Daumone fed late in life improves survival and reduces hepatic inflammation and fibrosis in mice

The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

(2014) Sarah J. Mitchell et al.   Cell Reports

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Fractalkine and its receptor mediate extracellular matrix accumulation in diabetic nephropathy in mice

(2013) K. H. Song et al.   DIABETOLOGIA

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Safranal ameliorates antioxidant enzymes and suppresses lipid peroxidation and nitric oxide formation in aged male rat liver

(2012) Seyed Kazem Farahmand et al.   BIOGERONTOLOGY

Resveratrol Attenuates Obesity-Associated Peripheral and Central Inflammation and Improves Memory Deficit in Mice Fed a High-Fat Diet

(2012) B. T. Jeon et al.   DIABETES

Hepatic activation of IKK/NFκB signaling induces liver fibrosis via macrophage-mediated chronic inflammation

(2012) Yoshiaki Sunami et al.   HEPATOLOGY

Determination of daumone in mouse plasma by HPLC/MS-MS

(2011) Keumhan Noh et al.   BIOMEDICAL CHROMATOGRAPHY

A mouse model of accelerated liver aging caused by a defect in DNA repair

(2011) Siobhán Q. Gregg et al.   HEPATOLOGY

Molecular Inflammation as an Underlying Mechanism of the Aging Process and Age-related Diseases

(2011) H.Y. Chung et al.   JOURNAL OF DENTAL RESEARCH

Quantitative determination of daumone in rat plasma by liquid chromatography–mass spectrometry

(2011) Keumhan Noh et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Exendin-4 Improves Blood Glucose Control in Both Young and Aging Normal Non-Diabetic Mice, Possible Contribution of Beta Cell Independent Effects

(2011) Rongrong Fan et al.   PLoS One

SRT1720 improves survival and healthspan of obese mice

(2011) Robin K. Minor et al.   Scientific Reports

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

(2010) V. P. Houde et al.   DIABETES

Restriction of calorie and iron intake results in reduction of visceral fat and serum alanine aminotransferase and ferritin levels in patients with chronic liver disease

(2010) Motoh Iwasa et al.   HEPATOLOGY RESEARCH

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

p66Shc has a pivotal function in impaired liver regeneration in aged mice by a redox-dependent mechanism

(2010) Sanae Haga et al.   LABORATORY INVESTIGATION

TheFat-1Transgene in Mice Increases Antioxidant Potential, Reduces Pro-Inflammatory Cytokine Levels, and Enhances PPARγ and SIRT-1 Expression on a Calorie Restricted Diet

(2010) Md Mizanur Rahman et al.   Oxidative Medicine and Cellular Longevity

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Molecular Time-Course and the Metabolic Basis of Entry into Dauer in Caenorhabditis elegans

(2009) Pan-Young Jeong et al.   PLoS One

Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A

(2008) Kate Petersen Shay et al.   BIOGERONTOLOGY

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

(2008) Jérôme N. Feige et al.   Cell Metabolism