Article
Nutrition & Dietetics
Fan Gao, Fanfan Guo, Yidan Zhang, Yufei Yuan, Dunjin Chen, Guiqin Bai
Summary: This study proposed pregnancy-specific reference ranges for vitamins A, D, and E, and identified factors such as age, season, gestational trimester, and region influencing the levels of these vitamins during pregnancy. These findings are important for vitamin management during pregnancy and prevention of deficiencies.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Ishani Jhamb, Alyssa Freeman, Michelle R. Lotfi, Matthew VanOrmer, Corrine Hanson, Ann Anderson-Berry, Melissa Thoene
Summary: This study aimed to evaluate the concentrations of alpha- and gamma-tocopherol in placental tissue and assess their relationships with maternal and umbilical cord plasma concentrations. The results demonstrated significant positive correlations of gamma-tocopherol concentrations among all sample types. Placental tissue had significantly lower alpha:gamma-tocopherol concentration ratio compared to maternal and umbilical cord plasma.
Article
Nutrition & Dietetics
Jun S. Lai, Keith M. Godfrey, Choon Nam Ong, Kok Hian Tan, Fabian Yap, Yap Seng Chong, Jerry K. Y. Chan, Shiao-Yng Chan, Mary F. -F. Chong
Summary: This study examined the associations between perinatal plasma carotenoids and E vitamers concentrations and glycemia, insulin resistance, and gestational and type 2 diabetes mellitus in GUSTO women. The findings suggest that higher concentrations of alpha- and beta-carotene and lutein may be beneficial for gestational fasting glycemia, while higher concentrations of vitamin E may increase gestational and post-pregnancy glycemia.
Article
Cardiac & Cardiovascular Systems
Jun S. Lai, Wen Lun Yuan, Choon Nam Ong, Kok Hian Tan, Fabian Yap, Yap Seng Chong, Peter D. Gluckman, Keith M. Godfrey, Yung Seng Lee, Jerry K. Y. Chan, Shiao-Yng Chan, Mary F. F. Chong
Summary: The concentration of a-carotene, β-carotene, and lutein in the blood during pregnancy is closely related to blood pressure in late pregnancy and post-pregnancy.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Athira Anilkumar Sudharma, Sivaramakrishna Siginam, Gulam M. Husain, Surekha Venkata Mullapudi, Ayesha Ismail
Summary: Vitamin D deficiency leads to cardiac atrophy and dysfunction, characterized by cardiac arrhythmia, decreased heart weight, increased apoptosis, and interstitial fibrosis. It reduces protein synthesis and increases protein degradation through the activation of proteolytic systems while suppressing the mTOR pathway. This results in decreased expression of myosin heavy chain and troponin genes, as well as decreased activities of metabolic enzymes. The heart responds to VDD by activating all three proteolytic systems.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Nutrition & Dietetics
Huifeng Shi, Yuanhui Jiang, Pengbo Yuan, Lian Chen, Xiaoli Gong, Yike Yang, Yuanyuan Wang, Hai Jiang, You Li, Mengxing Sun, Yangyu Zhao, Yuan Wei
Summary: This study revealed a non-linear association between vitamin E concentrations in the first trimester and gestational vitamin E change with pre-eclampsia. The findings showed that vitamin E concentrations below 7.3 mg/L and gestational decrease were associated with increased risk of pre-eclampsia.
FRONTIERS IN NUTRITION
(2022)
Article
Cell Biology
Sina Vakili, Fatemeh Zal, Zohreh Mostafavi-pour, Amir Savardashtaki, Farhad Koohpeyma
Summary: The study demonstrated that quercetin and vitamin E could prevent osteoporosis by regulating the total number of bone cells, possibly through modulating autophagy and apoptosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Neurosciences
Jehoon Lee, Marcus R. Orzabal, Vishal D. Naik, Jayanth Ramadoss
Summary: Electronic cigarette (e-cig) use during pregnancy has raised concerns about its impact on fetal brain development. A study using a rat model found that gestational e-cig vaping with nicotine increased levels of P-mTOR and altered the expression of related proteins in the fetal hippocampus. These findings suggest that dysregulation of the mTOR system may play a critical role in the neurobiological effects of prenatal e-cig aerosols.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Oncology
Sijing Duan, Yong Jiang, Kai Mou, Yi Wang, Shanshan Zhou, Bingxin Sun
Summary: The study indicates that serum levels of vitamin A and vitamin E are negatively correlated with the occurrence and severity of preeclampsia. Older age, vitamin A deficiency, and vitamin E deficiency are identified as independent risk factors for preeclampsia.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Review
Oncology
Shujia Wang, Minghua Shi, Li Zhou, Hui Huang, Shien Mo
Summary: A meta-analysis and systematic review were conducted to investigate the relationship between maternal vitamin E levels during pregnancy and maternal and neo-natal health outcomes. The results showed that pregnant women with adverse pregnancy outcomes had lower levels of vitamin E compared to those with normal pregnancy outcomes. However, there is limited research on the correlation between vitamin E levels during pregnancy and maternal BMI and neonatal body length and weight, highlighting the need for large-scale and well-designed cohort studies for further analysis.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Mousa-al-Reza Hadjzadeh, Hadi Khodadadi, Farzaneh Sohrabi, Mahdiyeh Hedayati-Moghadam, Atieh Ghorbani, Sara Hosseinian
Summary: Portulaca oleracea has a positive effect on cardiac dysfunction caused by subclinical hyperthyroidism.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Pharmacology & Pharmacy
Bingqing Zhu, Qi Zhang, Liye Lu, Junjie Bao, Xiaoyi Rong, Jian-Rong Wang, Xuefeng Mei
Summary: This study introduces a more effective method to stabilize and solidify d-alpha-tocopherol oil through cocrystallization, increasing its stability and transforming it into solid form.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Nutrition & Dietetics
Jose Luis Mansur, Beatriz Oliveri, Evangelina Giacoia, David Fusaro, Pablo Rene Costanzo
Summary: Vitamin D deficiency in pregnancy and infants may lead to health issues such as rickets, preeclampsia, and fetal growth restriction; supplementation with Vitamin D can reduce the risk of complications for pregnant women, fetuses, and newborns.
Article
Virology
Seyit A. Erol, Atakan Tanacan, Ali T. Anuk, Eda O. Tokalioglu, Derya Biriken, Huseyin L. Keskin, Ozlem T. Moraloglu, Nuray Yazihan, Dilek Sahin
Summary: This study evaluated the levels of maternal serum afamin and vitamin E in pregnant women with COVID-19 and their association with composite adverse perinatal outcomes. The COVID-19 group had a higher obstetric complication rate, higher afamin levels, and lower vitamin E levels. The results suggest that higher afamin and lower vitamin E levels may be related to increased oxidative stress in COVID-19 pathogenesis and adverse perinatal outcomes.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Claire Stenhouse, Emma Hurst, Richard J. Mellanby, Cheryl J. Ashworth
Summary: Recent evidence suggests that vitamin D plays a crucial role in pregnancy, fetal growth, and development in various mammalian species. However, little is known about the changes in maternal vitamin D levels during pregnancy in pigs and its relationship with litter characteristics. This study examined the levels of 25(OH)D in maternal plasma at different gestational days and found a significant increase between days 18 and 30. The study also investigated the association between maternal vitamin D levels and various litter characteristics, such as gilt weight, ovulation rate, mean litter weight, number of live fetuses, prenatal survival rate, and sex ratio of the litter. The results showed that maternal 25(OH)D levels were positively associated with prenatal survival rate on day 60 and inversely associated with gilt weight on day 90. Maternal plasma 25(OH)D levels were also inversely associated with the percentage of male fetuses in the litter on day 90. This study provides valuable insights into the temporal changes in maternal vitamin D levels during pregnancy and its impact on economically important litter characteristics. Understanding the role of vitamin D in fetal growth during key developmental stages is vital for improving reproductive success in livestock species.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Alireza Shirpoor, Hanieh Barmaki, Mohamadhasan Khadem Ansari, BehrouzI Ikhanizadeh, Haleh Barmaki
BIOMEDICINE & PHARMACOTHERAPY
(2016)
Article
Cardiac & Cardiovascular Systems
Asghar Tofighi, Minoo Shirpoor, Mohammad Hasan Khadem Ansari, Alireza Shirpoor, Mitra Zerehpoosh
ANATOLIAN JOURNAL OF CARDIOLOGY
(2017)
Article
Medicine, Research & Experimental
Alireza Shirpoor, Elaheh Heshmati, Fatemeh Kheradmand, Farzaneh Hosseini Gharalari, Leila Chodari, Roya Naderi, Farideh Nezami Majd, Mahrokh Samadi
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Toxicology
Asghar Tofighi, Shima Ahmadi, Seyyedeh Masoumeh Seyyedi, Alireza Shirpoor, Fatemeh Kheradmand, Farzaneh Hosseini Gharalari
TOXICOLOGY LETTERS
(2018)
Meeting Abstract
Cardiac & Cardiovascular Systems
Alireza Shirpoor, Elaheh Heshmati, Mohammad Alizadeh
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Mona Niazi, Alireza Shirpoor, Ali Taghizadeh Afshari, Roya Naderi, Morteza Bagheri, Masoumeh Pourjabali, Yousef Rasmi
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2020)
Article
Medicine, Research & Experimental
Hassan Saberi, Behnaz Keshavarzi, Alireza Shirpoor, Farzaneh Hosseini Gharalari, Yousef Rasmi
BIOMEDICINE & PHARMACOTHERAPY
(2017)
Article
Genetics & Heredity
Alireza Shirpoor, Mitra Zerehpoosh, Mohammad Hasan Khadem Ansari, Fatemeh Kheradmand, Yousef Rasmi
Article
Cardiac & Cardiovascular Systems
Yousef Rasmi, Morteza Bagheri, Sanaz Faramarz-Gaznagh, Mohadeseh Nemati, Mohammad Hasan Khadem-Ansari, Ehsan Saboory, Mir Hossein Seyed-Mohamadzad, Alireza Shirpoor
ARYA ATHEROSCLEROSIS
(2017)
Article
Medicine, Research & Experimental
Gholam Hossein Farjah, Shadi Salehi, Mohammad Hasan Ansari, Bagher Pourheidar
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2017)
Article
Endocrinology & Metabolism
Yousef Rasmi, Kani Emamy-Nagadeh, Neda Valizadeh, Masoud Saleh-Mogadam, Alireza Shirpoor, Ehsan Saboory
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2016)
Article
Endocrinology & Metabolism
Somayeh Atari-Hajipirloo, Neda Valizadeh, Mohammad-Hassan Khadem-Ansari, Yousef Rasmi, Fatemeh Kheradmand
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2016)
Article
Biochemistry & Molecular Biology
Sanaz Faramarz-Gaznagh, Yousef Rasmi, Mohammad-Hasan Khadem-Ansari, Mir-Hossein Seyed-Mohammadzad, Morteza Bagheri, Mohadeseh Nemati, Alireza Shirpoor, Ehsan Saboori
JOURNAL OF MEDICAL BIOCHEMISTRY
(2016)
Article
Medicine, General & Internal
Mahrokh Samadi, Alireza Shirpoor, Ali Taghizadeh Afshari, Fatemeh Kheradmand, Yousef Rasmi, Maryam Sadeghzadeh
INTERVENTIONAL MEDICINE AND APPLIED SCIENCE
(2018)
Article
Medicine, Research & Experimental
Alireza Shirpoor, Farzaneh Hosseini Gharalari, Yousef Rasmi, Elaheh Heshmati
JOURNAL OF BIOMEDICAL RESEARCH
(2017)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)