Review
Chemistry, Medicinal
Carlo Maria Bellanca, Egle Augello, Anna Flavia Cantone, Rosaria Di Mauro, Giuseppe Antonino Attaguile, Vincenza Di Giovanni, Guido Attilio Condorelli, Giulia Di Benedetto, Giuseppina Cantarella, Renato Bernardini
Summary: ADR has a significant impact on morbidity and mortality, particularly among older adults. Preventive measures such as accurate prescriptions and appropriate medication management, as well as digital health interventions, offer valuable solutions to alleviate the burden of ADRs.
Article
Multidisciplinary Sciences
Mitsuaki Yagi, Yuichiro Shindo, Yoshikazu Mutoh, Masahiro Sano, Toshihiro Sakakibara, Hironori Kobayashi, Akinobu Matsuura, Ryo Emoto, Shigeyuki Matsui, Taku Nakagawa, Kenji Ogawa
Summary: This study aimed to identify risk factors for adverse drug reactions (ADRs) or death and assess the association between antituberculosis drug dosage and outcomes in very elderly patients with pulmonary tuberculosis. The results showed that low serum albumin levels, respiratory failure, and dependent activities of daily living were independent risk factors for ADRs or death. However, a low dosage of rifampicin was associated with a lower risk of adverse outcomes. Therefore, careful monitoring and consideration of dosage reduction may be necessary for very elderly tuberculosis patients.
SCIENTIFIC REPORTS
(2023)
Review
Biochemical Research Methods
Duc Anh Nguyen, Canh Hao Nguyen, Hiroshi Mamitsuka
Summary: This paper provides an overview of ADR studies, focusing on data sources, three main tasks, machine learning methods, and performance comparisons for drug-ADR prediction. The study highlights the importance of utilizing machine learning approaches in analyzing and predicting ADRs, while also acknowledging ongoing challenges and open problems in this field.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Pharmacology & Pharmacy
Shuang Zhou, Boying Jia, Jiahe Kong, Xiaolin Zhang, Lili Lei, Zhenhui Tao, Lingyue Ma, Qian Xiang, Ying Zhou, Yimin Cui
Summary: This study aimed to analyze the risk signals of drug-induced falls in older patients and provide evidence for drug safety. The results showed that many drugs were closely associated with a high risk of falls in older patients. Drugs are an important and preventable factor for fall control, and the risk level of drug-induced falls should be considered to optimize drug therapy in clinical practice.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ramon Cacabelos, Vinogran Naidoo, Lola Corzo, Natalia Cacabelos, Juan C. Carril
Summary: Pharmacogenomics plays a crucial role in optimizing drug efficacy and safety in preventing adverse drug reactions, but its application in ADR prevention is hindered by limitations such as lack of education and training, unspecific biomarkers, cost-effectiveness issues, administrative challenges, and insufficient regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Laila Carolina Abu Esba, Ghada Al Mardawi, Mohammed AlJasser, Badr Aljohani, Amjed Abu Alburak
Summary: This study analyzed ADR reports in a large healthcare institution in the Middle East, finding that immune system disorders were the most commonly reported ADR, with a small portion being deemed avoidable. Despite an increase in ADR reporting over the years at the institution, there remains a lack of reporting by physicians.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2021)
Article
Medicine, General & Internal
Snezana Mugosa, Ivan Radosavljevic, Majda Sahman, Natasa Djordjevic, Zoran Todorovic
Summary: This study investigated the influence of various factors on clopidogrel adverse drug reactions (ADRs) in cardiology patients. The study found that CYP2C19 gene polymorphisms, co-medication, and gastrointestinal comorbidity are important factors contributing to clopidogrel ADRs.
Article
Chemistry, Medicinal
Anne T. M. Dittrich, Nori J. L. Smeets, Emma F. M. de Jong, Juliet L. Kamink, Yvet Kroeze, Jos M. Th Draaisma, Eugene P. van Puijenbroek, D. Maroeska W. M. te Loo
Summary: Knowledge about adverse drug reactions (ADRs) is crucial for drug safety in pediatric patients, but underreporting of ADRs is a serious problem. This study aimed to increase the quantity of ADR reporting while maintaining or improving the quality. By educating healthcare providers and introducing an active supporting system, the quantity of ADR reports significantly increased without compromising the quality. This study suggests that an active reporting system has the potential to enhance our knowledge about ADRs in pediatric patients.
Article
Pharmacology & Pharmacy
Caitriona Cahir, Carmel Curran, Caroline Walsh, Anne Hickey, Ross Brannigan, Ciara Kirke, David J. Williams, Kathleen Bennett
Summary: The study aimed to determine the prevalence and characteristics of ADR-related hospital admissions among older patients in Ireland and identify associated risk factors. The results showed that 10% of hospital admissions were ADR-related, with approximately 70% being potentially avoidable.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Yan-zhong Han, Yu-ming Guo, Peng Xiong, Fei-lin Ge, Jing Jing, Ming Niu, Xu Zhao, Zhao-fang Bai, Hai-bo Song, Xiao-he Xiao, Jia-bo Wang
Summary: This study found that the aging population is more susceptible to liver-related ADRs, with the relative risk increasing exponentially with age. It is important to address risk management for older adults when using drugs with a high correlation to the risk of ADRs.
FRONTIERS IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Solene Marie, Kayla L. Frost, Raymond K. Hau, Lucy Martinez-Guerrero, Jailyn M. Izu, Cassandra M. Myers, Stephen H. Wright, Nathan J. Cherrington
Summary: The liver plays a crucial role in the pharmacokinetics of drugs, but NASH can disrupt the absorption, distribution, metabolism, and excretion processes, leading to potential adverse drug reactions. This study identified 71 drugs with reported ADRs in liver disease patients, including 54 substrates of transporters and enzymes. Additionally, NASH-specific alterations to ADME processes were used to identify another list of 71 drugs at risk. These findings can help clinicians select appropriate drugs for NASH patients.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Infectious Diseases
Ursula Wolf, Henning Baust, Ruediger Neef, Thomas Steinke
Summary: This article highlights the importance of adverse drug reactions (ADRs) and drug-drug interactions (DDIs) in antimicrobial therapy, particularly for vulnerable patients. The study, based on over 52,000 medication analyses, emphasizes the need to prevent ADRs and DDIs and provides detailed practical guidance.
Article
Dermatology
Natthiya Pholmoo, Supitchaya Thaiwat, Jettanong Klaewsongkram
Summary: Vitamin D deficiency is associated with allergic diseases and dermatological disorders. Patients with severe vitamin D deficiency have an increased risk of drug-induced non-immediate hypersensitivity reactions and in-hospital mortality.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Susmitha Shankar, Ishita Bhandari, David T. Okou, Gowri Srinivasa, Prashanth Athri
Summary: The study developed an artificial neural network model using drug combination data to predict adverse drug reactions, achieving an average prediction accuracy of 82% through cross-validation.
CHEMICAL BIOLOGY & DRUG DESIGN
(2021)
Article
Pediatrics
Vaibhav Pandey, Preeti Tiwari, Mohammed Imran, Akash Mishra, Deepak Kumar, S. P. Sharma
Summary: This study assessed the adverse effects of propranolol therapy in infantile hemangioma, finding that children with lower body weight were at higher risk for adverse effects.
Editorial Material
Geriatrics & Gerontology
Denis O'Mahony, Marie N. O'Connor
Article
Medicine, General & Internal
Daniel James Ryan, Niamh Annmarie O'Regan, Ronan O. Caoimh, Josie Clare, Marie O'Connor, Maeve Leonard, John McFarland, Sheila Tighe, Kathleen O'Sullivan, Paula T. Trzepacz, David Meagher, Suzanne Timmons
Review
Geriatrics & Gerontology
Marie N. O'Connor, Paul Gallagher, Denis O'Mahony