☆ 4.4 Letter

Life-threatening immune reconstitution inflammatory syndrome after Pneumocystis pneumonia: a cautionary case series

AIDS (2009)

Journal

AIDS

Volume 23, Issue 13, Pages 1794-1796

Publisher

LIPPINCOTT WILLIAMS & WILKINS

DOI: 10.1097/QAD.0b013e32832d9b20

Keywords

-

Categories

Immunology Infectious Diseases Virology

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Review Pediatrics

Pneumocystis jirovecii-associated immune reconstitution inflammatory syndrome-like phenomenon in a child with leukaemia: a case report and literature review

Jia-ying Lei, Han Chen, Dun-hua Zhou, Lu-hong Xu, Jian-pei Fang, You-gang Mai

Summary: This case study highlighted the rapid aggravation of pulmonary lesions in a leukemia patient infected with Pneumocystis jirovecii during the process of immune recovery. The use of granulocyte stimulating factors may exacerbate inflammatory responses in the lungs. Further research is needed to explore the timing, dosage, and duration of glucocorticoid treatment and the impact of high-dose methylprednisolone pulse therapy on patient prognosis.

BMC PEDIATRICS (2022)

Add to Collection

Article Gastroenterology & Hepatology

Pneumocystis jirovecii Pneumonia in Patients with Inflammatory Bowel Disease-a Case Series

S. Vieujean, A. Moens, D. Hassid, K. Rothfuss, E. Savarino, S. R. Vavricka, C. Reenaers, B. Jacobsen, M. Allez, M. Ferrante, J. F. Rahier

Summary: This study aimed to describe the exposure to immunosuppressive treatment and outcomes in inflammatory bowel disease (IBD) patients with Pneumocystis jirovecii pneumonia (PJP). The results showed that among 17 IBD patients, 18 episodes of PJP were reported, with two deaths. The study highlights the importance of adjusted prophylactic therapy in immunosuppressed IBD patients.

JOURNAL OF CROHNS & COLITIS (2022)

Add to Collection

Article Medicine, General & Internal

Immune Reconstitution Inflammatory Syndrome-like Condition Associated with Pneumocystis jirovecii Pneumonia During Folinic Acid Treatment in a Rheumatoid Arthritis Patient

Naoki Arakawa, Kazuo Eguchi, Yuki Nakamura, Yuta Tsukahara, Youhei Koushima, Hidekazu Matsushima

Summary: A 94-year-old woman with rheumatoid arthritis was referred to hospital due to fever and pancytopenia. Despite recovery from pancytopenia, she was diagnosed with PCP and possible immune reconstruction inflammatory syndrome.

INTERNAL MEDICINE (2021)

Add to Collection

Review Oncology

Immune Reconstitution Inflammatory Syndrome Associated Kaposi Sarcoma

Isabelle Poizot-Martin, Sylvie Bregigeon, Romain Palich, Anne-Genevieve Marcelin, Marc-Antoine Valantin, Caroline Solas, Marianne Veyri, Jean-Philippe Spano, Alain Makinson

Summary: Kaposi sarcoma-immune reconstitution inflammatory syndrome (KS-IRIS) is a common disease among people living with HIV, despite the improvement of KS with antiretroviral therapy (ART), the occurrence of KS-IRIS still exists and is associated with significant morbidity and mortality.

CANCERS (2022)

Add to Collection

Article Immunology

An Inflammatory Composite Score Predicts Mycobacterial Immune Reconstitution Inflammatory Syndrome in People with Advanced HIV: A Prospective International Cohort Study

Caian L. Vinhaes, Virginia Sheikh, Deivide Oliveira-de-Souza, Jing Wang, Adam Rupert, Gregg Roby, Maria B. Arriaga, Kiyoshi F. Fukutani, Fred Sawe, Doug Shaffer, Jintanat Ananworanich, Nittaya Phanuphak, Bruno B. Andrade, Irini Sereti

Summary: The study found that systemic inflammatory profiles in people with severe immunosuppression can predict the development of immune reconstitution inflammatory syndrome (IRIS). By developing a composite score incorporating various biomarkers, including interleukin-6, IL-10, IL-27, sCD14, interferon-gamma, tumor necrosis factor-alpha, hyaluronic acid, D-dimer, body mass index, and hemoglobin, accurate predictions of IRIS occurrence and death risk can be made.

JOURNAL OF INFECTIOUS DISEASES (2021)

Add to Collection

Article Immunology

Lenalidomide Improves Cognitive Function and Reduces Immune Reconstitution Inflammatory Syndrome in HIV-1-Related Cryptococcal Meningitis

Ran Tao, Xiaorong Peng, Xiang Liu, Junwei Su, Guanjing Lang, Ying Huang, Yafei Zhang, Biao Zhu

Summary: Cryptococcal meningitis (CM) is a common opportunistic infection in HIV patients. This study reports two cases of CM-associated immune reconstitution inflammatory syndrome (IRIS) treated with lenalidomide, which resulted in rapid clinical remission and improved cognitive function. The study also suggests that lenalidomide may improve cognitive function by regulating intracranial inflammation through multiple pathways, not just by TNF-α blocking.

JOURNAL OF INFLAMMATION RESEARCH (2022)

Add to Collection

Article Immunology

Severe Mycobacterial Immune Reconstitution Inflammatory Syndrome (IRIS) in Advanced Human Immunodeficiency Virus (HIV) Has Features of Hemophagocytic Lymphohistiocytosis and Requires Prolonged Immune Suppression

Joseph M. Rocco, Elizabeth Laidlaw, Frances Galindo, Megan Anderson, Adam Rupert, Jeanette Higgins, Ornella Sortino, Ana M. Ortega-Villa, Virginia Sheikh, Gregg Roby, Safia Kuriakose, Andrea Lisco, Maura Manion, Irini Sereti

Summary: Severe mycobacterial IRIS in HIV can cause secondary HLH driven by pathologic IFN gamma production and T-cell activation, leading to worse outcomes. Increased ferritin, anemia, CXCL9, and sCD25 associate with this phenotype and may be used for risk stratification and treatment optimization.

CLINICAL INFECTIOUS DISEASES (2023)

Add to Collection

Article Immunology

Plasma Metabolomics Reveals Dysregulated Metabolic Signatures in HIV-Associated Immune Reconstitution Inflammatory Syndrome

Luxin Pei, Kiyoshi F. Fukutani, Rafael Tiburcio, Adam Rupert, Eric W. Dahlstrom, Frances Galindo, Elizabeth Laidlaw, Andrea Lisco, Maura Manion, Bruno B. Andrade, Irini Sereti

Summary: The study identified metabolic disturbances in IRIS before and during the event, linking oxidative stress, tryptophan pathway, and lipid signaling with IRIS development. Metabolic pathways of lipids and amino acids were significantly associated with inflammatory biomarkers like IL-12p70 and IL-8 during the IRIS event, suggesting the impact of cellular metabolism on immune cell activation and vice versa.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Immunology

Case Report: Central Nervous System Immune Reconstitution Inflammatory Syndrome Related to Bacterial Meningitis

Mengyan Hu, Sanxin Liu, Danli Lu, Yi Zhong, Dafan Yu, Wei Qiu, Zhengqi Lu, Bingjun Zhang

Summary: CNS-IRIS is an inflammatory syndrome that may occur in previously immunocompromised patients during the restoration of immunity function. This case report presents the first instance of CNS-IRIS associated with bacterial meningitis, where the patient gradually recovered with corticosteroid therapy.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Immunology

Immune Reconstitution Inflammatory Syndrome Complicating Cryptococcal Meningitis in a Pediatric Heart Transplant Patient

Chelsea Miller, Reza Daugherty, Michael McCulloch, Ina Stephens, Peter R. Williamson

Summary: This case report discusses the diagnosis and management of immune reconstitution inflammatory syndrome associated with cryptococcal meningitis in a 10-year-old pediatric heart transplant recipient.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2022)

Add to Collection

Article Infectious Diseases

Risk factors for IRIS in HIV-associated Pneumocystis-pneumonia following ART initiation

Gerrit Kann, Nils Wetzstein, Hannah Bielke, Gundolf Schuettfort, Annette E. Haberl, Timo Wolf, Claus P. Kuepper-Tetzel, Imke Wieters, Johanna Kessel, Philipp de Leuw, Markus Bickel, Pavel Khaykin, Christoph Stephan

Summary: The study aimed to identify risk factors and predictors for PCP-IRIS in HIV-infected patients receiving cART during PCPT. Results showed that patients with IRIS had higher re-hospitalization rate, longer hospitalization, and increased intensive care treatment. Higher HIV-RNA level and lower serum IgG levels before cART initiation were associated with the development of IRIS in PCP patients.

JOURNAL OF INFECTION (2021)

Add to Collection

Article Infectious Diseases

Pneumocystis jirovecii pneumonia in patients with decompensated cirrhosis: a case series

Erica Franceschini, Giovanni Dolci, Antonella Santoro, Marianna Meschiari, Alice Ricco, Marianna Menozzi, Giulia Jole Burastero, Biagio Cuffari, Nicola De Maria, Lucia Serio, Emanuela Biagioni, Barbara Catellani, Stefano Di Sandro, Antonio Colecchia, Massimo Girardis, Fabrizio Di Benedetto, Cristina Mussini

Summary: This study aims to describe a case series of patients with decompensated liver cirrhosis and Pneumocystis jirovecii pneumonia (PCP). The results show that liver cirrhosis can be an independent risk factor for PCP, especially in patients with severe alcoholic hepatitis who are on corticosteroid treatment for decompensated cirrhosis. Primary prophylaxis for PCP should be considered in these patients.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2023)

Add to Collection

Article Immunology

Mycobacterial Immune Reconstitution Inflammatory Syndrome in HIV is Associated With Protein-Altering Variants in Hemophagocytic Lymphohistiocytosis-Related Genes

Joseph M. Rocco, Elizabeth Laidlaw, Frances Galindo, Megan Anderson, Ornella Sortino, Safia Kuriakose, Andrea Lisco, Maura Manion, Irini Sereti

Summary: People with HIV and mycobacterial infections may develop immune reconstitution inflammatory syndrome (IRIS) after starting antiretroviral therapy. The pathophysiology of mycobacterial-IRIS overlaps with primary hemophagocytic lymphohistiocytosis (pHLH). By evaluating protein-altering variants in genes associated with HLH, it was found that 23.2% of IRIS patients had these variants, compared to only 3.8% of those without IRIS. These findings suggest a possible genetic component in the risk of mycobacterial IRIS in people with HIV and mycobacterial infections.

JOURNAL OF INFECTIOUS DISEASES (2023)

Add to Collection

Review Immunology

Current knowledge of the immune reconstitution inflammatory syndrome in Whipple disease: a review

Xiangyi Song, Ruifeng Duan, Liwei Duan, Lijuan Wei

Summary: Immune reconstitution inflammatory syndrome (IRIS) is an exaggerated and dysregulated inflammatory response that occurs as a result of immune reconstitution. It is associated with various microorganisms, and Whipple disease (WD) is one of the infectious disorders that can lead to IRIS. Recent studies on the intestinal mucosal immune system have provided new insights into the pathogenesis of IRIS, which can be used to develop monitoring tools for disease prevention and treatment strategies.

FRONTIERS IN IMMUNOLOGY (2023)

Add to Collection

Review Biology

Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome in Persons Living with HIV

Caian L. Vinhaes, Mariana Araujo-Pereira, Rafael Tiburcio, Juan M. Cubillos-Angulo, Fernanda O. Demitto, Kevan M. Akrami, Bruno B. Andrade

Summary: Antiretroviral therapy (ART) has greatly improved the care of people living with HIV, but can lead to immune reconstitution inflammatory syndrome (IRIS), causing significant morbidity and mortality. There are still gaps in understanding IRIS pathogenesis and optimizing therapeutic strategies.

LIFE-BASEL (2021)

Add to Collection

Article Cell Biology

Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity

Saborni Chakraborty, Joseph C. Gonzalez, Benjamin L. Sievers, Vamsee Mallajosyula, Srijoni Chakraborty, Megha Dubey, Usama Ashraf, Bowie Yik-Ling Cheng, Nimish Kathale, Kim Quyen Thi Tran, Courtney Scallan, Aanika Sinnott, Arianna Cassidy, Steven T. Chen, Terri Gelbart, Fei Gao, Yarden Golan, Xuhuai Ji, Seunghee Kim-Schulze, Mary Prahl, Stephanie L. Gaw, Sacha Gnjatic, Thomas U. Marron, Miriam Merad, Prabhu S. Arunachalam, Scott D. Boyd, Mark M. Davis, Marisa Holubar, Chaitan Khosla, Holden T. Maecker, Yvonne Maldonado, Elizabeth D. Mellins, Kari C. Nadeau, Bali Pulendran, Upinder Singh, Aruna Subramanian, Paul J. Utz, Robert Sherwood, Sheng Zhang, Prasanna Jagannathan, Gene S. Tan, Taia T. Wang

Summary: A damaging inflammatory response in severe COVID-19 is associated with early non-neutralizing, afucosylated IgG antibodies specific to SARS-CoV-2. Human IgG-Fc-gamma receptor interactions regulate inflammation in the lung, and antibodies elicited by mRNA SARS-CoV-2 vaccines have reduced inflammatory potential.

SCIENCE TRANSLATIONAL MEDICINE (2022)

Add to Collection

Article Cell Biology

Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria

Maureen Ty, Shenghuan Sun, Perri C. Callaway, John Rek, Kathleen D. Press, Kattria van der Ploeg, Jason Nideffer, Zicheng Hu, Sandy Klemm, William Greenleaf, Michele Donato, Stephen Tukwasibwe, Emmanuel Arinaitwe, Felistas Nankya, Kenneth Musinguzi, Dean Andrew, Lauren de la Parte, Diego Martinez Mori, Savannah N. Lewis, Saki Takahashi, Isabel Rodriguez-Barraquer, Bryan Greenhouse, Catherine Blish, P. J. Utz, Purvesh Khatri, Grant Dorsey, Moses Kamya, Michelle Boyle, Margaret Feeney, Isaac Ssewanyana, Prasanna Jagannathan

Summary: Repeated malaria exposure leads to expansion of atypical CD56neg NK cells in Ugandan children, characterized by transcriptional, epigenetic, and phenotypic differences from CD56dim NK cells. CD56neg NK cells display enhanced functionality and greater antibody-dependent cellular cytotoxicity. Higher frequencies of CD56neg NK cells are associated with protection against symptomatic malaria. Continuous exposure to Plasmodium falciparum is necessary to maintain this modified, adaptive-like NK cell subset, as frequencies rapidly decline after reductions in malaria transmission.

SCIENCE TRANSLATIONAL MEDICINE (2023)

Add to Collection

Article Immunology

Challenges in Harnessing Shared Within-Host Severe Acute Respiratory Syndrome Coronavirus 2 Variation for Transmission Inference

Katharine S. Walter, Eugene Kim, Renu Verma, Jonathan Altamirano, Sean Leary, Yuan J. Carrington, Prasanna Jagannathan, Upinder Singh, Marisa Holubar, Aruna Subramanian, Chaitan Khosla, Yvonne Maldonado, Jason R. Andrews

Summary: This study found that there is limited genetic diversity among SARS-CoV-2 samples from the same household, while individuals infected with the same viral strain from different households have lower genetic similarity. Shared within-host variations in a household are significantly associated with household membership. However, current sequencing and bioinformatic workflows may not consistently detect low-frequency within-host variants.

OPEN FORUM INFECTIOUS DISEASES (2023)

Add to Collection

Article Immunology

Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8+T cell responses post SARS-CoV-2 infection

Fei Gao, Vamsee Mallajoysula, Prabhu S. Arunachalam, Kattria van der Ploeg, Monali Manohar, Katharina Roltgen, Fan Yang, Oliver Wirz, Ramona Hoh, Emily Haraguchi, Ji-Yeun Lee, Richard Willis, Vasanthi Ramachandiran, Jiefu Li, Karan Raj Kathuria, Chunfeng Li, Alexandra S. Lee, Mihir M. Shah, Sayantani B. Sindher, Joseph Gonzalez, John D. Altman, Taia T. Wang, Scott D. Boyd, Bali Pulendran, Prasanna Jagannathan, Kari C. Nadeau, Mark M. Davis

Summary: T cells play a crucial role in the immune response to SARS-CoV-2, but their behavior after infection and vaccination is not well understood. This study examined the T cell responses of subjects receiving the Pfizer/BioNTech BNT162b2 vaccine. Vaccination induced strong spike-specific T cell responses for both CD4+ and CD8+ T cells, with CD4+ responses peaking 1 week after the second dose and CD8+ responses peaking 2 weeks later. These T cell responses were higher than those observed in COVID-19 patients. Additionally, prior SARS-CoV-2 infection was found to decrease CD8+ T cell activation and expansion, suggesting an influence of previous infection on the T cell response to vaccination.

IMMUNITY (2023)

Add to Collection

Article Immunology

Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230

Danton Ivanochko, Amanda Fabra-Garcia, Karina Teelen, Marga van de Vegete-Bolmer, Geert-Jan van Gemert, Jocelyn Newton, Anthony Semesi, Marloes de Bruijni, Judith Bolscher, Jordache Ramjith, Marta Szabat, Stefanie Vogt, Lucas Kraft, Sherie Duncan, Shwu-Maan Lee, Moses R. Kamya, Margaret E. Feeney, Prasanna Jagannathan, Bryan Greenhouse, Robert W. Sauerwein, C. Richter King, Randall S. MacGill, Teun Bousem, Matthijs M. Jore, Jean -Philippe Julien

Summary: Pfs230 is a crucial protein for Plasmodium falciparum transmission to mosquitoes and a target for the most advanced malaria-transmission-blocking vaccine candidate. Through screening the B cell repertoire of naturally exposed individuals, this study identified five potent monoclonal antibodies that bind to distinct epitopes on Pfs230. The highly potent antibodies from natural infection recognized a conserved conformational epitope, while antibodies from natural infection or vaccination recognized three different sites.

IMMUNITY (2023)

Add to Collection

Article Immunology

Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes

Amanda Fabra-Garcia, Sophia Hailemariam, Roos M. de Jong, Kirsten Janssen, Karina Teelen, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Danton Ivanochko, Anthony Semesi, Brandon McLeod, Martijn W. Vos, Marloes H. C. de Bruijni, Judith M. Bolscher, Marta Szabat, Stefanie Vogt, Lucas Kraft, Sherie Duncan, Moses R. Kamya, Margaret E. Feeney, Prasanna Jagannathan, Bryan Greenhouse, Koen J. Dechering, Robert W. Sauerwein, C. Richter King, Randall S. MacGill, Teun Bousema, Jean-Philippe Julien, Matthijs M. Jore

Summary: Malaria transmission-blocking vaccines aim to induce antibodies that interrupt parasite development in mosquitoes, providing a tool for malaria control. We isolated and characterized 81 human monoclonal antibodies specific to the Pfs48/45 protein, a leading vaccine candidate. Potent antibodies targeting specific domains achieved high transmission-reducing activity. Co-crystal structures identified protective epitopes, providing insight for refined vaccine design.

IMMUNITY (2023)

Add to Collection

Review Genetics & Heredity

Impact of high human genetic diversity in Africa on immunogenicity and efficacy of RTS,S/AS01 vaccine

Stephen Tukwasibwe, Gerald Mboowa, Ivan Sserwadda, Joaniter I. Nankabirwa, Emmanuel Arinaitwe, Isaac Ssewanyana, Yoweri Taremwa, Gerald Tumusiime, Moses R. Kamya, Prasanna Jagannathan, Annettee Nakimuli

Summary: Vaccination is a highly effective public health strategy in preventing infectious diseases and has saved millions of lives. However, the efficacy of the RTS,S/AS01 malaria vaccine is challenged by genetic variation in humans and malaria parasites, leading to variable responses. This review focuses on human genetic factors that determine variable responses to vaccination and how immune system gene variation affects the immunogenicity and efficacy of the RTS,S/AS01 vaccine.

IMMUNOGENETICS (2023)

Add to Collection

Article Medicine, General & Internal

Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection

Tanayott Thaweethai, Sarah E. Jolley, Elizabeth W. Karlson, Emily B. Levitan, Bruce Levy, Grace A. McComsey, Lisa McCorkell, Girish N. Nadkarni, Sairam Parthasarathy, Upinder Singh, Tiffany A. Walker, Caitlin A. Selvaggi, Daniel J. Shinnick, Carolin C. M. Schulte, Rachel Atchley-Challenner, Leora I. Horwitz, Andrea S. Foulkes

Summary: SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, known as postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID. This study developed a definition of PASC based on self-reported symptoms and described the frequencies of PASC across cohorts, vaccination status, and number of infections.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2023)

Add to Collection

Article Multidisciplinary Sciences

Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design

Leora I. Horwitz, Tanayott Thaweethai, Shari B. Brosnahan, Mine S. Cicek, Megan L. Fitzgerald, Jason D. Goldman, Rachel Hess, S. L. Hodder, Vanessa L. Jacoby, Michael R. Jordan, Jerry A. Krishnan, Adeyinka O. Laiyemo, Torri D. Metz, Lauren Nichols, Rachel E. Patzer, Anisha Sekar, Nora G. Singer, Lauren E. Stiles, Barbara S. Taylor, Shifa Ahmed, Heather A. Algren, Khamal Anglin, Lisa Aponte-Soto, Hassan Ashktorab, Ingrid V. Bassett, Brahmchetna Bedi, Nahid Bhadelia, Christian Bime, Marie-Abele C. Bind, Lora J. Black, Andra L. Blomkalns, Hassan Brim, Mario Castro, James Chan, Alexander W. Charney, Benjamin K. Chen, Li Qing Chen, Peter Chen, David Chestek, Lori B. Chibnik, Dominic C. Chow, Helen Y. Chu, Rebecca G. Clifton, Shelby Collins, Maged M. Costantine, Sushma K. Cribbs, Steven G. Deeks, John D. Dickinson, Sarah E. Donohue, Matthew S. Durstenfeld, Ivette F. Emery, Kristine M. Erlandson, Julio C. Facelli, Rachael Farah-Abraham, Aloke V. Finn, Melinda S. Fischer, Valerie J. Flaherman, Judes Fleurimont, Vivian Fonseca, Emily J. Gallagher, Jennifer C. Gander, Maria Laura Gennaro, Kelly S. Gibson, Minjoung Go, Steven N. Goodman, Joey P. Granger, Frank L. Greenway, John W. Hafner, Jenny E. Han, Michelle S. Harkins, Kristine S. P. Hauser, James R. Heath, Carla R. Hernandez, On Ho, Matthew K. Hoffman, Susan E. Hoover, Carol R. Horowitz, Harvey Hsu, Priscilla Y. Hsue, Brenna L. Hughes, Prasanna Jagannathan, Judith A. James, Janice John, Sarah Jolley, S. E. Judd, Joy J. Juskowich, Diane G. Kanjilal, Elizabeth W. Karlson, Stuart D. Katz, J. Daniel Kelly, Sara W. Kelly, Arthur Y. Kim, John P. Kirwan, Kenneth S. Knox, Andre Kumar, Michelle F. Lamendola-Essel, Margaret Lanca, Joyce K. Lee-Iannotti, R. Craig Lefebvre, Bruce D. Levy, Janet Y. Lin, Brian P. Logarbo Jr, Jennifer K. Logue, Michele T. Longo, Carlos A. Luciano, Karen Lutrick, Shahdi K. Malakooti, Gail Mallett, Gabrielle Maranga, Jai G. Marathe, Vincent C. Marconi, Gailen D. Marshall, Christopher F. Martin, Jeffrey N. Martin, Heidi T. May, Grace A. McComsey, Dylan McDonald, Hector Mendez-Figueroa, Lucio Miele, Murray A. Mittleman, Sindhu Mohandas, Christian Mouchati, Janet M. Mullington, Girish N. Nadkarni, Erica R. Nahin, Robert B. Neuman, Lisa T. Newman, Amber Nguyen, Janko Z. Nikolich, Igho Ofotokun, Princess U. Ogbogu, Anna Palatnik, Kristy T. S. Palomares, Tanyalak Parimon, Samuel Parry, Sairam Parthasarathy, Thomas F. Patterson, Ann Pearman, Michael J. Peluso, Priscilla Pemu, Christian M. Pettker, Beth A. Plunkett, Kristen Pogreba-Brown, Athena Poppas, J. Zachary Porterfield, John G. Quigley, Davin K. Quinn, Hengameh Raissy, Candida J. Rebello, Uma M. Reddy, Rebecca Reece, Harrison T. Reeder, Franz P. Rischard, Johana M. Rosas, Clifford J. Rosen, Nadine G. Rouphael, Dwight J. Rouse, Adam M. Ruff, Christina Saint Jean, Grecio J. Sandoval, Jorge L. Santana, Shannon M. Schlater, Frank C. Sciurba, Caitlin Selvaggi, Sudha Seshadri, Howard D. Sesso, Dimpy P. Shah, Eyal Shemesh, Zaki A. Sherif, Daniel J. Shinnick, Hyagriv N. Simhan, Upinder Singh, Amber Sowles, Vignesh Subbian, Jun Sun, Mehul S. Suthar, Larissa J. Teunis, John M. Thorp Jr, Amberly Ticotsky, Alan T. N. Tita, Robin Tragus, Katherine R. Tuttle, Alfredo E. Urdaneta, P. J. Utz, Timothy M. VanWagoner, Andrew Vasey, Suzanne D. Vernon, Crystal Vidal, Tiffany Walker, Honorine D. Ward, David E. Warren, Ryan M. Weeks, Steven J. Weiner, Jordan C. Weyer, Jennifer L. Wheeler, Sidney W. Whiteheart, Zanthia Wiley, Natasha J. Williams, Juan P. Wisnivesky, John C. Wood, Lynn M. Yee, Natalie M. Young, Sokratis N. Zisis, Andrea S. Foulkes

Summary: The RECOVER-Adult study aims to comprehensively study the post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID, in US adults. This national cohort study will characterize the prevalence, symptoms, natural history, and risk factors of PASC. The results will inform public health, stimulate clinical trials, and expand treatment options.

PLOS ONE (2023)

Add to Collection

Review Biology

Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC)

Sindhu Mohandas, Prasanna Jagannathan, Timothy J. Henrich, Zaki A. Sherif, Christian Bime, Erin Quinlan, Michael A. Portman, Marila Gennaro, Jalees Rehman, RECOVER Mechanist Pathways Task Force

Summary: With over 500 million cases of COVID-19 worldwide, there is increasing concern about the long-term effects known as long COVID. Exaggerated immune responses play a crucial role in the severity and outcomes of both the initial infection and long COVID. This review explores the mechanisms behind immune dysregulation in severe COVID-19 and the limited data on the immunopathology of long COVID, highlighting the need for further research to understand its distinct and heterogeneous immunopathology.

ELIFE (2023)

Add to Collection

Article Medicine, General & Internal

Seroprevalence of Antibodies to SARS-CoV-2 in Rural Households in Eastern Uganda, 2020-2022

Jessica Briggs, Saki Takahashi, Patience Nayebare, Gloria Cuu, John Rek, Maato Zedi, Timothy Kizza, Emmanuel Arinaitwe, Joaniter I. Nankabirwa, Moses Kamya, Prasanna Jagannathan, Karen Jacobson, Philip J. Rosenthal, Grant Dorsey, Bryan Greenhouse, Isaac Ssewanyana, Isabel Rodriguez-Barraquer

Summary: This cohort study in eastern Uganda estimated the seroprevalence, attack rates, and reinfection of SARS-CoV-2. The results showed a high seroprevalence rate of 67.7% during the Delta wave and high reinfection rates during the Omicron wave, with 84.8% of previously seronegative individuals and 50.8% of previously seropositive individuals being infected, respectively. Individuals with higher preexisting antibody levels had a lower probability of reinfection.

JAMA NETWORK OPEN (2023)

Add to Collection

Article Biotechnology & Applied Microbiology

The Tomato Brown Rugose Fruit Virus Movement Protein Gene Is a Novel Microbial Source Tracking Marker

Aravind Natarajan, Brayon J. Fremin, Danica T. Schmidtke, Marlene K. Wolfe, Soumaya Zlitni, Katherine E. Graham, Erin F. Brooks, Christopher J. Severyn, Kathleen M. Sakamoto, Norman J. Lacayo, Scott Kuersten, Jeff Koble, Glorianna Caves, Inna Kaplan, Upinder Singh, Prasanna Jagannathan, Andrew R. Rezvani, Ami S. Bhatt, Alexandria B. Boehm

Summary: Microbial source tracking (MST) uses host-associated fecal markers to identify sources of fecal contamination in the environment. We developed and tested novel viral MST markers based on the genomes of tomato brown rugose fruit virus (ToBRFV). These markers are sensitive and specific to human stool and wastewater, and are more prevalent and abundant compared to the commonly used viral marker PMMoV coat protein (CP) gene. This study suggests that ToBRFV is a promising viral human-associated MST marker.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2023)

Add to Collection

Article Medicine, General & Internal

Malaria-specific Type 1 regulatory T cells are more abundant in first pregnancies and associated with placental malaria

Adam S. Kirosingh, Alea Delmastro, Abel Kakuru, Kattria van der Ploeg, Sanchita Bhattacharya, Kathleen D. Press, Maureen Ty, Lauren de la Parte, Jimmy Kizza, Mary Muhindo, Sebastien Devachanne, Benoit Gamain, Felistas Nankya, Kenneth Musinguzi, Philip J. Rosenthal, Margaret E. Feeney, Moses Kamya, Grant Dorsey, Prasanna Jagannathan

Summary: This study compared the cellular immune response between primigravid and multigravid women living in a malaria-endemic region. It found that primigravid women had a higher proportion of malaria-specific, non-naive CD4(+) T cells, which was associated with increased risks of parasitaemia during pregnancy and placental malaria.

EBIOMEDICINE (2023)

Add to Collection

Article Medicine, General & Internal

Safety and efficacy of inhaled interferon-β1a (SNG001) in adults with mild-to-moderate COVID-19: a randomized, controlled, phase II trial

Prasanna Jagannathan, Kara W. Chew, Mark J. Giganti, Michael D. Hughes, Carlee Moser, Mark J. Main, Phillip D. Monk, Arzhang Cyrus Javan, Jonathan Z. Li, Courtney V. Fletcher, Caitlyn McCarthy, David A. Wohl, Eric S. Daar, Joseph J. Eron, Judith S. Currier, Upinder Singh, Davey M. Smith, William Fischer

Summary: This study evaluated the efficacy and safety of inhaled interferon-beta 1a (SNG001) for COVID-19. The results showed no significant differences between the SNG001 and placebo groups in adverse events, time to symptom improvement, and viral clearance. However, the SNG001 group had a lower hospitalization rate.

ECLINICALMEDICINE (2023)

Add to Collection

Article Medicine, General & Internal

Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection

Tanayott R. Thaweethai, Sarah E. Jolley, Elizabeth Karlson, Emily M. Levitan, Bruce Levy, Grace McComsey, Lisa S. McCorkell, Girish D. Nadkarni, Sairam E. Parthasarathy, Upinder J. Singh, Tiffany Walker, Caitlin W. Selvaggi, Daniel Shinnick, Carolin C. M. P. Schulte, Rachel M. Atchley-Challenner, Leora Horwitz, Andrea Foulkes

Summary: This study aims to develop a definition of postacute sequelae of SARS-CoV-2 infection (PASC) using self-reported symptoms and analyze the frequencies of PASC across different cohorts, vaccination status, and number of infections. The results show that PASC is associated with various symptoms and around 10% of participants were PASC positive at 6 months after infection.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2023)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.