Journal
AIDS RESEARCH AND HUMAN RETROVIRUSES
Volume 29, Issue 1, Pages 84-88Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/aid.2011.0397
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Funding
- St Stephens AIDS trust
- Campbell Foundation
- Medical Research Council (UK)
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Chronic HIV-1 infection results in the expansion of both NKG2C(+) and CD16(+)CD56(-) human natural killer cells. NKG2C(+) cells proliferate in response to human cytomegalovirus (HCMV) and expansion of the dysfunctional CD56(-)CD16(+) natural killer (NK) cells is associated with HIV-1 viremia. Here we report an association between increased proportions of CD56-CD16(+) NK cells in viremic HIV-1(+) individuals and an increased contribution of NKG2C(+) cells to this subset. These data, in addition to anti-HCMV IgG serology, indicate a potential contribution of both HCMV and HIV-1 to NK cell dysfunction in HIV-1-infected individuals.
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