Article
Dermatology
Katherine A. Whang, Thomas K. Le, Raveena Khanna, Kyle A. Williams, Youkyung Sophie Roh, Nishadh Sutaria, Justin Choi, Sylvie Gabriel, Rajeev Chavda, Yevgeniy Semenov, Shawn G. Kwatra
Summary: This study aimed to quantify the impact of prurigo nodularis (PN) on quality of life and its associated economic burden. The findings showed that PN patients had lower overall health performance compared to the controls, with pain being the most prominent domain. On average, each patient lost 6.5 quality-adjusted life years, resulting in an individual lifetime economic burden of $323,292 and a societal burden of $38.8 billion.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Review
Cell Biology
Kosha J. Mehta
Summary: Mesenchymal stem cells (MSCs) play a valuable role in cell-based therapy for various pathological conditions, but iron-loading can hinder their functionality and impact both allogeneic and autologous MSC therapy. Understanding MSC biology from an iron perspective is clinically significant, highlighting the importance of iron regulation for MSC physiology in health and disease.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Hematology
Maria Domenica Cappellini, Ali T. Taher, Antonio Piga, Farrukh Shah, Ersi Voskaridou, Vip Viprakasit, John B. Porter, Olivier Hermine, Ellis J. Neufeld, Alexis A. Thompson, Derek Tang, Aylin Yucel, Jennifer Lord-Bessen, Peiwen Yu, Shien Guo, Jeevan K. Shetty, Dimana Miteva, Tatiana Zinger, Jay T. Backstrom, Esther Natalie Oliva
Summary: This study evaluated the impact of luspatercept, a first-in-class erythroid maturation agent, versus placebo on the health-related quality of life (HRQoL) of patients with transfusion-dependent ss-thalassemia. The results showed that luspatercept reduced transfusion burden while maintaining patients' HRQoL.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Dermatology
Manuel P. Pereira, Alexandra Farcas, Claudia Zeidler, Sonja Staender
Summary: The study revealed that chronic pruritus of unknown origin tends to last long with high intensity and often accompanied by sensory abnormalities. Patients experience moderate impairment in quality of life, with some showing pathological anxiety and depression. Women tend to suffer more severely than men in terms of disease burden.
ACTA DERMATO-VENEREOLOGICA
(2021)
Article
Medicine, General & Internal
Claudia Zeidler, Manuel Pedro Pereira, Sonja Staender
Summary: Chronic prurigo is a severe skin disease characterized by chronic itch and scratching-related lesions, consisting of clinical phenotypes such as nodular, papular, plaque, umbilicated, and linear prurigo. Differences in age and duration of itch were found among the phenotypes, while itch intensity, sleep impairment, mood, and quality of life did not differ significantly. These findings suggest that the clinical phenotypes of chronic prurigo share similar disease characteristics and can be categorized under one disease umbrella term.
FRONTIERS IN MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Srinivas Abbina, Usama Abbasi, Arshdeep Gill, Heather Leitch, Jayachandran N. Kizhakkedathu
Summary: Liver dysfunction and failure are major causes of premature death in patients with iron-related pathologies. This study developed a new class of liver targeted nanochelators, which can rapidly reduce iron burden in patients with iron overload diseases, with favorable pharmacokinetics and biodistribution.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Health Care Sciences & Services
Teresa M. Wozniak, Amalie Dyda, Greg Merlo, Lisa Hall
Summary: This study estimated the health and economic impact of five hospital-associated AMR pathogens in Australia in 2020. It found that there were 1,031 AMR-associated deaths from these infections, with respiratory infections and bloodstream infections having the highest odds of dying and resulting in high hospital costs. The study highlights the need for country-level estimates of AMR impact to inform programs and policies to reduce morbidity and mortality.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
Article
Immunology
Zhuxin Mao, Xiao Li, Ana Dacosta-Urbieta, Marie-Noelle Billard, Joanne Wildenbeest, Koos Korsten, Federico Martinon-Torres, Terho Heikkinen, Steve Cunningham, Matthew D. Snape, Hannah Robinson, Andrew J. Pollard, Maarten Postma, Benoit Dervaux, Niel Hens, Louis Bont, Joke Bilcke, Philippe Beutels
Summary: The study aimed to evaluate the costs and health-related quality of life (HRQoL) effects associated with respiratory syncytial virus (RSV) infection in infants and their caregivers. The results showed that RSV infection resulted in significant cost burden and loss of HRQoL.
Article
Cardiac & Cardiovascular Systems
Alessia Pepe, Laura Pistoia, Maria Rita Gamberini, Liana Cuccia, Roberto Lisi, Valerio Cecinati, Aurelio Maggio, Francesco Sorrentino, Aldo Filosa, Rosamaria Rosso, Giuseppe Messina, Massimiliano Missere, Riccardo Righi, Stefania Renne, Antonino Vallone, Stefano Dalmiani, Vincenzo Positano, Massimo Midiri, Antonella Meloni
Summary: The tailored chelation therapy guided by MRI in the MIOT network has shown significant improvement in the prognosis of TM patients. Continuous monitoring of cardiac iron levels and personalized treatment can reduce cardiac burden, improve cardiac function, and reduce complications and death from heart failure related to myocardial iron overload.
EUROPEAN HEART JOURNAL
(2022)
Article
Surgery
Dexter Yak Seng Chan, Naren Kumar Surendra, Yi Zhen Ng, Sze-Han Lee, Enming Yong, Qiantai Hong, Cheng Cheng Goh, Tina Peiting Lai, Audrey Hui Min Tan, Chelsea Chiew Chie Law, Shanying Liang, Josip Car, Zhiwen Joseph Lo
Summary: This study aims to evaluate the clinical and economic burden of venous leg ulcers (VLUs) in an Asian population. The findings suggest that VLUs have a significant impact on patients and incur high treatment costs, but successful healing can improve patients' quality of life. These results provide important insights for economic evaluations of VLU treatments.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2023)
Article
Medicine, General & Internal
Doris Sau-Fung Yu, Polly Wai-Chi Li, Shirley Xue Li, Robert D. Smith, Sunny Chiu-Sun Yue, Bryan P. Y. Yan
Summary: This randomized clinical trial demonstrates that an empowerment-based self-care education program can significantly improve self-care and symptom perception in patients with heart failure. It also reduces the risk of emergency department visits and hospital admissions. The program also shows positive effects on improving patients' knowledge and confidence and is cost-effective.
Review
Behavioral Sciences
Joseph Sullivan, Alison M. Deighton, Maria Candida Vila, Shelagh M. Szabo, Benit Maru, Jacqueline S. Gofshteyn, Emma S. James, Salvador Rico, Sameer M. Zuberi
Summary: Dravet syndrome is a developmental and epileptic encephalopathy characterized by a changing disease course as individuals age. There is a lack of comprehensive systematic review of the contemporary literature on DS, but available evidence indicates that it is not limited to seizures; non-seizure manifestations appear early in life and increase over time, significantly contributing to the burden of the disease on individuals, families, and healthcare systems. The HRQoL in DS is primarily affected by seizure severity, cognition, and motor and behavioral problems.
EPILEPSY & BEHAVIOR
(2022)
Article
Immunology
Zhuxin Mao, Xiao Li, Koos Korsten, Louis Bont, Christopher Butler, Joanne Wildenbeest, Samuel Coenen, Niel Hens, Joke Bilcke, Philippe Beutels
Summary: The study aimed to estimate the average costs and health-related quality of life (HRQoL) in older adults with respiratory syncytial virus (RSV) and influenza infection. The results showed that the direct costs per nonhospitalized RSV episode were estimated to be 26.4 euros, with indirect costs of 4.4 euros. For nonhospitalized influenza episodes, the direct costs were estimated to be 42.5 euros, with indirect costs of 32.1 euros. The study also found a decrease in HRQoL during RSV and influenza infections.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Computer Science, Information Systems
Euripidis Loukis, Spyros Arvanitis, Dennis Myrtidis
Summary: The Greek banks initially responded to the economic crisis by reducing ICT-related expenses, but later proceeded to substantial rationalization and improvement of their ICT processes/practices, as well as adaptation of their ICT plans to crisis conditions.
INFORMATION SYSTEMS MANAGEMENT
(2021)
Review
Public, Environmental & Occupational Health
Huimin Zou, Meng Li, Qing Lei, Zejun Luo, Yan Xue, Dongning Yao, Yunfeng Lai, Carolina Oi Lam Ung, Hao Hu
Summary: Hepatocellular carcinoma (HCC) in greater China has significant economic and quality of life burden on patients. Studies have shown that HCC causes major economic impact on patients and their families, as well as negative effects on patients' quality of life.
FRONTIERS IN PUBLIC HEALTH
(2022)