Journal
AICHE JOURNAL
Volume 56, Issue 7, Pages 1932-1945Publisher
WILEY
DOI: 10.1002/aic.12104
Keywords
high throughput; protein-resistant surfaces; photo-induced graft polymerization; bovine serum albumin; membrane filtration
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Funding
- U.S. Environmental Protection Agency [RD83090901-0]
- U.S. National Science Foundation [CBET-0730449]
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A novel high throughput Method for synthesis and screening of customized protein-resistant surfaces was developed. This method is an inexpensive, fast, reproducible and scalable approach to synthesize and screen protein-resistance surfaces appropriate for a specific feed. The method is illustrated here by combining a high throughput platform (HTP) approach together with our patented photo-induced graft polymerization (PGP) method developed for facile modification of commercial poly(aryl sulfone) membranes. This new HTP-PGP method was validated by comparison with our previous published results obtained using a bench-scale filtration assay of six well-studied monomers. Optimally-performing surfaces for resisting a model protein, bovine serum albumin (BSA), were identified from a library of 66 monomers. Surfaces were prepared via graft polymerization onto poly(ether sulfone) (PES) membranes and were evaluated using a protein adsorption assay followed by pressure-driven filtration. Bench-scale verification was conducted.,for selected monomers using HTP-PGP method; a good correlation with HTP-PGP results was found. (C) 2009 American Institute of Chemical Engineers AIChE. J, 56: 1932-1945, 2010
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