Article
Microbiology
Ahizechukwu C. Eke, Kensuke Shoji, Brookie M. Best, Jeremiah D. Momper, Alice M. Stek, Tim R. Cressey, Mark Mirochnick, Edmund Capparelli
Summary: The pharmacokinetics of tenofovir in pregnant and postpartum women were affected by changes in apparent oral clearance and volume of distribution at steady state. These changes were primarily associated with increased body weight and enhanced renal function during pregnancy, leading to higher clearance rates compared to postpartum values. Dose adjustment of tenofovir disoproxil fumarate during pregnancy is generally not necessary, but any modifications should be made based on considerations of weight and renal function.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Gastroenterology & Hepatology
Kwan Soo Byun, Jonggi Choi, Ji-Hoon Kim, Yung Sang Lee, Han Chu Lee, Yoon Jun Kim, Byung Chul Yoo, So Young Kwon, Geum-Youn Gwak, Young-Suk Lim
Summary: The study findings suggest that TAF may have better bone and renal safety profiles compared to TDF in patients with multidrug-resistant HBV, without compromising efficacy. However, concerns may arise due to increases in body weight and cholesterol levels with TAF treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jihye Lim, Won-Mook Choi, Ju Hyun Shim, Danbi Lee, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, Jonggi Choi
Summary: Real-world data suggests that TAF and TDF have comparable efficacies in treating CHB, with similar virological responses and ALT normalization, and no higher risk of HCC.
LIVER INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Hye Yeon Chon, Sang Hoon Ahn, Yoon Jun Kim, Jung-Hwan Yoon, Jeong-Hoon Lee, Dong Hyun Sinn, Seung Up Kim
Summary: The study compared the effects of three antiviral agents on the risk of hepatocellular carcinoma and orthotopic liver transplantation or mortality in patients with chronic hepatitis B. It was found that the outcomes of entecavir, tenofovir disoproxil fumarate, and tenofovir alafenamide were statistically similar in treatment-naive patients with CHB.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Virology
Lilian Yan Liang, Terry Cheuk-Fung Yip, Jimmy Che-To Lai, Amy Shuk-Man Lam, Yee-Kit Tse, Vicki Wing-Ki Hui, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong, Grace Lai-Hung Wong
Summary: This study evaluated the impact of switching to TAF on ALT normalization and renal safety in CHB patients and described the indications for switching to TAF. The results showed that switching to TAF significantly reduced ALT levels and increased ALT normalization rate. TAF was found to be associated with improved ALT levels and better renal safety compared to TDF dominant therapy in CHB patients. The majority of CHB patients switched to TAF due to advanced age, followed by bone disease and renal alteration.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Gastroenterology & Hepatology
Baijun Li, Zhaozhe Liu, Xing Liu, Dongchun Liu, Mingyu Duan, Ye Gu, Qiong Liu, Qiang Ma, Yushi Wei, Yan Wang
Summary: The study demonstrated that both TAF and TDF effectively prevented mother-to-child transmission of hepatitis B. TAF showed superiority in terms of renal safety and breastfeeding compared to TDF.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Infectious Diseases
Siying Li, Jie Jin, Yi Jiang, Jinfeng Shi, Xiaoxian Jiang, Nengming Lin, Zhiyuan Ma
Summary: This study investigated the safety of infants whose mothers continued to receive TDF while breastfeeding. The results showed that the concentration of TDF in breast milk is much lower than that from placental transfer and swallowing amniotic fluid, indicating that breastfeeding is safe for infants of HBV-infected mothers who continue to receive TDF through three months postpartum.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Gastroenterology & Hepatology
Hidenori Toyoda, Jennifer Leong, Charles Landis, Masanori Atsukawa, Tsunamasa Watanabe, Daniel Q. Huang, Joanne Liu, Sabrina Xin Zi Quek, Toru Ishikawa, Taeang Arai, Keisuke Yokohama, Makoto Chuma, Koichi Takaguchi, Haruki Uojima, Tomonori Senoo, Hansen Dang, Mayumi Maeda, Joseph Hoang, Richard H. Le, Satoshi Yasuda, Khin N. Thin, Sally Tran, Nicholas Chien, Linda Henry, Akira Asai, Shinya Fukunishi, Ramsey Cheung, Seng Gee Lim, Huy N. Trinh, Mindie H. Nguyen
Summary: Following the switch to TAF, patients with chronic hepatitis B showed continued improvement in virologic response and ALT normalization, with no significant changes in estimated glomerular filtration rate. Patients with chronic kidney disease at baseline also showed improvement in kidney function after switching to TAF.
Article
Chemistry, Multidisciplinary
Martin Huliciak, Ivona Lhotska, Hana Kocova-Vlckova, Veronika Halodova, Tomas Dusek, Filip Cecka, Frantisek Staud, Ivan Vokral, Lukas Cerveny
Summary: This study aimed to compare the effects of P-glycoprotein (ABCB1) on the intestinal uptake of tenofovir disoproxil fumarate (TDF), tenofovir alafenamide fumarate (TAF), and their metabolites, tenofovir isoproxil monoester (TEM) and tenofovir (TFV), and to investigate the molecular mechanism of drug-drug interaction (DDI) between sofosbuvir (SOF) and TDF/TAF. The results showed that ABCB1 significantly reduced the intestinal transport and uptake of TFV(TDF) and TFV(TAF)-equivalents. However, TDF and TAF were absorbed more efficiently than TFV and TEM. SOF did not inhibit the efflux of TDF and TAF from the intestines and did not affect the accumulation of TFV(TDF) and TFV(TAF)-equivalents, but it did increase the proportion of absorbed TDF.
PHARMACEUTICAL RESEARCH
(2023)
Article
Immunology
Shahini Shah, Victoria Pilkington, Andrew Hill
Summary: Analysis of HIV-negative individuals suggests that the use of TDF may be associated with weight loss and increased odds of vomiting. Further research in HIV-positive individuals is needed to expand the evidence base.
Article
Infectious Diseases
Jingjing He, Yifei Guo, Yao Zhang, Jiajia Han, Jingwen Chen, Yidi Jia, Zhenxuan Ma, Jingwen Wu, Shenyan Zhang, Fahong Li, Richeng Mao, Jiming Zhang
Summary: The study compares the effectiveness of TAF and PegIFN-α regimen with TDF and PegIFN-α therapy in CHB patients. The results show that TAF plus PegIFN-α treatment has a higher HBsAg loss rate, quicker virological response, and better ALT normalization compared to TDF plus PegIFN-α treatment.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Medicine, General & Internal
Ya-ru Pan, Si-qi Liu, Yi-shan He, Yuan Xue, Jian Wang, Rui Huang, Chao Wu, Jian-chun Lu, Long-gen Liu
Summary: This study investigated the risk factors for eGFR recovery in patients with and without hypertriglyceridemia during Tenofovir disoproxil fumarate (TDF) treatment. The results showed that patients without hypertriglyceridemia experienced partial recovery of eGFR, while patients with hypertriglyceridemia did not. Baseline eGFR and age were identified as independent risk factors for eGFR recovery.
ANNALS OF MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Chien-Hung Chen, Wen-Juei Jeng, Tsung-Hui Hu, Yen-Chun Liu, Jing-Houng Wang, Chao-Hung Hung, Sheng-Nan Lu, Rong-Nan Chien
Summary: This study compared the relapse patterns in hepatitis B patients who stopped two different antiviral drugs and found that those who stopped TAF had higher rates of virological relapse, but there was no significant difference in clinical relapse pattern and severity compared to those who stopped TDF.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Multidisciplinary Sciences
Pei-Yuan Su, Wei-Wen Su, Yu-Chun Hsu, Siou-Ping Huang, Hsu-Heng Yen
Summary: The study demonstrated that switching from TDF to TAF resulted in good antiviral efficacy and stabilized renal function. Body weight and BMI decreased during TDF therapy and returned to normal levels after switching to TAF.
Article
Gastroenterology & Hepatology
Jinlin Hou, Qin Ning, Zhongping Duan, You Chen, Qing Xie, Fu-Sheng Wang, Lunli Zhang, Shanming Wu, Hong Tang, Jun Li, Feng Lin, Yongfeng Yang, Guozhong Gong, John F. Flaherty, Anuj Gaggar, Shuyuan Mo, Cong Cheng, Gregory Camus, Chengwei Chen, Yan Huang, Jidong Jia, Mingxiang Zhang
Summary: In Chinese patients with chronic hepatitis B, TAF treatment demonstrated efficacy similar to TDF after 3 years, but with improved renal and bone safety.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
News Item
Urology & Nephrology
Charlotte Osafo, Yemi R. Raji, Timothy Olanrewaju, Manmak Mamven, Fatiu Arogundade, Samuel Ajayi, Ifeoma Ulasi, Babatunde Salako, Jacob Plange-Rhule, Yewondwossen Mengistu, S. O. Mc'Ligeyo, George Moturi, Cheryl A. Winkler, Marva M. Moxey-Mims, Rebekah S. Rasooly, Paul Kimmel, Dwomoa Adu, Akinlolu Ojo, Rulan S. Parekh
KIDNEY INTERNATIONAL
(2016)
Review
Urology & Nephrology
Christopher Esezobor, Adebowale D. Ademola, Adewale E. Adetunji, Emmanuel A. Anigilaje, Anthony Batte, Fatima N. Jiya-Bello, Francis F. Furia, Uzoamaka Muoneke, Mignon McCulloch, Peter Nourse, Patience Obiagwu, Odutola Odetunde, Perditer Okyere, Adaobi Solarin, Elliot K. Tannor, Damien Noone, Rasheed Gbadegesin, Rulan S. Parekh
KIDNEY INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Yemi R. Raji, Samuel Ajayi, Abiodun M. Adeoye, Olukemi Amodu, Bamidele Tayo, Babatunde L. Salako
Summary: This study investigated the spectrum of CKD-MBD among Nigerians with CKD and found a high prevalence of the disease. FGF23 and iPTH were found to be useful assays in the diagnosis of CKD-MBD among Nigerians with CKD.
AFRICAN HEALTH SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Yusuf Olanrewaju Jinadu, Yemi Raheem Raji, Samuel Oluwole Ajayi, Babatunde Lawal Salako, Ayodeji Arije, Solomon Kadiri
Summary: The study revealed that intrarenal artery resistivity index was higher in patients with both diabetic nephropathy and diabetes mellitus without nephropathy, with elevated glycated haemoglobin (HbA1c) levels and hypertension being predictors of high RI in these patients.
CARDIOVASCULAR JOURNAL OF AFRICA
(2022)
Article
Urology & Nephrology
Timothy O. Olanrewaju, Charlotte Osafo, Yemi R. Raji, Manmak Mamven, Samuel Ajayi, Titilayo O. Ilori, Fatiu A. Arogundade, Ifeoma I. Ulasi, Rasheed Gbadegesin, Rulan S. Parekh, Bamidele Tayo, Adebowale A. Adeyemo, Olanrewaju T. Adedoyin, Adindu A. Chijioke, Clemen Bewaji, Diederick E. Grobbee, Peter J. Blankestijin, Kerstin Klipstein-Grobusch, Babatunde L. Salako, Dwomoa Adu, Akinlolu O. Ojo
Summary: This study investigated the prevalence of cardiovascular risk factors in CKD patients in Africa and found that hypertension, elevated cholesterol, and low BMI were independently associated with CKD.
KIDNEY INTERNATIONAL REPORTS
(2023)
Review
Health Care Sciences & Services
Ikechi G. Okpechi, Ijezie I. Chukwuonye, Udeme Ekrikpo, Jean Jacques Noubiap, Yemi R. Raji, Yusuf Adeshina, Samuel Ajayi, Zunaid Barday, Malini Chetty, Bianca Davidson, Emmanuel Effa, Stephen Fagbemi, Cindy George, Andre P. Kengne, Erika S. W. Jones, Hamidu Liman, Mohammad Makusidi, Hadiza Muhammad, Ikechukwu Mbah, Kwazi Ndlovu, Grace Ngaruiya, Chimezie Okwuonu, Ugochi Samuel-Okpechi, Elliot K. Tannor, Ifeoma Ulasi, Zulkifilu Umar, Nicola Wearne, Aminu K. Bello
Summary: Task shifting can help address the shortage of human resources for health in Africa and improve the treatment and detection of cardiovascular and kidney diseases. This scoping review found that shifting tasks to nurses, pharmacists, and community health workers can result in improved blood pressure levels and glycaemic indices for hypertension and diabetes.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Urology & Nephrology
Udeme E. Ekrikpo, Khuthala Mnika, Emmanuel E. Effa, Samuel O. Ajayi, Chimezie Okwuonu, Bala Waziri, Aminu Bello, Collet Dandara, Andre P. Kengne, Ambroise Wonkam, Ikechi Okpechi
AMERICAN JOURNAL OF KIDNEY DISEASES
(2020)
Article
Public, Environmental & Occupational Health
Samuel Ajayi, Yemi Raji, Temitope Bello, Ayodeji Arije
PAN AFRICAN MEDICAL JOURNAL
(2020)
Article
Medicine, Research & Experimental
Talishiea Croxton, Ndidi Agala, Emmanuel Jonathan, Olasinbo Balogun, Petronilla J. Ozumba, Enzenwa Onyemata, Shefiya Lawal, Manmak Mamven, Samuel Ajayi, Sylvia E. Melikam, Mayowa Owolabi, Bruce Ovbiagele, Dwomoa Adu, Akinlolu Ojo, Christine M. Beiswanger, Alash'le Abimiku
AFRICAN JOURNAL OF LABORATORY MEDICINE
(2020)
Article
Urology & Nephrology
Udeme Ekrikpo, Cecilia N. Okuku, Samuel O. Ajayi, Olugbenga E. Ayodele, Aminu K. Bello, Ambroise Wonkam, Collet Dandara, Andre-Pascal Kengne, Ikechi Okpechi
KIDNEY INTERNATIONAL REPORTS
(2019)
Letter
Urology & Nephrology
Shefali Sood, Akinlolu O. Ojo, Dwomoa Adu, Kurunthachalam Kannan, Akhgar Ghassabian, Tony Koshy, Suzanne M. Vento, Laura Jane Pehrson, Joseph F. Gilbert, Fatiu A. Arogundade, Adebowale D. Ademola, Babatunde O. Salako, Yami Raji, Charlotte Osafo, Sampson Antwi, Howard Trachtman, Leonardo Trasande, Samuel Ajayi, David Burke, Richard Cooper, Rasheed Gbadegesin, Titi Ilori, Manmak Mamven, Timothy Olanrewaju, Rulan Parekh, Jacob Rhule, Tunde Salako, Bamidele Tayo, Ifeoma Ulasi
KIDNEY INTERNATIONAL REPORTS
(2019)
Article
Urology & Nephrology
Adebowale D. Ademola, Adanze O. Asinobi, Esther Ekpe-Adewuyi, Adejumoke I. Ayede, Samuel O. Ajayi, Yemi R. Raji, Babatunde L. Salako, Matthew James, Michael Zappitelli, Susan M. Samuel
CLINICAL KIDNEY JOURNAL
(2019)
Article
Public, Environmental & Occupational Health
Yemi Raheem Raji, Samuel Oluwole Ajayi, Olusegun Aminu, Busayo Abiola, Oluwafemi Efuntoye, Babatunde lawal Salako, Ayodeji Arije, Solomon Kadiri
PAN AFRICAN MEDICAL JOURNAL
(2018)
Article
Public, Environmental & Occupational Health
Samuel Ajayi, Adewole Adebiyi, Solomon Kadiri
PAN AFRICAN MEDICAL JOURNAL
(2018)
Article
Medicine, General & Internal
Yemi Raheem Raji, Samuel Oluwole Ajayi, Titilola Stella Akingbola, Olupelumi A. Adebiyi, Kayode S. Adedapo, Batunde Lawal Salako
NIGERIAN POSTGRADUATE MEDICAL JOURNAL
(2018)