Article
Clinical Neurology
Aoibhin Clarke, Catriona Reddin, Robert Murphy, Martin J. O'Donnell
Summary: The study aimed to determine whether prior use of antiplatelet therapy affects the effectiveness of dual antiplatelet therapy in patients with acute minor ischaemic stroke or transient ischaemic attack. The results showed that there was no significant difference in the effectiveness of dual antiplatelet therapy between patients with and without prior aspirin therapy.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Editorial Material
Geriatrics & Gerontology
Ekow A. Mensah, Jane A. H. Masoli, Chakravarthi Rajkumar
Summary: With the ageing population increasing, the burden of cardiovascular disease is rising. Age and Ageing have compiled collections of their key cardiovascular themed papers, focusing on blood pressure, coronary heart disease, and heart failure. This commentary summarizes studies published in Age and Ageing that highlight the importance of a multidisciplinary, person-centered approach to care, conscientious identification and management of risk factors, and prevention strategies to ultimately reduce the burden of stroke care on healthcare financing.
Review
Medicine, General & Internal
Kailash Krishnan, Zhe Kang Law, Jatinder S. Minhas, Philip M. Bath, Thompson G. Robinson, Nikola Sprigg, Akash Mavilakandy, Timothy J. England, David Eveson, Amit Mistri, Jesse Dawson, Jason P. Appleton
Summary: Acute stroke is a leading cause of disability and mortality, necessitating urgent evaluation and treatment. This review examines four antiplatelet treatments for non-cardioembolic stroke prevention and highlights gaps in the evidence for potential future trials.
Article
Medicine, General & Internal
Ke-Hang Xie, Ling-Ling Liu, Yun-Ru Liang, Chu-Yin Su, Hua Li, Run-Ni Liu, Qing-Qing Chen, Jia-Sheng He, Yong-Kun Ruan, Wang-Kai He
Summary: The study found that red blood cell distribution width (RDW) can predict subsequent stroke in patients with transient ischaemic attack (TIA). The RDW values of patients with ischaemic stroke (IS) and haemorrhagic stroke (HS) after TIA were significantly higher than patients with TIA. RDW was independently associated with stroke, especially ischaemic stroke, after TIA.
ANNALS OF MEDICINE
(2022)
Article
Clinical Neurology
Jiahuan Guo, Jiaokun Jia, Jia Zhang, Xinmin Liu, Guangshuo Li, Xingquan Zhao, Yanfang Liu
Summary: The stress hyperglycaemia ratio (SHR) is associated with the severity and adverse outcomes of ischaemic stroke in young adults. Higher SHR values are linked to more severe stroke and poor functional outcomes at 90-day follow-up, especially in non-diabetic patients. This study suggests that SHR may be an important marker for assessing the prognosis of ischaemic stroke in young adults.
CEREBROVASCULAR DISEASES
(2023)
Article
Clinical Neurology
Lucio D'Anna, Maddison Brown, Sikdar Oishi, Natalya Ellis, Zoe Brown, Paul Bentley, Brian Drumm, Omid Halse, Sohaa Jamil, Harri Jenkins, Abid Malik, Dheeraj Kalladka, Marius Venter, Joseph Kwan, Soma Banerjee
Summary: The national lockdown in the UK during the COVID-19 pandemic led to a significant decrease in acute stroke admissions and TIA evaluations, as well as delays in treatment and reduced proportion of patients receiving reperfusion therapy. Further research is needed to assess the long-term impact on stroke care.
FRONTIERS IN NEUROLOGY
(2021)
Article
Rehabilitation
Jenni Andersson, Britt-Marie Stalnacke, Ann Sorlin, Gustaf Magaard, Xiaolei Hu
Summary: The study found that most disabilities after transient ischaemic attack involved emotion, strength, and participation domains, with women and elderly subjects reporting more disabilities. Activities of daily living/instrumental activities of daily living, participation, and overall recovery showed significant, although low-to-moderate, associations with other SIS domains.
JOURNAL OF REHABILITATION MEDICINE
(2021)
Article
Medicine, General & Internal
Zhihao Lei, Shuanglin Li, Hongye Feng, Yupeng Lai, Yanxia Zhou, Chao Li, Lijie Ren
Summary: This study aimed to develop and validate a prognostic nomogram for patients with minor stroke and TIA, which demonstrated favorable predictive accuracy. The nomogram has the potential to impact clinical decision-making.
POSTGRADUATE MEDICAL JOURNAL
(2021)
Review
Health Care Sciences & Services
Sean R. O'Connor, Frank Kee, David R. Thompson, Margaret E. Cupples, Michael Donnelly, Neil Heron
Summary: This study evaluated the quality of apps for supporting lifestyle change following a TIA or 'minor' stroke, finding that only a small number of apps met the criteria and that overall quality was low. Further development and testing of accessible, user-designed, and evidence-informed digital interventions are needed for this population.
Article
Cardiac & Cardiovascular Systems
Naja Emborg Vinding, Jawad H. Butt, Marie Dam Lauridsen, Soren Lund Kristensen, Soren Paaske Johnsen, Johanna Kroll, Peter L. Graversen, Christina Kruuse, Christian Torp-Pedersen, Lars Kober, Emil L. Fosbol
Summary: The incidence of ischemic stroke after a first-time transient ischemic attack (TIA) is 6.1% during a 5-year follow-up period, which is higher than the background population but lower than patients with recurrent ischemic stroke. TIA patients also have a higher mortality rate.
Article
Medicine, General & Internal
Yu-Yuan Xu, Wei-Qi Chen, Meng-Xing Wang, Yue-Song Pan, Zi-Xiao Li, Li-Ping Liu, Xing-Quan Zhao, Yi-Long Wang, Hao Li, Yong-Jun Wang, Xia Meng
Summary: This study aimed to assess the management of LDL-C and goal achievement in patients with ischemic stroke or TIA, as well as the association between baseline LDL-C level, LLT, and stroke recurrence. A post hoc analysis of the CNSR-III showed a mild increase in LDL-C goal achievement rate among stroke and TIA patients in mainland China. Lower baseline LDL-C level was significantly associated with a decreased short- and long-term risk of ischemic stroke.
Article
Clinical Neurology
Huihui Liu, Mengxing Wang, Xianglong Xiang, Yuesong Pan, Jiejie Li, Xia Meng, Hao Li, Zixiao Li, Jing Jing, Yongjun Wang
Summary: This study found that persistent high residual inflammatory risk (RIR) increased the risks of stroke recurrence, composite vascular events, mortality, and poor functional outcome in patients with acute ischemic stroke or transient ischemic attack.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ava L. Liberman, Hui Zhang, Sara K. Rostanski, Natalie T. Cheng, Charles C. Esenwa, Neil Haranhalli, Puneet Singh, Daniel L. Labovitz, Richard B. Lipton, Shyam Prabhakaran
Summary: Recent studies suggest that obtaining advanced neuroimaging in low-risk patients with transient or minor neurological symptoms is more cost-effective compared to standard care in the emergency department. Despite the slightly lower effectiveness of the advanced neuroimaging strategy, it is cheaper than the standard care strategy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Clinical Neurology
Andrew Micieli, Nishita Singh, Beate Jahn, Uwe Siebert, Bijoy K. Menon, Andrew M. Demchuk
Summary: The CHANCE-2 study compared different antiplatelet regimens for CYP2C19 loss-of-function allele carriers following a TIA/minor stroke and found that aspirin-ticagrelor can lower the risk of stroke recurrence but at the cost of increased bleeding. In the Canadian healthcare context, testing for CYP2C19 loss-of-function allele and using aspirin-ticagrelor may be a highly cost-effective strategy.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Cardiac & Cardiovascular Systems
Christian Boehme, Lena Domig, Silvia Komarek, Thomas Toell, Lukas Mayer, Benjamin Dejakum, Stefan Krebs, Raimund Pechlaner, Alexandra Bernegger, Christoph Mueller, Gerhard Rumpold, Andrea Griesmacher, Marion Vigl, Gudrun Schoenherr, Christoph Schmidauer, Julia Ferrari, Wilfried Lang, Michael Knoflach, Stefan Kiechl
Summary: This study aims to conduct a long-term follow-up of patients with ischaemic stroke or transient ischaemic attack to investigate whether the STROKE-CARD care program can prevent recurrent cardiovascular events and improve quality of life in the long run.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Neurosciences
Isabelle Jeffares, Niamh A. Merriman, Frank Doyle, Frances Horgan, Anne Hickey
Summary: This qualitative study explores the potential of cognitive rehabilitation for post-stroke cognitive impairment (PSCI) from the perspective of Irish stroke rehabilitation professionals. The study identifies barriers and facilitators to the delivery of cognitive rehabilitation, highlighting the under-resourcing of staffing and stroke-specific cognitive rehabilitation expertise in Ireland. The findings emphasize the urgent need for investment in specialist rehabilitation teams to deliver cognitive rehabilitation in the community setting.
NEUROPSYCHOLOGICAL REHABILITATION
(2023)
Editorial Material
Geriatrics & Gerontology
Desmond O'Neill
Summary: Close collaboration between patient advocacy groups and specialist societies is important for advancing policy and service improvements in medical specialties. Geriatricians need to promote themselves as guardians of the longevity dividend and engage more with older people and society.
Article
Neuroimaging
Rosalie McDonough, Johanna M. Ospel, Charles B. L. M. Majoie, Jeffrey L. Saver, Philip White, Diederik W. J. Dippel, Scott B. Brown, Andrew M. Demchuk, Tudor G. Jovin, Peter J. Mitchell, Serge Bracard, Bruce C. Campbell, Keith W. Muir, Michael D. Hill, Francis Guillemin, Mayank Goyal
Summary: This study examined the effect of pre-stroke functional levels on the outcome of endovascular therapy. The results showed that patients with mild pre-existing disability/symptoms had worse outcomes compared to those without disability. However, within the subgroup of patients with mild disability/symptoms, endovascular therapy still had a significant benefit.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Geriatrics & Gerontology
Adam H. Dyer, Claire Noonan, Matt McElheron, Isabella Batten, Conor Reddy, Emma Connolly, Rachel Pierpoint, Caroline Murray, Ann Leonard, Catriona Higgins, Phyllis Reilly, Gerard Boran, Thomas Phelan, William McCormack, Desmond O'Neill, Aoife Fallon, Gareth Brady, Cliona O'Farrelly, Nollaig M. Bourke, Sean P. Kennelly
Summary: In older nursing home residents, the history of SARS-CoV-2 infection is the strongest predictor of antibody titers at 6 months, while age and frailty are associated with lower titers. Antibody titers are significantly correlated with in vitro neutralization capacity.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Geriatrics & Gerontology
Adam H. Dyer, Aoife Fallon, Claire Noonan, Helena Dolphin, Cliona O'Farrelly, Nollaig M. Bourke, Desmond O'Neill, Sean P. Kennelly
Summary: Older adults in nursing homes are at the highest risk of morbidity and mortality from SARS-CoV-2 infection. Infection prevention and control measures, as well as the use of personal protective equipment, have significantly reduced infections and deaths in nursing homes. Factors such as community transmission levels, nursing home size and quality, for-profit status, and sociodemographic characteristics play important roles in determining the occurrence of SARS-CoV-2 outbreaks. The impact of visitation bans on the well-being of residents, friends or family, and staff needs to be carefully considered.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Review
Psychiatry
Mark J. Rapoport, Justin Nathaniel Chee, Thadshagini Prabha, Jamie Dow, Ian Gillespie, Sjaan Koppel, Judith L. Charlton, Desmond O'Neill, Paul C. Donaghy, Angela Onkay Ho, John-Paul Taylor, Mark Tant
Summary: This systematic review examined the risk of motor vehicle crashes (MVCs) for drivers with psychiatric disorders. The findings showed that 15 studies reported an increased risk of MVC associated with psychiatric disorders, while 9 studies did not find such an association. However, the available evidence is of mixed quality and does not support a blanket restriction on all drivers with psychiatric disorders. Therefore, an individualized approach is still recommended for managing this issue.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Editorial Material
Medicine, General & Internal
Desmond O'Neill, Shelby Zimmerman, Brendan D. Kelly, Hilary Moss
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Environmental Sciences
Frances Horgan, Vanda Cummins, Dawn A. Skelton, Frank Doyle, Maria O'Sullivan, Rose Galvin, Elissa Burton, Jan Sorensen, Samira Barbara Jabakhanji, Bex Townley, Debbie Rooney, Gill Jackson, Lisa Murphy, Lauren Swan, Mary O'Neill, Austin Warters
Summary: Embedding CTM within home support services is acceptable and feasible. The gathered data can support further research.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Donna Noonan, Margaret Ryan, Declan Whelan, Desmond O'Neill
Summary: Emergency service vehicle (ESV) drivers play a crucial role in health, fire, and police services. However, there is a lack of guidance in the literature regarding the impact of medical conditions on their crash risk. This study conducted a narrative review to examine the role of medical and other conditions in the crash risk of ESV drivers.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Chika Offiah, Sean Tierney, Bridget Egan, Ronan D. Collins, Daniel J. Ryan, Allan J. McCarthy, Deirdre R. Smith, James Mahon, Emily Boyle, Holly Delaney, Rory O.'Donohoe, Alison Hurley, Richard A. Walsh, Sinead M. Murphy, Petya Bogdanova-Mihaylova, Sean O.'Dowd, Mark J. Kelly, Taha Omer, Tara Coughlan, Desmond O'Neill, Mary Martin, Stephen J. X. Murphy, Dominick J. H. McCabe
Summary: This study aimed to analyze the frequency of 'consensus decisions' during neurovascular multidisciplinary meetings (MDM) and the post-MDM 'adherence' to such decisions in patients with carotid/vertebral stenosis. The study found that 96.5% of patients achieved consensus regarding management and 96.4% adhered to MDM advice. This highlights the importance of a collaborative multidisciplinary approach in treating patients with arterial stenosis.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Editorial Material
Geriatrics & Gerontology
Neasa Fitzpatrick, Desmond O'Neill
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Jennifer O'Donoghue, Dimitra Xidous, Tom Grey, Desmond O'Neill
Summary: This article discusses the impact of the built environment on infection control measures and quality of life in residential long-term care (RLTC), highlighting the need for a holistic design approach across all key spatial scales.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Christoph Leinert, Marina Fotteler, Thomas Derya Kocar, Dhayana A. Dallmeier, Hans Kestler, Dennis Wolf, Florian Gebhard, Adriane Uihlein, Florian Steger, Reinhold S. Kilian, Annabel W. Mueller-Stierlin, Christoph Michalski, Andre Mihaljevic, Christian Bolenz, Friedemann Zengerling, Elena Leinert, Sabine K. Schuetze, Thomas Hoffmann, Graziano Onder, Karen Andersen-Ranberg, Desmond O'Neill, Martin Wehling, Johannes Schobel, Walter Swoboda, Michael Denkinger
Summary: This study presents a digital application project aimed at improving inpatient surgical care and continuity of care for older adults by providing structured, relevant information and decision support tools. The project will develop a digital application with a dashboard-style user interface, displaying evidence-based recommendations for geriatric co-management and artificial intelligence-enhanced suggestions for continuity of care decisions. The development and implementation of the application will follow the Medical research council framework for complex medical interventions.
Article
Clinical Neurology
Vicky Chalos, Esmee Venema, Maxim J. H. L. Mulder, Bob Roozenbeek, Ewout W. Steyerberg, Marieke J. H. Wermer, Geert J. Lycklama a J. Nijeholt, H. Bart van der Worp, Mayank Goyal, Bruce C. V. Campbell, Keith W. Muir, Francis Guillemin, Serge Bracard, Philip White, Antoni Davalos, Tudor G. Jovin, Michael D. Hill, Peter J. Mitchell, Andrew M. Demchuk, Jeffrey L. Saver, Aad van der Lugt, Scott Brown, Diederik W. J. Dippel, Hester F. Lingsma, HERMES Collaborators, MR CLEAN Registry Investigators
Summary: To predict the functional outcome after endovascular treatment (EVT) for ischemic stroke, researchers developed and validated a model based on preprocedural and postprocedural characteristics. Using data from multiple clinical trials, the model showed high predictive ability for functional independence and survival. The prognostic tool can assist physicians in providing personalized follow-up and rehabilitation plans for patients.
Article
Clinical Neurology
Vicky Chalos, Esmee Venema, Maxim J. H. L. Mulder, Bob Roozenbeek, Ewout W. Steyerberg, Marieke J. H. Wermer, Geert J. Lycklama A. Nijeholt, H. Bart van der Worp, Mayank Goyal, Bruce C. V. Campbell, Keith W. Muir, Francis Guillemin, Serge Bracard, Philip White, Antoni Davalos, Tudor G. Jovin, Michael D. Hill, Peter J. Mitchell, Andrew M. Demchuk, Jeffrey L. Saver, Aad van der Lugt, Scott Brown, Diederik W. J. Dippel, Hester F. Lingsma
Summary: This study developed and validated a model to predict functional outcome for individual patients after endovascular treatment (EVT) for ischemic stroke. The model showed good discrimination and calibration in predicting functional independence and survival. It can be applied 1 day after EVT to provide accurate outcome expectations and personalize follow-up and rehabilitation plans.
