Article
Medicine, General & Internal
Mary Kagujje, Paul Somwe, Sisa Hatwiinda, Joel Bwalya, Tamala Zgambo, Moomba Thornicroft, Fiammetta Maria Bozzani, Clement Moonga, Monde Muyoyeta
Summary: The study found high prevalence of tuberculosis and HIV in Zambian correctional facilities, highlighting the need for strengthening TB and HIV programs, especially tailored for juveniles and gender-specific initiatives.
Article
Medicine, General & Internal
Bang Nguyen Pham, Norah Abori, Vinson D. Silas, Ronny Jorry, Chalapati Rao, Tony Okely, Willie Pomat
Summary: Tuberculosis and HIV/AIDS are significant public health concerns in Papua New Guinea. This study found that young adults, urban populations, and individuals from middle household wealth quintiles are at higher risk of mortality from these diseases.
Review
Medicine, General & Internal
Emmanuel Osei Bonsu, Isaac Yeboah Addo, Benjamin Noble Adjei, Muhib Mohammed Alhassan, Emmanuel Kweku Nakua
Summary: This study retrospectively reviewed the TB case register for the Kwabre East Municipality from 2010 to 2020 and found that 18% of TB patients were coinfected with HIV. The prevalence of TB-HIV coinfection was highest in 2015, accounting for 40% of all registered TB cases. Patients' age and TB treatment outcomes were significantly associated with TB-HIV coinfection.
Article
Infectious Diseases
Jill K. Gersh, Ruanne Barnabas, Daniel Matemo, John Kinuthia, Zachary Feldman, Sylvia M. Lacourse, Jerphason Mecha, Alex J. Warr, Maureen Kamene, David J. Horne
Summary: In Kenyan PLHIV treated with IPT, tuberculosis prevalence was low at a median of 1.4 years after IPT completion. WHO symptoms screening, Xpert, and candidate biomarkers were insensitive for identifying pulmonary tuberculosis in antiretroviral-treated PLHIV.
BMC INFECTIOUS DISEASES
(2021)
Review
Medicine, General & Internal
McEwen Khundi, James R. Carpenter, Marriott Nliwasa, Ted Cohen, Elizabeth L. Corbett, Peter MacPherson
Summary: This study aimed to systematically evaluate the effectiveness of spatially targeted community public health interventions for HIV, tuberculosis, leprosy, and malaria. The results showed that studies investigating spatially targeted interventions were limited in number and often had methodological limitations, impacting the interpretation of intervention impacts. Applying advanced epidemiological methodologies supporting robust hotspot identification and larger or more intensive interventions would strengthen the evidence base for this important approach.
Article
Medicine, General & Internal
Maartje Dijkstra, Henrieke Prins, Jan M. Prins, Peter Reiss, Charles Boucher, Annelies Verbon, Casper Rokx, Godelieve de Bree
Summary: The study focuses on individuals with early HIV infection who start combination antiretroviral therapy (cART) with the aim of investigating the size of the viral reservoir and HIV-specific immune responses in preparation for future HIV cure trials.
Article
Multidisciplinary Sciences
Terefe Gelibo, Sileshi Lulseged, Frehywot Eshetu, Saro Abdella, Zenebe Melaku, Solape Ajiboye, Minilik Demissie, Chelsea Solmo, Jelaludin Ahmed, Yimam Getaneh, Susan C. Kaydos-Daniels, Ebba Abate
Summary: The design and evaluation of national HIV programs in Ethiopia often rely on aggregated national data, which may not accurately reflect localized HIV epidemics. This study identified geographic locations and drivers of HIV transmission to inform targeted prevention efforts for specific populations.
Article
Medicine, General & Internal
Ana Lucia Espinosa Dice, Angela M. Bengtson, Kevin M. Mwenda, Christopher J. Colvin, Mark N. Lurie
Summary: This study investigates the geospatial characteristics and trends of clinic transfers among PLWH on ART in South Africa's Western Cape Province. The results show that clinic transfers are common and may cluster in urban areas, highlighting the need for improved integration of health information systems and HIV care.
Article
Medicine, General & Internal
Marion Mora, Giovanna Rincon, Michel Bourrelly, Gwenaelle Maradan, Anaenza Freire Maresca, Florence Michard, Elisabeth Rouveix, Julie Pannetier, Diane Leriche, Tristan Alain, Yazdan Yazdanpanah, David Michels, Bruno Spire
Summary: Transgender identity faces low acceptance in France with scarce data available, leading to increased stigmatization and potential burden of HIV infection among TRHIV. ANRS Trans&HIV aims to identify vulnerabilities, obstacles in medical care, and gender affirmation/HIV care needs of TRHIV through a comprehensive national survey.
Article
Medicine, General & Internal
Kennarey Seang, Keovathanak Khim, Kartavya Vyas, Dyna Khuon, Vonthanak Saphonn, Pamina Gorbach
Summary: This study examined medical injection/infusion behaviors among people living with HIV (PLWH) and those who were HIV negative in Cambodia. The results showed that both groups had similar rates of injection use in the past year, but PLWH had a higher proportion of receiving unsafe injections.
Article
Medicine, General & Internal
Li Wei Ang, Matthias Paul Han Sim Toh, Irving Charles Boudville, Chen Seong Wong, Sophia Archuleta, Vernon Lee, Angela Chow, Yee Sin Leo
Summary: The study found that nearly half of HIV-positive individuals had never been tested for HIV prior to diagnosis, with the most common reason being perceived lack of necessity. Those who had never been tested were more likely to be diagnosed at a late stage of HIV infection. Common risk factors associated with lack of previous HIV testing included older age, lower education level, diagnosis through medical care, and heterosexual transmission.
Article
Medicine, General & Internal
Jake M. Pry, Chilambwe Mwila, Herbert Kapesa, Musunge Mulabe, Christiana Frimpong, Misinzo Moono, Theodora Savory, Carolyn Bolton-Moore, Michael E. Herce, Shilpa Iyer
Summary: This study aimed to estimate potential silent transfer among individuals new to HIV care in Lusaka, Zambia. The results showed that participants aged 40+ years and those with no formal education had a significantly higher prevalence of potential silent transfer. The high proportion of potential silent transfers indicates an opportunity to improve care continuity at the time of HIV care entry.
Article
Medicine, General & Internal
Mikaela Mutru, Sanna Isosomppi, Inka Aho, Kirsi Liitsola, Henrikki Brummer-Korvenkontio, Jukka Ollgren, Oskari Luomala, Pia Kivela
Summary: The Finnish HIV Quality of Care Register (FINHIV) was created to estimate the number of people living with HIV in Finland, evaluate the use of antiretroviral medication and viral suppression, examine changes in the HIV epidemic, and evaluate the health of PLWH. The register includes all diagnosed and treated individuals since 1984 and currently consists of 4218 PLWH. Finland has achieved the UNAIDS targets for 2020, but there is an increasing proportion of late-stage HIV diagnoses.
Article
Medicine, General & Internal
Stanley W. Wanjala, Moses K. Nyongesa, Paul Mwangi, Agnes M. Mutua, Stanley Luchters, Charles R. J. C. Newton, Amina Abubakar
Summary: This study examined HIV-related stigma among adults living with HIV on the Kenyan coast. The 12-item short version of the Berger HIV stigma scale showed high reliability and validity in measuring HIV stigma. The study found that being female, non-disclosure of HIV status, and co-occurrence of depressive and anxiety symptoms were significant predictors of HIV-related stigma.
Article
Medicine, General & Internal
Patrick Lungu, Andrew D. Kerkhoff, Clara C. Kasapo, Judith Mzyece, Sulani Nyimbili, Rhehab Chimzizi, Andrew Silumesii, Mary Kagujje, Ramnath Subbaraman, Monde Muyoyeta, Kennedy Malama
Summary: Tuberculosis remains a major cause of morbidity and mortality in Zambia, especially for PLHIV. In 2018, the total burden of TB in Zambia was estimated at 72,495 cases, with significant gaps identified in the TB care cascade. Patients with HIV were less likely to complete treatment compared to HIV-negative individuals, and there was substantial attrition among those with drug-resistant TB.
Article
Gastroenterology & Hepatology
Maud Lemoine, Lambert Assoumou, Pierre-Marie Girard, Marc Antoine Valantin, Christine Katlama, Stephane De Wit, Pauline Campa, Hayette Rougier, Jean-Luc Meynard, Coca Necsoi, Anja D. Huefner, Jan Van Luzen, Julian Schulze Zur Wiesch, Jean-Philippe Bastard, Soraya Fellahi, Stefan Mauss, Metodi V. Stankov, Axel Baumgarten, Gerrit Post, Lawrence Serfaty, Vlad Ratziu, Yves Menu, Jerome Schlue, Pierre Bedossa, Jacqueline Capeau, Dominique Costagliola, Georg Behrens, Patrick Ingiliz
Summary: This study aimed to assess the prevalence and associated factors of liver steatosis and advanced fibrosis (AF) in HIV-monoinfected patients at risk of NAFLD. The results showed that two-thirds of the HIV-monoinfected patients with NAFLD had liver steatosis, and around 10% had advanced fibrosis. The CAP technique was accurate for screening steatosis in this population.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Immunology
Clotilde Allavena, Hubert Blain, Xian Abulizi, Laurence Slama, Christine Katlama, Pierre Delobel, Vanessa Rio, Carole Cagnot, Mariem Raho-Moussa, Alain Makinson, Laurence Meyer
Summary: This study aimed to assess the prevalence and risk factors of frailty in people aged 70 years or older with HIV who were on antiretroviral treatment. The results showed a low prevalence of frailty (13.5%) and a high prevalence of prefrailty (63.3%) in this population. Age, low socioeconomic status, and multimorbidities were associated with frailty. These findings highlight the importance of targeting these factors to promote successful aging in older individuals with HIV.
Article
Immunology
Laura Waters, Lambert Assoumou, Ana Gonzalez-Cordon, Stefano Rusconi, Pere Domingo, Mark Gompels, Stephane de Wit, Francois Raffi, Christoph Stephan, Mar Masia, Jurgen Rockstroh, Christine Katlama, Georg M. N. Behrens, Graeme Moyle, Margaret Johnson, Julie Fox, Hans-Jurgen Stellbrink, Giovanni Guaraldi, Eric Florence, Stefan Esser, Jose M. Gatell, Anton Pozniak, Esteban Martinez
Summary: In the NEAT022 trial, virologically suppressed HIV patients at high cardiovascular risk switching from protease inhibitors to dolutegravir showed noninferior virological suppression and significant reductions in lipid and cardiovascular disease risk, regardless of immediate or delayed switching.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Jade Ghosn, Delphine Bachelet, Marine Livrozet, Minerva Cervantes-Gonzalez, Julien Poissy, Francois Goehringer, Charlotte Salmon Gandonniere, Mylene Maillet, Firouze Bani-Sadr, Guillaume Martin-Blondel, Pierre Tattevin, Odile Launay, Laure Surgers, Emmanuel Dudoignon, Geoffroy Liegeon, David Zucman, Cedric Joseph, Eric Senneville, Cecile Yelnik, Pierre-Marie Roger, Karine Faure, Marie Gousseff, Andre Cabie, Xavier Duval, Catherine Chirouze, Cedric Laouenan
Summary: This study assessed the symptoms that persisted 12 months after admission for COVID-19 and found that approximately 27% of patients still had >= 3 persistent symptoms, especially fatigue, dyspnea, and joint pain. Women were more likely to experience persistent symptoms, as well as suffer from anxiety and depression, and were less likely to return to work compared to men.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Immunology
Romain Palich, Rachid Agher, Dimoke J. Wetshikoy, Lise Cuzin, Sophie Seang, Cathia Soulie, Roland Tubiana, Marc-Antoine Valantin, Luminita Schneider, Valerie Pourcher, Anne-Genevieve Marcelin, Lambert Assoumou, Christine Katlama
Summary: This study aims to explore the differences in antiretroviral therapy (ART) prescriptions between naive and virally suppressed HIV patients born in France and Sub-Saharan Africa. The findings suggest that the differences in ART prescriptions between these two groups cannot solely be explained by different clinical and virologic situations.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2023)
Article
Public, Environmental & Occupational Health
Emmanuel Delmas, Abderrahmane Bourredjem, Mathieu Nacher, Andre Cabie, Emmanuelle Mimeau, Claire Bonithon-Kopp, Devi Rochemont, Marie-Laure Lalanne-Mistrih, Caroline Misslin-Tritsch, Julien Joux, Annie Lannuzel, Isabelle Fournel, Yannick Bejot
Summary: This study aimed to assess the joint impact of deprivation and smoking on functional outcomes after ischemic stroke. The study found that smokers had a higher likelihood of moderate to severe disability at 12 months compared to nonsmokers in nondeprived patients. However, there was no significant association between smoking and disability in deprived patients.
Article
Chemistry, Medicinal
Peter J. Slavish, Maxime G. Cuypers, Mary Ashley Rimmer, Alireza Abdolvahabi, Trushar Jeevan, Gyanendra Kumar, Jamie A. Jarusiewicz, Sivaraja Vaithiyalingam, Jeremy C. Jones, John J. Bowling, Jeanine E. Price, Rebecca M. DuBois, Jaeki Min, Richard J. Webby, Zoran Rankovic, Stephen W. White
Summary: Influenza is a major cause of disease-related deaths globally. Strategies to inhibit influenza virus replication have resulted in the emergence of resistant strains. Baloxavir marboxil, a recently approved compound, is significantly less effective due to a mutation in the active site of the target enzyme. Raltegravir, an HIV inhibitor, shows moderate activity against the enzyme. In this study, researchers used structure-guided approaches to design molecules that effectively target the enzyme's active site and successfully developed potent inhibitors for both wild-type and baloxavir-resistant forms.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Editorial Material
Immunology
Dominique Costagliola
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Laurent Hocqueloux, Amelie Menard, Cedric Arvieux, Veronique Joly, Agathe Becker, Antoine Cheret, Claudine Duvivier, Andre Cabie, Cyrille Delpierre, Clotilde Allavena
Summary: This study aimed to describe the changes in weight and BMI following the substitution of TDF by TAF in PLWH. The results showed that there was a significant weight gain and increase in BMI in the Switch group, which should be taken into consideration in at-risk populations.
Article
Infectious Diseases
Lise Cuzin, Philippe Flandre, Clotilde Allavena, Romain Palich, Claudine Duvivier, Agathe Becker, Helene Laroche, Pascal Pugliese, Andre Cabie, Dat'AIDS Study Grp
Summary: This study analyzed the occurrence of virological failure (VF) in patients starting ART with an integrase strand transfer inhibitor (INSTI)-based regimen in recent years and its relationship with previous episodes of low-level viral load (LLVL). The results showed that LLVL was associated with VF, and even in the absence of subsequent failure, LLV episodes have a cost. Therefore, any viral load value above 50 copies/mL should lead to enhanced adherence counseling.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Virology
Djeneba B. Fofana, Houdou Diarra, Ibrahima Guindo, Mahamadou K. Savadogo, Marceline d'Almeida, Fatoumata I. Diallo, Aliou Balde, Cathia Soulie, Amadou Kone, Anne-Genevieve Marcelin, Almoustapha I. Maiga, Sidonie Lambert-Niclot, Mamoudou Maiga, Sally McFall, Claudia A. Hawkins, Robert L. Murphy, Mariam Sylla, Christine Katlama, Jane L. Holl, Vincent Calvez, Laurence Morand-Joubert
Summary: Limited data exist on INI resistance in children living with HIV/AIDS in West Africa. A study was conducted on HIV-1-infected children in Benin and Mali, and it was found that no major INI resistance mutations were detected in INI-naive patients.
Article
Critical Care Medicine
Marius Troseid, Jose R. Arribas, Lambert Assoumou, Aleksander Rygh Holten, Julien Poissy, Vida Terzic, Fulvia Mazzaferri, Jesus Rodriguez Bano, Joe Eustace, Maya Hites, Michael Joannidis, Jose-Artur Paiva, Jean Reuter, Isabel Puentmann, Thale D. J. H. Patrick-Brown, Elin Westerheim, Katerina Nezvalova-Henriksen, Lydie Beniguel, Tuva Borresdatter Dahl, Maude Bouscambert, Monika Halanova, Zoltan Peterfi, Sotirios Tsiodras, Michael Rezek, Matthias Briel, Serhat Unal, Martin Schlegel, Florence Ader, Karine Lacombe, Cecilie Delphin Amdal, Serge Rodrigues, Kristian Tonby, Alexandre Gaudet, Lars Heggelund, Joy Mootien, Asgeir Johannessen, Jannicke Horjen Moller, Beatriz Diaz Pollan, Anders Aune Tveita, Anders Benjamin Kildal, Jean-Christophe Richard, Olav Dalgard, Victoria Charlotte Simensen, Aliou Balde, Lucie de Gastines, Marta del Alamo, Burc Aydin, Fridtjof Lund-Johansen, Mary-Anne Trabaud, Alpha Diallo, Bente Halvorsen, John-Arne Rottingen, Evelina Tacconelli, Yazdan Yazdanpanah, Inge C. Olsen, Dominique Costagliola
Summary: The study conducted a placebo-controlled trial of baricitinib in severe/critical COVID cases. The results showed that baricitinib did not reduce mortality within 60 days, and there may be safety risks in vaccinated participants, which require further investigation.
Review
Critical Care Medicine
Alain Amstutz, Benjamin Speich, France Mentre, Corina Silvia Rueegg, Drifa Belhadi, Lambert Assoumou, Charles Burdet, Srinivas Murthy, Lori Elizabeth Dodd, Yeming Wang, Kari A. O. Tikkinen, Florence Ader, Maya Hites, Maude Bouscambert, Mary Anne Trabaud, Mike Fralick, Todd C. Lee, Ruxandra Pinto, Andreas Barratt-Due, Fridtjof Lund-Johansen, Fredrik Mueller, Olli P. O. Nevalainen, Bin Cao, Tyler Bonnett, Alexandra Griessbach, Ala Taji Heravi, Christof Schonenberger, Perrine Janiaud, Laura Werlen, Soheila Aghlmandi, Stefan Schandelmaier, Yazdan Yazdanpanah, Dominique Costagliola, Inge Christoffer Olsen, Matthias Briel
Summary: This systematic review and meta-analysis assessed the benefits and harms of remdesivir compared to placebo or usual care in COVID-19 patients hospitalized. The study found that remdesivir reduced mortality in patients who required no or conventional oxygen support but did not have enough evidence for patients on ventilators.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Infectious Diseases
O. Cabras, L. Sylvanise, A. Marquise, A. Cabie, L. Cuzin
Summary: This study aimed to assess the level of knowledge about HPV among a population attending a sexual health clinic in the University Hospital of Martinique. A validated questionnaire was used to survey 500 young adults, and the results indicated that 68% of participants had never heard of HPV, with the percentage rising to 74.6% among women. The median number of correct answers out of 28 questions was 15, and there was no significant difference related to age. Women had more correct answers on most of the items related to screening and vaccine. The study highlights the poor knowledge about HPV in Martinique and the need for new communication methods to reach young boys and girls.
INFECTIOUS DISEASES NOW
(2023)
