Journal
AGING-US
Volume 2, Issue 8, Pages 519-522Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100181
Keywords
Drosophila; sleep; feeding; obesity; diabetes; metabolism
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Funding
- NIGMS NIH HHS [F32 GM086207-02, F32 GM086207] Funding Source: Medline
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One of the brain's most important functions is the control of homeostatically regulated behaviors. Dysregulation of the neural systems controlling sleep and feeding underlies many chronic illnesses. In a recent study published in Current Biology we showed that flies, like mammals, suppress sleep when starved and identified the genes Clock and cycle as regulators of sleep during starvation. Here we show that starvation specifically disrupts sleep initiation without affecting sleep consolidation. The identification of genes regulating sleep-feeding interactions will provide insight into how the brain integrates and controls the expression of complex behaviors.
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