Article
Geriatrics & Gerontology
Mary E. Winger, Paolo Caserotti, Jane A. Cauley, Robert M. Boudreau, Sara R. Piva, Peggy M. Cawthon, Eric S. Orwoll, Kristine E. Ensrud, Deborah M. Kado, Elsa S. Strotmeyer
Summary: This study investigated the application of lower-extremity power and upper-extremity strength in fall injuries and found that lower leg power and grip strength predicted future fall injury risk in older men, independent of physical performance.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Maria Amasene, Ariadna Besga, Maria Medrano, Miriam Urquiza, Ana Rodriguez-Larrad, Ignacio Tobalina, Julia Barroso, Jon Irazusta, Idoia Labayen
Summary: The study reveals that over half of hospitalized older adults are at risk of malnutrition or malnourished, and the majority of older inpatients have poor physical performance. Handgrip strength and SPPB are recommended as alternative measures of muscle mass for malnutrition management in this population.
CLINICAL NUTRITION
(2021)
Article
Geriatrics & Gerontology
Jesse Zanker, David Scott, Dima Alajlouni, Ben Kirk, Stefanie Bird, Danielle DeBruin, Sara Vogrin, Dana Bliuc, Thach Tran, Peggy Cawthon, Gustavo Duque, Jacqueline R. Center
Summary: This study investigated which baseline measures best predict incident mortality and falls, and prevalent slow walking speed in older women and men. The results showed that age and walking speed adjusted for height were the most important predictors for mortality in women, while quadriceps strength (with adjustments) was the most important predictor for mortality in men. For predicting falls and prevalent slow walking speed, physical performance measures such as sit to stand (STS) test and timed up and go (TUG) test were the most important indicators.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Geriatrics & Gerontology
Vanessa Koh, David B. Matchar, Angelique Chan
Summary: This study aimed to investigate the mediating effects of poor physical strength and depression on the association between pain and recurrent and/or injurious falls in older adults. The results showed that pain significantly influenced recurrent and injurious falls, and poor physical strength and depression played a significant mediating role in this association.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Geriatrics & Gerontology
Reshma Aziz Merchant, Yiong Huak Chan, Natalie Ling, A. Denishkrshna, Zhiying Lim, Debra Waters
Summary: This study aimed to determine the demographics, physical function, and body composition in pre-frail older adults with poor physical performance, as well as the characteristics of fallers among them and the association between physical function and body composition measures with falls. The results showed that longer chair-stand time, lower balance, low muscle quality, and high fat mass were associated with falls in poor performers.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Geriatrics & Gerontology
Theng Choon Ooi, Devinder Kaur Ajit Singh, Suzana Shahar, Nor Fadilah Rajab, Divya Vanoh, Razinah Sharif, Maw Pin Tan
Summary: The study found that the incidence rate of falls among community-dwelling older Malaysians was 17.53%, with 27.51% experiencing two or more falls. Factors such as being female, single, having a history of falls, higher depression scale scores, lower hemoglobin levels, and lower chair stand test scores were independent predictors of occasional falls. While factors such as history of falls, being a stroke survivor, higher body fat percentage, and lower chair stand test scores were predictors of recurrent falls.
Article
Engineering, Industrial
Erika M. Pliner, Daina L. Sturnieks, Kurt E. Beschorner, Mark S. Redfern, Stephen R. Lord
Summary: This study identified key factors for safe and effective ladder use among older adults, including upper limb control, cognitive function, and psychological status. These findings can help identify individuals with greater ladder use ability and lower fall risk.
Review
Endocrinology & Metabolism
Dima A. Alajlouni, Dana Bliuc, Thach S. Tran, Robert D. Blank, Jacqueline R. Center
Summary: Osteoporotic fractures are a significant health problem in older people, leading to premature mortality, reduced quality of life, subsequent fractures, and increased costs. Current fracture risk assessment tools incorporating clinical risk factors show suboptimal predictive power, indicating a need for improvement. Muscle strength and physical performance have been associated with fracture risk, while muscle mass alone may not be a good predictor. Functional assessment focusing on muscle strength and performance may improve fracture prediction accuracy.
Article
Neurosciences
Ebrahim Bani Hassan, Steven Phu, Sara Vogrin, Gustavo Duque
Summary: This study aimed to investigate the relationship between muscle mass and strength and balance indices and fall risk in older persons. The results showed that appendicular and mid-thigh muscle mass and strength were associated with better dynamic balance, while the association with static balance was inconsistent.
Article
Geriatrics & Gerontology
Kevin A. Kerber, Ran Bi, Lesli E. Skolarus, James F. Burke
Summary: This study aimed to characterize trajectories in physical performance over time and determine if these trajectories could improve fall prediction. The results showed that the trajectory of physical performance did not meaningfully improve fall prediction from a baseline physical performance assessment.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Editorial Material
Geriatrics & Gerontology
Jacqueline C. T. Close, Stephen R. Lord
Summary: In the past 50 years, there has been a shift from accepting falls as an inevitable consequence of aging to recognizing the importance of fall prevention. Various studies have identified factors contributing to falls and methods of assessing fall risk. Effective approaches to preventing falls in older individuals include exercise and other targeted interventions. Multiple and multifactorial interventions have been found to be particularly effective for high-risk populations.
Article
Public, Environmental & Occupational Health
Tamires TerezinhaGallo da Silva, Jarbas Melo Filho, Simone Biesek, Audrin Said Vojciechowski, Victoria Zeghbi Cochenski Borba, Anna Raquel Silveira Gomes
Summary: This study analyzed and compared musculoskeletal and functional performance in community-dwelling pre-frail older women, and presented cutoff points to differentiate individuals with different fall histories. Recurrent fallers showed poorer performance in gait speed, step length, and muscle strength, which can be used to identify fall risk. These findings are important for guiding interventions and preventing falls and fractures.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Zhiming Lu, Pengpeng Ye, Yuan Wang, Leilei Duan, Yuliang Er
Summary: This study identified the epidemiological characteristics of falls among older people in China in 2018, including peak time, common sites, activities and types of injuries. Data from NISS can be used as an additional source for research and prioritizing control and prevention of falls.
Article
Medicine, General & Internal
Sergi Rodriguez-Rodriguez, Esther Jovell-Fernandez, Leonor Cuadra-Llopart, Jacobo Rodriguez-Sanz, Noe Labata-Lezaun, Carlos Lopez-de-Celis, Joan Bosch, Albert Perez-Bellmunt
Summary: With the increasing number of older adults and their declining motor and cognitive function, finding alternative methods for assessing physical functionality is crucial. This study evaluated the relationship between functional tests and upper limb muscle power, finding a strong correlation between them. Therefore, evaluating upper limb muscle power could be an interesting tool for assessing physical performance in bedridden older adults.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Linda M. Hengeveld, Stephanie Chevalier, Marjolein Visser, Pierrette Gaudreau, Nancy Presse
Summary: The study found that higher daily protein intake was associated with better knee extensor strength and physical performance in older men and women, especially with protein doses of 30-50g per meal. Different aspects of protein intake may contribute to muscle strength and physical performance, not just the daily quantity.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Quin E. Denfeld, Jonathan Q. Purnell, Christopher S. Lee, Eric S. Orwoll, S. Albert Camacho, Shirin O. Hiatt, Mary Roberts Davis, Kerri Winters-Stone, William R. Woodward, Beth A. Habecker
Summary: This study aimed to identify candidate biomarkers associated with physical frailty in heart failure (HF) using a multimarker strategy. The results showed that adiponectin, IGF-1, and myostatin were significantly associated with physical frailty in HF.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Genetics & Heredity
Yiheng Chen, Tianyuan Lu, Ulrika Pettersson-Kymmer, Isobel D. Stewart, Guillaume Butler-Laporte, Tomoko Nakanishi, Agustin Cerani, Kevin Y. H. Liang, Satoshi Yoshiji, Julian Daniel Sunday Willett, Chen-Yang Su, Parminder Raina, Celia M. T. Greenwood, Yossi Farjoun, Vincenzo Forgetta, Claudia Langenberg, Sirui Zhou, Claes Ohlsson, J. Brent Richards
Summary: Through genome-wide association studies, this study identified associations between 690 metabolites and 248 loci, as well as associations between 143 metabolite ratios and 69 loci. The integration of metabolite-gene and gene expression information revealed 94 effector genes for 109 metabolites and 48 metabolite ratios. The use of Mendelian randomization identified 22 metabolites and 20 metabolite ratios with estimated causal effects on 12 traits and diseases.
Article
Endocrinology & Metabolism
John A. A. Kanis, Helena Johansson, Nicholas C. C. Harvey, Mattias Lorentzon, Enwu Liu, Liesbeth Vandenput, Suzanne Morin, William D. D. Leslie, Eugene V. V. McCloskey
Summary: This study confirms the association between a greater propensity to falling and higher fracture risk, and provides adjustments to FRAX-based fracture probabilities accounting for the number of prior falls.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
John A. Kanis, Nicholas C. Harvey, Enwu Liu, Liesbeth Vandenput, Mattias Lorentzon, Eugene McCloskey, Roger Bouillon, Bo Abrahamsen, Lars Rejnmark, Helena Johansson
Summary: Patients with primary hyperparathyroidism have increased incidence of hip and major osteoporotic fractures, even if not referred for parathyroidectomy. The risk of death is also increased, which affects fracture probability. These findings support the need to widen the indications for parathyroidectomy in mild primary hyperparathyroidism.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Orthopedics
Henrik Damm, Anette Jonsson, Bjorn E. Rosengren, Lars Jehpsson, Claes Ohlsson, Eva Ribom, Dan Mellstrom, Magnus K. Karlsson
Summary: The purpose of this study was to determine the prevalence and morbidity of neck pain, cervical rhizopathy, upper extremity motor deficit, and/or thoracolumbar pain in elderly men. A cross-sectional questionnaire study of 3,000 community-dwelling older men was conducted, and the results showed that 29% of the participants reported experiencing neck pain and 54% reported thoracolumbar pain. Among those with neck pain, 13% had severe morbidity for those with only neck pain, while 46% had severe morbidity for those with neck pain, rhizopathy, and motor deficit.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Medicine, General & Internal
Kristian F. Axelsson, Henrik Litsne, Konstantina Kousoula, Stefan Franzen, Bjoern Eliasson, Mattias Lorentzon
Summary: This study aimed to determine whether patients with type 2 diabetes mellitus (T2DM) have an increased risk of fracture and to identify T2DM-related risk factors. The findings showed that the overall risk of fracture was only slightly increased for T2DM patients compared to controls, but for patients with specific risk factors, such as low BMI, long T2DM duration, insulin treatment, and/or low physical activity, the risk increase was more substantial and clinically relevant.
Article
Geriatrics & Gerontology
Leo D. Westbury, Charlotte Beaudart, Olivier Bruyere, Jane A. Cauley, Peggy Cawthon, Alfonso J. Cruz-Jentoft, Elizabeth M. Curtis, Kristine Ensrud, Roger A. Fielding, Helena Johansson, John A. Kanis, Magnus K. Karlsson, Nancy E. Lane, Laetitia Lengele, Mattias Lorentzon, Eugene McCloskey, Dan Mellstrom, Anne B. Newman, Claes Ohlsson, Eric Orwoll, Jean-Yves Reginster, Eva Ribom, Bjorn E. Rosengren, John T. Schousboe, Eric J. Shiroma, Nicholas C. Harvey, Elaine M. Dennison, Cyrus Cooper
Summary: The performance of recent sarcopenia definitions in terms of thresholds employed, concordance in individuals, and prediction of important health-related outcomes such as death is limited. This study addressed these limitations in a large multinational cohort study.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Endocrinology & Metabolism
Kristian F. Axelsson, Henrik Litsne, Mattias Lorentzon
Summary: There is limited evidence on which fracture types carry the highest risk for subsequent fractures. Recent fractures, including major osteoporotic fractures and non-major osteoporotic fractures, as well as older fractures, increase the risk of subsequent fracture. Therefore, it is recommended to include all recent fractures in fracture liaison services and consider case-finding strategies for those with older fractures to prevent further fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Raju Jaiswal, Michail Zoulakis, Kristian F. Axelsson, Anna Darelid, Robert Rudang, Daniel Sundh, Henrik Litsne, Lisa Johansson, Mattias Lorentzon
Summary: This prospective cohort study aimed to evaluate the association between the bone material strength index (BMSi) and the risk of incident fracture in older women. The study found that increasing BMSi was associated with a greater risk of fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
William D. Leslie, Neil Binkley, Eugene V. McCloskey, Helena Johansson, Nicholas C. Harvey, Mattias Lorentzon, John A. Kanis, Didier Hans
Summary: The study found that TBS can be used to predict fracture risk independently of FRAX. Adding TBS to the FRAX calculation can adjust for femoral neck BMD and improve fracture risk prediction, even without measuring hip DXA.
JOURNAL OF CLINICAL DENSITOMETRY
(2023)
Article
Endocrinology & Metabolism
Louise Grahnemo, Anna L. Eriksson, Maria Nethander, Robert Johansson, Mattias Lorentzon, Dan Mellstroem, Ulrika Pettersson-Kymmer, Claes Ohlsson
Summary: This study found a robust association between circulating valine and hip fractures, which was confirmed in a replication study. Further analysis showed that high circulating valine levels were associated with increased cortical bone area and trabecular thickness. Therefore, circulating valine may be an important marker for predicting hip fractures.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Lina Lilja, Maria Bygdell, Jari Martikainen, Annika Rosengren, Jenny M. Kindblom, Claes Ohlsson
Summary: The study found that high BMI during childhood and puberty is associated with an increased risk of venous and arterial thromboembolic events in adult men. Young adult overweight is a strong determinant, while childhood overweight is a moderate determinant, of VTE in adult life.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Kristian F. Axelsson, Henrik Litsne, Mattias Lorentzon
Summary: This retrospective cohort study investigated the risk of fracture and injurious falls in immobilized adults who used wheelchairs compared with matched ambulatory controls. The results showed that wheelchair users had a lower risk of any fracture, major osteoporotic fracture, and hip fracture compared with the controls, while the risk of fall injury was also lower. However, wheelchair users had a significantly increased risk of death.
Letter
Endocrinology & Metabolism
Raju Jaiswal, Michail Zoulakis, Kristian F. Axelsson, Daniel Sundh, Henrik Litsne, Lisa Johansson, Mattias Lorentzon
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
