Article
Biochemistry & Molecular Biology
Ibrahim Khan, Kamran Saeed, Min Gi Jo, Myeong Ok Kim
Summary: The study demonstrated that glutamate-induced oxidative stress and neuroinflammation in rat brain could be alleviated by E2 through upregulating antioxidant pathways and deactivating stress kinases. Additionally, E2 also protected against synaptic loss and apoptotic neurodegeneration caused by glutamate exposure. Thus, E2 shows potential as a neuroprotective and neurotherapeutic agent in various neurodegenerative diseases.
Article
Neurosciences
Alev Duygu Acun, Deniz Kantar, Hakan Er, Orhan Erkan, Narin Derin, Piraye Yargicoglu
Summary: Cyclo-Z is a chemical compound that has been found to increase the production of insulin-degrading enzyme (IDE) and reduce the number of inactive insulin fragments in cells. This study aimed to examine the effects of Cyclo-Z on the insulin pathway, memory functions, and brain oscillations in an Alzheimer's disease rat model. The results demonstrated that Cyclo-Z was able to prevent some of the abnormal changes observed in the ADZ group and attenuate the increased levels of A beta 42 oligomers.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fernanda dos Santos Petry, Juliana Bender Hoppe, Caroline Peres Klein, Bernardo Gindri dos Santos, Regis Mateus Hozer, Felippo Bifi, Cristiane Matte, Christianne Gazzana Salbego, Vera Maria Treis Trindade
Summary: This study evaluated the protective effect of genistein against Aβ(1-42)-induced cognitive impairment and elucidated some possible mechanisms involved in its neuroprotective effects in the hippocampus, including attenuation of synaptotoxicity, prevention of Tau hyperphosphorylation, and inactivation of ERK.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Reine Khoury, Joelle Saad, Vanessa Jabre, Litsa Maria Ghayad, Mohamad Khalifeh, Rouba Houbeika, Perla El Ahmad, Amar Mezher, Diala El Masri, Zena Haddad, Fady Eid, Nour Barmo, Patrick Nasrallah, Sama F. Sleiman, Joseph S. Stephan
Summary: Exercise enhances learning and memory recall and counteracts cognitive decline associated with aging. The positive effects of exercise are mediated by circulatory factors, specifically Brain Derived Neurotrophic Factor (BDNF) signaling in the hippocampus. Identifying the mechanisms behind the release of these factors and their effects on hippocampal Bdnf expression will help harness the therapeutic potential of exercise.
Article
Pharmacology & Pharmacy
Fang Yuan, Satoshi Obayashi, Ayumi Yamaguchi, Natsuki Yatabe, Chihiro Mano, Makoto Iizuka, Yoshinori Ohkura, Naoyuki Miyasaka
Summary: This study investigated the effects of EE2 on endothelial function and found that EE2 has a weaker ability than E2 to produce NO and can enhance the activity of endothelial-derived hyperpolarizing factor.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Zahra Niavarani, Daniel Breite, Andrea Prager, Isabell Thomas, Mathias Kuehnert, Bernd Abel, Roger Glaeser, Agnes Schulze
Summary: Composite microfiltration polyethersulfone membranes with molecularly imprinted particles (MIPs) were developed for efficient and selective adsorption of 17β-estradiol from water. The membranes exhibited significant adsorption loading and high selectivity for 17β-estradiol, even in the presence of other micropollutants. The membranes also showed excellent reusability and a maximum adsorption capacity more than 200 times higher than commercial nanofiltration.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Geriatrics & Gerontology
Lucas K. Debarba, Hashan S. M. Jayarathne, Richard A. Miller, Michael Garratt, Marianna Sadagurski
Summary: The study suggests that the effects of estrogen on longevity and neuroinflammatory responses in mice are sexually dimorphic and partially dependent on the presence of sex-specific gonads, with castration potentially reducing the impact of 17aE2.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Biochemical Research Methods
Jun-Seong Ahn, Chang-Hyun Jang
Summary: An LC-based aptasensor has been developed to detect 17 beta-estradiol (E2) at picomolar levels by utilizing competitive reactions and interfacial events. The aptasensor changes the optical response of liquid crystals (LCs) through electrostatic interactions with a cationic surfactant (CTAB) and the aptamer. The conformational change of the aptamer due to binding with E2 weakens the electrostatic attraction, resulting in a dark optical image. The E2 sensor showed a detection limit of 3.1 pM in TBS and 6.8 pM in human urine, demonstrating high sensitivity and selectivity without the need for complex analysis equipment.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Reproductive Biology
Marion Rouge, Maeva Drouault, Vincent Hanoux, Christelle Delalande, Helene Bouraima-Lelong
Summary: This ex vivo study found that early exposure to estrogen can either accelerate or delay the establishment of spermatogenesis, depending on the age of the testicular tissue. This effect may be mediated by estrogen's modulation of steroidogenesis.
REPRODUCTIVE TOXICOLOGY
(2023)
Review
Endocrinology & Metabolism
Weijuan Cui, Ling Zhao
Summary: Through a systematic review and meta-analysis of randomized controlled trials, we found that the co-administration of 17-beta-estradiol and norethisterone acetate has a positive impact on glycated hemoglobin, fasting glucose, insulin, and C-peptide concentrations in females. Future research is needed to confirm the potential benefits of this drug combination in the prevention and/or management of cardiometabolic disorders.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Jasmine Fusi, Maria Cristina Veronesi, Alberto Prandi, Monica Probo, Massimo Faustini, Tanja Peric
Summary: This study investigated the changes in sexual hormones in dogs during puberty using hair and nail samples to analyze the concentrations of testosterone (T), 17 beta-estradiol (E2), and progesterone (P4). Traditional methods using blood samples are not suitable for long-term studies, but hair and nails have been identified as suitable retrospective biological specimens. The results showed significant increases in T levels in male dogs and E2 levels at puberty and P4 levels after puberty in female dogs. Hair and nail T and nail P4 concentrations could differentiate between male and female dogs at specific sampling times. This study demonstrates the usefulness of hair and nails as biological specimens for studying the changes in T, E2, and P4 during the peripubertal period in dogs.
Article
Geriatrics & Gerontology
Silvana Sidhom, Augusto Schneider, Yimin Fang, Samuel McFadden, Justin Darcy, Roshini Sathiaseelan, Allyson K. Palmer, Frederik J. Steyn, Johannes Grillari, John J. Kopchick, Andrzej Bartke, Shadab Siddiqi, Michal M. Masternak, Michael B. Stout
Summary: 17α-estradiol has been shown to promote health benefits in male mice by increasing hepatic insulin-like growth factor 1 (IGF1) production in a growth hormone (GH)-dependent manner. However, this effect was not observed in female mice.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Endocrinology & Metabolism
Xu Tian, Shujie Lou, Rengfei Shi
Summary: Sarcopenia, a degenerative muscle condition in older adults, is linked to loss of mitochondrial integrity and decreased sex hormones. Damaged mitochondria, caused by age-related impairments in various mitochondrial quality control processes, contribute to muscle mass decline. Additionally, decreased levels of sex hormones such as 17 beta-estradiol and testosterone also play a role in mitochondrial dysfunction and sarcopenia. This review examines the mechanisms behind mitochondrial dysfunction in sarcopenia and the potential therapeutic approaches.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Zeinab Farhadi, Mohammad Khaksari, Hossein Azizian, Shahriar Dabiri
Summary: The study found that the effects of E2 on young animals included reducing weight and calorie intake, improving leptin sensitivity, increasing levels of neuropeptides, and enhancing p-STAT3 expression in the hypothalamic arcuate nucleus.
METABOLIC BRAIN DISEASE
(2022)
Correction
Cell Biology
Jesper Backdahl, Lovisa Franzen, Lucas Massier, Qian Li, Jutta Jalkanen, Hui Gao, Alma Andersson, Nayanika Bhalla, Anders Thorell, Mikael Ryden, Patrik L. Stahl, Niklas Mejhert
Summary: Through mining a multimodal resource, we identify that human WAT consists of three classes of mature adipocytes, only one of which is insulin responsive.
Article
Behavioral Sciences
Maria Banqueri, Alba Gutierrez-Menendez, Marta Mendez, Nelida M. Conejo, Jorge L. Arias
Summary: Adverse early life environments can lead to cognitive impairments, as shown in an animal model of repeated maternal separation. The study found changes in brain energy oxidative metabolism and delays in spatial working memory acquisition, indicating a need for further research on long-term effects of early stress.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2021)
Article
Neurosciences
Hector Gonzalez-Pardo, Jorge L. Arias, Eneritz Gomez-Lazaro, Isabel Lopez Taboada, Nelida M. Conejo
Review
Behavioral Sciences
Marta Mendez-Couz, Denise Manahan-Vaughan, Ana Paula Silva, Hector Gonzalez-Pardo, Jorge Luis Arias, Nelida Maria Conejo
Summary: The neuropeptide Y2 receptors play a significant role in hippocampus-dependent spatial memory, with receptor expression dynamically regulated by learning experiences. Antagonism of the receptors in the dorsal intrahippocampal area improves spatial reference memory.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Environmental Sciences
Judit Biosca-Brull, Cristian Perez-Fernandez, Santiago Mora, Beatriz Carrillo, Helena Pinos, Nelida Maria Conejo, Paloma Collado, Jorge L. Arias, Fernando Martin-Sanchez, Fernando Sanchez-Santed, Maria Teresa Colomina
Summary: Autism spectrum disorder is a complex set of neurodevelopmental pathologies with both genetic and environmental factors likely playing a role. Research on the relationship between pesticide exposure and ASD is lacking specific reviews, highlighting the need for future experimental studies to further explore the impact of exposure on ASD symptoms.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Obstetrics & Gynecology
Carmen Fernandez-Ferrera, David Llaneza-Suarez, Daniel Fernandez-Garcia, Vanesa Castanon, Cristina Llaneza-Suarez, Placido Llaneza
Summary: Women with high resilience levels are less likely to experience perceived stress or depressed mood during their first IVF attempt, but this protective effect diminishes after a negative outcome.
REPRODUCTIVE SCIENCES
(2022)
Review
Environmental Sciences
Helena Pinos, Beatriz Carrillo, Ana Merchan, Judit Biosca-Brull, Cristian Perez-Fernandez, Maria Teresa Colomina, Fernando Sanchez-Santed, Fernando Martin-Sanchez, Paloma Collado, Jorge L. Arias, Nelida M. Conejo
Summary: The study indicates that the effects of pesticide exposure on body weight are inconclusive, with conflicting results in both humans and experimental animals. These outcomes depend on factors such as dosage, species, sex, and treatment duration, emphasizing the need for further research to effectively evaluate the combined impact of different pesticides on human health.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Behavioral Sciences
Marta Mendez-Couz, Hector Gonzalez-Pardo, Jorge L. Arias, Nelida M. Conejo
Summary: This study found that neuropeptide Y modulates spatial memory recall through its Y2 receptor and exerts control over patterns of brain activation relevant for associative learning.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2022)
Review
Clinical Neurology
M. C. Sousa-Fraguas, G. Rodriguez-Fuentes, N. M. Conejo
Summary: This study analyzed the relationship between frailty and cognitive impairment in patients with Parkinson's disease (pwPD) and found significant variability in the assessment tools used. More research is needed to provide more evidence and determine the optimal tool for assessing frailty in pwPD.
NEUROLOGICAL SCIENCES
(2022)
Article
Psychology, Biological
Isabel Lopez-Taboada, Saul Saul-Sarria, Guillermo Vallejo, Ana Coto-Montes, Nelida M. Conejo, Hector Gonzalez-Pardo
Summary: Prolonged intake of a Western-type diet rich in fats and sugars and exposure to early life stress can negatively impact neurodevelopment and behavior. This study investigates the combined effects of a high-fat and high-sugar diet and early life stress in male and female rats, specifically looking at spatial learning and memory, behavioral flexibility, and oxidative capacity in different brain regions. The results show gender-specific effects, with males performing better on the HFS diet but experiencing impaired behavioral flexibility. Both maternal separation and the HFS diet increased the metabolic capacity and oxidative stress levels in the prefrontal cortex and hippocampus, although maternal separation seemed to dampen oxidative stress levels. These findings suggest a compensatory effect resulting from the interaction between prolonged exposure to a HFS diet and early life stress.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Geriatrics & Gerontology
Pluvio J. Coronado, Maria Fasero, Borja Otero, Sonia Sanchez, Esther de la Viuda, Isabel Ramirez-Polo, Placido Llaneza, Nicolas Mendoza, Laura Baquedano
Summary: During the Covid-19 confinement, peri- and postmenopausal women who engaged in physical and sexual activities showed higher health-related quality of life and resilience levels, while those using antidepressants had lower quality of life and resilience levels. Living with others was associated with higher quality of life in women.
Review
Psychology, Multidisciplinary
Isabel Lopez-Taboada, Hector Gonzalez-Pardo, Nelida Maria Conejo
FRONTIERS IN PSYCHOLOGY
(2020)