Journal
AIDS RESEARCH AND HUMAN RETROVIRUSES
Volume 27, Issue 6, Pages 655-657Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/aid.2010.0261
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Funding
- Reseau SIDA et maladies infectieuses of the Fonds de la Recherche en Sante du Quebec (FRSQ)
- Canadian Institute of Health Research (CIHR)
- FRSQ
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Dendritic cells (DCs) are important mediators of the immune response against HIV and yet blood DC numbers fall substantially during HIV infection. Here we report that blood levels of the DC-tissue tropic chemokines monocyte chemotactic protein (MCP-1/CCL2), macrophage inflammatory proteins (MIP-3 alpha/CCL20), and MIP-3 beta/CCL19 remained elevated throughout the course of HIV infection suggesting that the relatively low levels of blood circulating DCs may be due to active recruitment of these cells to peripheral sites to fight disease progression.
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