus on protein-coding sequences, rather than non-coding variants, which can be challenging to predict. Our UTRannotator plugin offers a new approach to annotate variants in 5'UTRs, providing insights into their impact.
Review
Chemistry, Multidisciplinary
Xiao-Fan Chen, Zhi-Cheng Lin, Zenghua Qi, Zongwei Cai, Zhi-Feng Chen
Summary: Exposure to pollutants can cause damage to the eyes of aquatic organisms. Zebrafish is a commonly used model to study ocular toxicity and has shown morphological changes, retinal damage, and abnormalities in visual signal processes. The underlying mechanisms involve thyroid hormone signaling, retinoic acid signaling, and retinal glucose metabolism. This review discusses the phenotypes and signaling pathways associated with ocular toxicity from contaminants, detection methods, and a predictive model for potential ocular toxicity.
ENVIRONMENTAL CHEMISTRY LETTERS
(2023)
Article
Geosciences, Multidisciplinary
Yongjie Wang, Guitao Shi, Danhe Wang, Qian Zhao, Su Jiang, Yangjie Li, Dongqi Wang, Chuanjin Li, Zhenlou Chen, Roberto Bargagli
Summary: This study investigated soil mercury levels in different areas of Antarctica and found a close relationship between mercury distribution and organic carbon content. The findings contribute to a better understanding of the biogeochemical cycle of mercury in Antarctic terrestrial ecosystems.
Article
Plant Sciences
Yan Wang, Wei Dong, Qin Zhang, Zhen-Peng Li, Yue-Xing Wang, Xiu-Fen Li, Long-Jiang Huang
Summary: An efficient and scalable process for the synthesis of 19-hydroxyprogesterone was developed, achieving a total yield of 34.5%, which is significantly higher than the previously reported process (11.0% total yield). The plausible ring-opening mechanism of the 6,19-epoxy bridge in compound 7 was proposed, and the structures of intermediates were confirmed by LC-MS analysis.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Environmental Sciences
Wei Huang, Guodong Cao, Chengliang Deng, Yanyan Chen, Tao Wang, Da Chen, Zongwei Cai
Summary: This study investigated the effects of TCS exposure on kidney function in mice. The results showed that TCS caused renal injury, oxidative stress, inflammation, and fibrosis in a dose-dependent manner. Metabolite analysis revealed lipid accumulation and defective fatty acid metabolism in TCS-exposed mouse kidney, which may contribute to renal function impairment.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Huiyan Li, Huilin Zhang, Xiaofang He, Peiran Zhao, Tong Wu, Jinxuan Xiahou, Yelin Wu, Yanyan Liu, Yang Chen, Xingwu Jiang, Guanglei Lv, Zhenwei Yao, Jian Wu, Wenbo Bu
Summary: A communication interception strategy is developed to block spatiotemporal crosstalk between lysosomes and endoplasmic reticulum (ER) using amorphous-core@crystalline-shell Fe@Fe3O4 nanoparticles (ACFeNPs). This strategy induces autophagy and ER stress, leading to a significant therapeutic effect for cancer treatment.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Pengfei Hou, Yumiao Tian, Yu Xie, Fei Du, Gang Chen, Aleksandra Vojvodic, Jianzhong Wu, Xing Meng
Summary: This study develops a neural network potential (NNP) for aqueous MXene systems using deep neural networks and an active learning scheme, providing ab initio precision at low cost. The oxidation behaviors of super large aqueous MXene systems are investigated at nanosecond timescales, revealing the atomic-level process of MXenes oxidation and the inhibitory effects of free protons and oxides on subsequent oxidation reactions. These findings contribute to the development of effective protection strategies for controlling the stability of MXenes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Applied
Yinchun Fang, Jianguo Wu, Guojie Ma, Qufu Wei
Summary: Polylactic acid (PLA) fibre is a renewable and biodegradable synthetic polymer that has gained attention in textiles. However, its dyeing process faces challenges, and a waterless dyeing method using disperse dyes is being explored as an alternative. This study investigated the waterless dyeing of PLA fibre using different disperse dyes and decamethylcyclopentasiloxane (D5) as the medium. Optimal dyeing process conditions were determined, and it was found that disperse dyes with a monoazo structure were most suitable for PLA waterless dyeing. The research provides a basis for developing suitable dyes for waterless dyeing of PLA using D5.
COLORATION TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Yuanrong Li, Jianguo Wu, Chuanjiang He, Honghui He, Mingjun Xie, Ke Yao, Jing He, Yan Duan, Liujing Zhaung, Ping Wang, Yong He
Summary: Many mammalian tissues have specific cellular arrangements under stress stimulus, but conventional 3D encapsulation fails to replicate these arrangements accurately, so advanced cellular arrangement approaches are needed. In this study, a novel 3D prestress bioprinting approach is developed, using static sustained tensile stress, molecular chain orientation, and slow crosslinking in bioink to guide tissue construction. The semi-crosslinking state of the bioink provides excellent elasticity for applying stress on cells during the printing process. After printing, the bioink gradually crosslinks and maintains the applied stress force to induce cell-orientated growth. This approach allows for directional arrangement of multiple cell types, with adjustable internal stress in the hydrogel filament, and has potential applications in engineering skeletal muscles, tendons, ligaments, vascular networks, or combinations thereof.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Industrial
Ruiyu Xu, Song Huang, Zheren Song, Yuanyuan Gao, Jianguo Wu
Summary: This article proposes a deep mixed-effects modeling approach for anomaly detection in additive manufacturing. It captures the relationship between the melt pool temperature and other sensing data using a deep neural network, and incorporates random-effect and residual terms to account for variations and autocorrelations. Control charts based on T2 and generalized likelihood ratio statistics are developed for online monitoring.
Article
Environmental Sciences
Guanghui Zhao, Taihu Sun, Dongqi Wang, Shu Chen, Yan Ding, Yilan Li, Guitao Shi, Hechen Sun, Shengnan Wu, Yizhe Li, Chenyang Wu, Yufang Li, Zhongjie Yu, Zhenlou Chen
Summary: This study used stable isotopes to investigate the sources and transformation processes of nitrate in Suzhou Creek. The results showed that treated wastewater, soil nitrogen, and nitrogen fertilizer were the main sources of nitrate in the river. Reducing nitrate concentrations in treated wastewater is crucial for addressing nitrogen pollution in urban rivers.
ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Environmental
Guodong Cao, Wei Wang, Jing Zhang, Pengfei Wu, Han Qiao, Huankai Li, Gefei Huang, Zhu Yang, Zongwei Cai
Summary: para-Phenylenediamine quinones (PPD-Qs) are newly discovered transformation products derived from para-phenylenediamine (PPD) antioxidants. Their occurrence and fate in wastewater treatment plants (WWTPs) need further investigation to improve pollutant removal efficiency.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Virology
Yi Meng, Chengcheng Li, Yicong Liang, Yu Jiang, Haonan Zhang, Jianhua Ouyang, Wen Zhang, Rumei Deng, Qiuping Tan, Xiaolan Yu, Zhen Luo
Summary: This study demonstrates the potential of exosomes derived from umbilical cord mesenchymal stem cells (ucMSC-EXO) in anti-oxidative stress and antiviral effects, showing the ability to repair oxidative damage and inhibit enteroviral replication.
Review
Engineering, Biomedical
Haiyan Li, Keerthi Subramanian Iyer, Lei Bao, Jiali Zhai, Jiao Jiao Li
Summary: Granular microporous hydrogels made of non-spherical microgels show enhanced characteristics compared to traditional nanoporous hydrogels, promoting cell viability, migration, and tissue regeneration. These hydrogels have higher macroporosity and improved mechanical properties, allowing for better alignment and differentiation of cells in anisotropic tissue. The development of these hydrogels is gaining increasing interest in regenerative medicine.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Hui Chen, Cheng Jin, Li Xie, Jian Wu
Summary: Succinate, an intermediate of the TCA cycle, is crucial in mitochondrial metabolism, energy production, and is also considered a signaling molecule in metabolism and hepatic diseases. Its downstream signaling pathway through GPR91 leads to various intracellular responses, including succinylation, ROS production, HIF-1 alpha stabilization, and significant impact in cellular metabolism due to its role in the TCA cycle. Understanding the signaling mechanisms of succinate in hepatic fibrosis, metabolic reprogramming, inflammatory or immune responses, and carcinogenesis is of great interest. This review aims to provide the current understanding of succinate in mediating metabolism, inflammatory and immune responses in liver diseases, with the aim of establishing a molecular basis for therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Rui Su, Jialing Yin, Xiaolan Ruan, Yanxi Chen, Pin Wan, Zhen Luo
Summary: In this study, we analyzed the interaction of HERP protein in HeLa cells using co-immunoprecipitation and mass spectrometry, and identified 123 proteins that significantly interacted with HERP. These interactions involve various biological processes and pathways, and some of the interacted proteins showed altered expression and localization under ER stress.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)