Article
Neurosciences
Carlos Costas-Insua, Estefania Moreno, Irene B. Maroto, Andrea Ruiz-Calvo, Raquel Bajo-Graneras, David Martin-Gutierrez, Rebeca Diez-Alarcia, M. Teresa Vilaro, Roser Cortes, Nuria Garcia-Font, Ricardo Martin, Marc Espina, Joaquin Botta, Silvia Gines, Peter J. McCormick, Jose Sanchez-Prieto, Ismael Galve-Roperh, Guadalupe Mengod, Leyre Uriguen, Giovanni Marsicano, Luigi Bellocchio, Enric Canela, Vicent Casado, Ignacio Rodriguez-Crespo, Manuel Guzman
Summary: The study identified BiP as a protein interacting with CB1R to modulate the effects of cannabinoids in the brain, showing a selective impact on signaling pathways and neuron types.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Oncology
Kristin A. Altwegg, Suryavathi Viswanadhapalli, Monica Mann, Dimple Chakravarty, Samaya Krishnan, Zexuan Liu, Junhao Liu, Uday P. Pratap, Behnam Ebrahimi, John R. Sanchez, Xiaonan Li, Shihong Ma, Ben H. Park, Bindu Santhamma, Yidong Chen, Zhao Lai, Ganesh V. Raj, Yaxia Yuan, Daohong Zhou, Gangadhara R. Sareddy, Rajeshwar R. Tekmal, Stan McHardy, Tim H. -M. Huang, Manjeet K. Rao, Hariprasad Vankayalapati, Ratna K. Vadlamudi
Summary: A novel peptide inhibitor called SMIP34 has been found to efficiently inhibit the oncogenic signaling of PELP1, a coregulator implicated in therapy-resistant ER+ breast cancer. SMIP34 blocks the interaction between PELP1 and its target, reduces cell growth, induces PELP1 degradation, and alters gene expression related to estrogen response, cell cycle, and apoptosis pathways.
Article
Cell Biology
Yongjia Wang, Yuqin Zhang, Zixuan Wang, Lu Yu, Keli Chen, Yuwen Xie, Yang Liu, Weijie Liang, Yilin Zheng, Yizhi Zhan, Yi Ding
Summary: NUPR1 is overexpressed in hepatocellular carcinoma and is associated with poor prognosis. NUPR1 overexpression correlates with highly proliferative and aggressive phenotype of HCC cells. Inhibition of NUPR1 may be a therapeutic alternative for hepatocellular carcinoma.
CELL DEATH DISCOVERY
(2022)
Article
Neurosciences
Sara A. Ferreira, Conghui Li, Ida H. Klaestrup, Zagorka Vitic, Rikke K. Rasmussen, Asger Kirkegaard, Gitte U. Toft, Cristine Betzer, Pia Svendsen, Poul H. Jensen, Yonglun Luo, Anders Etzerodt, Soren K. Moestrup, Marina Romero-Ramos
Summary: Alpha-synuclein aggregation and immune activation are hallmark events in Parkinson's disease. CD163 upregulation in blood monocytes and microglia may represent a protective mechanism in PD.
NPJ PARKINSONS DISEASE
(2023)
Article
Biology
Maria I. Lazaro-Pena, Adam B. Cornwell, Carlos A. Diaz-Balzac, Ritika Das, Zachary C. Ward, Nicholas Macoretta, Juilee Thakar, Andrew V. Samuelson
Summary: This study reveals that HPK-1 acts as a key transcriptional effector to preserve neuronal integrity, function, and proteostasis during aging. HPK-1 improves proteostasis through kinase activity and functions in a cell non-autonomous manner to regulate distinct components of the proteostatic network. This research significantly advances our understanding of aging and protein homeostasis by identifying a new player in this process and uncovering its mode of action.
Article
Biochemistry & Molecular Biology
Sergey A. Vishnivetskiy, Liana D. Weinstein, Chen Zheng, Eugenia V. Gurevich, Vsevolod V. Gurevich
Summary: Arresin-1 shows selectivity for light-activated phosphorylated rhodopsin, and this selectivity is mediated by two structural elements in the molecule. In the crystal structure, there are some residues close to rhodopsin that do not belong to the selectivity mechanism. Mutations in these residues enhance binding to unphosphorylated rhodopsin and increase its selectivity for phosphorylated rhodopsin. This challenges the current model of arrestin-receptor interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Natasha L. Pacheco, Nicole Noren Hooten, Yongqing Zhang, Calais S. Prince, Nicolle A. Mode, Ngozi Ezike, Kevin G. Becker, Alan B. Zonderman, Michele K. Evans
Summary: The study revealed sex-specific transcriptional changes in middle-aged frailty, aiding in the understanding of frailty progression and providing potential therapeutic targets for preventing frailty.
Article
Cell Biology
Anita Pirabe, Sabine Fruehwirth, Laura Brunnthaler, Hubert Hackl, Anna Schmuckenschlager, Waltraud C. Schrottmaier, Alice Assinger
Summary: Aging affects platelet count and reactivity, leading to various pathological conditions. Older mice and RNA-rich immature platelets display hyperactivity and increased surface receptor expression, contributing to an elevated thrombotic risk.
Article
Cell Biology
Sicong Hou, Xin Hao, Jiajia Li, Siwei Weng, Jiaxin Wang, Tiantian Zhao, Wenqian Li, Xiaolin Hu, Bing Deng, Jianguo Gu, Qinglei Hang
Summary: This study reveals that TM4SF1 is upregulated in ESCC and positively correlates with clinical characteristics and poor prognosis. TM4SF1 promotes cell adhesion, spreading, migration, and invasion in a laminin-dependent manner by interacting with integrin alpha 6. The TM4SF1/integrin alpha 6/FAK axis signal pathway mediates cell migration under laminin-coating condition.
CELL DEATH & DISEASE
(2022)
Article
Neurosciences
Yong Liu, You Wang, Juan Yang, Tao Xu, Changhong Tan, Peng Zhang, Qiankun Liu, Yangmei Chen
Summary: The study identified that GIPC1 is downregulated in patients with epilepsy and mice with induced epilepsy, and it interacts with mGluR7 to regulate epileptogenesis by increasing mGluR7 expression.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Mathematical & Computational Biology
Yassene Mohammed, Sarah A. Michaud, Helena Petrosova, Juncong Yang, Milan Ganguly, David Schibli, Ann M. Flenniken, Lauryl M. J. Nutter, Hibret A. Adissu, K. C. Kent Lloyd, Colin McKerlie, Christoph H. Borchers
Summary: The research utilized targeted proteomics to quantify proteins in blood plasma samples from mouse knockout strains and wild-type mice, providing insights into genetic effects at the protein level. Gender differences in baseline protein abundance were observed, emphasizing the importance of including both sexes in research. The study demonstrated how proteome analysis can reveal the impact of gene deficiency beyond traditional tests, highlighting the potential for systematic study using proteomics and gene knockout strategies.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2021)
Article
Endocrinology & Metabolism
Huayun Hou, Cadia Chan, Kyoko E. Yuki, Dustin Sokolowski, Anna Roy, Rihao Qu, Liis Uuskula-Reimand, Mariela Faykoo-Martinez, Matt Hudson, Christina Corre, Anna Goldenberg, Zhaolei Zhang, Mark R. Palmert, Michael D. Wilson
Summary: The study reveals the identity and postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary. It also highlights the importance of considering sex biases in cell-type composition when understanding sex differences in the processes regulated by the pituitary gland.
BIOLOGY OF SEX DIFFERENCES
(2022)
Article
Multidisciplinary Sciences
Junil Kim, Michaela Mrugala Rothova, Esha Madan, Siyeon Rhee, Guangzheng Weng, Antonio M. Palma, Linbu Liao, Eyal David, Ido Amit, Morteza Chalabi Hajkarim, Vignesh Vudatha, Andres Gutierrez-Garcia, Eduardo Moreno, Robert Winn, Jose Trevino, Paul B. Fisher, Joshua M. Brickman, Rajan Gogna, Kyoung Jae Won
Summary: Development of multicellular organisms relies on persistent cell-cell communication, which drives lineage specification and cell fate decisions. The current single-cell RNA-seq technology lacks spatial information needed to analyze cell-cell contact-dependent gene expression. To overcome this, we performed RNA sequencing of physically interacting cells (PIC-seq) and compared them with single-cell transcriptomes from developing mouse embryos. Our analysis identified cell-type-dependent gene expression signatures, and we developed a computational model to predict the impact of one cell type on neighboring cell types. We also developed a spatial embedding method to visualize the distribution of cells in a 2D space. This innovative approach allows us to study contact-specific gene regulation during embryogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Cheng-Chao Lin, Luis F. Menezes, Jiahe Qiu, Elisabeth Pearson, Fang G. Zhou, Yu Ishimoto, D. Eric Anderson, Gregory G. Germino
Summary: This study reports a new mouse model in which HA epitopes and eGFP are inserted into the endogenous mouse Pkd1 gene using CRISPR/Cas9. The researchers were able to visualize endogenous PC1-eGFP and performed affinity-purification mass spectrometry (AP-MS) and network analyses. The findings suggest that this mouse model and interactome data will be valuable for understanding the function of PC1, but new methods and brighter tags are needed to track endogenous PC1.
Article
Food Science & Technology
Alicia M. Hendrix, Kathi A. Lefebvre, Emily K. Bowers, Rudolph Stuppard, Thomas Burbacher, David J. Marcinek
Summary: The excitatory neurotoxin domoic acid (DA) consistently contaminates food webs in coastal regions, causing Amnesic Shellfish Poisoning. Age and sex can affect individual susceptibility to DA, with advanced age and female sex showing increased symptoms. This study found that aged mice and females demonstrated more severe neurotoxic symptoms and higher tissue DA concentrations after acute exposure to DA. These findings contribute to developing evidence-based public health protections against DA-producing algal blooms.
Article
Multidisciplinary Sciences
Karim C. El Kasmi, Padade M. Vue, Aimee L. Anderson, Michael W. Devereaux, Swati Ghosh, Natarajan Balasubramaniyan, Sophie A. Fillon, Carola Dahrenmoeller, Ayed Allawzi, Crystal Woods, Sarah McKenna, Clyde J. Wright, Linda Johnson, Angelo D'Alessandro, Julie A. Reisz, Eva Nozik-Grayck, Frederick J. Suchy, Ronald J. Sokol
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
M. K. Thakur, Swati Ghosh
JOURNAL OF MOLECULAR NEUROSCIENCE
(2009)
Article
Neurosciences
Swati Ghosh, M. K. Thakur
JOURNAL OF NEUROSCIENCE RESEARCH
(2009)
Article
Neurosciences
Swati Ghosh, M. K. Thakur
JOURNAL OF NEUROSCIENCE RESEARCH
(2009)
Article
Biochemistry & Molecular Biology
M. K. Thakur, Swati Ghosh
MOLECULAR BIOLOGY REPORTS
(2010)
Article
Neurosciences
Swati Ghosh, M. K. Thakur
NEUROSCIENCE LETTERS
(2009)
Article
Biochemistry & Molecular Biology
Johannes M. Freudenberg, Swati Ghosh, Brad L. Lackford, Sailu Yellaboina, Xiaofeng Zheng, Ruifang Li, Suresh Cuddapah, Paul A. Wade, Guang Hu, Raja Jothi
NUCLEIC ACIDS RESEARCH
(2012)
Article
Multidisciplinary Sciences
Senthilkumar Cinghu, Sailu Yellaboina, Johannes M. Freudenberg, Swati Ghosh, Xiaofeng Zheng, Andrew J. Oldfield, Brad L. Lackford, Dmitri V. Zaykin, Guang Hu, Raja Jothi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Gastroenterology & Hepatology
Karim C. El Kasmi, Swati Ghosh, Aimee L. Anderson, Michael W. Devereaux, Natarajan Balasubramaniyan, Angelo D'Alessandro, David J. Orlicky, Frederick J. Suchy, Colin T. Shearn, Ronald J. Sokol
Summary: The use of FXR agonist can prevent PNAC in a mouse model by restoring hepatic FXR signaling, increasing the expression of canalicular bile and sterol and phospholipid transporters, and suppressing macrophage recruitment and activation.
Article
Gastroenterology & Hepatology
Swati Ghosh, Michael W. Devereaux, Aimee L. Anderson, Sarah Gehrke, Julie A. Reisz, Angelo D'Alessandro, David J. Orlicky, Mark Lovell, Karim C. El Kasmi, Colin T. Shearn, Ronald J. Sokol
Summary: This study has shown that LRH-1 plays a crucial role in PNAC pathogenesis, with IL-1β-deficient mice being protected from PNAC. NF-kappa B regulation of LRH-1 and downstream genes may impact the phytosterol-mediated antagonism of FXR signaling in PNAC development.
Article
Multidisciplinary Sciences
Jeong-Rang Jo, Seungwon An, Swati Ghosh, Balachandar Nedumaran, Yong Deuk Kim
Summary: This study investigated the link between GH and the BTG2-YY1 signaling pathway in glucose metabolism, showing that GH treatment elevated Btg2 and Yy1 expression in the liver, leading to increased glucose production. The findings suggest that BTG2 and YY1 are novel regulators of GH-dependent regulation of hepatic gluconeogenic genes and glucose production.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Swati Ghosh, Michael W. W. Devereaux, David J. J. Orlicky, Ronald J. J. Sokol
Summary: Prolonged parenteral nutrition (PN) can lead to PN associated cholestasis (PNAC) due to the activation of NF kappa B. In this study, researchers investigated the inhibition of HNF4 alpha as a potential treatment for PNAC. They found that HNF4 alpha antagonist BI6015 prevented liver damage and inflammation while promoting the expression of bile and sterol transporters. This suggests that HNF4 alpha antagonism could be a therapeutic target for PNAC.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Swati Ghosh, Michael W. Devereaux, Aimee L. Anderson, Karim C. El Kasmi, Ronald J. Sokol
Summary: The study showed that FXR activation through IL-6-STAT3 signaling in a PNAC mouse model alleviated cholestatic liver injury and prevented cholestasis.
HEPATOLOGY COMMUNICATIONS
(2023)
Correction
Multidisciplinary Sciences
Swati Ghosh, Michael W. W. Devereaux, David J. J. Orlicky, Ronald J. J. Sokol
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Jeong-Rang Jo, Sung-Eun Lee, Seungwon An, Balachandar Nedumaran, Swati Ghosh, Keun-Gyu Park, Yong Deuk Kim
Summary: The study reveals that CRBN and KLF15 are novel mediators of gluconeogenic signal-induced hepcidin gene expression and production, suggesting they might be new potential therapeutic targets to intervene metabolic dysfunction.