Review
Gastroenterology & Hepatology
Jer-Wei Wu, Jia-Horng Kao, Tai-Chung Tseng
Summary: HBcrAg, as a marker of HBV replication, is associated with HCC risk in treatment-naive patients, but its value in treated patients needs further validation. The next challenge is to combine HBcrAg with other viral markers to construct a better HCC prediction model.
CLINICAL AND MOLECULAR HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Hui-Chun Li, Chee-Hing Yang, Shih-Yen Lo
Summary: Several dysregulated lncRNAs have been found to play important roles in HBV-related hepatocellular carcinoma, and may serve as biomarkers for early diagnosis and therapeutic targets.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Immunology
Jade Pattyn, Greet Hendrickx, Alex Vorsters, Pierre Van Damme
Summary: The coverage of hepatitis B vaccines is increasing, and the effective implementation of vaccination programs has significantly reduced the morbidity and mortality related to hepatitis B.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Qingqin Hao, Zheng Wang, Qinghui Wang, Bo Chen, Huizhong Qian, Xiao Liu, Hong Cao, Wei Xia, Jian Jiang, Zhonghua Lu
Summary: In patients with OBI, the plasma level of AP000253 decreased significantly, similar expression was observed in liver tissues. Functional experiments suggested that AP000253 could promote HBV transcription and replication in hepatoma cell lines.
Article
Virology
Shahrzad Shoraka, Seyed Reza Mohebbi, Seyed Masoud Hosseini, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali
Summary: The study found that circulating lncRNA-ATB levels were significantly elevated in HBV-related cirrhosis patients compared to healthy controls, while they were significantly decreased in non-cirrhotic CHB patients. Overall, lncRNA-ATB showed good specificity for diagnosing HBV-related cirrhosis and good sensitivity for diagnosing non-cirrhotic CHB patients.
Article
Gastroenterology & Hepatology
Wenshi Wang, Florian A. Lempp, Franziska Schlund, Lisa Walter, Charlotte C. Decker, Zhenfeng Zhang, Yi Ni, Stephan Urban
Summary: Research has shown that HDVs from different genotypes replicate with varying efficacies. Variations in HDV genomes and HBV envelope proteins are major determinants of HDV egress and entry efficacy.
JOURNAL OF HEPATOLOGY
(2021)
Article
Virology
Andreas Laras, Margarita Papatheodoridi, Eleni Panopoulou, George Papatheodoridis, Stephanos J. Hadziyannis, Emilia Hadziyannis
Summary: Serum HBV RNA in HBeAg-negative chronically infected patients primarily consists of pgRNA and a minor fraction of preC mRNA transcripts. Serum pgRNA is associated with disease activity and can serve as a marker for the decision of cessation of therapy.
Article
Immunology
Qingqin Hao, Qinghui Wang, Huizhong Qian, Jian Jiang, Xiao Liu, Wei Xia
Summary: This study found that miR-451a and miR-340-3p were significantly up-regulated in plasma of OBI, ASC, and CHB patients compared to healthy controls. ROC curve analysis showed that both miR-451a and miR-340-3p could moderately distinguish OBI from HCs. Functional experiments demonstrated that overexpression of miR-451a might suppress HBV replication and gene expression by directly targeting ATF2.
MICROBIAL PATHOGENESIS
(2021)
Review
Gastroenterology & Hepatology
Ming-He Zhang, Yu-Feng Yuan, Li-Juan Liu, Yu-Xin Wei, Wan-Yue Yin, Lan-Zhuo-Yin Zheng, Ying-Ying Tang, Zhao Lv, Fan Zhu
Summary: Hepatitis B virus (HBV) infection is a significant risk factor for hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) have potential as biomarkers for early detection and therapy of HBV-associated HCC. This review summarizes the current progress on the role of miRNAs in the diagnosis and treatment of HBV-HCC, discussing the mechanism by which HBV regulates miRNAs and the exact effect of miRNAs on HCC promotion. In the near future, miRNA-based diagnostic, prognostic, and therapeutic applications will be integrated into clinical practice.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Ying Li, Ronghua Li, Da Cheng, Xiaoyu Fu, Lei Fu, Shifang Peng
Summary: High-throughput sequencing technology was used to explore circRNA expression profiles, and circRNA1002 was identified as a potential reliable serum biomarker for HCC, which could improve early detection.
Article
Biophysics
Ru Cheng, Fu Zhu, Min Huang, Qiang Zhang, Hui Hong Yan, Xiao Hui Zhao, Fu Kang Luo, Chun Mei Li, Hui Liu, Gao Lin Liang, Cheng Zhi Huang, Jian Wang
Summary: In this study, a new biosensor named hepatitis virus indicator was developed for the simultaneous detection of HBV and HCV. The biosensor utilized Exo III assisted signal amplification strategy and particle counting technology with a dark-field microscopy, enabling sensitive and selective detection.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Clinical Neurology
Zerui You, Chengyu Wang, Xiaofeng Lan, Weicheng Li, Dewei Shang, Fan Zhang, Yanxiang Ye, Haiyan Liu, Yanling Zhou, Yuping Ning
Summary: This study reveals the metabolic differences between patients with treatment-resistant depression (TRD), first-episode drug-naive major depressive disorder (DN-MDD), and healthy controls (HCs), and identifies potential biomarkers. The analysis of metabolic pathways suggests that changes or imbalances in polyamine metabolism and energy metabolism may be primary altered pathways associated with depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Biochemistry & Molecular Biology
Wei Feng Low, Yun Fong Ngeow, Jack Bee Chook, Kok Keng Tee, Seng-Kai Ong, Suat Cheng Peh, Jan Jin Bong, Rosmawati Mohamed
Summary: Hepatitis B virus (HBV) infection is responsible for 66% of liver deaths worldwide in 2015, with 37% of these deaths attributed to chronic hepatitis B (CHB)-associated hepatocellular carcinoma (HCC). Methylation of HBV DNA, particularly in the covalently closed circular DNA (cccDNA), is more frequently observed in HCC cases compared to CHB and cirrhosis. The methylation of HBV cccDNA affects viral replication and protein expression, and may be associated with disease pathogenesis and HCC development.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2022)
Review
Virology
Alicia Vachon, Carla Osiowy
Summary: Despite the lack of predictive markers for guiding clinical management and allowing treatment cessation with reduced risk of viral reactivation, the development of novel HBV biomarkers is helping to improve the management of individuals with chronic hepatitis B. The utility of these biomarkers in both treatment-naive and treated CHB patients has been widely discussed.
Article
Pharmacology & Pharmacy
Simin Emamzadeh Yazdi, Heino Martin Heyman, Gerhard Prinsloo, Thomas Klimkait, Jacobus Johannes Marion Meyer
Summary: This study identified biomarkers for anti-HIV activity in Helichrysum species using metabolomics, and revealed the differences in chemical composition associated with anti-HIV activity.
FRONTIERS IN PHARMACOLOGY
(2022)