FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs

Impact of exercise on muscle and nonmuscle organs

(2015) Pontus A. Boström et al.   IUBMB LIFE

Plasma irisin levels predict telomere length in healthy adults

(2014) Karan S. Rana et al.   AGE

Myokines in insulin resistance and type 2 diabetes

(2014) Kristin Eckardt et al.   DIABETOLOGIA

Implication of Circulating Irisin Levels with Brown Adipose Tissue and Sarcopenia in Humans

(2014) Hae Yoon Choi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Common single nucleotide polymorphisms in the FNDC5 gene are associated with glucose metabolism but do not affect serum irisin levels in Japanese men with low fitness levels

(2014) Kumpei Tanisawa et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

PTK2 rs7460 and rs7843014 Polymorphisms and Exceptional Longevity: A Functional Replication Study

(2014) Nuria Garatachea et al.   REJUVENATION RESEARCH

Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects

(2014) P Lopez-Legarrea et al.   Nutrition & Diabetes

Association of the K153R polymorphism in the myostatin gene and extreme longevity

(2013) Nuria Garatachea et al.   AGE

Irisinemia: A Novel Concept to Coin in Clinical Medicine

(2013) Fabian Sanchis-Gomar et al.   ANNALS OF NUTRITION AND METABOLISM

Irisin

(2013) Ulf Elbelt et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Banting Lecture 2012: Regulation of Adipogenesis: Toward New Therapeutics for Metabolic Disease

(2013) B. M. Spiegelman   DIABETES

Serum irisin levels in new-onset type 2 diabetes

(2013) Yeon-Kyung Choi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Irisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans

(2013) Maria T Vamvini et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Irisin Is Expressed and Produced by Human Muscle and Adipose Tissue in Association With Obesity and Insulin Resistance

(2013) José María Moreno-Navarrete et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lower circulating irisin is associated with type 2 diabetes mellitus

(2013) Jian-Jun Liu et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Irisin in obesity and type 2 diabetes

(2013) Kurt Højlund et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Are skeletal muscleFNDC5gene expression and irisin release regulated by exercise and related to health?

(2013) Satu Pekkala et al.   JOURNAL OF PHYSIOLOGY-LONDON

Irisin: A renaissance in metabolism?

(2013) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Irisin, the metabolic syndrome and follistatin in humans

(2013) Pontus A. Boström et al.   Nature Reviews Endocrinology

Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity

(2013) Harald Staiger et al.   PLoS One

Evidence against a Beneficial Effect of Irisin in Humans

(2013) Silja Raschke et al.   PLoS One

The p38–PGC-1α–irisin–betatrophin axis

(2013) Fabian Sanchis-Gomar et al.   Adipocyte

Irisin and FNDC5 in retrospect

(2013) Harold P Erickson   Adipocyte

Irisin, Turning Up the Heat

(2012) Francesc Villarroya   Cell Metabolism

Expression of the Irisin Precursor FNDC5 in Skeletal Muscle Correlates With Aerobic Exercise Performance in Patients With Heart Failure

(2012) Stewart H. Lecker et al.   Circulation-Heart Failure

Bien vieillir

(2012) Anne Brunet   M S-MEDECINE SCIENCES

FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

(2012) Joo Young Huh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells

(2012) M.-S. Hashemi et al.   NEUROSCIENCE

Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity – Correlation with body mass index

(2012) Andreas Stengel et al.   PEPTIDES

Irisin: A new potential hormonal target for the treatment of obesity and type 2 diabetes

(2012) Fabian Sanchis-Gomar et al.   Journal of Diabetes

Are Calcineurin Genes Associated with Athletic Status? A Function, Replication Study

(2011) ZI-HONG HE et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Generations of longevity

(2011) Susan E. Mango   NATURE

Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

(2011) J. Guevara-Aguirre et al.   Science Translational Medicine

Favorable Glucose Tolerance and Lower Prevalence of Metabolic Syndrome in Offspring without Diabetes Mellitus of Nonagenarian Siblings: The Leiden Longevity Study

(2010) Maarten P. Rozing et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Preliminary Evidence of a Genetic Association Between Chromosome 9p21.3 and Human Longevity

(2010) Enzo Emanuele et al.   REJUVENATION RESEARCH

Association ofFOXO3Avariation with human longevity confirmed in German centenarians

(2009) Friederike Flachsbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FOXO3A genotype is strongly associated with human longevity

(2008) B. J. Willcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic aspects of the extreme longevity

(2007) M. Barbieri et al.   EXPERIMENTAL GERONTOLOGY