Review
Biochemistry & Molecular Biology
Hollie Speer, Andrew J. McKune
Summary: Hypertension is a major risk factor for cardiovascular diseases, and studying the factors involved in its progression is crucial for healthy aging. Aging is associated with a loss of skeletal muscle quantity and quality, as well as an increase in Reactive Oxygen and Nitrogen Species, which may accelerate the aging process.
Review
Food Science & Technology
Joseph Festa, Aamir Hussain, Zakia Al-Hareth, Harprit Singh, Mariasole Da Boit
Summary: Anthocyanins, a type of flavonoid polyphenols, have been studied for their potential in improving cardiovascular health and preventing endothelial dysfunction. However, their poor bioavailability raises questions about the role of their metabolites in the observed biological activity. Recent studies have used different models and concentrations to better understand the mechanisms of action of these compounds. The review highlights the need for further research on improving the bioavailability of the metabolites and exploring the effects of metabolites in mixtures.
Article
Endocrinology & Metabolism
Matthew C. Babcock, Lyndsey E. DuBose, Teresa L. Witten, Brian L. Stauffer, Kerry L. Hildreth, Robert S. Schwartz, Wendy M. Kohrt, Kerrie L. Moreau
Summary: Low testosterone in middle-aged/older men is associated with age-associated endothelial dysfunction, potentially due to increased oxidative stress and inflammation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Claudia Rodriguez, Ana Sanchez, Javier Saenz-Medina, Mercedes Munoz, Medardo Hernandez, Miguel Lopez, Luis Rivera, Cristina Contreras, Dolores Prieto
Summary: Obesity-induced dysregulation of AMPK activity is the underlying cause of kidney vascular dysfunction, and activation of AMPK improves metabolic state, protects renal endothelial function, and exerts potent vascular antioxidant and anti-inflammatory effects.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Thi Thuy Uyen Nguyen, Ji-hyun Yeom, Won Kim
Summary: Vitamin E supplementation significantly decreased inflammation and oxidative stress biomarkers in adult patients receiving hemodialysis, suggesting that it may help alleviate endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Gonzalez-Amor, Ana B. Garcia-Redondo, Inmaculada Jorge, Guillermo Zalba, Martina Becares, Maria J. Ruiz-Rodriguez, Cristina Rodriguez, Hugo Bermeo, Raquel Rodrigues-Diez, Francisco J. Rios, Augusto C. Montezano, Jose Martinez-Gonzalez, Jesus Vazquez, Juan Miguel Redondo, Rhian M. Touyz, Susana Guerra, Mercedes Salaices, Ana M. Briones
Summary: The study revealed that ISG15 plays a crucial role in vascular damage associated with hypertension by inducing oxidative stress and inflammation. The expression of ISG15 was positively correlated with high systolic and diastolic blood pressure as well as carotid intima-media thickness, while ISG15 knockout mice showed protection against hypertension and vascular damage.
CARDIOVASCULAR RESEARCH
(2022)
Review
Geriatrics & Gerontology
Yunqiu Jiang, Andriy Yabluchanskiy, Jielin Deng, Faris A. Amil, Sunny S. Po, Tarun W. Dasari
Summary: Aging of the cardiovascular regulatory function leads to an imbalance in the autonomic nervous system, with sympathetic overdrive and unclear changes in vagal nerve activity. Reduced vagus output with age is associated with endothelial dysfunction and inflammation. Assessing autonomic imbalance through heart rate variability and muscle sympathetic nerve activity may predict inflammation.
Article
Biochemistry & Molecular Biology
Rosalba Siracusa, Ramona D'Amico, Marika Cordaro, Alessio Filippo Peritore, Tiziana Genovese, Enrico Gugliandolo, Rosalia Crupi, Daniela Impellizzeri, Salvatore Cuzzocrea, Roberta Fusco, Rosanna Di Paola
Summary: CDDO-Me demonstrated anti-fibrotic, anti-inflammatory, and anti-oxidative effects in the treatment of endometriosis, effectively suppressing the disease by modulating the Nrf2 and NF-κB pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Min Li, Wingyan Yun, Guibin Wang, Anqi Li, Jing Gao, Qingyong He
Summary: The prevention and treatment of cardiovascular diseases (CVDs) have made initial progress, but the number of CVDs patients will rise rapidly in the future. Garlic plays a remarkable role in preventing and treating atherosclerosis (AS), with mechanisms involving lipid-lowering, antioxidant, anti-thrombotic effects, etc. Therefore, the clinical application and mechanistic study of garlic are of great significance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Evan Paul Tracy, William Hughes, Jason E. Beare, Gabrielle Rowe, Andreas Beyer, Amanda Jo LeBlanc
Summary: The vasculature responds to tissue respiratory needs by modulating luminal diameter, but age-related reduction in blood flow contributes to and exacerbates pathological processes. Current research focuses on mechanisms behind aging-mediated vascular dysfunction and therapeutic strategies to restore youthful vascular responsiveness, aiming at symptom management, tissue damage reversal, and prevention of aging-induced vascular damage and dysfunction. Antioxidative therapeutic strategies are being developed to restore mitochondrial redox homeostasis and subsequently vascular function.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Marcelo Queiroz, Adriana Leandro, Lara Azul, Artur Figueirinha, Raquel Seica, Cristina M. Sena
Summary: Luteolin was found to improve endothelial function, vascular oxidative stress, and perivascular adipose tissue in type 2 diabetes mellitus rats, showing therapeutic potential for vascular complications associated with type 2 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Cristina Banfi, Maura Brioschi, Lucia M. Vicentini, Maria Grazia Cattaneo
Summary: The human long pentraxin PTX3 has complex regulatory roles in innate immunity, inflammation, and tissue repair. This study compared the proteomic profiles of human endothelial cells (ECs) and found that PTX3 regulates angiogenesis, oxidative stress, and inflammation. Knockdown of PTX3 resulted in an increase in pro-inflammatory markers and a shift to a more oxidative state in ECs. These findings support the idea of a protective function for PTX3 in endothelial homeostasis and cardiovascular biology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Camila B. Vidigal, Kawane F. Moura, Tiago J. Costa, Lorena Borges, Pedro M. M. Figaro, Ingrid C. Pinto, Fabio G. de Andrade, Daniela C. C. Gerardin, Rubia Casagrande, Rita C. Tostes, Maria do Carmo Franco, Graziela S. Ceravolo
Summary: This study found that treatment with TPM during childhood leads to altered aortic reactivity in adult male and female rats. The mechanism underlying the vascular effects of TPM is sex-specific.
Article
Food Science & Technology
Lamia Remila, Nazende Guenday-Tuereli, Ursula Houngue, Eugenia Belcastro, Christophe Bruckert, Thierry Vandamme, Emre Tuereli, Paul Kerth, Cyril Auger, Valerie Schini-Kerth
Summary: This study found that nanoencapsulation of EPA:DHA 6:1 has a greater beneficial effect on age-related endothelial dysfunction, including improved relaxation and contraction responses, reduced vascular oxidative stress, and normalized expression of the angiotensin system.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Vasily N. Sukhorukov, Alexandra A. Melnichenko, Victoria A. Khotina, Alexander N. Orekhov
Summary: This review discusses the anti-inflammatory, anti-oxidative, and lipid-lowering properties of plant-derived essential oils (EOs) and examines their mechanisms of action. It also explores recent clinical trials investigating the anti-inflammatory and anti-oxidative activities of EOs. Future research on EOs has the potential to discover new bioactive compounds and develop effective agents for the treatment of atherosclerosis and related diseases such as diabetes, metabolic syndrome, and obesity.
Editorial Material
Neurosciences
Md Torikul Islam, Shelby A. Hall, Lisa A. Lesniewski
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Editorial Material
Endocrinology & Metabolism
Md Torikul Islam, William L. Holland, Lisa A. Lesniewski
Summary: Through live-cell imaging, researchers demonstrate that cellular metabolism, determined by glycolysis and ATP, is spontaneously heterogeneous, plastic, and regulatory.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Geriatrics & Gerontology
Daniel W. Trott, Md Torikul Islam, David J. Buckley, Anthony J. Donato, Tavia Dutson, Eric S. Sorensen, Jinjin Cai, Venkateswara R. Gogulamudi, Tam T. T. Phuong, Lisa A. Lesniewski
Summary: The study reveals that aging leads to increased T cell infiltration in eWAT, liver, and skeletal muscle, resulting in greater CD4+ and CD8+ cell numbers and a decreased CD4 to CD8 ratio. In old mice, T cells producing interferon-gamma and tumor necrosis factor-alpha accumulate in eWAT and liver, contributing to metabolic dysfunction associated with age. Anti-CD3 treatment improves glucose tolerance in old mice by enhancing insulin utilization and reducing gluconeogenesis-related gene expression in the liver.
Meeting Abstract
Biochemistry & Molecular Biology
Samuel I. Bloom, Jordan R. Tucker, Yu Liu, Hossein Abdeahad, Daniel R. Machin, Tyler G. Thomas, R. Colton Bramwell, Md Torikul Islam, Lisa A. Lesniewski, Anthony J. Donato
Meeting Abstract
Biochemistry & Molecular Biology
Md Torikul Islam, Shelby A. Hall, Samuel I. Bloom, R. Colton Bramwell, Tavia Dutson, Jordan R. Tucker, John Kim, Daniel R. Machin, Anthony J. Donato, Lisa A. Lesniewski
Article
Physiology
Venkateswara R. Gogulamudi, Daniel R. Machin, Grant D. Henson, Jisok Lim, Richard C. Bramwell, Jessica R. Durrant, Anthony J. Donato, Lisa A. Lesniewski
Summary: Overexpression of Sirt1 can limit the increase in arterial stiffness induced by a Western diet and also protect mice from glucose intolerance caused by a Western diet.
PHYSIOLOGICAL REPORTS
(2022)
Review
Cardiac & Cardiovascular Systems
Samuel Bloom, Md Torikul Islam, Lisa A. Lesniewski, Anthony J. Donato
Summary: This review discusses the consequences of endothelial cell exposure to damaging stimuli and the cellular and molecular mechanisms that induce endothelial cell senescence. It also explores how endothelial cell senescence contributes to arterial dysfunction and clinical cardiovascular diseases and metabolic disorders.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Geriatrics & Gerontology
Samuel Bloom, Jordan R. Tucker, Jisok Lim, Tyler G. Thomas, Gregory J. Stoddard, Lisa A. Lesniewski, Anthony J. Donato
Summary: Aging leads to DNA damage and telomere dysfunction in both endothelial cells and vascular smooth muscle cells; however, the effects are more pronounced in endothelial cells and atheroprone arterial regions.
Article
Cell Biology
Samuel I. Bloom, Yu Liu, Jordan R. Tucker, Md Torikul Islam, Daniel R. Machin, Hossein Abdeahad, Tyler G. Thomas, R. Colton Bramwell, Lisa A. Lesniewski, Anthony J. Donato
Summary: In advanced age, oxidative stress and inflammation increase and impair endothelial function, leading to cardiovascular disease (CVD). Senescent endothelial cells are a possible source of this oxidative stress and inflammation. In this study, reducing the telomere shelterin protein Trf2 in young mice resulted in endothelial cell telomere dysfunction, cellular senescence, increased inflammatory signaling, oxidative stress, and impairments in endothelial function. These findings suggest that age-related telomere dysfunction leads to endothelial cell senescence, contributing to age-related increases in oxidative stress, inflammation, and cardiovascular dysfunction.
Article
Multidisciplinary Sciences
Venkateswara R. Gogulamudi, Md Torikul Islam, Jessica R. Durrant, Adelola O. Adeyemo, Daniel W. Trott, Mi Ho Hyuhn, Weiquan Zhu, Anthony J. Donato, Ashley E. Walker, Lisa A. Lesniewski
Summary: This study investigated the impact of ADP-ribosylation factor 6 (Arf6) on atherosclerosis using ApoE(-/-) mice. The results showed that reducing Arf6 could alleviate the severity and burden of atherosclerotic plaque. The plaque burden in the descending aorta was significantly lower in heterozygous Arf6 mice compared to wildtype mice (p<0.001) after consuming an atherogenic diet for 5 weeks. Similarly, the atheroma area, plaque grade, and other factors were significantly lower in the carotid artery of heterozygous Arf6 mice compared to wildtype mice (all p≤0.04).
Article
Geriatrics & Gerontology
Daniel R. Machin, Daniel W. Trott, Venkateswara R. Gogulamudi, Md. Torikul Islam, Samuel I. Bloom, Hans Vink, Lisa A. Lesniewski, Anthony J. Donato
Summary: Advanced age is associated with arterial dysfunction and a decrease in glycocalyx, which may be linked to reduced synthesis of high molecular weight-hyaluronan (HMW-HA). Manipulation of glycocalyx properties can alter arterial function. The study demonstrates that reducing hyaluronan synthase 2 (Has2) leads to a decrease in glycocalyx thickness and induces arterial dysfunction. However, glycocalyx-targeted therapy can enhance glycocalyx properties and improve arterial function in old mice.
Article
Geriatrics & Gerontology
Venkateswara R. Gogulamudi, Jessica R. Durrant, Adelola O. Adeyemo, Huynh Mi Ho, Ashley E. Walker, Lisa A. Lesniewski
Summary: Using multiple mouse models, the impact of aging on the size and severity of atherosclerotic lesions was explored. It was found that aging is associated with higher levels of total and LDL cholesterol, as well as triglycerides. Aortic plaque burden increased with duration of atherogenic diet in all age groups. The size and severity of aortic root atheromas increased with age, but there was no effect of age on carotid atheromas induced by partial carotid ligation.
Meeting Abstract
Cardiac & Cardiovascular Systems
Eric Tuday, Torikul Islam, Johntaehwan Kim, Lisa A. Lesniewski, Anthony J. Donato
Meeting Abstract
Cardiac & Cardiovascular Systems
Eric Tuday, Torikul Islam, Johntaehwan Kim, Lisa A. Lesniewski, Anthony Donato
Meeting Abstract
Cardiac & Cardiovascular Systems
Torikul Islam, Shelby A. Hall, Samuel I. Bloom, R. Colton C. Bramwell, Tavia Dutson, Jordan R. Tucker, John Kim, Daniel R. Machin, Anthony J. Donato, Lisa A. Lesniewski
