Article
Multidisciplinary Sciences
Kae M. Pusic, Richard P. Kraig, Aya D. Pusic
Summary: IFN gamma-DC-EVs, secreted from dendritic cells and containing miRNAs promoting myelination, show enhanced uptake by oligodendrocytes when delivered nasally in rats. Imaging studies revealed widespread distribution throughout the brain and cervical spinal cord post-nasal administration. The preferential targeting of the CNS and reduced accumulation in the liver indicate that intranasal delivery is an effective route for EV-based neurotherapeutics targeting oligodendrocytes.
Article
Pharmacology & Pharmacy
Hiba Natsheh, Elka Touitou
Summary: In this study, a phospholipid oily gel for nasal administration was designed and tested for its effectiveness in improving memory. The results showed significantly improved behavior in animals treated nasally, and enhanced delivery of fluorescent probes to the brain through nasal administration.
Article
Immunology
Emilie Jacque, Claire Chottin, Daphne Laubreton, Michel Nogre, Cecile Ferret, Sandrine de Marcos, Linda Baptista, Carole Drajac, Philippe Mondon, Christophe De Romeuf, Marie-Anne Rameix-Welti, Jean-Francois Eleouet, Sami Chtourou, Sabine Riffault, Gerald Perret, Delphyne Descamps
Summary: The article introduces a new type of anti-respiratory syncytial virus (RSV) immunoglobulin, manufactured through an innovative bioprocess, with high purity and concentration, and strong neutralizing effects on the virus. Experimental results show that low doses of hyper-enriched anti-RSV IgG can be administered locally to ensure rapid and efficient inhibition of virus infection, which may have promising applications in preventing and treating other infectious diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Tomoko Ishikura, Hideaki Shiga, Yuka Nakamura, Takako Kanitani, Yasuhito Ishigaki, Takaki Miwa
Summary: This study aimed to determine whether nasally administered murine adipose-derived stem cells (ADSCs) could support olfactory regeneration in vivo. The results showed that ADSCs can promote the repair of olfactory epithelium damage and enhance olfactory perception. This finding indicates that nasally administered ADSCs secreting neurotrophic factors can stimulate the regeneration of olfactory epithelium, thereby improving odor aversion behavior in vivo.
Article
Pharmacology & Pharmacy
Arzu Ari, James B. Fink
Summary: This study compared drug delivery efficiency between jet and mesh nebulizers during various modes of ventilation in acutely ill children, finding that mesh nebulizers delivered a greater amount of drug during mechanical ventilation and had up to 3-fold higher delivery efficiency compared to jet nebulizers.
Article
Engineering, Biomedical
Kathleen Marulanda, Alexandra Mercel, David C. Gillis, Kui Sun, Maria Gambarian, Joshua Roark, Jenna Weiss, Nick D. Tsihlis, Mark R. Karver, S. Ruben Centeno, Erica B. Peters, Tristan D. Clemons, Samuel I. Stupp, Sean E. McLean, Melina R. Kibbe
Summary: The study developed peptide amphiphile nanofibers that target lung tissue with pulmonary hypertension, demonstrating the potential of a RAGE-targeted nanomaterial as a drug delivery platform to treat the disease. The targeted nanofibers significantly accumulated in the lungs, showing specific localization to diseased pulmonary tissue and reduced off-target toxicity.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Polymer Science
Virali Arora, Mohammed A. S. Abourehab, Gyan Modi, Prashant Kesharwani
Summary: Dendrimers are synthetic nano-molecules with a spherical structure and a stardust topology. They are effective in solving the solubility problem in drug delivery and have been successfully used in chemotherapeutic drug delivery. Research has shown that dendrimers have potential in treating lung cancer and outperform other nanoparticles in terms of bioavailability and stability.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Xiyang Sun, Ye Xu, Qingkui Guo, Ning Wang, Bin Wu, Chen Zhu, Wen Zhao, Wenliang Qiang, Min Zheng
Summary: This study successfully constructed a targeted nanoprobe that can efficiently load the photosensitive drug ICG into lung cancer cells. The nanoprobe not only has excellent ICG loading and stability, but also improves the efficiency of thermal conversion and singlet oxygen generation, resulting in optimal photothermal/photodynamic therapy effects.
Article
Biochemistry & Molecular Biology
Minwook Shin, Io Long Chan, Yuming Cao, Alisha M. Gruntman, Jonathan Lee, Jacquelyn Sousa, Tomas C. Rodriguez, Dimas Echeverria, Gitali Devi, Alexandre J. Debacker, Michael P. Moazami, Pranathi Meda Krishnamurthy, Julia M. Rembetsy-Brown, Karen Kelly, Onur Yukselen, Elisa Donnard, Teagan J. Parsons, Anastasia Khvorova, Erik J. Sontheimer, Rene Maehr, Manuel Garber, Jonathan K. Watts
Summary: The study investigated the effectiveness of antisense oligonucleotides (ASOs) in different cell types of the lung using lineage markers, flow cytometry, and single-cell RNA sequencing. Fibroblasts were found to be the most susceptible to ASOs, with significant silencing also observed in endothelial cells.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Roshni Iyer, Harish Ramachandramoorthy, Trinh Nguyen, Cancan Xu, Huikang Fu, Tanviben Kotadia, Benjamin Chen, Yi Hong, Debabrata Saha, Kytai Truong Nguyen
Summary: Lung cancer is a major cause of cancer-related deaths worldwide. Conventional clinical therapies have limitations in treating lung cancer, but a new study has developed dual-stimuli nanoparticles that target cancer cells and release chemotherapy drugs and radiation sensitizer, potentially improving treatment efficacy and reducing side effects.
Article
Pharmacology & Pharmacy
Jinpeng Zheng, Caihong Lu, Meiyan Yang, Jiejie Sun, Jinbang Zhang, Yuanyuan Meng, Yuli Wang, Zhiping Li, Yang Yang, Wei Gong, Chunsheng Gao
Summary: This study demonstrates the outstanding advantages of erythrocyte-anchored CPA-CNPs in improving the pharmacokinetics and bioavailability of CPA, which offers great promise for a lung-targeted drug delivery system for the effective treatment of ALI.
Review
Pharmacology & Pharmacy
Rajeswari Raguraman, Santny Shanmugarama, Meghna Mehta, Jo Elle Peterson, Yan D. Zhao, Anupama Munshi, Rajagopal Ramesh
Summary: Lung cancer is often diagnosed at an advanced stage with limited treatment options. RNA binding proteins, particularly Human antigen R (HuR), have been identified as key players in tumorigenesis, including lung cancer. This review explores the role of HuR in lung cancer progression and highlights various approaches, such as small molecule inhibitors, siRNAs, and shRNAs, for inhibiting HuR expression and function. These approaches have shown promising results in reducing tumor growth, invasion, migration, angiogenesis, and metastasis. Nanomedicine-based HuR targeting approaches using siRNA and shRNA delivery hold immense potential for enhancing cancer therapies in lung cancer patients.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Cristina Fornaguera, Antoni Torres-Coll, Laura Olmo, Coral Garcia-Fernandez, Marta Guerra-Rebollo, Salvador Borros
Summary: Non-small cell lung cancer (NSCLC) is a leading cause of death worldwide, and current standard of care has limitations in terms of efficacy and safety. Targeted therapies that modify specific subcellular routes aberrantly expressed in tumor cells, such as siRNA delivery, could provide a promising solution. This study demonstrates that oligopeptide end-modified poly(beta aminoester) (OM-pBAE) polymers can efficiently encapsulate siRNA, protecting it from degradation and allowing for targeted delivery to tumor cells. These nanoparticles are stable in the presence of serum and have shown efficacy in inhibiting lung tumor cell growth both in vitro and in vivo. The addition of anisamide functionalization further enhances the selectivity of the nanoparticles to lung tumor cells. Overall, this research represents a significant step towards developing a targeted nanotherapy for improving survival in NSCLC patients.
Article
Engineering, Biomedical
Junmei Zhang, Bo Wang, Hui Wang, Zheng Wang, Pan Zhang, Xin Huang, Hongliang Qian, Dechun Huang, Wei Chen, Yinan Zhong
Summary: In this study, a reversibly double-locked hydroxycamptothecin (HCPT) prodrug nanoparticle was developed for safe and efficient chemotherapy of orthotopic lung cancer. The nanoparticle demonstrated high stability against dilution and acid-triggered drug release, leading to targeted tumor treatment.
ACTA BIOMATERIALIA
(2023)
Article
Oncology
Ruolan Liu, Qiong Li, Siyuan Qin, Ling Qiao, Mei Yang, Shanshan Liu, Edouard C. Nice, Wei Zhang, Canhua Huang, Shaojiang Zheng, Wei Gao
Summary: A drug-repurposed nanoplatform was prepared to enhance the anti-tumor efficiency against lung cancer. The nanoplatform improved the solubility and accumulation of sertaconazole in tumor cells. Mechanistically, the nanoplatform achieved excellent anti-tumor effects through ROS-mediated apoptosis and pro-apoptotic autophagy. Furthermore, it showed strong inhibitory ability in a xenograft lung cancer model without significant side effects.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Engineering, Chemical
Arun Kolanjiyil, Sana Hosseini, Ali Alfaifi, Dale Farkas, Ross Walenga, Andrew Babiskin, Michael Hindle, Laleh Golshahi, P. Worth Longest
Summary: A verified computational fluid dynamics (CFD) model was developed to simulate nasal spray deposition for different spray-pump designs, incorporating cloud motion effects. The accuracy of the CFD model was confirmed by comparing predictions with in vitro measurements, demonstrating the importance of two-way coupling for most nasal spray pumps.
AEROSOL SCIENCE AND TECHNOLOGY
(2022)
Article
Respiratory System
Connor Howe, Mohammad A. M. Momin, Karl Bass, Ghali Aladwani, Serena Bonasera, Michael Hindle, Philip Worth Longest
Summary: Modifications to the nasal interface of an infant air-jet DPI were found to improve aerosol delivery performance, particularly in preterm nasal-throat models. By using a rigid curved prong and adding a metal mesh to dissipate turbulent jet, lung delivery efficiency was increased while nasal-throat deposition was reduced. The platform performed similarly in two different preterm airway models, with no statistically significant difference observed in performance metrics.
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY
(2022)
Article
Chemistry, Multidisciplinary
Worth Longest, Amr Hassan, Dale Farkas, Michael Hindle
Summary: The study aimed to determine the best spray drying conditions for a tobramycin excipient enhanced growth (Tobi-EEG) formulation in a pediatric air-jet dry powder inhaler (DPI) through computational fluid dynamics (CFD) simulations and aerosol characterization experiments. The newly recommended spray dryer conditions improved delivery performance of the lead Tobi-EEG formulation in pediatric inhalers.
PHARMACEUTICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Karl Bass, Mohammad A. M. Momin, Connor Howe, Ghali Aladwani, Sarah Strickler, Arun Kolanjiyil, Michael Hindle, Robert M. DiBlasi, Worth Longest
Summary: The objective of this study was to investigate the effects of different nasal prong configurations on nostril deposition of pharmaceutical aerosols in preterm infants. The results showed that the use of nasal prongs significantly affected the deposition of aerosols in the infant nasal cavity, calling for design alterations to improve lung delivery efficiency.
Article
Pharmacology & Pharmacy
Ali Alfaifi, Sana Hosseini, Amir R. Esmaeili, Ross Walenga, Andrew Babiskin, Theodore Schuman, Worth Longest, Michael Hindle, Laleh Golshahi
Summary: This study developed a set of in vitro adult nasal geometries to improve the relationships between commonly conducted in vitro studies for locally-acting nasal spray drug products with in vivo regional deposition. By statistically analyzing and validating the performance of the models, this research aims to facilitate the development of locally-acting nasal sprays and provide a better understanding of how in vitro metrics relate to in vivo regional nasal deposition.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Dale Farkas, Morgan L. Thomas, Amr Hassan, Serena Bonasera, Michael Hindle, Worth Longest
Summary: This study evaluated the in vitro aerosol performance of a dry powder antibiotic product in pediatric subjects aged 2-10 years. The results showed that the product nearly eliminated extrathoracic depositional loss, demonstrated high efficiency nose-to-lung antibiotic aerosol delivery, and had little variability across subject age and administered air volume.
PHARMACEUTICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Connor Howe, Mohammad A. M. Momin, Ghali Aladwani, Michael Hindle, P. Worth Longest
Summary: The study successfully incorporated a passive cyclic loading strategy into the infant air-jet dry powder inhaler (DPI) platform and demonstrated high efficiency aerosol lung delivery under various conditions.
PHARMACEUTICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Benjamin M. M. Spence, Worth Longest, Rabijit Dutta, Mohammad A. M. Momin, Sarah Strickler, Michael Hindle
Summary: The objective of this study was to develop a new heated dryer system for efficient lung delivery of nebulized aerosol and demonstrate its performance through in vitro testing. The results showed that the system had high lung delivery efficiency and reduced drug loss.
Article
Pharmacology & Pharmacy
Rudra Pangeni, Tuo Meng, Sagun Poudel, Divya Sharma, Hallie Hutsell, Jonathan Ma, Bruce K. Rubin, Worth Longest, Michael Hindle, Qingguo Xu
Summary: Airway mucus is a complex gel that acts as a barrier against foreign pathogens and assists in their removal through mucociliary clearance. In respiratory diseases, changes in mucus properties lead to decreased pathogen capture and lung function decline. Designing aerosol delivery systems, such as muco-adhesive particles and muco-penetrating particles, can improve drug retention and absorption in the lungs. This review provides insight into airway mucus composition, rheological characteristics, techniques to study flow dynamics and particle diffusion, and advancements in engineering muco-penetrating particles.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Chemical
Sana Hosseini, Ali Alfaifi, Amir Reza Esmaeili, David Edwards, Theodore Schuman, Worth Longest, Michael Hindle, Laleh Golshahi
Summary: This study investigated the relationship between nasal anatomical characteristics and drug deposition. The results showed no clear correlation between nasal anatomical characteristics and drug deposition, but a combination of specific variables can predict the range of drug deposition.
JOURNAL OF AEROSOL SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Arun Kolanjiyil, Ross Walenga, Andrew Babiskin, Laleh Golshahi, Michael Hindle, Worth Longest
Summary: This study analyzed the effects of changes in spray cone angle, spray velocity, spray ovality, and droplet size distribution on regional nasal deposition using a computational fluid dynamics model. The results showed that spray cone angle had the greatest impact on nasal deposition, followed by plume ovality and characteristic droplet size. Spray velocity and droplet size distribution uniformity had only minimal influence. The study established quantitative relationships for predicting changes in nasal deposition.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Ghali Aladwani, Mohammad A. M. Momin, Benjamin Spence, Dale R. Farkas, Serena Bonasera, Amr Hassan, Michael Hindle, Worth Longest
Summary: The objective of this study was to investigate the spray performance of powders produced by different mesh nebulizers in the initial design of a new small-particle spray dryer system. Various mesh sources were used to spray dry an aqueous excipient enhanced growth (EEG) model formulation and the resulting powders were characterized. The medical-grade Aerogen Solo and Aerogen Pro mesh sources were selected as lead candidates for their superior aerosolization performance.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Medicine, Research & Experimental
Rudra Pangeni, Amr Ali Mohamed Hassan, Dale Farkas, Hadi Sudarjat, Worth Longest, Michael Hindle, Qingguo Xu
Summary: This study investigated the aerosol performance of a novel small animal air-jet dry powder insufflator (Rat AJ DPI) for delivering albuterol EEG aerosol to rat lungs. The Rat AJ DPI showed narrower aerosol size distribution profiles compared to the Penn-Century Insufflator. It also delivered significantly larger doses to rat lungs at a higher loaded mass and had a higher delivery efficiency compared to the manual actuation of the same dose.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Connor Howe, Mohammad A. M. Momin, Ghali Aladwani, Sarah Strickler, Michael Hindle, Worth Longest
Summary: This study focused on the development of an infant air-jet dry powder inhaler (DPI) that could be actuated multiple times with minimal user interaction. The metering system, consisting of a powder delivery tube (PDT) and a powder supporting shelf, could be tuned for individual powder formulations to maintain high efficiency lung delivery. The optimized infant air-jet DPI provided efficient and consistent lung delivery of aerosols based on in vitro testing.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Meeting Abstract
Respiratory System
Dale Farkas, Karl Bass, Serena Bonasera, Michael Hindle, P. Worth Longest
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY
(2021)