Article
Clinical Neurology
Guangyao Wang, Jing Jing, Anxin Wang, Xiaoli Zhang, Xingquan Zhao, Zixiao Li, Chunjuan Wang, Hao Li, Liping Liu, Yongjun Wang, Yilong Wang
Summary: The study suggests that non-high-density lipoprotein cholesterol may be a qualified predictor for recurrent ischemic stroke and all-cause death within 1 year in patients with acute ischemic stroke, but not predictive for intracranial hemorrhage.
Review
Clinical Neurology
Yajing Chen, Yuxia Ma, Jiangxia Qin, Xiaoqin Wei, Yiyi Yang, Yue Yuan, Fanghong Yan, Xiaoning Huo, Lin Han
Summary: This study systematically reviewed the association between blood pressure variability and prognosis in acute stroke patients. The results showed that higher systolic blood pressure variability is associated with a higher risk of poor outcome among acute stroke patients without thrombolysis, including function disability, mortality, early neurological deterioration, and stroke recurrence. Higher diastolic blood pressure variability is associated with a higher risk of mortality and functional disability.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Anissa Pelouto, Jorieke Reimer, Ewout J. Hoorn, Adrienne A. M. Zandbergen, Heleen M. den Hertog
Summary: This study analyzed data from patients treated with IVT and/or EVT at Isala Hospital in the Netherlands, and found that admission hyponatremia in patients with acute ischemic stroke was associated with unfavorable postreperfusion outcomes, a larger infarct core, and a larger core to penumbra ratio.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Ying Bai, Hui Ren, Yi Zhu, Xufeng Chen, Li Yang, Jiangyan Xia, Guofang Shu, Bing Han
Summary: This study found that circular RNA circDLGAP4 is significantly decreased in the plasma of patients with acute ischemic stroke (AIS), and its level is associated with smoking history and previous transient ischemic attack/stroke/myocardial infarction. CircDLGAP4 has high sensitivity and specificity in diagnosing AIS. Furthermore, the change rate of circDLGAP4 can predict stroke outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Hyungwoo Lee, Il Hyung Lee, JoonNyung Heo, Minyoul Baik, Hyungjong Park, Hye Sun Lee, Hyo Suk Nam, Young Dae Kim
Summary: Sarcopenia is associated with functional outcomes in patients with acute ischemic stroke, leading to unfavorable functional outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Moo-Seok Park, Jin-Hee Park, Ahran Joo, Yoonkyung Chang, Tae-Jin Song
Summary: This study demonstrates a correlation between higher plasma OPG levels and poor functional outcomes in acute ischemic stroke patients who have undergone EVT.
Article
Clinical Neurology
Hongbing Liu, Kai Liu, Lulu Pei, Shen Li, Jiawei Zhao, Ke Zhang, Ce Zong, Lu Zhao, Hui Fang, Jun Wu, Shilei Sun, Bo Song, Yuming Xu, Yuan Gao
Summary: This study revealed a significant association between AIP and poor outcomes in patients with acute ischemic stroke, especially in the large-artery atherosclerosis subtype. Higher AIP levels were found to be an important predictor of dysfunction outcomes in stroke patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Liang Jiang, Zhengfei Miao, Huiyou Chen, Wen Geng, Wei Yong, Yu-Chen Chen, Hong Zhang, Shaofeng Duan, Xindao Yin, Zhiqiang Zhang
Summary: This study aimed to construct a prognostic model for patients with acute ischemic stroke by using diffusion-weighted imaging radiomics. The CrrScore model, based on clinical and imaging features, accurately predicted unfavorable outcomes and could potentially guide rehabilitation therapies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yiran Zhou, Di Wu, Su Yan, Yan Xie, Shun Zhang, Wenzhi Lv, Yuanyuan Qin, Yufei Liu, Chengxia Liu, Jun Lu, Jia Li, Hongquan Zhu, Weiyin Vivian Liu, Huan Liu, Guiling Zhang, Wenzhen Zhu
Summary: This study developed a model incorporating radiomic features and clinical factors to accurately predict the outcomes of acute ischemic stroke (AIS). By selecting features and establishing a model, it was found that factors such as age, sex, and stroke history were related to the outcomes. The clinical-radiomics model outperformed other models in predicting AIS outcomes.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Medicine, General & Internal
Chen-Chih Chung, Emily Chia-Yu Su, Jia-Hung Chen, Yi-Tui Chen, Chao-Yang Kuo
Summary: This study developed an extreme gradient boosting (XGBoost)-based model using age, fasting glucose, and National Institutes of Health Stroke Scale (NIHSS) scores as predictors to accurately predict three-month functional outcomes after acute ischemic stroke (AIS). The model showed reliable predictive power and identified factors associated with unfavorable prognoses, such as NIHSS score > 5, age over 64 years, and fasting blood glucose > 86 mg/dL. Furthermore, it demonstrated the importance of different predictors for patients receiving different AIS treatments.
Article
Clinical Neurology
Hyuk-Je Lee, Taewon Kim, Jaseong Koo, Young-Do Kim, Seunghee Na, Yun Ho Choi, In-Uk Song, Sung-Woo Chung
Summary: This study aimed to evaluate the clinical outcomes associated with multiple chronic lacunes (MCL) according to stroke etiology. The results showed that the presence of MCL was associated with early neurological deterioration (END) and long-term poor functional outcome, but only in patients with large artery atherosclerosis (LAA).
NEUROLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Fangfang Zhao, Rongliang Wang, Yuyou Huang, Lingzhi Li, Liyuan Zhong, Yue Hu, Ziping Han, Junfen Fan, Ping Liu, Yangmin Zheng, Yumin Luo
Summary: This study found that plasma levels of syndecan-1 were significantly higher in AIS patients receiving rt-PA thrombolysis, and higher levels were associated with poor prognosis. Syndecan-1 may serve as a potential marker for predicting patient outcomes in this population, and adding it to conventional models could improve risk stratification.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Neurosciences
Ying Huang, Zhenzhen Wang, Zhi-Xin Huang, Zhenguo Liu
Summary: This review summarizes a range of important biomarkers, including glutamate, S100B, glial fibrillary acidic protein, receptor for advanced glycation end-products, intercellular adhesion molecule-1, von willebrand factor, matrix metalloproteinase-9, interleukin-6, tumor necrosis factor-a, activated protein C, copeptin, neuron-specific enolase, tau protein, gamma-aminobutyric acid, blood glucose, endothelial progenitor cells, and circulating CD34-positive cells, which may potentially indicate the disease burden and/or predict clinical outcomes of ischemic stroke. The relationship between specific biomarkers, disease burden, and outcomes is examined, along with potential underlying mechanisms. The clinical significance and implications of these biomarkers are also discussed.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
Romain Sonneville, Mikael Mazighi, Magalie Collet, Etienne Gayat, Vincent Degos, Jacques Duranteau, Charles Gregoire, Tarek Sharshar, Giulia Naim, David Cortier, Paul-Henri Jost, Arnaud Foucrier, Francois Bagate, Etienne de Montmollin, Gregory Papin, Eric Magalhaes, Bertrand Guidet, Omar Ben Hadj Salem, Sarah Benghanem, Loic le Guennec, Eric Delpierre, Stephane Legriel, Bruno Megarbane, Karim Toumert, Marc Tran, Guillaume Geri, Mehran Monchi, Eric Bodiguel, Eric Mariotte, Alexandre Demoule, Jonathan Zarka, Jean-Luc Diehl, Damien Roux, Eric Barre, Sebastien Tanaka, David Osman, Pierre Pasquier, Fariza Lamara, Isabelle Crassard, Perrine Boursin, Stephane Ruckly, Quentin Staiquly, Jean-Francois Timsit, France Woimant
Summary: This study investigated the one-year outcomes of patients with stroke requiring mechanical ventilation in ICUs in France. The results showed that 66.5% of the included patients had a poor functional outcome. Age ≥70 years, Charlson comorbidity index ≥2, Glasgow Coma Scale <8 at ICU admission, and stroke subtype were independently associated with poor functional outcome.
Article
Clinical Neurology
Dixia Zhang, Qiuru Li, Jun Liu, Lijuan Ma, Jing Ye, Guifen Hu, Guangzong Li
Summary: This study investigated the association between calculated plasma volume status (PVS) and 90-day functional outcomes after endovascular treatment (EVT) for acute ischemic stroke (AIS). The results showed that a higher PVS value was associated with poor outcomes after EVT. Further research is needed to assess the utility of PVS in AIS patients treated with EVT.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Matthew Checketts, Mauro Mancuso, Helena Fordell, Peii Chen, Kimberly Hreha, Gail A. Eskes, Patrik Vuilleumier, Andy Vail, Audrey Bowen
Summary: Spatial neglect has significant impact on quality of life after stroke, and this study examined the usage of neglect tests by different professionals in various countries. The results showed inter-professional differences but less variation between countries, with professionals mainly reporting clinical autonomy in their choices. This study highlights the need for a combined approach to screening and further training in order to reach consensus on screening and diagnostic measures.
NEUROPSYCHOLOGICAL REHABILITATION
(2021)
Article
Rehabilitation
Richard Drake, Kim Parker, Kerry-Lee Clifton, Stefan Allen, James Adderson, Anita Mountain, Gail A. Eskes
Summary: This study aimed to investigate the effects of AFO on dual-task walking in post-stroke hemiplegic patients. The results suggest that AFO can improve gait but does not reduce cognitive-motor dual-task costs.
TOPICS IN STROKE REHABILITATION
(2021)
Article
Behavioral Sciences
Jasmine R. Aziz, Samantha R. Good, Raymond M. Klein, Gail A. Eskes
Summary: This study investigated the impact of different domains of working memory on visual search performance in young and older adults and found that visuospatial executive working memory plays a key role in locating complex search targets quickly. Working memory storage capacity can predict search performance, with visuospatial storage capacity being more predictive for young adults and verbal storage capacity being more predictive for older adults. Displaying a target template during search reduces the involvement of working memory in search performance, particularly in young adults.
Article
Cardiac & Cardiovascular Systems
Danielle S. Burstein, Heather Griffis, Xuemei Zhang, Ryan S. Cantor, Dingwei Dai, Pirouz Shamszad, Yuan-Shung Huang, David L. S. Morales, Matthew Hall, Kimberly Y. Lin, Matthew J. O'Connor, Matthew Zinn, R. Erik Edens, P. Eugene Parrino, James K. Kirklin, Joseph W. Rossano
Summary: The study found that pediatric resource utilization of PCF VAD is staggeringly high, primarily driven by pre-implantation patient illness, hospital LOS, and clinical care costs.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Health Care Sciences & Services
Dingwei Dai, Paula J. Alvarez, Steven D. Woods
Summary: The study developed a predictive model to identify CKD patients at high risk of progressing to kidney failure.
The model demonstrated good accuracy and calibration in predicting progression to kidney failure.
Early identification using this model could potentially improve health outcomes and reduce healthcare expenditures in the at-risk population.
CLINICOECONOMICS AND OUTCOMES RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Christopher M. Janson, Marisa E. Millenson, Oluwatimilehin Okunowo, Dingwei Dai, Zane Christmyer, Reina Bianca Tan, V. Ramesh Iyer, Maully J. Shah, Michael L. O'Byrne
Summary: This study evaluated the incidence of life-threatening events (LTE) in children with Wolff-Parkinson-White (WPW) syndrome using a large database. The results showed a significant increase in ventricular fibrillation (VF) and LTE risk in pediatric patients with WPW syndrome. This finding contributes to a better understanding of the risk profile of WPW syndrome in children.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jakub Kaczynski, Stephanie Sellers, Michael A. Seidman, Maaz Syed, Martin Dennis, Gillian Mcnaught, Maurits Jansen, Scott I. Semple, Carlos Alcaide-Corral, Adriana A. S. Tavares, Thomas MacGillivray, Samuel Debono, Rachael Forsythe, Andrew Tambyraja, Piotr J. Slomka, Jonathon Leipsic, Marc R. Dweck, William Whiteley, Joanna Wardlaw, Edwin J. R. van Beek, David E. Newby, Michelle C. Williams
Summary: This study evaluated the association between F-18-NaF activity and culprit carotid plaque in patients with acute neurovascular syndrome. The results showed that culprit carotids had greater stenoses and higher prevalence of adverse plaque features, as well as increased F-18-NaF uptake, compared to nonculprit carotids.
Article
Clinical Neurology
William N. Whiteley, Allan MacRaild, Ying Wang, Martin Dennis, Rustam Al-Shahi Salman, Alasdair Gray, Matthew J. Reed, Catriona Graham, Joanna M. Wardlaw
Summary: This study examined the utility of MRI brain in patients with transient or minor neurological symptoms. The results showed that about 1 in 6 patients had evidence of acute brain ischemia on MRI.
Article
Cardiac & Cardiovascular Systems
Alexander Chye, Maree L. Hackett, Graeme J. Hankey, Erik Lundstrom, Osvaldo P. Almeida, John Gommans, Martin Dennis, Stephen Jan, Gillian E. Mead, Andrew H. Ford, Christopher Etherton Beer, Leon Flicker, Candice Delcourt, Laurent Billot, Craig S. Anderson, Katharina Stibrant Sunnerhagen, Qilong Yi, Severine Bompoint, Thang Huy Nguyen, Thomas Lung
Summary: This study compares the analytical implications of single-measure and repeated-measures analyses of the modified Rankin Scale (mRS) in evaluating functional recovery after acute stroke. The findings suggest that repeated-measures analysis can improve trial precision in identifying trial associations and effects.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Editorial Material
Clinical Neurology
Elizabeth R. Skidmore, Gail Eskes, Amy Brodtmann
Summary: This review provides an overview of executive function impairment among stroke survivors, including definitions, concepts, and measures. It summarizes current best evidence on executive function impairment and recovery trajectories, correlates of change over time, and emerging intervention research. The review also offers recommendations for research and clinical practices, as well as future priorities in executive function research.
Article
Economics
Dingwei Dai, Henriette E. Coetzer, Sean R. Zion, Michael J. Malecki
Summary: Breast cancer patients often experience anxiety, depression, and stress. This study found that 38.2% of newly diagnosed patients were diagnosed with psychiatric disorders. These disorders were associated with higher healthcare resource utilization and costs.
JOURNAL OF HEALTH ECONOMICS AND OUTCOMES RESEARCH
(2023)
Article
Economics
Dingwei Dai, Ali Samiian, Joaquim Fernandes, Henriette Coetzer
Summary: This study examined comorbidities, psychiatric disorders, healthcare resource utilization (HCRU), and costs in patients with essential tremor (ET). Results showed that ET patients had higher comorbidity rates, higher prevalence of psychiatric disorders, and higher healthcare costs compared to non-ET patients. These findings highlight the importance of innovative care for ET patients.
JOURNAL OF HEALTH ECONOMICS AND OUTCOMES RESEARCH
(2022)
Article
Economics
Dingwei Dai, Ajay Sharma, Amy L. Phillips, Carroline Lobo
Summary: Comorbidities are common in patients with multiple sclerosis (MS), increasing the complexity of disease management and burden. A study compares comorbidity and multimorbidity patterns in commercially insured and Medicare Advantage MS patients. The results show differences in comorbidities and multimorbidity between the two groups.
JOURNAL OF HEALTH ECONOMICS AND OUTCOMES RESEARCH
(2022)
Article
Oncology
Dingwei Dai, Henriette Coetzer, Sean R. R. Zion, Michael J. J. Malecki
Summary: This study aimed to examine the prevalence of multimorbidity and its associations with anxiety and depression among newly diagnosed patients with breast cancer. The results showed that multimorbidity was highly prevalent among patients with breast cancer and was strongly associated with an increased risk of anxiety and depression in the first year following diagnosis.
Article
Health Care Sciences & Services
Ajay Sharma, Paula J. Alvarez, Steven D. Woods, Jeanene Fogli, Dingwei Dai
Summary: This study investigated a cohort of hyperkalemic patients in a large US health plan, finding that these patients are typically older with comorbidities such as chronic kidney disease, hypertension, and hyperlipidemia. Patients using optimal-dose RAASi had the lowest healthcare resource utilization in terms of inpatient admissions, emergency department visits, primary care physician visits, and length of stay.
JOURNAL OF PHARMACEUTICAL HEALTH SERVICES RESEARCH
(2021)